Article
Medicine, Research & Experimental
Eunbi Cho, Kumju Youn, Huiyoung Kwon, Jieun Jeon, Wan-Seob Cho, Se Jin Park, Seung Hwan Son, Dae Sik Jang, Chan Young Shin, Minho Moon, Mira Jun, Nam-Jung Kim, Dong Hyun Kim
Summary: This study investigated the effects of eugenitol in an AD mouse model and found that it inhibits the formation of A beta plaques and reduces neuronal cell death. In silico docking simulation showed that eugenitol may interact with A beta monomers and fibrils.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Guilian Xu, Brittany S. Ulm, John Howard, Susan E. Fromholt, Qing Lu, Brian Benedict Lee, Ariel Walker, David R. Borchelt, Jada Lewis
Summary: The study aims to investigate the pathological interaction between amyloidosis and tauopathy in Alzheimer's disease, and found that the development of tauopathy is exacerbated by the presence of newly forming amyloid deposits in younger brains and mature deposits in older brains.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Krista Mineia Wartchow, Leticia Rodrigues, Izabela Swierzy, Michael Buchfelder, Diogo Onofre de Souza, Carlos-Alberto Goncalves, Andrea Kleindienst
Summary: The study found that long-term increased S100B levels have sex-dependent and brain region-specific effects on amyloid-beta processing, highlighting the importance of further investigating signaling pathways and behavioral responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Jiacheng Chen, Ning Guo, Yuting Ruan, Yingren Mai, Wang Liao, Yanqing Feng
Summary: This study found that isoniazid administration can effectively improve cognitive performance, clear Aβ plaques, protect dendritic synapses, and reduce innate immune cells around the Aβ plaques in a transgenic mouse model of Alzheimer's disease. These results suggest that isoniazid could be a potential drug for AD treatment.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Rahim Ullah, Gowhar Ali, Ajmal Khan, Sajjad Ahmad, Ahmed Al-Harrasi
Summary: The study investigated the effects of 3NCP on AD using 5xFAD mouse models, showing potential therapeutic effects in reducing amyloid plaques and improving learning and memory. In vivo studies demonstrated that 3NCP did not induce anxiety, significantly reduced beta-amyloid plaques, and decreased BACE-1 expression in the brain tissues. This suggests that 3NCP may be a promising candidate for future AD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Biotechnology & Applied Microbiology
Karthivashan Govindarajan, Satyabrata Kar
Summary: Evidence suggests that increased levels of Aβ and aggregated tau protein play a critical role in the development of Alzheimer's disease. Current diagnosis of AD is based on cognitive assessment, neuroimaging, and immunological assays. Nanoparticles, specifically native PLGA, have been used as a diagnostic agent to accurately detect changes in AD patients. The injection of labelled native PLGA can identify Aβ plaques in mouse brains, providing evidence for its potential as a therapeutic and diagnostic agent for AD pathology.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Neurosciences
Suzanne D. Lanooij, W. H. I. M. Drinkenburg, U. L. M. Eisel, E. A. van der Zee, Martien J. H. Kas
Summary: Social factors are linked to the risk of developing Alzheimer's Disease. Social housing conditions have a significant effect on amyloid plaques and microglia, particularly in certain genotypes.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Geriatrics & Gerontology
Deebika Balu, Ana C. Valencia-Olvera, Zarak Islam, Clare Mielczarek, Allison Hansen, Tamara M. Perez Ramos, Jason York, Mary Jo Ladu, Leon M. Tai
Summary: Increasing evidence supports the interaction of age, APOE, and sex in modulating Alzheimer's disease risk. Female APOE4 mice have the highest levels of Aβ deposition, fibrillar amyloid deposits, neuroinflammation, and earlier behavior deficits. The combination of female sex and APOE4 genotype may be the most detrimental for Alzheimer's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Immunology
Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L. Namminga, Katherine E. Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M. Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D. Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y. Poluektova, Channabasavaiah B. Gurumurthy, R. Lee Mosley, Howard E. Gendelman
Summary: Alzheimer's disease is characterized by pathological deposition of misfolded self-protein amyloid beta, leading to neuroinflammation. Effector T cells induced by self-antigens accelerate disease progression, suggesting a potential therapeutic target in controlling AD pathology.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Tomas Jorda-Siquier, Melina Petrel, Vladimir Kouskoff, Una Smailovic, Fabrice Cordelieres, Susanne Frykman, Ulrike Mueller, Christophe Mulle, Gael Barthet
Summary: The distribution of amyloid precursor protein (APP) and its fragments is altered in Alzheimer's disease (AD), leading to their accumulation around amyloid plaques with presynaptic proteins. This finding is associated with histopathological features and familial AD.
