Article
Cell Biology
Xinye Han, Peipei Wu, Linli Li, Hassan Mohamud Sahal, Cheng Ji, Jiahui Zhang, Yi Wang, Qichen Wang, Hui Qian, Hui Shi, Wenrong Xu
Summary: DF-Ex can reverse the damage caused by high glucose in HUVECs and accelerate diabetic cutaneous wound healing; DF-Ex exerts its effects by activating the Akt/beta-catenin pathway; This research provides a new treatment strategy for diabetic cutaneous wound healing.
Article
Biochemistry & Molecular Biology
Masaya Yokota, Nicola Haeffner, Matthew Kassier, Matthias Brunner, Srikanth Mairpady Shambat, Fabian Brennecke, Janine Schniering, Ewerton Marques Maggio, Oliver Distler, Annelies Sophie Zinkernagel, Britta Maurer
Summary: The study revealed that Staphylococcus aureus affects dermal fibroblasts, leading to impaired tissue repair functions such as upregulation of pro-inflammatory cytokines and degradation of collagen. This impact is not limited to specific cell sources and affects key mechanisms of wound healing.
Article
Biochemistry & Molecular Biology
Ji Eun Lee, Yong Chool Boo
Summary: The study introduces a new strategy utilizing glycianamide and ascorbic acid (AA) to enhance collagen production in cells, leading to improved wound healing capabilities.
Article
Environmental Sciences
Xue Wen, Man Zhu, Zehua Li, Tao Li, Xuewen Xu
Summary: This study explores the effects of BPA on wound repair and finds that dietary intake of BPA delays wound healing, while wound application of BPA accelerates skin regeneration. This is because BPA up-regulates the expression of ERβ in the wound area, and enhances the function of fibroblasts to promote wound repair. For diabetic patients, application of BPA on wounds significantly speeds up wound healing without significant adverse effects on ovarian hormone levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Chemistry, Multidisciplinary
Lucas Schirmer, Passant Atallah, Uwe Freudenberg, Carsten Werner
Summary: Excessive inflammation can hinder chronic wound healing. A composite wound contact layer with selective sequestering ability for pro-inflammatory chemokines was developed by manipulating the affinity profile of the hydrogel component. Testing in a porcine model showed that this treatment could dampen inflammatory signals while promoting healing.
Article
Cell Biology
Mariliis Klaas, Kristina Maemets-Allas, Elizabeth Heinmae, Heli Lagus, Claudia Griselda Cardenas-Leon, Terje Arak, Mart Eller, Kulli Kingo, Esko Kankuri, Viljar Jaks
Summary: The study revealed the important role of THBS4 in skin regeneration, promoting cell migration and proliferation, likely through the central signaling role of beta-catenin. These findings provide a promising strategy for the development of novel therapies for treating cutaneous wounds.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nur Izzah Md Fadilah, Shou Jin Phang, Nurkhuzaiah Kamaruzaman, Atiqah Salleh, Mazlan Zawani, Arka Sanyal, Manira Maarof, Mh Busra Fauzi
Summary: Natural antioxidant-incorporated biomaterials have shown promise in promoting skin wound healing and tissue regeneration. However, the low bioavailability of these biomaterials limits their therapeutic activity at the injury site. This review summarizes recent literature on the role of antioxidant-incorporated biomaterials and their mechanisms in promoting wound healing, supported by in vitro, in vivo, and clinical studies.
Review
Biochemistry & Molecular Biology
Preety Sharma, Arun Kumar, Tarun Agarwal, Asmita Deka Dey, Farnaz Dabbagh Moghaddam, Ilnaz Rahimmanesh, Mahsa Ghovvati, Satar Yousefiasl, Assunta Borzacchiello, Abbas Mohammadi, Venkata Rajesh Yella, Omid Moradi, Esmaeel Sharifi
Summary: This review explores the application of nucleic acid therapy in treating non-healing wounds. Different nucleic acids can be applied to wound healing using various delivery techniques. However, the translational possibility of nucleic acids remains a significant challenge.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Plant Sciences
Yuhui Mi, Lei Zhong, Saijian Lu, Po Hu, Yang Pan, Xuelin Ma, Binghui Yan, Zhenhuan Wei, Guangming Yang
Summary: The study aimed to evaluate the healing effect of quercetin on cutaneous wound models in vivo and in vitro, and to reveal the mechanisms involved, including the Wnt/beta-catenin pathway and TERT.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Chang Liu, Qun Zhang, Zhenan Liu, Dexuan Zhuang, Shuangshuang Wang, Huiting Deng, Yuxin Shi, Jianfeng Sun, Jing Guo, Fulan Wei, Xunwei Wu
Summary: miR-21 plays an important role in skin wound healing by promoting the migration and growth of epidermal and dermal cells through controlling the expression of inflammatory cytokines.
