Article
Chemistry, Analytical
Emmanouil Mavrakis, Spiros A. Pergantis
Summary: Microfluidics coupled with ICP-MS allows for powerful quantitation procedures utilizing internal standardization and standard additions, improving determination accuracy for various sample types. The efficient coupling of microfluidic chip to ICP-MS system using a combination of commercially available components enables highly sensitive detection of metal isotopes with minimal sample consumption. High average recoveries and low relative standard deviations were achieved for determined elements across multiple matrices, showcasing the advantages of this newly developed chip-based microfluidic SDA ICP-MS technique.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Jesse R. Ingham, Lucas T. Minas, George L. Donati, Bradley T. Jones
Summary: This study applies a semiautomated version of the standard dilution analysis calibration method (SDA) to determine the concentrations of Ba, Be, Cd, Co, Cr, Cu, Mn, Ni, V, and Zn in various matrices using inductively coupled plasma optical emission spectrometry (ICP-OES). The SDA method utilizes two calibration solutions and is implemented by creating an analysis sequence in the instrument's software. The results show that the semiautomated SDA method provides high precision and low LOD for all analytes, and comparable or superior accuracy compared to other calibration methods.
MICROCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Christine Brauckmann, Axel Pramann, Olaf Rienitz, Alexander Schulze, Pranee Phukphatthanachai, Jochen Vogl
Summary: A new method combining isotope dilution mass spectrometry and standard addition has been developed for determining the mass fractions of different elements in complex matrices. The method requires the use of inductively coupled plasma mass spectrometry, gravimetric preparation of blends, and derivation of basic equations through linear regression analysis.
Article
Chemistry, Analytical
Elif Yazici, Suleyman Bodur, Sezin Erarpat, Ulas Emre Arslan, Sezgin Bakirdere
Summary: Acrylamide, a potentially neurotoxic and carcinogenic compound, is commonly found in environmental bodies due to industrial usage. This study compared different calibration strategies and proposed a highly accurate and precise method, LC-ID4-MS/MS, to quantify acrylamide in wastewater samples. The ID4 strategy showed superior accuracy and precision compared to EC and ISC methods.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Andreas Schweikert, Sarah Theiner, Martin Sala, Petra Vician, Walter Berger, Bernhard K. Keppler, Gunda Koellensperger
Summary: This study utilizes laser ablation-inductively coupled plasma time-of-flight mass spectrometry for quantitative bioimaging, establishing standardized methods based on robotic micro-droplet dispensing to produce controlled and precise pL-volume droplets. On-tissue isotope dilution and standard addition were employed to achieve high metrological traceability to SI units, with both strategies eliminating matrix effects. Different quantification approaches, including isotope dilution, standard addition, and external calibration using gelatin-based micro-droplets, were successfully cross-validated, demonstrating consistent quantitative results and proving the effectiveness of gelatin micro-droplets for high-throughput matrix-matched calibrations.
ANALYTICA CHIMICA ACTA
(2022)
Article
Agronomy
Bo Yao, Xiaolong Wang, Gilles Lemaire, David Makowski, Qiang Cao, Xiaojun Liu, Leilei Liu, Bing Liu, Yan Zhu, Weixing Cao, Liang Tang
Summary: The study evaluated the uncertainty in Nc dilution curves using wheat planting data, finding that the uncertainty of the fitted curve decreases with increasing plant biomass. Differences in curve parameters among genotype x environment x management combinations are mainly due to variables related to genotype and growth environment, such as maximum N concentration, maximum biomass, and accumulated growing degree days.
EUROPEAN JOURNAL OF AGRONOMY
(2021)
Article
Chemistry, Multidisciplinary
Yulin Du, Yifan Lyu, Shiquan Li, Ding Ding, Jianghuai Chen, Cai Yang, Yang Sun, Fengli Qu, Zeyu Xiao, Jianhui Jiang, Weihong Tan
Summary: Cell-specific aptamers are a strong tool for studying membrane receptors at the single-molecule level. Ligand dilution analysis (LDA) is proposed as a random sampling-based strategy to study aptamer-based receptors. This strategy allows for the calculation of receptor density, colocalization and differentiation of aptamer and monoclonal antibody binding, and determination of binding site and aptamer-receptor binding mode.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Electrical & Electronic
Daiki Matsumaru, Shuji Nakamura, Michitaka Maruyama, Nobu-Hisa Kaneko
Summary: We achieved voltage generation in a dilution refrigerator using a Josephson voltage standard (JVS) with a NbN-based superconductor-normal metal-superconductor Josephson junction (JJ) array. The thermal design of wiring was optimized to ensure stable JVS operation and temperature stability of the 4 K stage. The quantized voltage steps showed flatness, with combined relative uncertainties of 2.4 x 10(-10) V/V and 2.1 x 10(-8) V/V for 1028 and 2 mV generation, respectively.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Physics, Multidisciplinary
Hong-Ye Zu, Wei-Jun Cheng, Ya-Nan Wang, Xiao-Tao Wang, Li Ke, Dai Wei
Summary: This study investigates a condensation-pump dilution refrigerator, which utilizes a condensation pump to achieve the cold cycle of 3He. It has the advantages of compact structure, convenience operation, and low cost. The operating characteristics of the system are analyzed, and experiments are conducted to validate the performance. The system's performance can be improved by adjusting the spiral mode and position of the heat exchanger and increasing the heat transfer area in the mixing chamber.
