Article
Chemistry, Analytical
William Romine, Noah Schroeder, Tanvi Banerjee, Josephine Graft
Summary: The use of wearable sensors to monitor mental effort shows potential in improving productivity for work and study. By analyzing electrodermal activity (EDA) data, this study found that features related to signal intensity and peak intensity were effective in predicting self-reported mental effort. The findings suggest that EDA may be a promising physiological indicator for sensor-based self-monitoring of mental effort throughout the day.
Article
Engineering, Electrical & Electronic
Massimo Donelli, Giuseppe Espa, Paola Feraco, Mohammedhusen Manekiya
Summary: This research introduces a wearable system for non-invasive measurement of blood glucose levels by correlating blood glucose variations with skin resistance. The system is useful for monitoring blood glucose levels in diabetic patients and conducting OGTT tests for early diagnosis of diabetes. Promising preliminary results show the device's potential as a diagnostic and home care tool.
ELECTRONICS LETTERS
(2021)
Article
Biophysics
Xin Li, Jingying Pan, Yue Wu, Huan Xing, Zijian An, Zhenghan Shi, Jingjiang Lv, Fenni Zhang, Jing Jiang, Di Wang, Ray P. S. Han, Bin Su, Yanli Lu, Qingjun Liu
Summary: A wireless facemask based on Ti3C2Tx MXene is developed for the noninvasive monitoring of breath acetone (BrAC) and real-time tracking of lipid metabolism. The facemask can not only detect acetone but also filter out breath interference. It is integrated with a miniaturized flexible detection tag for easy BrAC detection and wireless data transmission. The system enables detection of BrAC down to 0.31 ppm in breath.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Shubham Patel, Faheem Ershad, Jimmy Lee, Lourdes Chacon-Alberty, Yifan Wang, Marco A. Morales-Garza, Arturo Haces-Garcia, Seonmin Jang, Lei Gonzalez, Luis Contreras, Aman Agarwal, Zhoulyu Rao, Grace Liu, Igor R. Efimov, Yu Shrike Zhang, Min Zhao, Roslyn Rivkah Isseroff, Alamgir Karim, Abdelmotagaly Elgalad, Weihang Zhu, Xiaoyang Wu, Cunjiang Yu
Summary: This article presents a novel, fully biocompatible electronics fabricated on the skin for multiple cell types and tissues, which can capture electrophysiological signals with high fidelity and has improved mechanical and electrical properties. The drawn-on-skin ink shows excellent biocompatibility and holds potential for personalized, long-term, and accurate electrophysiological health monitoring.
Article
Computer Science, Hardware & Architecture
Wei Zhang, Jie Li, Yonggang Wen, Yong Luo
Summary: This research utilizes wearable devices to develop a system for monitoring respiratory symptoms, with a focus on improving cough detection accuracy through machine learning algorithms. The study has the potential to transform the future implementation of pandemic early warning and response to public health crises.
Review
Multidisciplinary Sciences
Junbo Zhu, Jingchen Tao, Wei Yan, Weixing Song
Summary: Wearable hydrogel sensors offer a user-friendly option for wearable electronics and align well with the manufacturing strategy for Internet of Things devices. This review focuses on the structural elements of wearable hydrogels, highlighting strategies for enhancing mechanical and electrical properties. It categorizes wearable hydrogel sensors for an extensive exploration of their composition, mechanism, and design approach. The review provides a comprehensive understanding of wearable hydrogels and offers guidance for high-performance sensor design.