Review
Neurosciences
Divya Gupta, Dhirender Kaushik, Vandana Mohan
Summary: Wound healing is a complex process of tissue repair after injury, in which neurotransmitters play important roles. Serotonin, for example, is involved in promoting healing. Understanding how neurotransmitters regulate the immune system to control wound healing is crucial for the development of potential therapeutic measures.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Fengze Miao, Ying Li, Zongguang Tai, Yong Zhang, Yue Gao, Menghong Hu, Quangang Zhu
Summary: Chronic wound infections have become a significant issue, and the development of functional wound dressings has made progress. Antimicrobial peptides are attracting attention as an emerging therapeutic option for wound healing.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Chemistry, Physical
Yueyue Li, Weifeng Zhong, Junjie Wu, Yuan Jia, Zhonghua Chen, Kaiwen Zhang, Danyang Guo, Yifei Fu, Mengnan Chen, Weiwei Chen, Fan Tian, Xia Li, Hongji Zhang, Xiaojin Zhou, Feng-Lai Yuan
Summary: Recruiting key cells to regeneration sites is a promising strategy for promoting functional wound healing. Papillary fibroblasts, with central regulatory roles in skin appendage regeneration, can be recruited using Grass Carp Fishing multifunctional hydrogels, which deliver Lrig1 antibodies and IGF1 to the surface of these fibroblasts. Injectable self-healing multifunctional hydrogels, with sustained release of Lrig1 antibodies and IGF1, were shown to accelerate the migration and proliferation of Lrig1(+) fibroblasts and promote wound healing and skin regeneration.
Review
Biochemistry & Molecular Biology
Aditya Kaul, Walker D. Short, Sundeep G. Keswani, Xinyi Wang
Summary: Hyaluronic acid plays a crucial role in wound healing by interacting with the immune system, with its molecular weight determining its immune-modulating effects on the repair process.
Article
Biochemistry & Molecular Biology
Nudjanad Heebkaew, Wilasinee Promjantuek, Nipha Chaicharoenaudomrung, Ruchee Phonchai, Phongsakorn Kunhorm, Natchadaporn Soraksa, Parinya Noisa
Summary: In this study, the HaCaT secretome was combined with polyesters and cassava starch, which enhanced cell proliferation, migration, and anti-aging effects while reducing reactive oxygen species levels. This suggests that the HaCaT secretome may have potential applications in cosmetics for wound prevention and healing.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fernanda S. Schanuel, Bruna Romana-Souza, Andrea Monte-Alto-Costa
Article
Developmental Biology
Kelly C. Demarque, Ana C. Dutra-Tavares, Andre L. Nunes-Freitas, Ulisses C. Araujo, Alex C. Manhaes, Yael Abreu-Villaca, Claudio C. Filgueiras, Anderson Ribeiro-Carvalho
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2020)
Article
Clinical Neurology
Jefferson P. Galvanho, Alex C. Manhaes, Ana Cristina C. Carvalho-Nogueira, Joyce de M. Silva, Claudio C. Filgueiras, Yael Abreu-Villaca
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2020)
Article
Food Science & Technology
Bruna Romana-Souza, Bianca Oliveira Saguie, Natalia Pereira de Almeida Nogueira, Marcia Paes, Samuel dos Santos Valenca, Georgia Correa Atella, Andrea Monte-Alto-Costa
FOOD RESEARCH INTERNATIONAL
(2020)
Article
Dermatology
Bruna Romana-Souza, Welker Silva-Xavier, Andrea Monte-Alto-Costa
JOURNAL OF COSMETIC DERMATOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Isabella Cattani-Cavalieri, Helber da Maia Valenca, Joao Alfredo Moraes, Lycia Brito-Gitirana, Bruna Romana-Souza, Martina Schmidt, Samuel Santos Valenca
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Editorial Material
Cell Biology
Reggiani Vilela Goncalves, Andrea M. A. Costa, Lukasz Grzeskowiak
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Bruna Romana-Souza, Lin Chen, Trevor R. Leonardo, Zhenlong Chen, Luisa A. DiPietro
Summary: The study shows that fibroblasts can engulf apoptotic endothelial cells (ApoEC) and acquire a pro-healing phenotype in the process. The uptake of ApoEC is partly mediated by the milk fat globule-EGF factor 8 protein/integrin alpha(v)beta(5) pathway, which enhances cell migration, contractility, alpha-smooth muscle actin expression, and collagen deposition in fibroblasts.
