Article
Multidisciplinary Sciences
Mohammad Hazaymeh, Ronja Loeber-Handwerker, Katja Doering, Tammam Abboud, Dorothee Mielke, Veit Rohde, Vesna Malinova
Summary: Approximately 25% of glioblastomas show corpus callosum infiltration at diagnosis, which is associated with poor prognosis. The extent of corpus callosum involvement ranges from partial unilateral to complete bilateral infiltration. The role of surgery in glioblastoma with corpus callosum involvement is controversial.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Vicente Llorente, Pedro Velarde, Manuel Desco, Maria Victoria Gomez-Gaviro
Summary: This review summarizes the latest research on neural stem cells and their canonical niches, including their structure, behaviors, and role in neural diseases.
Article
Multidisciplinary Sciences
Anneline Pinson, Lei Xing, Takashi Namba, Nereo Kalebic, Jula Peters, Christina Eugster Oegema, Sofia Traikov, Katrin Reppe, Stephan Riesenberg, Tomislav Maricic, RazVan derihaci, Pauline Wimberger, Svante Paabo, Wieland B. Huttner
Summary: This study found that the modern human variant hTKTL1, but not the Neanderthal variant, can increase the abundance of bRG without affecting bIPs, thereby affecting the generation of neocortical neurons. This indicates differences in neocortical neurogenesis between modern humans and Neanderthals.
Article
Biochemistry & Molecular Biology
Zizhen Yao, Cindy T. J. van Velthoven, Thuc Nghi Nguyen, Jeff Goldy, Adriana E. Sedeno-Cortes, Fahimeh Baftizadeh, Darren Bertagnolli, Tamara Casper, Megan Chiang, Kirsten Crichton, Song-Lin Ding, Olivia Fong, Emma Garren, Alexandra Glandon, Nathan W. Gouwens, James Gray, Lucas T. Graybuck, Michael J. Hawrylycz, Daniel Hirschstein, Matthew Kroll, Kanan Lathia, Changkyu Lee, Boaz Levi, Delissa McMillen, Stephanie Mok, Thanh Pham, Qingzhong Ren, Christine Rimorin, Nadiya Shapovalova, Josef Sulc, Susan M. Sunkin, Michael Tieu, Amy Torkelson, Herman Tung, Katelyn Ward, Nick Dee, Kimberly A. Smith, Bosiljka Tasic, Hongkui Zeng
Summary: This study provides a comprehensive analysis of cell types in the mammalian isocortex and hippocampal formation, revealing a shared neural circuit organization between the two structures. The research also uncovers large-scale variations in cell types along different dimensions within these brain regions.
Article
Pediatrics
Daniel Alonso-Alconada, Pierre Gressens, Xavier Golay, Nicola J. Robertson
Summary: Hypoxia-ischemia can lead to a decrease in cell proliferation and neurogenesis in the neurogenic niche of the neonatal piglet, which may hinder the replacement of lost neurons and overall repair.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Jonathan Isacco Battistini, Valentina Mastrorilli, Vittoria Nicolis di Robilant, Daniele Saraulli, Sara Marinelli, Stefano Farioli Vecchioli
Summary: Traumatic brain injury (TBI) is a common cause of death and disability worldwide, with no effective treatments available. Recent studies have suggested that adult neurogenesis may be a new approach to counteract post-traumatic neurodegeneration. It has been shown that long-term running can enhance adult neurogenesis and promote neuroregeneration and functional recovery after injury. These findings suggest that running could be a promising method to increase neural stem cells and improve endogenous neuroregenerative responses following brain trauma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ana C. Delgado, Angel R. Maldonado-Soto, Violeta Silva-Vargas, Dogukan Mizrak, Thomas von Kanel, Kelly R. Tan, Alex Paul, Aviv Madar, Henar Cuervo, Jan Kitajewski, Chyuan-Sheng Lin, Fiona Doetsch
Summary: Adult neural stem cells in the ventricular-subventricular zone of mice can generate glial cells in addition to neurons, with certain domains remaining quiescent under normal conditions. Our study also uncovers an intraventricular oligodendrocyte progenitor derived from NSCs that is recruited upon injury.