NATIONAL SCIENCE REVIEW
(2023)
Article
Nanoscience & Nanotechnology
Linkai Lan, Feng Li, Wen Li, Rui Chen, Zhuang Xiong, Yongjie He, Nabonswende Aida Nadege Ouedraogo, Bin Ai, Luqi Tao, Kuan Sun, Shanshan Chen
Summary: This study demonstrates a strategy to regulate the blend of polymeric electrodes by embedding a double network, achieving both biocompatibility and high conductivity. The optimal polymeric electrode shows high-quality electromyogram and electrocardiogram signals.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Yuyao Lu, Yusuke Fujita, Satoko Honda, Shin-Hsin Yang, Yan Xuan, Kaichen Xu, Takayuki Arie, Seiji Akita, Kuniharu Takei
Summary: This study investigated the thermoregulatory responses of different individuals under cold stimulation and exercise by measuring temperature and moisture variations on the finger skin using a wireless and flexible sensor sheet. The results showed distinct thermoregulation abilities among the volunteers, with a sudden increase in finger moisture observed during the cold-stimulus test caused by excitation of the sympathetic nerve. Further research is needed to predict potential diseases resulting from thermoregulation disorders, but this study presents the possibility of continuous and real-time monitoring of thermoregulatory activities through skin moisture and temperature detection using a flexible sensor sheet.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Cardiac & Cardiovascular Systems
Antonella Groppelli, Martina Rafanelli, Giuseppe Dario Testa, Samuele Agusto, Giulia Rivasi, Andrea Ungar, Erika Carbone, Davide Soranna, Antonella Zambon, Michele Brignole, Gianfranco Parati
Summary: This study assessed the feasibility and accuracy of a new wearable watch-type blood pressure monitor in detecting hypotensive syncope induced by tilt table test. The results showed that the device was able to detect low blood pressure and its measurements of blood pressure changes were consistent with continuous blood pressure monitoring.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Chemistry, Analytical
Pin-Wei Chen, Megan K. O'Brien, Adam P. Horin, Lori L. McGee Koch, Jong Yoon Lee, Shuai Xu, Phyllis C. Zee, Vineet M. Arora, Arun Jayaraman
Summary: Sleep plays a critical role in stroke recovery, but measuring sleep quality for stroke patients is challenging. This study investigated the feasibility of using wireless sensors to collect biophysical data during sleep and developed machine-learned algorithms to detect sleep stages.
Article
Chemistry, Analytical
Yiping Huang, Yatong Song, Li Gou, Yuanwen Zou
Summary: Wearable flexible silver electrodes based on cowhide were prepared and tested for their waveform transmission and impedance. The results showed that these electrodes were comparable to standard gel electrodes when the skin is moist enough, and had higher signal-to-noise ratios than the standard electrodes in the standing posture.
Article
Nanoscience & Nanotechnology
Yapeng Shi, Xuelian Wei, Kaimeng Wang, Dongdong He, Zhihao Yuan, Jiahui Xu, Zhiyi Wu, Zhong Lin Wang
Summary: This study presents a novel wearable electronic skin based on a triboelectric nanogenerator, which is flexible, breathable, and antibacterial, demonstrating excellent performance in volleyball reception statistics and analytics, and self-powered sensing capabilities.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Cell Biology
Ying Lyu, Yejing Ge
Summary: Skin, the largest organ in the human body, undergoes aging processes such as wrinkling and hair graying, which are associated with epigenetic and metabolic deregulations. In the skin epithelium, the epigenome and metabolome play important roles in shaping cell lineage plasticity and regulating stem cell function during aging. This review summarizes recent studies on the molecular mechanisms of hair follicle degeneration, comparing findings from skin with model organisms and adult stem cells from other tissues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Sakiko Fukui, Kasumi Ikuta, Isseki Maeda, Satoshi Hattori, Yutaka Hatano, Miyae Yamakawa, Momoe Utsumi, Yoko Higami, Haruka Tanaka, Akari Higuchi
Summary: By monitoring respiratory and heart rate values, the study found a significant association between maximum respiratory rate and mean heart rate values and death occurring within the following 3 days. These results can help alert family caregivers and care staff when patients are dying at home or in other facilities.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Agriculture, Dairy & Animal Science
Stephanie Buijs, Jennifer Weller, Alexandre Budan
Summary: Wearable technology is increasingly being used in dairy research and commercial farming, but its effects on cows are not well understood. This study assessed the effects of a head/neck mounted wearable on dairy cow behavior, health, and productivity. The wearable had significant effects on bald spots, social grooming, drinking time, milk yield, and lactose content. Some effects were minor or short-lived, while others persisted or increased throughout the 3-week deployment period.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Byeongwook Jo, Yuya Morimoto, Shoji Takeuchi
Summary: Interest in skeletal muscle tissue has grown due to its unique ability to control body movements. Recent research in engineered skeletal muscle tissue has expanded its potential applications in nonclinical models. However, limitations in satisfying in vivo-like position and proportion of intermuscular fat have led to the proposal of a fabrication method for cocultured tissue composed of both skeletal muscle and adipose tissues.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Biochemical Research Methods
Kazuto Ogishi, Toshihisa Osaki, Yuya Morimoto, Shoji Takeuchi
Summary: This paper verifies the feasibility of single-step and monolithic fabrication of 3D structural lipid bilayer devices using stereolithography, and explores the key factors for successful formation of lipid bilayers. The study shows that devices fabricated by stereolithography have comparable measurement performances to those fabricated by conventional procedures, and demonstrates the extendibility of the technology.
