Article
Engineering, Biomedical
Yanan Zhao, Honglei Kang, Xiaopei Wu, Pengzhen Zhuang, Rong Tu, Takashi Goto, Feng Li, Honglian Dai
Summary: A drug carrier system composed of gelatin-coated hollow mesoporous silica nanoparticles loaded with pro-osteogenic parathyroid (PTH) and anti-osteoclastogenic alendronate (ALN) is constructed and compounded into calcium magnesium phosphate cement (MCPC). It enhances osteoporotic bone regeneration in ovariectomized rats by promoting osteogenic differentiation, inhibiting osteoclastogenesis, and accelerating vascularization. The MCPC/HMSNs@ALN-PTH/GM demonstrates a synergistic effect on osteogenesis, osteoclastogenesis, and angiogenesis, holding potential for other biomaterials design and clinical management.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jun-Kyu Lee, Da-Seul Kim, So-Yeon Park, Seung-Woon Baek, Ji-Won Jung, Tae-Hyung Kim, Dong Keun Han
Summary: In this study, a novel nitric oxide-releasing bioinspired scaffold with bioactive agents was proposed for the regeneration of osteoporotic bone. The scaffold, made of bone-like biomimetic poly(lactic-co-glycolic acid), organic/inorganic ECM, and magnesium hydroxide, incorporated nanoparticles containing zinc oxide (ZO), alendronate, and BMP2. The scaffold exhibited multifunctionality, such as anti-inflammation, angiogenesis, anti-osteoclastogenesis, and bone regeneration, mainly attributed to the nitric oxide generated from ZO. The new bone formation was significantly enhanced in the osteoporotic rat model, suggesting the potential of this bioinspired scaffold for regenerating osteoporotic bones.
Article
Materials Science, Multidisciplinary
Siyu Chen, Rui Zhao, Zhengyi Xing, Tieliang Shang, Xiao Yang, Xiangdong Zhu, Xingdong Zhang
Summary: The study showed that implantation of bioceramics with SrRAN systematic treatment is more effective in promoting new bone formation and osteointegration in repairing critical-sized osteoporotic bone defects compared to pure Sr doping.
APPLIED MATERIALS TODAY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Nikos Mardas, Xanthippi Dereka, Andreas Stavropoulos, Mansi Patel, Nikolaos Donos
Summary: The study demonstrated that SR has a moderate promoting effect on bone healing in calvarial defects in healthy and osteoporotic rats. Osteoporosis and absence of strontium ranelate treatment had a negative impact on new bone formation.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Cell Biology
Liqing Zang, Kazuhiro Kagotani, Hiroko Nakayama, Jacky Bhagat, Yuki Fujimoto, Akihito Hayashi, Ryoji Sono, Hirotaka Katsuzaki, Norihiro Nishimura, Yasuhito Shimada
Summary: The study found that 10-gingerol can suppress osteoclastic activity in both in vitro and in vivo conditions, promoting normal bone regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Geriatrics & Gerontology
ZuFu Lu, Liting Jiang, Pooria Lesani, WenJie Zhang, Ning Li, Danyang Luo, Yusi Li, Yulin Ye, Ji Bian, Guocheng Wang, Colin R. Dunstan, XinQuan Jiang, Hala Zreiqat
Summary: This study shows that nicotinamide mononucleotide (NMN) could partially reverse the negative effects of tumor necrosis factor-alpha (TNF-α) on osteoblasts, including inducing senescence, reducing differentiation ability, and affecting mitochondrial function. In addition, NMN can protect cells from aging damage by increasing mitophagy activity.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Zhaocong Luo, Xuening Chen, Minjun Liu, Yuyi Wang, Dongxiao Li, Xiangfeng Li, Yumei Xiao, Yan Wang, Xingdong Zhang
Summary: The use of Ica-SH/BCP scaffolds resulted in lower drug release rate, promoting osteoblastic cell proliferation, migration, and differentiation, as well as up-regulating angiogenic gene expression in vitro. In an osteoporotic animal model, Ica-SH/BCP scaffolds were shown to enhance bone regeneration.
