Article
Endocrinology & Metabolism
Gail A. Greendale, Weijuan Han, Joel S. Finkelstein, Sherri-Ann M. Burnett-Bowie, MeiHua Huang, Deborah Martin, Arun S. Karlamangla
Summary: The menopause transition is associated with the development of central adiposity, while waist or hip circumferences are less sensitive to changes in fat distribution.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Gail A. Greendale, Weijuan Han, Joel S. Finkelstein, Sherri-Ann M. Burnett-Bowie, Mei Hua Huang, Deborah Martin, Arun S. Karlamangla
Summary: The menopause transition is associated with the development of central adiposity, as evidenced by increases in waist and hip circumferences during this period, indicating changes in fat distribution, with a slower growth rate in hip circumference.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Ruizhi Zheng, Mian Li, Min Xu, Jieli Lu, Tiange Wang, Meng Dai, Di Zhang, Yuhong Chen, Zhiyun Zhao, Shuangyuan Wang, Hong Lin, Weiqing Wang, Yufang Bi, Yu Xu, Guang Ning
Summary: The study found that residual waist circumference was significantly associated with all cardiometabolic risk factors in mainland Chinese adults, but not necessarily for other racial/ethnic populations. Furthermore, Chinese adults are more susceptible to the effects of overall obesity and fat distribution on cardiometabolic risk factors compared to other racial/ethnic groups.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Marie Mathieu, Pascale Guillot, Typhaine Riaudel, Anne-Sophie Boureau, Guillaume Chapelet, Celine Brouessard, Laure de Decker, Gilles Berrut
Summary: This study aimed to explore the relationship between osteoporosis and sarcopenia in women aged 75 or older, revealing a significant association between fat mass and bone density, with osteosarcopenic patients having lower fat mass and body mass index.
Article
Multidisciplinary Sciences
Kosuke Imai, Santiago Olivella, Evan T. R. Rosenman
Summary: Prediction of individuals' race and ethnicity is crucial in studying racial disparity. Bayesian Improved Surname Geocoding (BISG) is a leading methodology for this task, but it faces data problems. We introduce a fully Bayesian BISG (fBISG) method that addresses census measurement error and utilizes additional name data to improve race imputation accuracy.
Article
Medicine, General & Internal
Paivi E. Korhonen, Tuija Mikkola, Hannu Kautiainen, Johan G. Eriksson
Summary: This study found that both fat mass and lean mass index are positively associated with blood pressure levels, independently of other factors. Lean body mass is shown to be an important determinant of blood pressure levels, with a magnitude similar to fat mass. Excess muscle mass may not be beneficial to cardiovascular health.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Sabrina A. Assoumou, Alicia Peterson, Ellen Ginman, Thea James, Cassandra M. Pierre, Sebastian Hamilton, Sheila Chapman, John Goldie, Robert Koenig, Elena Mendez-Escobar, Hannah Leaver, Robert Graham, Renee Crichlow, Tarsha Weaver, Sandra Cotterell, Guale Valdez, Denise De Las Nueces, Nancy A. Scott, Benjamin P. Linas, Petrina Martin Cherry
Summary: Academic medical centers are crucial in increasing access to and uptake of SARS-CoV-2 vaccines. The Boston Medical Center implemented a vaccination program that focused on community-based sites, mobile vaccination events, and strong partnerships to ensure equitable distribution. Challenges included the need for a robust operational infrastructure and addressing community mistrust.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Evan T. R. Rosenman, Santiago Olivella, Kosuke Imai
Summary: This research provides the largest compiled dictionaries of names, covering first, middle, and surnames, which are used for imputing race and ethnicity using Bayesian Improved Surname Geocoding (BISG). The data, based on voter files of six U.S. Southern States, contains a larger set of names than any comparable dataset, including 136 thousand first names, 125 thousand middle names, and 338 thousand surnames. Each name is categorized into five mutually exclusive racial and ethnic groups, and conditional probabilities are provided for imputation purposes.
Article
Endocrinology & Metabolism
Ya Shao, Longti Li, Huiqin Zhong, Xiaojun Wang, Yu Hua, Xu Zhou
Summary: The study found a negative correlation between lean body mass and insulin resistance, while visceral fat mass was positively correlated. The Log LM/VFM ratio showed a nonlinear relationship with IR, with threshold and saturation effects observed. Subgroup analysis showed robustness in the relationship between Log LM/VFM and IR across different demographic and health variables.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Mengyi Liu, Zhuxian Zhang, Chun Zhou, Ziliang Ye, Panpan He, Yuanyuan Zhang, Huan Li, Chengzhang Liu, Xianhui Qin
Summary: This study explores the association between predicted fat mass and lean mass with mortality in the US general population, finding that both fat mass and lean mass are independent predictors of overall and cause-specific mortality. Age was found to significantly modify the associations.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Endocrinology & Metabolism
Jingzheng Fan, Yuyan Jiang, Junlian Qiang, Bin Han, Qiang Zhang
Summary: This study investigated the relationship between body fat accumulation, fat distribution, and bone mineral density in non-obese postmenopausal women. The results showed a positive association between total fat mass and bone mineral density, while fat distribution had a negative correlation with bone mineral density.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Anda Botoseneanu, Sheila Markwardt, Corey L. Nagel, Heather G. Allore, Jason T. Newsom, David A. Dorr, Ana R. Quinones
Summary: This study found that obesity and multimorbidity are more prevalent among racial/ethnic minority groups in the United States. Non-Hispanic Black and Hispanic participants had higher rates of overweight and obesity compared to non-Hispanic White participants. The accumulation of chronic diseases was faster in the obese class 2/3 and marginally in the obese class 1 categories. Black participants across BMI categories had a higher initial burden and faster accumulation of disease over time, while Hispanics had a lower initial burden and similar rate of accumulation compared with Whites. Black participants, including those with normal BMI, reached the multimorbidity threshold 5-6 years earlier than White participants.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Seong Rae Kim, Gyeongsil Lee, Seulggie Choi, Yun Hwan Oh, Joung Sik Son, Minseon Park, Sang Min Park
Summary: This study found that increased predicted muscle mass or decreased predicted fat mass were associated with a reduced risk of cardiovascular disease (CVD) in young adults. Conversely, decreased predicted muscle mass or increased predicted fat mass were associated with an elevated risk of CVD.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Jason Amartey, Chichi Okagbue, Adama Saccoh, Stanley Buffonge, Ashley Francois, Catherine Tcheandjieu, Shaneice Mitchell, Daniel J. Tyrrell, Debora Kamin Mukaz
Summary: Black In Cardio is a trainee-led initiative that aims to promote Black individuals in the cardiovascular field and raise awareness about cardiovascular health issues within Black communities.
NATURE REVIEWS CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Lauren A. Eberly, Lohit Garg, Lin Yang, Timothy M. Markman, Ashwin S. Nathan, Nwamaka D. Eneanya, Sanjay Dixit, Francis E. Marchlinski, Peter W. Groeneveld, David S. Frankel
Summary: This study found that despite increased use of rhythm control strategies for treatment of paroxysmal AF, catheter ablation use remained low and patients from racial/ethnic minority groups and those with lower income were less likely to receive rhythm control treatment, especially catheter ablation. These findings highlight inequities in paroxysmal AF management based on race/ethnicity and socioeconomic status.
Article
Education, Scientific Disciplines
Lauren E. O'Connor, Tracy K. Eaton, Dennis A. Savaiano
JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR
(2015)
Article
Nutrition & Dietetics
Dennis A. Savaiano
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2014)
Article
Anthropology
Daniel L. Osborne, Connie M. Weaver, Linda D. McCabe, George P. McCabe, Rachel Novotny, Carol Boushey, Dennis A. Savaiano
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2011)
Article
Medicine, Research & Experimental
David G. Marrero, Emily J. Hardwick, Lisa K. Staten, Dennis A. Savaiano, Jere D. Odell, Karen Frederickson Comer, Chandan Saha
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2013)
Review
Food Science & Technology
O. Brown-Esters, P. Mc Namara, D. Savaiano
INTERNATIONAL DAIRY JOURNAL
(2012)
Article
Nutrition & Dietetics
Dennis A. Savaiano, Andrew J. Ritter, Todd R. Klaenhammer, Gareth M. James, Amy T. Longcore, Justin R. Chandler, W. Allan Walker, Howard L. Foyt
Review
Nutrition & Dietetics
Rebecca A. Lapides, Dennis A. Savaiano
Review
Nutrition & Dietetics
Dennis A. Savaiano, Robert W. Hutkins
Summary: Consumption of yogurt and other fermented products has positive effects on gastrointestinal and cardiovascular health, cancer risk, weight management, diabetes and metabolic health, and bone density. There is a causal relationship between lactose digestion and tolerance and yogurt consumption, and consistent associations between fermented milk consumption and reduced risk of breast and colorectal cancer and type 2 diabetes, improved weight maintenance, and improved cardiovascular, bone, and gastrointestinal health. Dairy product consumption, including fermented products like yogurt, should be encouraged as part of national dietary guidelines for favorable health outcomes.
Article
Nutrition & Dietetics
William Chey, William Sandborn, Andrew J. Ritter, Howard Foyt, M. Andrea Azcarate-Peril, Dennis A. Savaiano
Article
Nutrition & Dietetics
Monica Ramakrishnan, Tracy K. Eaton, Omer M. Sermet, Dennis A. Savaiano
Article
Nutrition & Dietetics
Monica Ramakrishnan, Xiaopeng Zhou, Ulrike Dydak, Dennis A. A. Savaiano
Summary: Lactose maldigesters experience increased abdominal pain after consuming milk with a mixture of A1 and A2 beta-casein compared to milk with only A2 beta-casein. The speed of gastric transit affects gastrointestinal symptoms, and faster transit is associated with more abdominal pain. In a study involving 10 lactose maldigesters, it was found that the volume of milk in the stomach was significantly lower at 30, 60, and 120 minutes after consuming milk with 75% A1 beta-casein and 25% A2 beta-casein compared to milk with 100% A2 beta-casein. The transit of New-World milk containing both A1 and A2 beta-casein was faster than Old-World milk containing only A2 beta-casein, and this difference may contribute to lactose intolerance symptoms.
Review
Nutrition & Dietetics
Sindusha Mysore Saiprasad, Olivia Grace Moreno, Dennis A. Savaiano
Summary: Supplementing with Bifidobacterium and galacto-oligosaccharides (GOS) can improve gut health and benefit lactose intolerant individuals. Most studies have reported positive effects of Bifidobacterium and GOS in managing lactose intolerance.
Article
Pediatrics
Marie K. Fialkowski, Reynolette Ettienne, Yurii B. Shvetsov, Rebecca L. Rivera, Marta D. Van Loan, Dennis A. Savaiano, Carol J. Boushey
ADOLESCENT HEALTH MEDICINE AND THERAPEUTICS
(2015)
Article
Education & Educational Research
Onikia N. Brown, Lauren E. O'Connor, Dennis Savaiano
JOURNAL OF AMERICAN COLLEGE HEALTH
(2014)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.