Article
Clinical Neurology
Margaret A. French, Matthew L. Cohen, Ryan T. Pohlig, Darcy S. Reisman
Summary: This study investigates the relationship between locomotor learning and retention and cognition after stroke, finding that cognitive abilities play a significant role in understanding locomotor learning and retention after stroke.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Environmental Sciences
Chuchu Xi, Zhao Yang, Yiyi Yu, Shaoheng Li, Jing He, Tarek Mohamed Abd El-Aziz, Fang Zhao, Zhengyu Cao
Summary: Perinatal exposure to deltamethrin causes attention-deficit/hyperactivity disorder-like behaviors, with the most vulnerable time window being GD 16-B. Prenatal exposure to deltamethrin impairs locomotor activity, learning and memory, and causes neuron loss in male offspring, while having no effect on female offspring. Prenatal deltamethrin exposure decreases NR2A and NR2B protein levels in the hippocampi and cerebral cortices of male offspring, while GD 16-B exposure increases NR2A and NR2B expression levels in the hippocampi of female mice.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Psychology, Multidisciplinary
Dana T. Arthur, Michael T. Ullman, F. Sayako Earle
Summary: This study investigated the contribution of declarative and procedural memory to phonological processing performance in native English-speaking young adults. The results showed that declarative memory, but not procedural memory, was highly predictive of phonological processing abilities in adulthood. Specifically, declarative memory shortly after learning was associated with non-word repetition, while declarative memory after an overnight delay was associated with phonological awareness.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Behavioral Sciences
Elizabeth McManus, Deborah Talmi, Hamied Haroon, Nils Muhlert
Summary: The impact of psychosocial stress on episodic memory and related cognitive abilities is still unclear. Some studies found a small positive effect of post-learning psychosocial stress with a long retention interval, but no other effects of psychosocial stress were seen. Re-analysis showed no significant effect of psychosocial stress on episodic memory, highlighting potentially different effects between stressor types. Psychosocial stress also had a moderately different effect when emotional vs. neutral stimuli were compared. Additionally, psychosocial stress decreased performance on executive function, but not working memory tasks.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Xiao-Hui Li, Cheng Xue, Meng-Qi Liu, Meng-Yu Zhang, Yang Zhou, Xu Xiao, Jia Wang, Xi-Jia Xu, Yun Shi, Wei-Ning Zhang
Summary: The introduction of a novel rat strain with a mutation in the ATRN gene reveals learning and memory impairments, as well as slight motor deficits and behavioral abnormalities in these mutant rats. These findings provide new insights into the mechanisms by which mutant ATRN induces neurodegenerative changes.
Article
Psychology, Multidisciplinary
Samantha Gualtieri, Amy S. Finn
Summary: Cognitive development involves age-related improvements, but there are cases where young children outperform older ones. This article explores the instances where younger children perform better, such as in language acquisition, using probabilistic information, detecting causal relations, remembering specific information, and problem-solving. The reduced cognitive abilities, ongoing brain development, limited prior knowledge, and heightened tendency to explore in children contribute to their learning, reasoning, perception, and memory.
PERSPECTIVES ON PSYCHOLOGICAL SCIENCE
(2022)
Article
Neurosciences
Quanjing Chen, Timothy M. Baran, Adam Turnbull, Zhengwu Zhang, George W. Rebok, Feng Vankee Lin
Summary: This study retrospectively analyzed data from a randomized controlled trial comparing the neurocognitive effects of speed of processing training in older adults with MCI. The findings suggest that learners showed significantly greater global and nodal clustering coefficients in brain networks after training, indicating a relationship between broad training effects and enhanced segregation in selective brain networks.
