Review
Biochemistry & Molecular Biology
Antonino B. D'Assoro, Roberto Leon-Ferre, Eike-Benjamin Braune, Urban Lendahl
Summary: The Notch signaling pathway is important for normal development, but dysregulation of this pathway is associated with various types of tumors. In addition to its role in tumor cells, Notch signaling also affects non-mutated cells in the tumor microenvironment and their interactions with tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Yawen Liu, Anke Vandekeere, Min Xu, Sarah-Maria Fendt, Patricia Altea-Manzano
Summary: Malignant growth is characterized by aberrant cellular features, including metabolic rewiring, inactivation of tumor suppressors and activation of oncogenes which have mutual regulatory relationships. Changes in gene expression/activity impact cellular metabolism and protein modifications, highlighting the importance of understanding the crosstalk between tumor suppressors/oncogenes and metabolism-induced alterations.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ihor Arkhypov, Feyza Gul Ozbay Kurt, Rebekka Bitsch, Daniel Novak, Vera Petrova, Samantha Lasser, Thomas Hielscher, Christopher Groth, Alisa Lepper, Xiaoying Hu, Wei Li, Jochen Utikal, Peter Altevogt, Viktor Umansky
Summary: Soluble HSP90 alpha can convert monocytes into MDSC, which inhibits the antitumor function of T and NK cells. Higher levels of HSP90 alpha in plasma of patients with melanoma are associated with increased PD-L1 expression on MDSC and shorter PFS after ICI therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Endocrinology & Metabolism
Armel H. H. Nwabo Kamdje, Paul F. Seke Etet, Maulilio J. Kipanyula, Lorella Vecchio, Richard Tagne Simo, Alfred K. Njamnshi, Kiven E. Lukong, Patrice N. Mimche
Summary: The tumor microenvironment plays a role in tumorigenesis and drug resistance through the overexpression of insulin-like growth factor 1 (IGF-1). Anti-IGF therapies have shown potential in inhibiting cancer and overcoming chemotherapy drug resistance in preclinical studies, but toxicity and resistance are challenges in clinical trials.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Youxi Yu, Xiaoju Shi, Qianqian Zheng, Xingtong Wang, Xingkai Liu, Min Tan, Guoyue Lv, Ping Zhang, Robert C. Martin, Yan Li
Summary: The study found that increased FGF15 in NASH-FGF21KO mice could not substitute for FGF21 to prevent NASH development. Up-regulated FGFR4 signaling in NASH-FGF21KO mice was associated with proliferation and epithelial-mesenchymal transition events, which are commonly linked to carcinogenic transformation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ruiwen Ruan, Li Li, Xuan Li, Chunye Huang, Zhanmin Zhang, Hongguang Zhong, Shaocheng Zeng, Qianqian Shi, Yang Xia, Qinru Zeng, Qin Wen, Jingyi Chen, Xiaofeng Dai, Jianping Xiong, Xiaojun Xiang, Wan Lei, Jun Deng
Summary: FGF/FGFR signaling is important in cell fate and angiogenesis, and its dysregulation can drive tumorigenesis. Combining FGFR inhibitors with immune checkpoint blockade may be a promising treatment option for patients with dysregulated FGF/FGFR signaling.
Review
Medicine, Research & Experimental
Maura Lima Pereira Bueno, Sara Teresinha Olalla Saad, Fernanda Marconi Roversi
Summary: The investigation of tumor microenvironment is crucial for cancer diagnosis, prognosis, and treatment. WNT5A plays a critical role in tumorigenesis by regulating multiple signaling pathways and affecting cell growth, migration, and invasiveness.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Ningning Zhu, Yueyang Yang, Haitong Wang, Peng Tang, Hongdian Zhang, Haiyan Sun, Lei Gong, Zhentao Yu
Summary: CSF2RB has been found to play an important role in the tumor microenvironment of LUAD. It is expressed at a lower level in tumor tissues compared to normal tissues. Low expression of CSF2RB is associated with poor survival and is an independent risk factor for prognosis in LUAD patients, regardless of chemotherapy or radiotherapy. High expression of CSF2RB is associated with early T, N, and clinical stages. CSF2RB is involved in various immune-related pathways and correlates positively with infiltrating CD4+ T cells, macrophages, NK cells, and monocytes in LUAD. The study suggests that CSF2RB could be a potential target for cancer treatment and has prognostic value in LUAD patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Jennifer Patritti Cram, Jianqiang Wu, Robert A. Coover, Tilat A. Rizvi, Katherine E. Chaney, Ramya Ravindran, Jose A. Cancelas, Robert J. Spinner, Nancy Ratner
Summary: This study identifies P2ry14 as a critical regulator of neurofibroma by increasing cAMP through the G(i) signaling pathway and affecting self-renewal and proliferation of neurofibroma-related cells.