MATERIALS & DESIGN
(2021)
Article
Engineering, Biomedical
Wei Qiao, Huizhi Xie, Jinghan Fang, Jie Shen, Wenting Li, Danni Shen, Jun Wu, Shuilin Wu, Xuanyong Liu, Yufeng Zheng, Kenneth M. C. Cheung, Kelvin W. K. Yeung
Summary: The study demonstrates that different phenotypes of macrophages play different roles in regulating bone tissue regeneration, and sequential activation of heterogeneous macrophages triggered by metal ions can effectively promote bone healing.
Article
Medicine, Research & Experimental
Min Chu, Zhenyu Sun, Zhanghao Fan, Degang Yu, Yuanqing Mao, Yaping Guo
Summary: La-LDH nanohybrid scaffolds exhibit dual functions of promoting osteogenesis and inhibiting osteoclastogenesis, showing potential value for bone regeneration in osteoporotic patients.
Article
Engineering, Biomedical
Rui Zhao, Tieliang Shang, Bo Yuan, Xiangdong Zhu, Xingdong Zhang, Xiao Yang
Summary: This study developed a new type of bioceramic for osteoporotic bone repair. The bioceramic was shown to promote the proliferation and differentiation of osteoblasts, and in in vivo experiments, it significantly enhanced bone regeneration and delayed adjacent bone loss. The study also discovered two different types of osteogenesis within the bioceramic pores, which is of importance for osteoporotic bone formation.
BIOACTIVE MATERIALS
(2022)
Review
Chemistry, Physical
Cristina Chircov, Ion Iulian Miclea, Valentina Grumezescu, Alexandru Mihai Grumezescu
Summary: While bone has the ability to self-heal small defects, the rising prevalence of bone diseases in the elderly is a burden affecting quality of life. Conventional treatments are limited, prompting a focus on developing bone-regenerative strategies and identifying new therapeutic agents.
Article
Chemistry, Physical
Yuwei Zhu, Jiaxin Guo, Yifeng Sheng, Jiankun Xu, Ling Qin, To Ngai
Summary: In this study, a hierarchical porous MOC foam (MOCF)-derived scaffold with favorable bio-resorption kinetic and superior bioactivity was fabricated through Pickering foaming technique. Compared with the traditional bone cement CDHA, the MOCF scaffold showed a higher biodegradation tendency and better cell recruitment ability. It is anticipated that the MOCF scaffold will be competitive for clinical therapies to augment osteoporotic bone regeneration.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Analytical
Dongni Han, Bertrand Goudeau, Dechen Jiang, Danjun Fang, Neso Sojic
Summary: Electrochemiluminescence (ECL) microscopy is successfully used for imaging cells, micro-/nano-objects, and electrochemical processes. The decrease of ECL signal during successive image recordings is a key limitation for ECL microscopy development. An electrochemical approach involving cathodic regenerative treatment can restore the ECL signal intensity, allowing for continuous image recording without signal loss.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Marwa Y. Shaheen, Amani M. Basudan, Abdurahman A. Niazy, Jeroen J. J. P. van den Beucken, John A. Jansen, Hamdan S. Alghamdi
Summary: The study demonstrates that systemic intravenous administration of zoledronate either before or after surgery improves the regeneration of bone defects grafted with inorganic cancellous bovine bone particles in osteoporotic conditions. However, continued pre- and post-surgical zoledronate treatment did not show a favorable effect on bone repair.