Article
Engineering, Biomedical
Byeongwook Jo, Yuya Morimoto, Shoji Takeuchi
Summary: This study presents a 3D-printed centrifugal pump driven by magnetic force for microfluidics and biological analysis. The pump has a compact size and contactless driving part, making it suitable for conventional experimental setups. It is demonstrated that this device has a high potential for applications in microfluidic devices and perfusion culture of cells.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Ayano Minami, Peidong Hu, Yuki Sada, Hiroki Yamada, Koji Ohara, Yasuo Yonezawa, Yukichi Sasaki, Yutaka Yanaba, Masanori Takemoto, Yuki Yoshida, Tatsuya Okubo, Toru Wakihara
Summary: This study investigates the amorphous-to-crystalline transformation of SSZ-13 zeolite during hydrothermal synthesis using in situ high-energy X-ray total scattering measurement. The results show that ordered four-membered rings dominate the induction period, while six- and eight-membered rings increase significantly during the crystal growth stage. These preformed ordered rings contribute to the formation of composite building units containing six- and eight-membered rings, facilitating the construction and growth of zeolite crystals.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biotechnology & Applied Microbiology
Satoshi Inagaki, Yuya Morimoto, Ikuo K. Suzuki, Kazuo Emoto, Shoji Takeuchi
Summary: This study presents a co-culture system of human skin equivalents (HSEs) and dorsal root ganglion (DRG) neurons. Spheroids of mouse DRG neurons with or without Schwann cells (SCs) were prepared. Spheroids with DRG neurons and SCs exhibited longer neurite extensions compared to those with DRG neurons alone. Neurite extension of more than 1 mm was observed from spheroids cultured inside HSEs, while neurite extension was primarily observed on the surface of HSEs from spheroids cultured on HSEs. This model may be a useful tool for studying neurite extension in human skin.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2023)
Article
Engineering, Biomedical
Minghao Nie, Shogo Nagata, Haruka Oda, Shoji Takeuchi
Summary: In this study, a microfluidic bioprinting method was developed to fabricate three-dimensional tissue constructs consisting of core-shell microfibers, which enabled the encapsulation of cells and extracellular matrices. The optimized printhead design and printing parameters allowed for the printing of core-shell microfibers into macroscale constructs with high cell viability. Analysis of the tissues cultured using dynamic culture methods showed the establishment of intensive cell-cell contacts in the fiber cores, leading to enhanced albumin secretion function compared to 2D cultured cells. The densely cellularized tissues formed in the fiber cores had similar cell density to in-vivo solid organ tissues. Future improvements in culture techniques are expected to enable the fabrication of thicker tissues for applications in tissue modeling and cell therapy.
Article
Biophysics
Kazuto Ogishi, Toshihisa Osaki, Hisatoshi Mimura, Izumi Hashimoto, Yuya Morimoto, Norihisa Miki, Shoji Takeuchi
Summary: This paper presents a novel signal processing method for real-time and quantitative characterization of ion channel activities on a lipid bilayer system. The characterization of ion channel activities has traditionally relied on time-consuming analyses after recording, posing a challenge in incorporating the system into practical applications. The proposed system divides the ion channel signal into short segments for processing during the recording, allowing for real-time characterization and response.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Biomedical
Kazuma Morita, Yuya Morimoto, Shoji Takeuchi
Summary: Biohybrid robots composed of both biological and artificial materials can exhibit unique characteristics of living organisms. To enable multiple degrees of freedom (DOFs), we propose a biohybrid actuator with a tensegrity structure that arranges multiple muscle tissues in a 3D configuration. By using muscle tissues as tension members, the actuator can tilt in multiple directions through muscle contractions. The actuator also demonstrates stability and robustness, providing a platform for the development of muscle-driven biohybrid robots with complex and flexible movements.