Article
Oncology
Maxine Umeh-Garcia, Henriette O'Geen, Catalina Simion, Melanie Hayden Gephart, David J. Segal, Colleen A. Sweeney
Summary: This study reveals the association between DNA methylation and the silencing of the LRIG1 gene in basal/triple-negative breast cancer. The global demethylating agent 5-aza-2'-deoxycytidine decreases methylation and increases LRIG1 expression. Targeted demethylation and transcriptional activation using CRISPR/deadCas9 technology significantly enhances LRIG1 expression and reduces cancer cell viability.
BRITISH JOURNAL OF CANCER
(2022)
Article
Cell Biology
Ziqian Yan, Zhimei Sheng, Yuanhang Zheng, Ruijun Feng, Qinpei Xiao, Lihong Shi, Hongli Li, Chonggao Yin, Hao Luo, Chong Hao, Wenhao Wang, Baogang Zhang
Summary: Studies compared the effects of CAFs-derived exosomes and NFs-derived exosomes on breast cancer cells, finding that CAFs-derived exosomes had a stronger enhancing effect on migration and invasion.
CELL DEATH & DISEASE
(2021)
Article
Biology
Marion Rosello, Juliette Vougny, Francois Czarny, Marina C. Mione, Jean-Paul Concordet, Shahad Albadri, Filippo Del Bene
Summary: Researchers have successfully generated precise point mutations in zebrafish models using gene editing technology, mimicking oncogenic mutations in human genes and creating new disease models.
Article
Biology
Xin Zhou, Jennifer W. Li, Zirong Chen, Wei Ni, Xuehui Li, Rongqiang Yang, Huangxuan Shen, Jian Liu, Francesco J. DeMayo, Jianrong Lu, Frederic J. Kaye, Lizi Wu
Summary: This study reveals the overlap in expression patterns and potential functional redundancy of CRTC1-3 in lung cancer. A dominant-negative mutant (dnCRTC) was designed and shown to efficiently inhibit aberrant oncogenic transcription induced by LKB1 deficiency, specifically blocking the growth of LKB1-inactivated lung cancer. These findings provide direct evidence for the essential role of the CRTC-CREB activation in promoting the malignant phenotypes of LKB1-null lung cancer, suggesting a novel therapeutic target.
Article
Oncology
Naizhi Sun, Jiacheng Shen, Yuhua Shi, Biao Liu, Shengguo Gao, Yichuan Chen, Jinwei Sun
Summary: This study aimed to investigate the molecular mechanisms of TRIM58 in colorectal cancer (CRC) development. TRIM58 is an E3 ubiquitin ligase and a potential prognostic marker for cancer. The study found that TRIM58 acts as a tumor suppressor in CRC by promoting RECQL4 ubiquitination and inhibiting the AKT signaling pathway, suggesting it could be a potential target for CRC treatment.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Xiuhui Shi, Min Wang, Yuqing Zhang, Xingjun Guo, Mingyang Liu, Zhijun Zhou, Yan Zhao, Ruizhi He, Yang Gao, Yuhui Liu, Shutao Pan, Min Zhou, Chunle Zhao, Taoyuan Yin, Xu Li, Hebin Wang, Jingxuan Yang, Feng Zhu, Min Li, Renyi Qin
Summary: High expression levels of alpha-SMA and hypoxia markers are associated with poor prognosis in pancreatic cancer patients. Mechanistically, hypoxia induces HGF expression and secretion in PSC via HIF-1 alpha, which then activates Met and suppresses pancreatic cancer cell sensitivity to EGFR inhibitors. The combination of EGFR inhibitor and Met inhibitor shows promise for pancreatic cancer treatment based on the demonstrated signaling axis between PSC and cancer cells.