HUMAN BRAIN MAPPING
(2021)
Article
Biochemistry & Molecular Biology
Thais T. Ravache, Alice Batistuzzo, Gabriela G. Nunes, Thiago G. B. Gomez, Fernanda B. Lorena, Bruna P. P. Do Nascimento, Maria Martha Bernardi, Eduarda R. R. Lima, Daniel O. Martins, Ana Carolina P. Campos, Rosana L. Pagano, Miriam O. Ribeiro
Summary: This study aimed to reverse memory impairment caused by Adr β3KO inactivation through multisensory stimulation. The research found that the protocol reduced GFAP and Iba-1 expression in the hippocampus of young mice, but not in older mice. Additionally, in the amygdala of older mice, an increase in GFAP and EAAT2 expression was observed which could not be reduced by multisensory stimulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Connor J. Phipps, Daniel L. Murman, David E. Warren
Summary: Human memory systems can be affected by age and disease, but interventions like non-invasive brain stimulation through rTMS offer potential to modulate memory performance. While challenges exist, recent advances in cognitive neuroscience could provide methodological tools for designing new studies with improved reproducibility and successful translation.
Review
Behavioral Sciences
Sihai Li, Matthew C. Rosen, Suha Chang, Samuel David, David J. Freedman
Summary: This article reviews the neural correlates and functional importance of working memory-related activity in higher-order cortical regions, particularly the prefrontal cortex. It also discusses emerging evidence of electrical stimulation as a potential therapy for ameliorating working memory deficits.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Education & Educational Research
Nurit Paz-Baruch, Rotem Maor
Summary: Recent studies have shown the importance of cognitive abilities in creative thinking, but most of them focused on adults and only a few examined the correlations among young children. This study explores the role of different cognitive abilities in creativity among school children. The results indicate that visual processing abilities are associated with creativity, while verbal short-term memory and working memory are not significantly related. These findings shed light on the cognitive processes underlying creativity in young children.
THINKING SKILLS AND CREATIVITY
(2023)
Article
Geriatrics & Gerontology
Mojitola I. Idowu, Andre J. Szameitat
Summary: A prominent feature of cognitive aging is the decline of executive function abilities, and older adults have been found to perform poorer than younger adults in such tasks. In this study, the effects of age on four executive functions (inhibition, shifting, updating, and dual-tasking) were examined, and it was found that all four functions showed age-related decline, with inhibition declining the most and dual-tasking declining the least.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Maren H. Wehrheim, Joshua Faskowitz, Olaf Sporns, Christian J. Fiebach, Matthias Kaschube, Kirsten Hilger
Summary: Human functional brain connectivity can be decomposed into high and low cofluctuation states, reflecting the coactivation of brain regions over time. Rare states with particularly high cofluctuation have been shown to reflect intrinsic functional network architecture and individual differences, but their contribution to cognitive abilities is unclear.
Article
Neurosciences
Marco Calabria, Francesco Ciongoli, Nicholas Grunden, Celia Ordas, Carmen Garcia-Sanchez
Summary: Recent research has explored the effects of background music on memory performance in individuals with amnestic mild cognitive impairment (MCI). The findings suggest that while background music does not improve or worsen memory performance overall, individual preferences towards music and mood regulation play a role in the relationship between music and memory performance.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Environmental Sciences
Chuchu Xi, Xiaoqian Shi, Yujing Wang, Jing He, Shan Jiang, Bo Niu, Ying Chen, Fang Zhao, Zhengyu Cao
Summary: Perinatal exposure to bifenthrin (BF) has been found to affect neurodevelopment. This study investigated the susceptible time period for BF exposure and its possible mechanisms. The results showed that BF exposure during late gestation caused neurobehavioral deficits in offspring, but these deficits remitted with age. The study also revealed that altered protein levels of VGluT1, NR1, NR2A, NR2B, and VGAT1, as well as increased gene expression levels of Il-1β, Il-6, and Tnf-α, were associated with BF exposure-induced neurobehavioral impairments.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Behavioral Sciences
Deanne Tak On Wah, Martin Kavaliers, Indra R. Bishnoi, Klaus-Peter Ossenkopp
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Developmental Biology
Soaleha Shams, Kelly A. Foley, Martin Kavaliers, Derrick F. MacFabe, Klaus-Peter Ossenkopp
DEVELOPMENTAL PSYCHOBIOLOGY
(2019)
Article
Neurosciences
Jennifer R. Mepham, Francis H. Boon, Kelly A. Foley, Donald P. Cain, Derrick F. MacFabe, Klaus-Peter Ossenkopp
NEUROTOXICITY RESEARCH
(2019)
Article
Psychology, Biological
Deanne Tak On Wah, Klaus-Peter Ossenkopp, Indra Bishnoi, Martin Kavaliers
PHYSIOLOGY & BEHAVIOR
(2019)
Article
Behavioral Sciences
Martin Kavaliers, Douglas D. Colwell, Deanne T. O. Wah, Indra R. Bishnoi, Klaus-Peter Ossenkopp, Elena Choleris
HORMONES AND BEHAVIOR
(2019)
Article
Clinical Neurology
Melissa M. Meeking, Derrick F. MacFabe, Jennifer R. Mepham, Kelly A. Foley, Lisa J. Tichenoff, Francis H. Boon, Martin Kavaliers, Klaus-Peter Ossenkopp
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2020)
Article
Developmental Biology
Indra R. Bishnoi, Klaus-Peter Ossenkopp, Martin Kavaliers
Summary: The study found that adolescent rats are more likely to display risky locomotor and anxiety-like behaviors compared to adult rats, with females showing more of these behaviors than males. However, being injected with LPS twice in early adolescence did not have a significant impact on these behaviors.