ALZHEIMERS & DEMENTIA
(2022)
Article
Medicine, Research & Experimental
Si Li, Ziqi Tian, Xiaohui Xian, Cuihuan Yan, Qiang Li, Nan Li, Xiaokang Xu, Xiaojie Hou, Xiaoyun Zhang, Yinan Yang, Sisi Xue, Shengkai Ma, Shuanlong Cui, Lijun Sun, Xiaoguang Yao
Summary: The study aimed to investigate the effects of catalpol on anti-amyloid beta (Aβ) and anti-neuroinflammatory effects in an Alzheimer's disease (AD) mouse model. Catalpol inhibited Aβ formation, reduced proinflammatory cytokines and cytotoxicity, downregulated neuroinflammation production, decreased Aβ deposits, and alleviated cognitive impairment. The administration of catalpol may be a promising strategy for treating AD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Clara Munoz-Castro, Marina Mejias-Ortega, Elisabeth Sanchez-Mejias, Victoria Navarro, Laura Trujillo-Estrada, Sebastian Jimenez, Juan Antonio Garcia-Leon, Juan Jose Fernandez-Valenzuela, Maria Virtudes Sanchez-Mico, Carmen Romero-Molina, Ines Moreno-Gonzalez, David Baglietto-Vargas, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica
Summary: Monocyte-derived cells infiltrate the brain parenchyma in advanced stages of Alzheimer's disease (AD), acquiring a microglial-like morphology and contributing to plaque-associated myeloid cell heterogeneity. These findings provide an opportunity to develop targeted therapies for both microglia and peripheral immune cells to modulate amyloid pathology and gain a better understanding of the immunological mechanisms underlying AD progression.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Neurosciences
Raquel Sanchez-Varo, Elisabeth Sanchez-Mejias, Juan Jose Fernandez-Valenzuela, Vanessa De Castro, Marina Mejias-Ortega, Angela Gomez-Arboledas, Sebastian Jimenez, Maria Virtudes Sanchez-Mico, Laura Trujillo-Estrada, Ines Moreno-Gonzalez, David Baglietto-Vargas, Marisa Vizuete, Jose Carlos Davila, Javier Vitorica, Antonia Gutierrez
Summary: Alzheimer's disease is a devastating neurodegenerative disorder characterized by initial memory impairments that progress to dementia. Synaptic dysfunction and loss have been established as the pathological features that best correlate with the typical early cognitive decline in this disease.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Mincheol Park, Gia Minh Hoang, Thien Nguyen, Eunkyung Lee, Hyun Jin Jung, Youngshik Choe, Moon Hwan Lee, Jae Youn Hwang, Jae Gwan Kim, Tae Kim
Summary: The study showed that ultrasound stimulation can reduce A beta load in the brain of an AD mouse model and improve brain connectivity. Levels of A beta 42, especially insoluble A beta 42, were decreased in the pre- and infra-limbic cortex in the treatment group, and a reduction in the number of A beta plaques was observed.
TRANSLATIONAL NEURODEGENERATION
(2021)
Article
Neurosciences
Wangchen Tsering, Stefan Prokop
Summary: This article reviews the research on neuritic plaques and discusses their association with AD progression and symptoms. Neuritic plaques are linked to local immune activation, neuronal network dysfunction, and cognitive decline, highlighting the importance of understanding their formation mechanism for developing targeted therapies for AD.
MOLECULAR NEUROBIOLOGY
(2023)