Article
Chemistry, Analytical
Hisatoshi Mimura, Toshihisa Osaki, Sho Takamori, Kenji Nakao, Shoji Takeuchi
Summary: This study proposes a device for repeated measurements of ion channels incorporated into individually arrayed lipid bilayers, overcoming the limitations of existing parallelized approaches. By optimizing the surface properties and clearance of a wiping blade module, the device achieves repeated bilayer formation and a 5-fold improvement in data throughput during ion channel activity measurements. The practical utility of the device is validated by evaluating the effects of an ion channel inhibitor. This device opens new avenues for high-throughput analysis and screening of ion channels, leading to significant advancements in drug discovery and functional studies of membrane proteins.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Koji Sakai, Shigenori Miura, Tetsuhiko F. Teshima, Toichiro Goto, Shoji Takeuchi, Masumi Yamaguchi
Summary: Researchers have developed a 3D culture model of small vascular tissue using a self-folding graphene-based porous film. This model replicates the structural features of a small artery and can help in understanding intercellular communications in physiological and pathological conditions.
NANOSCALE HORIZONS
(2023)
Article
Chemistry, Physical
Koji Sakai, Shigenori Miura, Tetsuhiko F. Teshima, Toichiro Goto, Shoji Takeuchi, Masumi Yamaguchi
Summary: In this study, we developed a three-dimensional culture model of small vascular tissue using a self-folding graphene-based porous film. This model successfully recapitulates the structural features of a small artery and provides insights into intercellular communications at the artery wall under physiological and pathological conditions.
NANOSCALE HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Sho Takamori, Pietro Cicuta, Shoji Takeuchi, Lorenzo Di Michele
Summary: DNA-assisted selective electrofusion (DASE) utilizes membrane-anchored DNA constructs to bring together objects for fusion, and an electric impulse is applied to trigger fusion, combining the efficiency of standard electrofusion and the selectivity of fusogenic nanostructures.
Article
Materials Science, Multidisciplinary
Michio Kawai, Minghao Nie, Haruka Oda, Yuya Morimoto, Shoji Takeuchi
Summary: This research proposes using skin equivalent as a coverage material for robots to achieve more harmonious and natural human-robot interactions. By replicating human appearance and self-healing ability, the researchers created a three-joint robotic finger covered with skin equivalent and demonstrated wound repair using grafted collagen sheet. The results indicate the potential of using skin equivalent as a human-like and self-healing coverage material for robots.
Article
Materials Science, Multidisciplinary
Masanori Takemoto, Kenta Iyoki, Yuki Otsuka, Hiroaki Onozuka, Anand Chokkalingam, Toshiyuki Yokoi, Susumu Tsutsuminai, Takahiko Takewaki, Toru Wakahira, Tatsuya Okubo
Summary: This study demonstrates the remarkably prolonged lifetime of a CON-type zeolite in methanol-to-olefins reaction via a multistep strategy including post-milling recrystallisation and liquid-mediated healing of residual defects. The defect-healed zeolite nanoparticles showed a lifetime more than twice that of the parent zeolite owing to the increased external surface area and the reduced subnano-scale defects. This protocol could play a significant role in designing robust catalysts with controlled particle sizes and reduced subnano-scale defects.
MATERIALS ADVANCES
(2022)
Article
Materials Science, Ceramics
Kenta Iyoki, Takako Onishi, Mariko Ando, Sohei Sukenaga, Hiroyuki Shibata, Tatsuya Okubo, Toru Wakihara
Summary: When zeolites are synthesized in fluoride-containing media, large crystals tend to be obtained. In this research, a multi-stage synthesis strategy for size reduction of silicalite-1 in fluoride-containing media is presented. Increasing the number of effective nuclei is crucial for size reduction.
JOURNAL OF THE CERAMIC SOCIETY OF JAPAN
(2022)