APPLIED SCIENCES-BASEL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Winston Adam Camargo, Jan Willem Hoekstra, John A. Jansen, Jeroen J. J. P. van den Beucken
Summary: In this study, the effect of alendronate (ALN) treatment on bone defect regeneration in osteoporotic rats was evaluated. The results showed that oral administration of ALN can enhance bone formation in the defects, increasing it to 10 times compared to the non-treated group. Additionally, Bio-Oss(R) was found to be an effective bone substitute, promoting bone formation in both healthy and osteoporotic conditions. The study highlights the beneficial effects of oral ALN in mitigating the adverse effects of osteoporosis on bone defect regeneration.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Review
Ophthalmology
Ying-kun Cui, Li Pan, Tim Lam, Chun-yi Wen, Chi-wai Do
Summary: Systemic hypertension is a common chronic disease globally, often linked to various ocular diseases, with the main risk being the development of glaucoma, particularly open angle glaucoma. Blood pressure may be involved in the pathogenesis of open angle glaucoma by affecting intraocular pressure or ocular blood flow.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2022)
Review
Orthopedics
Kenneth Lo, Manting Au, Junguo Ni, Chunyi Wen
Summary: Hypertension is significantly associated with osteoarthritis, especially in knee joints. The association is stronger in radiographic knee OA, particularly notable in women. These findings suggest further investigations into genetic, hormonal, and environmental factors for potential sex differences in the relationship between hypertension and OA.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Behavioral Sciences
Suk-Yu Yau, Yvette Siu Ling Yip, Douglas A. Formolo, Siyuen He, Thomas Ho Yin Lee, Chunyi Wen, Deanne H. Hryciw
Summary: This study found that chronic consumption of a diet rich in high linoleic acid during pregnancy, lactation, and post-weaning did not affect sociability and social recognition memory in female offspring, but induced depression-like behavior in male offspring.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Marianne Lauwers, Manting Au, Shuofeng Yuan, Chunyi Wen
Summary: This review examines the impact of SARS-CoV-2 on endothelial and adipose tissue, as well as its effect on musculoskeletal aging. It suggests that the long-lasting symptoms of COVID-19 may be due to an accelerated aging process. Analysis of musculoskeletal symptoms in COVID-19 patients reveals characteristics associated with bone and joint aging. The study highlights the similarities between SARS-CoV-2 and osteoarthritis in their effects on tissues and neuronal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Zhou Zou, Xiaohe Luo, Zhengkun Chen, Yu Shrike Zhang, Chunyi Wen
Summary: This article introduces the application of microfluidic technology in the treatment of osteoarthritis (OA). OA is a prevalent degenerative joint disease with no effective treatment currently available. Microfluidic technology is considered a promising approach for OA modeling and drug screening, early diagnosis, and clinical therapy.
Review
Medicine, Research & Experimental
Yingying Zhou, Junguo Ni, Chunyi Wen, Puxiang Lai
Summary: An inflatable bed is a portable sleeping mattress that can be easily inflated and deflated, providing a comfortable sleeping experience. It is made of puncture-resistant materials and is designed to withstand wear and tear. The advantages of an inflatable bed include its portability and easy storage, making it suitable for outdoor activities and temporary accommodations.
Review
Medicine, Research & Experimental
Bohan Yin, Junguo Ni, Claire E. Witherel, Mo Yang, Jason A. Burdick, Chunyi Wen, Siu Hong Dexter Wong
Summary: Osteoarthritis is a common chronic whole-joint disease, and the secretion of extracellular vesicles plays a role in its pathogenesis. Extracellular vesicles derived from mesenchymal stem cells or platelet-rich plasma have high therapeutic value for treating osteoarthritis and can be modified or incorporated into biomaterials for enhanced targeting and prolonged retention. By analyzing pathological biomarkers associated with osteoarthritis, we discuss current diagnostic and therapeutic methods and propose the potential of using extracellular vesicles for the diagnosis and treatment of osteoarthritis in the future.
Article
Orthopedics
Ruiyan Ni, X. Edward Guo, ChunHoi Yan, Chunyi Wen
Summary: Osteoarthritis is not only a problem of articular cartilage, but also involves other tissues in the joint. Hypertension has been linked to osteoarthritis, but the exact relationship is not fully understood. Based on clinical observations, a vascular etiology hypothesis has been proposed.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Review
Orthopedics
Hin Ting Victor Yick, Ping Keung Chan, Chunyi Wen, Wing Chiu Fung, Chun Hoi Yan, Kwong Yuen Chiu
Summary: AI can provide assistance in the field of osteoarthritis. Diagnostic models can improve diagnostic efficiency, prediction models can assess the risk of osteoarthritis, and morphological models can detect biomechanical changes. Through reviewing present evidence, it is demonstrated that AI can assist doctors in diagnosis and prediction, and guide future research.
