Article
Clinical Neurology
Marcantonio M. Spada, Ana Niksevic, Daniel C. Kolubinski, Alessia Offredi, Simona Giuri, Antonella Gemelli, Alessandra Brugnoni, Andrea Ferrari, Gabriele Caselli
Summary: Research on metacognitions and repetitive negative thinking in patients with Personality Disorder is limited, but findings suggest that these factors differ between patients with PD and those without PD, with metacognitions playing a role in predicting repetitive negative thinking in patients with PD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Amy E. Joubert, Ashlee B. Grierson, Aileen Z. Chen, Michelle L. Moulds, Aliza Werner-Seidler, Alison E. J. Mahoney, Jill M. Newby
Summary: This study developed an unguided online treatment program targeting both rumination and worry, and conducted an open pilot trial in Australian adults. The results showed a high completion rate among participants, significant effects in reducing RNT, anxiety, depression, and general psychological distress symptoms, which were maintained at 1-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Dominik Langgartner, Raphael Winkler, Jonas Brunner-Weisser, Nicolas Rohleder, Marc N. N. Jarczok, Harald Guendel, Katja Weimer, Stefan O. O. Reber
Summary: Ex vivo culturing of isolated PBMCs from individuals vaccinated with the COVID-19 vaccine BNT162b1 showed enhanced T cell response to the RBD of the SARS-CoV-2 spike protein. The study also investigated the long-lasting effects of COVID-19 vaccination on various physiological and immunological parameters. The results showed significant increases in IL-6 secretion in vaccinated individuals compared to non-vaccinated individuals.
SCIENTIFIC REPORTS
(2023)
Article
Psychology, Clinical
Cope Feurer, Jagan Jimmy, Fini Chang, Scott A. Langenecker, K. Luan Phan, Olusola Ajilore, Heide Klumpp
Summary: This study explored the relationship between brain activity and rumination and worry in internalizing conditions. The results indicate the involvement of the affective network in rumination and worry, as well as distinct connectivity patterns observed in patients with internalizing conditions. The findings suggest different mechanisms contribute to rumination as a unitary construct and worry as a unique construct.
DEPRESSION AND ANXIETY
(2021)
Article
Psychology, Experimental
Nathaniel S. Eckland, Sarah H. Sperry, Ariana A. Castro, Howard Berenbaum
Summary: This study examined the association between transdiagnostic dimensions of psychopathology and intensity, frequency, and differentiation of discrete emotion categories in daily life. The results showed that psychopathology was more strongly associated with intensity and frequency of pleasant emotions, while also showing associations with unpleasant emotions, particularly in terms of frequency.
Article
Psychology, Clinical
Luke F. Heggeness, Daniel J. Paulus, Desirae N. Vidaurri, C. Laurel Franklin, Amanda M. Raines
Summary: Veterans are more vulnerable to experiencing concurrent issues related to depression and alcohol misuse, and this study found that ruminative thought processing plays an explanatory risk factor role in this relationship. By testing the simultaneous indirect effects of brooding rumination and reflective pondering, novel insights were provided concerning the circumstances under which reflection may become a maladaptive process.
ADDICTIVE BEHAVIORS
(2021)
Article
Psychology, Clinical
Amy E. Joubert, Ashlee B. Grierson, Ian Li, Maria J. Sharrock, Michelle L. Moulds, Aliza Werner-Seidler, Eileen P. Stech, Alison E. J. Mahoney, Jill M. Newby
Summary: This study evaluated the effectiveness of an internet intervention targeting rumination and worry. The results showed that both clinician-guided and self-help formats were effective in reducing negative thinking, anxiety, depression, and distress. The intervention was most effective when delivered with clinician guidance.
BEHAVIOUR RESEARCH AND THERAPY
(2023)
Article
Psychology, Multidisciplinary
Kristoffer Tunheim, Toril Dammen, Silje Baardstu, Torbjorn Moum, John Munkhaugen, Costas Papageorgiou
Summary: Psychological distress, including depression and anxiety, and Type-D personality are prevalent in patients with coronary heart disease (CHD) and associated with poor cardiovascular outcomes. Worry and rumination may be core features responsible for driving psychological distress in these patients. The study found an overlap between depression and negative affectivity, with worry being most strongly associated with anxiety and rumination being most strongly associated with depression and negative affectivity. Targeting worry and/or rumination in the treatment of CHD outpatients presenting with symptoms of psychological distress could be beneficial.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Multidisciplinary
Lara Gama Cavalcanti, Stanley R. Steindl, Marcela Matos, Mark J. Boschen
Summary: The study found that the indirect effects of self-criticism on depression through rumination and worry were conditional on levels of fears of compassion for self and from others. Fears of compassion for oneself and from others magnified the impact of self-criticism and rumination on depression.