Article
Dermatology
Eduarda Cristina da Silva Carlos, Gabrielly Alves Cristovao, Alcimar Alves Silva, Bianca Cristina de Santos Ribeiro, Bruna Romana-Souza
Summary: A new model of psoriasis-like dermatitis using human skin under in vitro conditions was created in this study for studying the mechanisms involved in psoriasis and screening new antipsoriatic drugs. Topical application of imiquimod (IMQ) in human skin promoted epidermal changes resembling human psoriatic skin lesions. The production of IL-17 by Langerhans cells (LCs) and T cells was found critical to the development of psoriasis-like inflammation in this model. This new model is suitable for in vitro screening of antipsoriatic drugs.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bianca C. de S. Ribeiro, Regina V. de C. Faria, Jeane de S. Nogueira, Samuel Santos Valenca, Lin Chen, Bruna Romana-Souza
Summary: Olive oil promotes skin wound healing by activating the Nrf2 pathway, which enhances cell survival and migration in fibroblasts. This is achieved through the production of reactive oxygen and nitrogen species, as well as the activation of specific proteins. The findings suggest that olive oil has potential therapeutic applications in wound healing.
Article
Cell Biology
Aline Donato-Trancoso, Regina V. de Carvalho Faria, Bianca C. de S. Ribeiro, Jeane S. S. Nogueira, Georgia C. Atella, Lin Chen, Bruna Romana-Souza
Summary: This study investigated the effects of a diet rich in extra virgin olive oil (EVOO) on acute wound healing. Short-term administration of EVOO increased oxidative damage and pro-inflammatory responses, impairing wound closure. Long-term administration, on the other hand, reduced oxidative damage and enhanced anti-inflammatory responses, improving wound closure.
WOUND REPAIR AND REGENERATION
(2023)
Article
Neurosciences
Ana Carolina Dutra-Tavares, Thaina P. Souza, Juliana O. Silva, Keila A. Semeao, Felipe F. Mello, Claudio C. Filgueiras, Anderson Ribeiro-Carvalho, Alex C. Manhaes, Yael Abreu-Villaca
Summary: Sex-biased differences in schizophrenia are evident in several features of the disease, including symptomatology and response to pharmacological treatments. As a neurodevelopmental disorder, these differences might originate early in life and emerge later during adolescence. Neonatal phencyclidine can induce sex-dependent behavioral and neurochemical changes associated with schizophrenia during adolescence.
PSYCHOPHARMACOLOGY
(2023)
Article
Biology
A. Ribeiro-Carvalho, P. H. Leal-Rocha, J. Isnardo-Fernandes, U. C. Araujo, Y. Abreu-Villaca, C. C. Filgueiras, A. C. Manhaes
Summary: The study found that varenicline can reduce MPTP-induced hyperactivity, but does not provide protection against dopaminergic damage.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Toxicology
Ulisses C. Araujo, Thomas E. Krahe, Anderson Ribeiro-Carvalho, Regina A. A. Gomes, Bruna M. Lotufo, Maria de Fatima R. Moreira, Yael de Abreu-Villaca, Alex C. Manhaes, Claudio C. Filgueiras
Summary: The study revealed that lead exposure in mice can lead to increased swimming activity during the forced swimming test, indicating an influence on stress-associated behavioral responses. Blood-lead levels above 40 mu g/dL were associated with significant differences in brain glutathione levels, suggesting a correlation between lead toxicity and behavioral changes in response to stress.
TOXICOLOGICAL RESEARCH
(2021)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)