DEVELOPMENTAL PSYCHOBIOLOGY
(2021)
Review
Behavioral Sciences
Martin Kavaliers, Klaus-Peter Ossenkopp, Elena Choleris
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Article
Behavioral Sciences
Jennifer R. Mepham, Derrick F. MacFabe, Francis H. Boon, Kelly A. Foley, Donald P. Cain, Klaus-Peter Ossenkopp
Summary: The research found that rats treated with propionic acid showed differences in spatial learning performance, with increased search latencies, longer distances traveled, fewer direct and circle swims, and more time spent in the periphery. This indicates that PPA treatment blocked the effects of the pretraining procedure, likely by impairing sensorimotor components or memory of the pretraining.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Martin Kavaliers, Indra R. Bishnoi, Klaus-Peter Ossenkopp, Elena Choleris
Summary: The study demonstrates that female deer mice can engage in mate choice copying by replicating the odor preferences and appetitive components of other females' mate choices, showing social learning behavior.
Editorial Material
Behavioral Sciences
Martin Kavaliers, Indra R. Bishnoi, Klaus-Peter Ossenkopp, Elena Choleris
HORMONES AND BEHAVIOR
(2022)
Article
Psychology, Biological
Minakshi Doobay, Shelly K. Cross-Mellor, Deanne T. O. Wah, Martin Kavaliers, Klaus-Peter Ossenkopp
Summary: This study investigated escape behaviors in rats experiencing the conditioned aversive effects of lithium chloride (LiCl) in a distinct context, finding that the LiCl-treated rats exhibited significantly increased rearing behavior, indicative of conditioned aversion.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Behavioral Sciences
Indra R. Bishnoi, Caylen J. Cloutier, Cashmeira-Dove Tyson, Vangel M. Matic, Martin Kavaliers, Klaus -Peter Ossenkopp
Summary: This article reviews the effects of immune activation, primarily via LPS, on learning and memory, including the impact on fear and disgust responses and taste and place-related conditioned disgust memory. The central role of immune activation, particularly pro-inflammatory cytokine activity, in these effects is highlighted.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Behavioral Sciences
Indra R. Bishnoi, Martin Kavaliers, Klaus-Peter Ossenkopp
Summary: The present study investigated the effects of the endotoxin lipopolysaccharide (LPS) on the acquisition, consolidation, and extinction of LiCl-induced anticipatory nausea. The results showed that LPS exposure significantly attenuated the conditioned nauseating responses during the acquisition and consolidation stages, but had no significant effect on extinction.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Biology
Martin Kavaliers, Klaus-Peter Ossenkopp, Cashmeira-Dove Tyson, Indra R. Bishnoi, Elena Choleris
Summary: This article discusses the evolutionary causes and neurobiological mechanisms of pathogen avoidance. Animals evaluate the infection status and threat based on sensory and social cues. The article also explores the relationship between pathogen avoidance and social factors, brain regions, and neuromodulators, as well as the reasons for male and female involvement in pathogen avoidance.
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)