CURRENT PSYCHOLOGY
(2021)
Article
Geriatrics & Gerontology
Helmet T. Karim, Maria Ly, Gary Yu, Robert Krafty, Dana L. Tudorascu, Howard J. Aizenstein, Carmen Andreescu
Summary: In older adults, anxiety and rumination are associated with greater brain age, while male sex, anxiety, and rumination are linked to accelerated aging in late life. Expressive suppression may have a protective effect against these negative impacts.
NEUROBIOLOGY OF AGING
(2021)
Article
Psychology, Multidisciplinary
Daniel Wallsten, Annika Norell, Malin Anniko, Oskar Eriksson, Varja Lamourin, Ida Halldin, Tina Kindbom, Hugo Hesser, Edward Watkins, Maria Tillfors
Summary: Group-administered RF-CBT significantly reduced self-reported insomnia and depression symptoms, but showed no significant effects on anxiety, RNT, or quality of life. The study suggests that RF-CBT may be effective for insomnia and potentially effective for depression, but caution should be taken due to the study's low power to detect small and moderate effects.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Immunology
Kristen M. Kelly, Jennifer A. Smith, Briana Mezuk
Summary: The study using Mendelian Randomization found a causal relationship between soluble interleukin-6 receptor and depression, potentially through different signaling pathways. The results suggest involvement of the IL-6 signaling pathway in depression and further research is needed.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Multidisciplinary Sciences
Annelies Vennekens, Emma Laporte, Florian Hermans, Benoit Cox, Elodie Modave, Adrian Janiszewski, Charlotte Nys, Hiroto Kobayashi, Bert Malengier-Devlies, Joel Chappell, Patrick Matthys, Marie-Isabelle Garcia, Vincent Pasque, Diether Lambrechts, Hugo Vankelecom
Summary: The study identifies IL-6 as a pituitary stem cell activator upon local damage, with the competence quenched at aging. In aging pituitary, cells exhibit elevated basal IL-6 levels and an inflammatory state, inhibiting the activation response to IL-6. Interestingly, in vitro stem cell activation by IL-6 was observed in organoid culture not only from young but also from aging pituitary.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Psychology, Clinical
Hanjoo Kim, Michelle G. Newman
Summary: The Contrast Avoidance Model suggests that worry increases negative affect and decreases positive affect. This study aimed to test whether rumination, as well as worry, enhances emotion contrasts and whether the emotions involved are specific. Participants with generalized anxiety disorder (GAD), depression symptoms, and healthy controls engaged in induction tasks before watching an amusement video. Results showed that both worry and rumination increased sadness and fear and decreased amusement compared to relaxation. Worry increased fear more than rumination, while rumination increased sadness more than worry.
JOURNAL OF ANXIETY DISORDERS
(2023)
Article
Psychiatry
Lindsey Marwood, Jess Kerr-Gaffney, Toby Wise, Rebecca Strawbridge, Adam M. Perkins, Anthony J. Cleare
Summary: The current study aimed to pilot a new measure of self-reflection, the Fake IQ Test (FIQT), and explore its relation to major depressive disorder (MDD). Results showed that participants with MDD demonstrated higher negative self-comparison and lower self-satisfaction on the FIQT task, but FIQT scores were not related to existing self-report measures of self-reflection. This suggests that the FIQT may be measuring a different construct or aspects of self-reflection inaccessible to current questionnaires.
Review
Psychology, Clinical
Elizabeth R. Wallace, Suzanne C. Segerstrom, Craig G. van Horne, Frederick A. Schmitt, Lisa M. Koehl
Summary: This study conducted a meta-analysis on PD-MCI patients and found significant differences in cognitive test performance, with cognitive screeners showing the most pronounced effect. In the progression from PD-MCI to PDD, executive dysfunction exhibits a significant impact.
