Glioblastoma, Cancer Stem Cells and Hypoxia

The functional role of Notch signaling in human gliomas

(2011) M.-T. Stockhausen et al.   NEURO-ONCOLOGY

The IGFR1 inhibitor NVP-AEW541 disrupts a pro-survival and pro-angiogenic IGF-STAT3-HIF1 pathway in human glioblastoma cells

(2010) Marzia B. Gariboldi et al.   BIOCHEMICAL PHARMACOLOGY

LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1α via upregulation of VHL in a colon cancer cell line

(2010) Kyeong Lee et al.   BIOCHEMICAL PHARMACOLOGY

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

(2010) Sascha Seidel et al.   BRAIN

Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability

(2010) I. M. Pires et al.   CANCER RESEARCH

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Hypoxia-induced metabolic shifts in cancer cells: Moving beyond the Warburg effect

(2010) Aalim M. Weljie et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Knock down of HIF-1α in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres

(2010) Olga Méndez et al.   Molecular Cancer

Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacity

(2010) M. Rasper et al.   NEURO-ONCOLOGY

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

CD133+ Glioblastoma Stem-like Cells are Radiosensitive with a Defective DNA Damage Response Compared with Established Cell Lines

(2009) A. M. McCord et al.   CLINICAL CANCER RESEARCH

Hypoxia Helps Glioma to Fight Therapy

(2009) Verena Amberger-Murphy   CURRENT CANCER DRUG TARGETS

Hypoxia-inducible factor-1α blocks differentiation of malignant gliomas

(2009) Huimin Lu et al.   FEBS Journal

Limits of CD133 as a marker of glioma self-renewing cells

(2009) Virginie Clément et al.   INTERNATIONAL JOURNAL OF CANCER

The role of oxygen in regulating neural stem cells in development and disease

(2009) David M. Panchision   JOURNAL OF CELLULAR PHYSIOLOGY

Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target

(2009) Randy L. Jensen   JOURNAL OF NEURO-ONCOLOGY

Physiologic Oxygen Concentration Enhances the Stem-Like Properties of CD133+ Human Glioblastoma Cells In vitro

(2009) A. M. McCord et al.   MOLECULAR CANCER RESEARCH

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution

(2009) S G M Piccirillo et al.   ONCOGENE

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

(2009) A Soeda et al.   ONCOGENE

Angiogenesis and Anti-Angiogenic Molecularly Targeted Therapies in Malignant Gliomas

(2009) Andreas A. Argyriou et al.   ONCOLOGY

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

(2009) Gregg L. Semenza   PHYSIOLOGY

CD133 (Prominin) Negative Human Neural Stem Cells Are Clonogenic and Tripotent

(2009) Yirui Sun et al.   PLoS One

Glioblastoma Formation from Cell Population Depleted of Prominin1-Expressing Cells

(2009) Kenji Nishide et al.   PLoS One

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

Proliferation of Human Glioblastoma Stem Cells Occurs Independently of Exogenous Mitogens

(2009) John J. P. Kelly et al.   STEM CELLS

Cell Cycle-Dependent Variation of a CD133 Epitope in Human Embryonic Stem Cell, Colon Cancer, and Melanoma Cell Lines

(2008) M. Jaksch et al.   CANCER RESEARCH

Tumor Angiogenic and Hypoxic Profiles Predict Radiographic Response and Survival in Malignant Astrocytoma Patients Treated With Bevacizumab and Irinotecan

(2008) Sith Sathornsumetee et al.   JOURNAL OF CLINICAL ONCOLOGY

Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

(2008) X. Li et al.   JNCI-Journal of the National Cancer Institute

Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas

(2008) Kyeung Min Joo et al.   LABORATORY INVESTIGATION

Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration

(2008) G.-M. Zou et al.   MOLECULAR CANCER THERAPEUTICS

IDENTIFICATION OF A2B5+CD133− TUMOR-INITIATING CELLS IN ADULT HUMAN GLIOMAS

(2008) Alfred T. Ogden et al.   NEUROSURGERY

Identification of CD133-Positive Radioresistant Cells in Atypical Teratoid/ Rhabdoid Tumor

(2008) Shih-Hwa Chiou et al.   PLoS One

CD133 Is a Marker of Bioenergetic Stress in Human Glioma

(2008) Corinne E. Griguer et al.   PLoS One

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A HIF-1α-dependent autocrine feedback loop promotes survival of serum-deprived prostate cancer cells

(2008) Rusha Thomas et al.   PROSTATE

Imaging and Analytical Methods as Applied to the Evaluation of Vasculature and Hypoxia in Human Brain Tumors

(2008) Sydney M. Evans et al.   RADIATION RESEARCH

Enumeration of Neural Stem and Progenitor Cells in the Neural Colony-Forming Cell Assay

(2008) Sharon A. Louis et al.   STEM CELLS

Hypoxia and HIF1α Repress the Differentiative Effects of BMPs in High-Grade Glioma

(2008) Francesca Pistollato et al.   STEM CELLS

CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells

(2007) Jian Wang et al.   INTERNATIONAL JOURNAL OF CANCER