ACTA PHYSICA SINICA
(2023)
Article
Energy & Fuels
Shuofeng Wang, Yifan Zhai, Zhe Wang, Ruifeng Hou, Tianyue Zhang, Changwei Ji
Summary: This study compares the effects of lean combustion and exhaust gas recirculation (EGR) on the combustion behavior of hydrogen fuel. It is found that EGR dilution has a more significant impact on laminar burning velocity, while EGR dilution more effectively reduces the NO mole fraction in the final products.
Article
Biochemical Research Methods
Andrei Dmitrenko, Michelle Reid, Nicola Zamboni
Summary: We propose a new method, RALPS, for the normalization of multi-batch untargeted metabolomics data using deep adversarial learning. RALPS outperforms six state-of-the-art methods for batch correction, preserving biological identity, spectral properties, and coefficients of variation. It demonstrates good scalability, robustness, ability to handle missing values, and adaptability to different experimental designs.
Article
Cell Biology
John R. Speakman, Yosuke Yamada, Hiroyuki Sagayama, Elena S. F. Berman, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V. C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G. J. A. Camps, Graeme L. Close, Jamie A. Cooper, Seth A. Creasy, Sai Krupa Das, Richard Cooper, Lara R. Dugas, Cara B. Ebbeling, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk, Kitty P. Kempen, Misaka Kimura, William E. Kraus, Robert F. Kushner, Estelle Lambert, William R. Leonard, Nader Lessan, David S. Ludwig, Corby K. Martin, Anine C. Medin, Erwin P. Meijer, James C. Morehen, James P. Morton, Marian L. Neuhouser, Theresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietilainen, Yannis P. Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Roberto A. Rabinovich, Susan B. Racette, David A. Raichlen, Eric Ravussin, Rebecca M. Reynolds, Susan B. Roberts, Albertine J. Schuit, Anders M. Sjodin, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, Jonathan C. K. Wells, George Wilson, Brian M. Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia U. Loechl, Edward L. Melanson, Amy H. Luke, Herman Pontzer, Jennifer Rood, Dale A. Schoeller, Klaas R. Westerterp, William W. Wong
Summary: The study showed that the use of different equations may introduce considerable variability in estimating total energy expenditure. Based on validation studies, the authors proposed a new equation for estimating rCO(2) sensitive to dilution space ratio and found DSR decreases at body masses below 10 kg.
CELL REPORTS MEDICINE
(2021)
Article
Medicine, General & Internal
Nicole Innerhofer, Sasa Rajsic, Marco Ronzani, Robert Breitkopf, Can Gollmann Tepekoeylue, Corinna Velik-Salchner, Lisa Schlosser, Dietmar Fries, Werner Streif, Michael Schirmer, Judith Martini
Summary: This study found that intraoperative fluid therapy leads to hemodilution, which affects the interpretation of laboratory parameters. A calculation-based approach could provide important information for guiding blood product substitution. Further research on the impact of dilution and decision-making for blood product substitution is needed.
Article
Chemistry, Analytical
JinHyeok Jang, Dana Park, Sangkyung Sung, Young Jae Lee
Summary: This study introduces a satellite selection method that associates ideal satellite placement with the minimum GDOP, and verifies the results through mathematical derivation and simulations. The research finds that simply selecting satellites closest to the ideal placement can result in large values of dilution of precision (DOP), thus proposing a satellite changing algorithm considering dual GNSS to reduce DOP values.