JOURNAL OF ORTHOPAEDICS TRAUMA AND REHABILITATION
(2022)
Article
Cell Biology
Lok Chun Chan, Yuqi Zhang, Xiaoqing Kuang, Mohamad Koohi-Moghadam, Haicui Wu, Theo Yu Chung Lam, Jiachi Chiou, Chunyi Wen
Summary: This study investigated the alteration of gut microbiota in a DOCA-induced hypertensive rat model and found that gut microbiota dysbiosis may contribute to chondrocyte senescence induced by DOCA. Captopril can alleviate joint damage and exert its effects by modulating specific bacterial genera levels in the gut microbiota.
Article
Orthopedics
Yuhe Yang, Jingdong Rao, Huaqian Liu, Zhifei Dong, Zhen Zhang, Ho -Pan Bei, Chunyi Wen, Xin Zhao
Summary: This article provides a systematic overview of the development of biomimicking design of artificial periosteum, including the universal strategies, novel versatile biomimicking artificial periosteum, and potential implications and prospects. Future research should consider the integration of innervation, osteochondral regeneration, and osteoimmunomodulation.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Materials Science, Multidisciplinary
Xiangbo Meng, Ling Li, Cuishan Huang, Keda Shi, Qingqiang Zeng, Chunyi Wen, Sibylle Grad, Mauro Alini, Ling Qin, Xinluan Wang
Summary: This study developed a biphasic porous and degradable scaffold incorporating anti-inflammatory and anabolic molecules for osteochondral regeneration. The results showed that the scaffold promoted subchondral bone and cartilage regeneration and reversed subchondral osteosclerosis caused by inflammation in vivo. It provides a potential strategy for the treatment of patients with osteoarthritis-related osteochondral defects.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Bohan Yin, Qin Zhang, Jiaxiang Yan, Yingying Huang, Chuanqi Li, Jiareng Chen, Chunyi Wen, Siu Hong Dexter Wong, Mo Yang
Summary: Nanosubstrate engineering can modulate stem cell differentiation in tissue engineering through biomechanical means. The effect of clathrin-mediated processes on this behavior has not been explored. In this study, we developed integrin-binding nanosubstrates with confined nanogeometries to regulate clathrin-mediated signaling pathways for modulating stem fates. Isotropic ligand presentation on the nanoscale enhanced clathrin expression and facilitated uptake of dexamethasone-loaded nanoparticles, promoting osteogenesis. In contrast, anisotropic ligand nanogeometry suppressed clathrin-mediated nanoparticle entry and reinforced mechanotransduced signaling by strengthening the association between clathrin and adhesion spots. Inhibiting focal adhesion formation hindered cell spreading and increased endocytosis efficiency.
Article
Health Care Sciences & Services
Fadi M. Al Zoubi, Arnold Y. L. Wong, Gladys L. Y. Cheing, Jason P. Y. Cheung, Siu Ngor Fu, Helen H. L. Tsang, Rainbow K. Y. Law, Billy Chun Lung So, Raymond Tsang, Sharon Tsang, Chunyi Wen, Michael Wong, Yim Ching Yau, Andre E. Bussieres
Summary: This study used the ADAPTE framework to adapt high-quality guideline recommendations for knee and hip osteoarthritis in Hong Kong. A total of 28 recommendations for knee osteoarthritis and 20 recommendations for hip osteoarthritis were adapted. The study recommends a multimodal treatment approach, including exercise therapy, patient education, and self-management.
Review
Orthopedics
Lok Sze Lee, Ping Keung Chan, Chunyi Wen, Wing Chiu Fung, Amy Cheung, Vincent Wai Kwan Chan, Man Hong Cheung, Henry Fu, Chun Hoi Yan, Kwong Yuen Chiu
Summary: Artificial intelligence shows promise in diagnosing knee osteoarthritis and predicting outcomes of total knee arthroplasty. Machine learning models have demonstrated positive results in automatic grading of knee radiographs and predicting the need for total knee arthroplasty. However, important weaknesses of current artificial intelligence algorithms include lack of external validation, limitations in clinical data biases, the requirement of large datasets, and significant research gaps in the literature.
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.
