Journal
ANALYTICAL CHEMISTRY
Volume 87, Issue 21, Pages 11130-11136Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b03311
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Funding
- Novartis Center for Continuous Manufacturing
- NSERC Postdoctoral Fellowship
- National Science Foundation Graduate Research Fellowship Program [1122374]
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Taking advantage of the difference between the surface energies of aqueous and organic solvents on a Teflon substrate, a fully automated small-scale strategy is developed on the basis of gas-driven oscillatory motion of a biphasic slug for high-throughput in situ measurement and screening of partition coefficients of organic substances between aqueous and organic phases. The developed oscillatory flow strategy enables single partition coefficient data point measurement within 8 min (including the sample preparation time) which is 360 times faster than the conventional shake-flask method, while using less than a 30 mu L volume of the two phases and 9 nmol of the target organic substance. The developed multiphase strategy is validated using a conventional shake-flask technique. Finally, the developed strategy is extended to include automated screening of partition coefficients at physiological temperature.
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