Article
Biochemistry & Molecular Biology
Mikhail Semenov
Summary: The study focused on cell proliferation in the postnatal mouse brain, identifying four compartments with different densities of proliferating cells. It estimated the number of new cells produced in each compartment and concluded that adult neurogenesis only supports compensatory regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Louis Scheurer, Rebecca R. Das Gupta, Annika Saebisch, Thomas Grampp, Dietmar Benke, Hanns Ulrich Zeilhofer, Hendrik Wildner
Summary: The study reveals the expression of two heavy chain immunoglobulin genes in neurons of the mouse brain and spinal cord, suggesting a previously unknown function of these neuronal proteins. Protein translation from these neuronal transcripts contains four Immunoglobulin domains, supported by immunohistochemical, Western blot, and in silico analyses.
LIFE SCIENCE ALLIANCE
(2021)
Article
Biochemistry & Molecular Biology
Jana Osacka, Alexander Kiss, Zuzana Bacova, Andrej Tillinger
Summary: Aberrant neurogenesis in the subventricular zone and hippocampus contributes to schizophrenia pathogenesis. The commonly prescribed antipsychotics haloperidol and olanzapine affect neurogenesis. This study investigates the effects of these drugs on cell proliferation and gene expression in vitro and in an animal schizophrenia model. The results suggest that chronic treatment with haloperidol and olanzapine can inhibit gene expression, but olanzapine can reverse the inhibitory effect of another drug in the model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Maria Angeles Marques-Torrejon, Charles A. C. Williams, Benjamin Southgate, Neza Alfazema, Melanie P. Clements, Claudia Garcia-Diaz, Carla Blin, Nerea Arranz-Emparan, Jane Fraser, Noor Gammoh, Simona Parrinello, Steven M. Pollard
Summary: Neural stem cells can transition between states of proliferation and quiescence, with LRIG1 identified as a crucial regulator in maintaining cells in a quiescent state and priming them for cell cycle re-entry and EGFR responsiveness by modulating the EGFR pathway.
NATURE COMMUNICATIONS
(2021)
Review
Pediatrics
Andi Chen, Xiaohui Chen, Jianhui Deng, Xiaochun Zheng
Summary: Hypoxic-ischemic brain damage is the leading cause of perinatal mortality and neurological complications in neonates. Promoting endogenous neurogenesis can improve neonatal neurological dysfunction post-HIBD. However, the capacity for spontaneous endogenous neurogenesis is limited, emphasizing the importance of seeking therapeutic techniques that can enhance neurogenesis.
FRONTIERS IN PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Xiaoqing Zhu, Yicheng Guo, Chu Chu, Dahai Liu, Kui Duan, Yu Yin, Chenyang Si, Yu Kang, Junjun Yao, Xuewei Du, Junliang Li, Shumei Zhao, Zongyong Ai, Qingyuan Zhu, Weizhi Ji, Yuyu Niu, Tianqing Li
Summary: This study found that BRN2 is a conserved gene that plays a key role in primate brain development. Through gene knockout experiments in cynomolgus monkeys, it was found that the absence of BRN2 leads to embryonic death before midgestation and has negative effects on brain development. Further analysis revealed that BRN2 is responsible for controlling the specification and differentiation of ganglionic eminences. Additionally, the study also found that BRN2 has a similar function in retinal ganglion cells of cynomolgus monkeys and humans.
Article
Veterinary Sciences
Mahmoud Dahab, Cyrine Ben-Dhaou, Maeva Cherif-Feildel, Marie Moftah, Hussein Khamis Hussein, Emmanuel Moyse, Sherine Abdel Salam
Summary: This study directly addresses the existence of neural stem cells in the neurogenic niche of the vagal centre in adult ovine mammals. The findings show the formation of expandable and self-renewing spheres in the neurogenic niche, as well as differences in the expression of specific markers compared to other neurogenic regions. This discovery has important implications for understanding the dynamics of adult mammalian neurogenesis and corresponding features in other species.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Guillaume Marcy, Louis Foucault, Elodie Babina, Timothy Capeliez, Emeric Texeraud, Stefan Zweifel, Christophe Heinrich, Hector Hernandez-Vargas, Carlos Parras, Denis Jabaudon, Olivier Raineteau
Summary: By performing single-cell RNA sequencing of the ventricular-subventricular zone, researchers found that neural stem cells enter a state of deep quiescence and suppress the production and differentiation of glutamatergic neurons, leading to rapid silencing of pallial germinal activity.