Article
Medicine, General & Internal
Franklin Chu Buh, Peter J. A. Hutchinson, Fahim Anwar
Summary: Traumatic brain injury (TBI) is a global public health challenge, and early neuro-rehabilitation guidelines have not yet been developed and implemented in most of Africa. This article proposes a collective reflection on the development and implementation of early neuro-rehabilitation guidelines in TBI care.
Article
Clinical Neurology
Andrea Klang, Yasmina Molero, Paul Lichtenstein, Henrik Larsson, Brian Matthew D'Onofrio, Niklas Marklund, Christian Oldenburg, Elham Rostami
Summary: The study found that there is insufficient and unequal access to rehabilitation for traumatic brain injury (TBI) patients. It highlights the importance of organizing and standardizing post-TBI rehabilitation to meet the needs of all patients, regardless of their age, socioeconomic status, or living area.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Review
Critical Care Medicine
Amelia J. Hicks, Fiona J. Clay, Malcolm Hopwood, Amelia C. James, Luke A. Perry, Mahesh Jayaram, Rachel Batty, Jennie L. Ponsford
Summary: Research on pharmacological interventions for anxiety after TBI is currently limited, with only a few studies available, making it difficult to provide clear recommendations on pharmacotherapy. Future studies should focus on conducting more adequately powered and controlled research on pharmacological interventions for anxiety symptoms after TBI to gain a better understanding of their effectiveness.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Neurosciences
Matthew J. Lee, Yi Zhou, Brian D. Greenwald
Summary: Post-traumatic headache (PTH) is a common sequela of traumatic brain injury (TBI), and its management poses challenges for clinicians. Non-pharmacological interventions offer an intriguing alternative, but more high-quality trials are needed to establish their effectiveness.
Review
Neurosciences
Miyamoto Akira, Takata Yuichi, Ueda Tomotaka, Kubo Takaaki, Mori Kenichi, Miyamoto Chimi
Summary: This paper discusses the importance of traumatic brain injury and its potential long-term consequences for public health professionals, as well as the distinct features of neurorehabilitation for affected individuals. It also addresses common medical issues that may occur at different stages of neurorehabilitation, and the importance of scheduling rehabilitation programs and the availability of comprehensive rehabilitative neuropsychology techniques.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Rakesh Mishra, William Andres Florez-Perdomo, Adesh Shrivatava, Pradeep Chouksey, Sumit Raj, Luis Rafael Moscote-Salazar, Md Moshiur Rahman, Roshan Sutar, Amit Agrawal
Summary: Music therapy shows statistically significant improvement in rehabilitation outcomes for TBI patients, particularly in stride length and executive function. However, the improvement in cadence and gait velocity is not statistically significant, and the effect of music therapy on memory function is also not significant in these patients.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Valeria Pingue, Chiara Mele, Stefania Biscuola, Antonio Nardone, Sergio Bagnato, Diego Franciotta
Summary: This study found that the severity of brain injury and occurrence of seizures during neurorehabilitation are key factors contributing to poor functional outcomes in patients with traumatic or hemorrhagic brain injury. Prophylactic AED therapy can reduce the frequency of acute symptomatic seizures, but long-term use may be associated with unprovoked seizures.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Valeria Pingue, Valentina Boetto, Anna Bassetto, Maruska Nava, Antonio Nardone, Chiara Mele
Summary: This study retrospectively evaluated the impact of decompressive craniectomy on functional outcomes, mortality, and the occurrence of seizures in patients with traumatic brain injury (TBI). The results showed that decompressive craniectomy was not significantly associated with poor functional outcomes or mortality, but it was associated with the occurrence of seizures.
Review
Psychology, Clinical
Sarah L. Carrier, Jennie Ponsford, Ruby K. Phyland, Amelia J. Hicks, Adam McKay
Summary: This systematic review aims to evaluate the effectiveness of non-pharmacological interventions for managing agitation during post-traumatic amnesia (PTA) in adults with traumatic brain injury (TBI). It found that music therapy had the highest level of evidence as an intervention, although the overall quality of the studies was generally low to moderate. Further research is needed to evaluate other non-pharmacological interventions for reducing agitation during PTA.
NEUROPSYCHOLOGY REVIEW
(2023)
Review
Pharmacology & Pharmacy
Matthew I. Hiskens
Summary: This minireview provides an up-to-date summary of the key Phase III clinical trials that have been undertaken in the development of a neuropharmacological treatment for traumatic brain injury. The article discusses the key targets for treatment, the potential reasons for the lack of translation of promising preclinical compounds, and the most promising avenues for future development.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Cell Biology
Alessia Filippone, Laura Cucinotta, Valentina Bova, Marika Lanza, Giovanna Casili, Irene Paterniti, Michela Campolo, Salvatore Cuzzocrea, Emanuela Esposito
Summary: Moderate traumatic brain injury (mTBI) is associated with emotional dysregulation. This study investigates the role of LRRK2 in reducing depression-related symptoms after mTBI and tests the antidepressant effects of LRRK2 inhibition by PF-06447475. The results show that mTBI promotes the development of depression-like behavior, but LRRK2 inhibition reduces histological damage and behavioral disturbances, suggesting an antidepressant effect.
Review
Clinical Neurology
Rosaria De Luca, Mirjam Bonanno, Carmela Rifici, Angelo Quartarone, Rocco Salvatore Calabro
Summary: Post-traumatic Olfactory Dysfunction (PTOD) refers to the loss of olfactory function after a traumatic brain injury (TBI), which may be linked to neuropsychiatric symptoms and can be diagnosed through medical history, clinical data, and objective/subjective measures. Olfactory training (OT), a non-pharmacological and non-invasive treatment option, can improve olfactory function through central and peripheral processes. Early detection and proper treatment of PTOD using various therapeutic approaches, including neuromodulation, is important in managing TBI patients.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Mirjam Bonanno, Rosaria De Luca, Alessandro Marco De Nunzio, Angelo Quartarone, Rocco Salvatore Calabro
Summary: Motor and cognitive rehabilitation in individuals with traumatic brain injury is a rapidly growing field of clinical and research interest. Innovative rehabilitative approaches, such as using robotic devices and virtual reality, show promising results in improving neuroplasticity and facilitating cognitive recovery. However, evidence regarding the effectiveness of these technologies in motor rehabilitation for TBI patients is still limited and controversial.
Article
Music
Sarah Thompson, Kaitlin Hays, Alan Weintraub, Jessica M. Ketchum, Robert G. Kowalski
Summary: This pilot study examines the feasibility and potential benefits of Rhythmic Auditory Stimulation (RAS) for individuals who have experienced traumatic brain injury (TBI). The results showed improvements in gait parameters and half of the participants were no longer at high risk of falls after receiving RAS treatment.
JOURNAL OF MUSIC THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Klara Suneson, Jesper Lindahl, Simon Chamli Harsmar, Gustav Soderberg, Daniel Lindqvist
Summary: The treatment of depression is hindered by the lack of distinct symptom profiles with different pathophysiologies. Inflammatory depression is identified as a subtype associated with specific symptoms and biological abnormalities. Future clinical trials should consider inflammatory markers when testing non-pharmacological interventions for this subtype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)