NEUROPSYCHOLOGY REVIEW
(2022)
Article
Geriatrics & Gerontology
Suzanne C. Segerstrom, Addison D. Monroe, Leslie J. Crofford
Summary: Pain may limit social and leisure activities in older adults, but autonomously motivated goal engagement can alleviate the negative effects of pain on goal engagement and amplify the positive effects of goal engagement on well-being.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2022)
Article
Psychology, Multidisciplinary
Kathleen D. Vohs, Brandon J. Schmeichel, Sophie Lohmann, Quentin F. Gronau, Anna J. Finley, Sarah E. Ainsworth, Jessica L. Alquist, Michael D. Baker, Ambra Brizi, Angelica Bunyi, Grant J. Butschek, Collier Campbell, Jonathan Capaldi, Chuting Cau, Heather Chambers, Nikos L. D. Chatzisarantis, Weston J. Christensen, Samuel L. Clay, Jessica Curtis, Valeria De Cristofaro, Kareena Del Rosario, Katharina Diel, Yasemin Dogruol, Megan Doi, Tina L. Donaldson, Andreas B. Eder, Mia Ersoff, Julie R. Eyink, Angelica Falkenstein, Bob M. Fennis, Matthew B. Findley, Eli J. Finkel, Victoria Forgea, Malte Friese, Paul Fuglestad, Natasha E. Garcia-Willingham, Lea F. Geraedts, Will M. Gervais, Mauro Giacomantonio, Bryan Gibson, Karolin Gieseler, Justina Gineikiene, Elana M. Gloger, Carina M. Gobes, Maria Grande, Martin S. Hagger, Bethany Hartsell, Anthony D. Hermann, Jasper J. Hidding, Edward R. Hirt, Josh Hodge, Wilhelm Hofmann, Jennifer L. Howell, Robert D. Hutton, Michael Inzlicht, Lily James, Emily Johnson, Hannah L. Johnson, Sarah M. Joyce, Yannick Joye, Jan Helge Kaben, Lara K. Kammrath, Caitlin N. Kelly, Brian L. Kissell, Sander L. Koole, Anand Krishna, Christine Lam, Kelemen T. Lee, Nick Lee, Dana C. Leighton, David D. Loschelder, Heather M. Maranges, E. J. Masicampo, Kennedy Mazara, Samantha McCarthy, Ian McGregor, Nicole L. Mead, Wendy B. Mendes, Carine Meslot, Nicholas M. Michalak, Marina Milyavskaya, Akira Miyake, Mehrad Moeini-Jazani, Mark Muraven, Erin Nakahara, Krishna Patel, John Petrocelli, Katja M. Pollak, Mindi M. Price, Haley J. Ramsey, Maximilian Rath, Jacob A. Robertson, Rachael Rockwell, Isabella F. Russ, Marco Salvati, Blair Saunders, Anne Scherer, Astrid Schutz, Kristin N. Schmitt, Suzanne C. Segerstrom, Benjamin Serenka, Konstantyn Sharpinskyi, Meaghan Shaw, Janelle Sherman, Yu Song, Nicholas Sosa, Kaitlyn Spillane, Julia Stapels, Alec J. Stinnett, Hannah R. Strawser, Kate Sweeny, Dominic Theodore, Karine Tonnu, Yasmijn van Oldenbeuving, Michelle R. VanDellen, Raiza C. Vergara, Jasmine S. Walker, Christian E. Waugh, Feline Weise, Kaitlyn M. Werner, Craig Wheeler, Rachel A. White, Aaron L. Wichman, Bradford J. Wiggins, Julian A. Wills, Janie H. Wilson, Eric-Jan Wagenmakers, Dolores Albarracin
Summary: The preregistered study did not find evidence for ego-depletion effects. Exploratory analyses showed a statistically significant effect in the full sample, with moderator tests indicating that participants who reported more fatigue were more affected by depletion effects, while trait self-control, willpower beliefs, or action orientation did not moderate the effect.
