P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis

Purinergic signaling in peripheral nervous system glial cells

(2021) Jennifer Patritti‐Cram et al.   GLIA

Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice

(2020) Maria Agustina Battistone et al.   JOURNAL OF CLINICAL INVESTIGATION

Phenotypic heterogeneity of neurofibromatosis type 1 in a large international registry

(2020) Mika M. Tabata et al.   JCI Insight

Schwann Cell Precursors; Multipotent Glial Cells in Embryonic Nerves

(2019) Kristjan R. Jessen et al.   Frontiers in Molecular Neuroscience

Contributions of inflammation and tumor microenvironment to neurofibroma tumorigenesis

(2018) Chung-Ping Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

The regulation of the homeostasis and regeneration of peripheral nerve is distinct from the CNS and independent of a stem cell population

(2018) Salome Stierli et al.   DEVELOPMENT

STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma

(2018) Jonathan S. Fletcher et al.   ONCOGENE

Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway

(2018) Zhiguo Chen et al.   Cancer Discovery

Prevalence of neurofibromatosis type 1 in the Finnish population

(2017) Roope A Kallionpää et al.   GENETICS IN MEDICINE

Functional screen identifies regulators of murine hematopoietic stem cell repopulation

(2016) Per Holmfeldt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Drug-like Antagonists of P2Y Receptors—From Lead Identification to Drug Development

(2016) Sean Conroy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Physical interaction between neurofibromin and serotonin 5-HT6receptor promotes receptor constitutive activity

(2016) Wissem Deraredj Nadim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation

(2016) Jianqiang Wu et al.   Cell Reports

Cells of Origin in the Embryonic Nerve Roots for NF1-Associated Plexiform Neurofibroma

(2014) Zhiguo Chen et al.   CANCER CELL

Neuronal NF1/RAS regulation of cyclic AMP requires atypical PKC activation

(2014) Corina Anastasaki et al.   HUMAN MOLECULAR GENETICS

The G Protein-coupled Receptor P2Y14Influences Insulin Release and Smooth Muscle Function in Mice

(2014) Jaroslawna Meister et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purinergic P2Y14 receptor modulates stress-induced hematopoietic stem/progenitor cell senescence

(2014) Joonseok Cho et al.   JOURNAL OF CLINICAL INVESTIGATION

Modulation of cAMP and Ras Signaling Pathways Improves Distinct Behavioral Deficits in a Zebrafish Model of Neurofibromatosis Type 1

(2014) Marc A. Wolman et al.   Cell Reports

In Vivo Regulation of TGF-  by R-Ras2 Revealed through Loss of the RasGAP Protein NF1

(2012) D. M. Patmore et al.   CANCER RESEARCH

PTEN and NF1 Inactivation in Schwann Cells Produces a Severe Phenotype in the Peripheral Nervous System That Promotes the Development and Malignant Progression of Peripheral Nerve Sheath Tumors

(2012) V. W. Keng et al.   CANCER RESEARCH

GPR105 Ablation Prevents Inflammation and Improves Insulin Sensitivity in Mice with Diet-Induced Obesity

(2012) J. Xu et al.   JOURNAL OF IMMUNOLOGY

Growth dynamics of plexiform neurofibromas: a retrospective cohort study of 201 patients with neurofibromatosis 1

(2012) Rosa Nguyen et al.   Orphanet Journal of Rare Diseases

Applying the pro-drug approach to afford highly bioavailable antagonists of P2Y14

(2010) Joël Robichaud et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cyclic AMP Suppression Is Sufficient to Induce Gliomagenesis in a Mouse Model of Neurofibromatosis-1

(2010) N. M. Warrington et al.   CANCER RESEARCH

Gi- and Gq-Coupled ADP (P2Y) Receptors Act in Opposition to Modulate Nociceptive Signaling and Inflammatory Pain Behavior

(2010) Sacha A Malin et al.   Molecular Pain

The UDP-Glucose Receptor P2RY14 Triggers Innate Mucosal Immunity in the Female Reproductive Tract by Inducing IL-8

(2009) T. Arase et al.   JOURNAL OF IMMUNOLOGY

Quantification of Gi-Mediated Inhibition of Adenylyl Cyclase Activity Reveals That UDP Is a Potent Agonist of the Human P2Y14 Receptor

(2009) R. L. Carter et al.   MOLECULAR PHARMACOLOGY

Induction of Abnormal Proliferation by Nonmyelinating Schwann Cells Triggers Neurofibroma Formation

(2008) Huarui Zheng et al.   CANCER CELL

Plexiform and Dermal Neurofibromas and Pigmentation Are Caused by Nf1 Loss in Desert Hedgehog-Expressing Cells

(2008) Jianqiang Wu et al.   CANCER CELL

The Loss of Nf1 Transiently Promotes Self-Renewal but Not Tumorigenesis by Neural Crest Stem Cells

(2008) Nancy M. Joseph et al.   CANCER CELL

Nf1 Mutation Expands an EGFR-Dependent Peripheral Nerve Progenitor that Confers Neurofibroma Tumorigenic Potential

(2008) Jon P. Williams et al.   Cell Stem Cell

TORC1 Is Essential for NF1-Associated Malignancies

(2008) Cory M. Johannessen et al.   CURRENT BIOLOGY

Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation

(2008) Rhona Mirsky et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM