Review
Cell Biology
Elena V. Mitroshina, Maria O. Savyuk, Evgeni Ponimaskin, Maria V. Vedunova
Summary: Hypoxia is a common pathological condition induced by various events, with the body's adaptation to it being crucial for health and disease. HIFs, a family of transcription factors, play a key role in cellular responses to hypoxia and are increasingly viewed as potential targets for treating a range of hypoxia-associated diseases. The role of HIFs in adaptation to hypoxia is universal across tissue types, including the CNS, where they are involved in regulating neurogenesis, nerve cell differentiation, and neuronal apoptosis, potentially offering new therapeutic opportunities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Orthopedics
Jiarui Zhang, Yoshihiro Nishida, Hiroshi Koike, Kan Ito, Lisheng Zhuo, Kazuki Nishida, Koji Kimata, Kunihiro Ikuta, Tomohisa Sakai, Hiroshi Urakawa, Taisuke Seki, Shiro Imagama
Summary: This study investigated the metabolism of HA in OA and ONFH, finding that KIAA1199 is overexpressed in OA cartilage but less expressed in ONFH cartilage. Additionally, the molecular weight of HA increased in OA cartilage but decreased in ONFH cartilage.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xueliang Lu, Junlong Wu, Yannan Qin, Jialin Liang, Hang Qian, Jidong Song, Chengjuan Qu, Ruiyu Liu
Summary: This study identified glycoproteins in ONFH hip cartilage and found differentially expressed glycoproteins related to cartilage degeneration processes. Analysis of KEGG pathways and protein-protein interactions indicated that these significantly differential glycoproteins are associated with multiple signaling pathways and protein biosynthesis processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Huixia Liu, Yujuan Li, Jing Xiong
Summary: The kidney maintains a relatively stable level of oxygen partial pressure through a complex interplay of various factors. Hypoxia is a key factor in the pathogenesis of acute kidney injury and chronic kidney disease, as well as in the development of renal cancer.
Article
Biochemistry & Molecular Biology
Gul Merve Yalcin-Ulker, Murat Gunbatan, Gonca Duygu, Merva Soluk-Tekkesin, Ceyda Ozcakir-Tomruk
Summary: This study examines the preventive effect of deferoxamine (DFO) on medication-related osteonecrosis of the jaw (MRONJ). Female Sprague Dawley rats were treated with zoledronic acid (ZA) to create an osteonecrosis model, and DFO was applied locally to prevent MRONJ. The results showed no significant difference in new bone formation between the treatment groups, although HIF-1 alpha levels were higher in the DFO-treated group. Further large-scale studies are needed to understand the preventive effects of DFO on MRONJ.
Review
Pharmacology & Pharmacy
Zirong Pan, Guodong Ma, Linglei Kong, Guanhua Du
Summary: Stroke is an acute cerebrovascular disease caused by sudden rupture or blockage of blood vessels in the brain, and HIF-1 plays an important role in regulating various pathways in the pathological process. The roles of HIF-1 in stroke are controversial, involving factors such as ischemic time and degree, and its regulatory mechanisms include inflammation, autophagy, oxidative stress, and apoptosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Orthopedics
J. Song, J. Wu, B. Poulet, J. Liang, C. Bai, X. Dang, K. Wang, L. Fan, R. Liu
Summary: In this study, proteomic analysis was used to compare the protein profiles of ONFH cartilage with fracture control. The results revealed 303 differentially expressed proteins, implicating the altered protein expressions in the development of ONFH. Key proteins such as AHSG and Cytl1 were found to be significantly modified in ONFH cartilage.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Cell Biology
Yaling Yu, Lishan Lin, Kangping Liu, Yixin Jiang, Zhenlei Zhou
Summary: This study found that the occurrence of steroid-induced osteonecrosis of the femoral head (SONFH) is related to the activation of the glucocorticoid receptor (GR) and hypoxia-inducible factor (HIF) pathway, as well as an imbalance in cartilage homeostasis. Simvastatin and a GR inhibitor maintain cartilage homeostasis through the GR and HIF pathways.
Review
Genetics & Heredity
Zhenjia Che, Yang Song, Liwei Zhu, Tengyue Liu, Xudong Li, Lanfeng Huang
Summary: Osteonecrosis of the femoral head is a orthopedic condition that often requires total hip arthroplasty. Dysregulated growth factor-related genes may play a role in its development. Tissue and genetic engineering may be potential treatment strategies.
FRONTIERS IN GENETICS
(2022)
Article
Orthopedics
Yongheng Ye, Yue Peng, Peiheng He, Qinqin Zhang, Dongliang Xu
Summary: This study identified 13 differentially abundant miRNAs in the urine of patients with idiopathic osteonecrosis of femoral head (ONFH), indicating their diagnostic and prognostic value as biomarkers for ONFH. The noninvasive nature of urinary miRNAs testing makes it potentially useful for the diagnosis and monitoring of ONFH progression.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Medical Laboratory Technology
Shao-Wei Zheng, Chun-Han Sun, Zhi-Jia Wen, Wei-Le Liu, Xu Li, Tian-Yu Chen, Yu-Cong Zou, Hao-Bo Zhong, Zhan-Jun Shi
Summary: This study found that serum CXCL12 levels were negatively associated with disease severity in patients with non-traumatic ONFH and may serve as a favorable marker for FICAT grading.
CLINICA CHIMICA ACTA
(2022)
Article
Cell Biology
Jiahe Liu, Chenzhi Li, Fan Yang, Minde Li, Baolin Wu, Haojie Chen, Shaopeng Li, Xiuzhi Zhang, Jiahui Yang, Yan Xia, Mingjian Wu, Yancheng Li, Baoyi Liu, Dewei Zhao
Summary: This study aimed to establish a new mouse model of osteonecrosis using angiotensin II combined with asparaginase and dexamethasone, and to study the effects of this drug combination on femoral head osteonecrosis in mice. The results showed that this drug combination can significantly promote necrosis of the femoral head and disrupt the local blood supply.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Peixu Wang, Xingyu Liu, Jia Xu, Tengqi Li, Wei Sun, Zirong Li, Fuqiang Gao, Lijun Shi, Zhizhuo Li, Xinjie Wu, Xin Xu, Xiaoyu Fan, Chengxin Li, Yiling Zhang, Yicheng An
Summary: A fully automatic deep learning model was developed in this study to detect early-stage ONFH lesions on MRI, showing promising diagnostic performance. The model's AUC was 0.97 with high sensitivity and specificity, and it exhibited good correlation with the ground truth definition. More extensive multicenter studies are needed to further validate and refine the model.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Orthopedics
Noriko Yamamoto, Goro Motomura, Satoshi Ikemura, Ryosuke Yamaguchi, Takeshi Utsunomiya, Koichiro Kawano, Mingjian Xu, Hidenao Tanaka, Yusuke Ayabe, Yasuharu Nakashima
Summary: This study found that articular surface irregularities are often observed in collapsed femoral heads with osteonecrosis, and the degree of collapse has a significant impact on these irregularities. The presence of articular surface irregularities is positively correlated with the degree of collapse, and even in the absence of macroscopically determined gross irregularities, the articular cartilage is already altered.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Medicine, Research & Experimental
Min Kyung Park, Jun Ji, Keeok Haam, Tae-Hee Han, Seona Lim, Mi-Jung Kang, Soon Sung Lim, Hyun Seung Ban
Summary: Licochalcone A, a component of Glycyrrhiza uralensis, demonstrates potential as a therapeutic agent in hypoxic cancer cells by inhibiting HIF-1 alpha accumulation and mitochondrial respiration, leading to increased oxygen content and suppression of cancer cell viability.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Orthopedics
Casey P. Johnson, Ferenc Toth, Cathy S. Carlson, Alexandra R. Armstrong, Stefan Zbyn, Baolin Wu, Jutta M. Ellermann, Harry K. W. Kim
Summary: The study found that T1 rho and T2 relaxation time mapping were sensitive in detecting acute ischemic injury to the secondary ossification center and epiphyseal cartilage of the femoral head in a piglet model of Legg-Calve-Perthes disease as early as 48 h after ischemia induction.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Orthopedics
Jeffrey B. Peck, Dustin A. Greenhill, William Z. Morris, Dang-Huy Do, Molly F. McGuire, Harry K. W. Kim
Summary: The study investigates the potential benefits of prolonged non-weightbearing treatment for early-stage LCPD. The results show that initiating prolonged non-weightbearing treatment during the initial stage of LCPD can decrease femoral head deformity.
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2022)
Article
Endocrinology & Metabolism
Zhuo Deng, Yinshi Ren, Min Sung Park, Harry K. W. Kim
Summary: The study revealed that DAMPs and inflammatory cytokines present in necrotic femoral heads inhibit osteogenesis of MSCs and promote fibrogenesis, potentially contributing to impaired bone regeneration as seen in LCPD.
Article
Orthopedics
Dang-Huy Do, Angel A. Valencia, Chan-Hee Jo, Harry K. W. Kim
Summary: This study explores the impact of weightbearing and activity restrictions on the mental, social, and physical health of children aged 5 to 7 with Perthes disease. The results suggest that moderate restrictions are associated with worse depressive symptoms and anxiety, but not with anger, peer relationships, pain interference, and fatigue. These findings provide important guidance for providing appropriate mental health support and treatment recommendations.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2022)
Article
Orthopedics
Emily K. Schaeffer, Ethan Ponton, Wudbhav N. Sankar, Harry K. W. Kim, Simon P. Kelley, Peter J. Cundy, Charles T. Price, Nicholas M. P. Clarke, John H. Wedge, Kishore Mulpuri
Summary: Avascular necrosis (AVN) of the femoral head is a concerning complication that can result from treatments for developmental dysplasia of the hip (DDH). The incidence of AVN varies widely in the literature, and despite using commonly referenced diagnostic criteria, radiographic diagnosis of AVN following closed reduction in DDH patients shows only moderate agreement among surgeons.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2022)
Article
Orthopedics
Hitesh Shah, Kumar A. Singh, Ishaan Swarup, William Morris, Harry K. W. Kim, Benjamin Joseph
Summary: This study assessed the reproducibility of using DI to predict the shape of the femoral head when LCPD healed. The results showed that the predictive value of DI was not high enough to justify its use as an outcome measure.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2022)
Article
Orthopedics
William Z. Morris, Angel A. Valencia, Molly F. McGuire, Harry K. W. Kim
Summary: This study found that in early Legg-Calve-Perthes disease, half of the hips showed separate and distinct medial and lateral sources of perfusion. As the disease progressed, there was a trend towards increased coalescence of medial and lateral perfusion. A weak negative correlation was observed between lower initial perfusion grade and worsened lateral pillar classification at mid-fragmentation.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2022)
Article
Orthopedics
William Z. Morris, Sai Chilakapati, Sean A. Hinds, John A. Herring, Harry K. W. Kim
Summary: The presence of an infolded limbus during closed reduction for hip dysplasia was more common in older patients with more severe dislocations. However, it was not associated with increased residual dysplasia or the need for secondary surgery, indicating limited utility in decision-making during closed reduction.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2022)
Article
Orthopedics
A. R. Armstrong, S. Bhave, E. O. Buko, K. L. Chase, F. Toth, C. S. Carlson, J. M. Ellermann, H. K. W. Kim, C. P. Johnson
Summary: This study investigated the sensitivity of T2 and T1 rho quantitative MRI techniques to ischemic injury in epiphyseal cartilage of Legg-Calve-Perthes disease using a clinical 3T MRI scanner. It was found that T2 and T1 rho relaxation times were significantly increased in the ischemic cartilage. These techniques may have clinical utility in assessing and staging ischemic damage in Legg-Calve-Perthes disease.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Orthopedics
Graham Andre, Francesco Boschetto, Vishal Gokani, Mo Singhal, Yan Jing, Harry K. W. Kim, Chi Ma
Summary: Avascular necrosis (AVN) is a condition characterized by ischemic cell death of the bone, which leads to joint deformities and osteoarthritis. In this study, we tested a novel approach using poloxamer 407 (P407) to remove necrotic lipids and debris from the bone marrow. The results showed that the P407 wash effectively cleaned the necrotic bone environment without altering osteogenesis or inflammatory responses.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
H. K. W. Kim, R. Almakias, M. B. Millis, B. Vakulenko-Lagun
Summary: This study collected treatment history, demographic details, activity scores, survey results, and outcomes of PD patients using a web-based survey method, and compared them to a normative population. The results showed that PD patients had significantly worse pain, physical health, mental health, and social health.
BONE & JOINT JOURNAL
(2022)
Article
Orthopedics
Michael J. Kutschke, Harry K. W. Kim
Summary: This study used three-dimensional analysis to quantify proximal femur growth modulation and identified associations between the growth modulation outcomes and screw placement parameters.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Cell & Tissue Engineering
Chi Ma, Min Sung Park, Felipe Alves do Monte, Vishal Gokani, Olumide O. Aruwajoye, Yinshi Ren, Xiaohua Liu, Harry K. W. Kim
Summary: The study developed a promising BMP2-hydrogel treatment for Legg-Calve-Perthes disease, which effectively prevented leakage through bone wash and hydrogel injection and produced homogeneous bone regeneration without heterotopic ossification in animal experiments.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Orthopedics
W. Z. Morris, A. Kak, L. M. Mayfield, M. S. Kang, C-H. Jo, H. K. W. Kim
Summary: Abduction bracing after closed reduction for developmental dysplasia of the hip does not significantly improve acetabular index or reduce the need for secondary surgery, but may reduce the risk of early secondary surgery.
BONE & JOINT JOURNAL
(2023)
Article
Orthopedics
Zhuo Deng, Maria Aguirre-Flores, Harry K. W. Kim, Yinshi Ren
Summary: This study investigates the effects of obesity and weight loss on the healing of osteonecrosis. The findings suggest that obesity impairs revascularization and bone remodeling, while weight loss can rescue these defects.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.