PSYCHOLOGICAL SCIENCE
(2021)
Article
Psychology, Clinical
Rebecca G. Reed, Iris B. Mauss, Nilam Ram, Suzanne C. Segerstrom
Summary: The study found that more frequent daily stressors were associated with lower inflammation markers, while more severe stressors were associated with higher inflammation markers. Daily stressor frequency and severity may interact and synergistically associate with inflammatory markers.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Kristen Nishimi, Karestan C. Koenen, Brent A. Coull, Suzanne C. Segerstrom, S. Bryn Austin, Laura D. Kubzansky
Summary: Psychological resilience is associated with diurnal salivary cortisol levels in young adults. A high burden of early adversity may disrupt the physiological stress system, while psychological health may be associated with more normative cortisol levels when adversity is low.
PSYCHONEUROENDOCRINOLOGY
(2022)
Editorial Material
Psychiatry
Suzanne C. Segerstrom
Summary: The new Editor-in-Chief expresses gratitude to the outgoing editorial team, reflects on the long-lasting impact of the journal, and looks forward to future challenges and opportunities. Science and scientific publications need to address and embrace reproducibility and replication, inclusivity and diversity, statistical advances, and more.
PSYCHOSOMATIC MEDICINE
(2022)
Article
Psychiatry
Suzanne C. Segerstrom, Rebecca G. Reed, Justin E. Karr
Summary: This study found that CMV latent infection is associated with more problems in self-regulation among older adults, while T. gondii is only associated with self-regulation problems in women. This suggests that latent infection might affect self-regulation factors, but not neuropsychological test performance.
PSYCHOSOMATIC MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Elana M. Gloger, Suzanne C. Segerstrom
Summary: This study found an interaction effect between cognition and repetitive thought on different inflammatory biomarkers. Individuals with lower cognition and more negative repetitive thoughts had higher levels of inflammation, while those with higher cognition and fewer negative repetitive thoughts had lower levels of inflammation.
PSYCHOLOGY & HEALTH
(2022)
Article
Psychology, Clinical
Suzanne C. Segerstrom, Rebecca G. Reed, Steven R. Presnell, Ahmad Al-Attar, Charles T. Lutz
Summary: This study found that women's financial resources were associated with more terminal maturity in natural killer lymphocytes, particularly during the Great Recession. Psychological resources were negatively correlated with terminal maturity in T cells.
Article
Psychology, Clinical
Suzanne C. A. Segerstrom, Michael A. Diefenbach, Kyra B. Hamilton, Daryl B. A. O'Connor, Janet A. Tomiyama, Behav Med Res Council
Summary: Open Science practices involve registering and publishing study protocols, making preprints and research materials available, and sharing de-identified data sets and analytic codes. This article summarizes the methods of Open Science, including preregistration, registered reports, preprints, and open research, and discusses the reasons to engage in Open Science and how to address shortcomings and objections.
Article
Gerontology
Suzanne C. Segerstrom, Paris Crosby, Dakota D. Witzel, Maria L. Kurth, Soyoung Choun, Carolyn M. Aldwin
Summary: The COVID-19 pandemic has had a negative impact on older adults' psychological health. The severity of the pandemic and age play a role in their coping efficacy. Older adults may be more vulnerable to long-term psychological effects but more resilient to short-term effects of the pandemic.
PSYCHOLOGY AND AGING
(2023)
Article
Psychology, Multidisciplinary
Suzanne C. Segerstrom, Michael A. Diefenbach, Kyra Hamilton, Daryl B. O'Connor, A. Janet Tomiyama, Behav Med Res Council
Summary: Open Science practices involve registering and publishing study protocols, making preprints and research materials available, and sharing de-identified data sets and analytic codes. The Behavioral Medicine Research Council gives an overview of these practices, including preregistration, registered reports, preprints, and open research. They also discuss the benefits of Open Science and how to address potential concerns.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Article
Psychiatry
Suzanne C. Segerstrom
PSYCHOSOMATIC MEDICINE
(2023)
Meeting Abstract
Psychiatry
Elana M. Gloger, Kate A. Leger, Leslie J. Crofford, Suzanne C. Segerstrom
PSYCHOSOMATIC MEDICINE
(2022)
Meeting Abstract
Psychology, Multidisciplinary
Addison D. Monroe, Stephanie T. Judge, Chelsea L. Bass, Leslie J. Crofford, Suzanne C. Segerstrom
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)