Review
Oncology
Nicole M. Brossier, David H. Gutmann
EXPERT REVIEW OF ANTICANCER THERAPY
(2015)
Article
Clinical Neurology
Nicole M. Brossier, Amanda M. Prechtl, Jody Fromm Longo, Stephen Barnes, Landon S. Wilson, Stephanie J. Byer, Stephanie N. Brosius, Steven L. Carroll
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2015)
Article
Clinical Neurology
Stephanie N. Brosius, Amy N. Turk, Stephanie J. Byer, Nicole M. Brossier, Latika Kohli, Amber Whitmire, Fady M. Mikhail, Kevin A. Roth, Steven L. Carroll
ACTA NEUROPATHOLOGICA
(2014)
Article
Cell Biology
Jody Fromm Longo, Stephanie N. Brosius, Laurel Black, Stuart H. Worley, Robert C. Wilson, Kevin A. Roth, Steven L. Carroll
CELL COMMUNICATION AND SIGNALING
(2019)
Article
Oncology
Nicole M. Brossier, Sharanya Thondapu, Olivia M. Cobb, Sonika Dahiya, David H. Gutmann
Summary: The study identified three factors that may contribute to the temporal patterning and penetrance of NF1 optic glioma: different populations of TVZ NPCs, decreased NPC proliferation after birth, and differential impact of germline Nf1 mutations on TVZ NPC expansion during embryogenesis.
Review
Pathology
Shannon M. Weber, Steven L. Carroll
Summary: The R-Ras subfamily, including R-Ras, R-Ras2/TC21, and M-Ras, has been found to be occasionally mutated in diseases like Noonan syndrome, leading to physiological and pathological changes in cellular morphology, adhesion, and migration, particularly in the cardiovascular, immune, and nervous systems. Dysregulated R-Ras signaling is also implicated in the pathogenesis of cardiovascular disease, intellectual disabilities, and human cancers.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Cell Biology
Shannon M. Weber, Nicole M. Brossier, Amanda Prechtl, Stephen Barnes, Landon S. Wilson, Stephanie N. Brosius, Jody Fromm Longo, Steven L. Carroll
Summary: Loss of the neurofibromin protein in patients with neurofibromatosis type 1 can lead to activation of multiple Ras proteins, promoting tumor formation. While classic Ras proteins drive proliferation and survival in MPNST cells, they do not affect migration. R-Ras proteins, on the other hand, regulate distinct signaling pathways that promote tumorigenesis by mediating migration and invasion in MPNST cells.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biotechnology & Applied Microbiology
Pengfei Li, Yan Wu, Eric D. Hamlett, Andrew J. Goodwin, Perry Halushka, Steven L. Carroll, Meng Liu, Hongkuan Fan
Summary: The transcription factor Fli-1 plays a role in the loss of pericytes, inflammatory response, AD deposition, vascular dysfunction, and cognitive decline in AD. Inhibition of Fli-1 may represent a novel therapeutic strategy for AD.
Article
Clinical Neurology
Evan Cantor, Ashley Meyer, Stephanie M. Morris, Judith L. Z. Weisenberg, Nicole M. Brossier
Summary: In a patient with NF1, MRE, and OPG, treatment with selumetinib showed promise in improving dose-dependent seizure control. Seizure frequency rebounded after dose adjustment, but eventually ceased after restarting full dosing. This suggests that selumetinib may be effective in managing epilepsy in children with NF1 or LGG.
CHILDS NERVOUS SYSTEM
(2022)
Article
Biochemistry & Molecular Biology
Larissa Erben, Jacqueline P. Welday, Marie E. Cronin, Ricardo Murphy, Miguel Skirzewski, Detlef Vullhorst, Steven L. Carroll, Andres Buonanno
Summary: This study reveals the importance of different isoforms of ErbB4 in dopamine balance and adult behaviors.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Neurosciences
Shannon Weber Doutt, Jody Fromm Longo, Steven L. Carroll
Summary: This study examined the expression and mutational status of LPA receptors in malignant peripheral nerve sheath tumors (MPNSTs) and evaluated their roles in MPNST physiology. The results suggest that LPA mediates distinct effects in MPNSTs through LPAR1 and aberrantly expressed LPAR3, making them potential therapeutic targets.
Article
Pathology
Laurel E. Black, Jody F. Longo, Joshua C. Anderson, Steven L. Carroll
Summary: Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive tumors derived from Schwann cells, and erbB3, calmodulin, proviral integration site of Moloney murine leukemia kinases, and Src family members are important therapeutic targets in MPNSTs. Combinatorial therapies targeting critical MPNST signaling pathways, involving mitogen-activated protein kinase and mammalian target of rapamycin, are more effective in reducing MPNST proliferation and survival compared to monotherapy.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Letter
Oncology
Evan Cantor, Rachel Berkovich, Pournima Navalkele, Nicole M. Brossier
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Nicole M. Brossier, Jennifer M. Strahle, Samuel J. Cler, Michael Wallendorf, David H. Gutmann
NEURO-ONCOLOGY ADVANCES
(2022)
Editorial Material
Pediatrics
Amy E. Armstrong, Nicole M. Brossier, Angela C. Hirbe
LANCET CHILD & ADOLESCENT HEALTH
(2020)