Article
Agriculture, Multidisciplinary
Xuejie Li, Wentao Zhang, Xiangquan Zeng, Yu Xi, Yan Li, Bowen Hui, Jian Li
Summary: The major off-flavor odorants of normal and lipoxygenase-lacking soy protein isolates were identified through sensory-directed flavor analysis. A total of 32 odor-active compounds were detected, and 19 of them were quantified. Hexanal and nonanal were found to dominate the off-flavor profile, followed by octanal, 1-hexanol, 1-octen-3-ol, 2-heptone, and benzaldehyde. The differences between NOR and LOX-lack SPIs were mainly attributed to reduced C6/C9 aldehydes and alcohols.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Doreen Yvonne Larvie, Jeanne Lynn Doherty, George L. Donati, Seth Mensah Armah
Article
Microbiology
Panatda Saenkham, Matthew Ritter, George L. Donati, Sargurunathan Subashchandrabose
Article
Biochemical Research Methods
John T. Sloop, Daniel A. Goncalves, Logan M. O'Brien, Jake A. Carter, Bradley T. Jones, George L. Donati
Summary: This study compares the extrapolation approach with alternative strategies such as interpolation, reversed-axis, and normalization in analytical methods. While all strategies provide similar trueness and precision for most applications, extrapolation and reversed-axis show more consistent values in ICP OES, and normalization works better in MIP OES. Additionally, normalization and reversed-axis are identified as the most suitable approaches for SA applications involving MIP OES and ICP-based methods.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
John T. Sloop, Sean C. Allen, Jake A. Carter, George L. Donati, Bradley T. Jones
Summary: A two-point calibration method based on SDA was used to accurately analyze complex-matrix samples, requiring only two calibration solutions per sample. The method calculates analyte concentration by utilizing the slope and intercept of an analyte vs. IS plot, the analyte concentration in the standard added to S1, and the signal intensity of the IS in S1. This approach yielded similar or superior results compared to EC, IS, and SA methods, without the need for mixing solutions or additional equipment modifications.
MICROCHEMICAL JOURNAL
(2021)
Review
Chemistry, Analytical
Renata S. Amais, George L. Donati, Marco A. Zezzi Arruda
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Jake A. Carter, Logan M. O'Brien, Tina Harville, Bradley T. Jones, George L. Donati
Summary: Supervised and unsupervised machine learning methods were used to evaluate matrix effects on ICP OES analytical signals induced by carbon and EIEs. A series of synthetic solutions with varying levels of matrix complexity were prepared, and machine learning models trained with normalized non-analyte signals to predict analyte recoveries. The study also utilized dimension reduction techniques to provide representations correlating with observed matrix effects on atomic and ionic emission lines.
Article
Chemistry, Analytical
John T. Sloop, George L. Donati, Bradley T. Jones
Summary: The MISC method utilizes signal ratios between multiple internal standard species for calibration, eliminating the need for time-consuming search for ideal internal standard species. The accuracy and repeatability of MISC are comparable to traditional methods.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Daniel A. Goncalves, Jessica S. Carmo, Layne Taynara S. Zanon, Bruno S. Marangoni, Cicero Cena, Giuseppe A. Camara, George L. Donati, Magno A. G. Trindade
Summary: This study presents a simple and fast univariate calibration method for the simultaneous quantification of emerging multi-class contaminants in different water sources. The method is comparable to traditional calibration methods in terms of precision and accuracy, and can significantly improve sample throughput.
Article
Chemistry, Analytical
Jesse R. Ingham, Bradley T. Jones, George L. Donati
Summary: A switching valve accessory in newer models of ICP-OES instruments is used for the automation of the standard dilution analysis calibration method (SDA). This method allows for the determination of multiple elements in various sample matrices with simple sample dilution. Only two calibration solutions are used, providing high sample throughputs and accurate results.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Review
Chemistry, Analytical
Beatriz M. Fontoura, Florencia Cora Jofre, Trey Williams, Marianela Savio, George L. Donati, Joaquim A. Nobrega
Summary: Microwave-induced plasma optical emission spectrometry (MIP-OES) has made significant advancements in recent years, positioning itself as a competitive alternative to traditional inductively coupled plasma optical emission spectrometry (ICP-OES). This review compares the performance and matrix effect handling of MIP-OES with ICP-OES, and discusses strategies to overcome limitations of MIP-OES. Improvements in instrument accessories, plasma diagnostics, calibration methods, and sample preparation have enhanced the sensitivity and accuracy of MIP-OES.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Chemistry, Multidisciplinary
Raquel C. Machado, Ana Beatriz S. Silva, Daniel F. Andrade, Fernanda C. Pinheiro, Charles B. Williams, George L. Donati, Ana Rita A. Nogueira, Edenir R. Pereira-Filho
Summary: Multi-flow calibration (MFC) method demonstrates superior accuracy and stability in analyzing complex matrix samples using ICP OES and ICP-MS, showing equal or better performance compared to traditional external standard calibration (EC). Additionally, the two-flow calibration (TFC) method can also achieve accurate results with high sample throughput.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2021)
Article
Engineering, Environmental
Jake A. Carter, Robert J. Erhardt, Bradley T. Jones, George L. Donati
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2020)
Article
Chemistry, Analytical
Alex Virgilio, Ana Beatriz S. Silva, Ana Rita A. Nogueira, Joaquim A. Nobrega, George L. Donati
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2020)
Article
Chemistry, Analytical
Willis B. Jones, George L. Donati, Clifton P. Calloway, Bradley T. Jones
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2020)
Article
Chemistry, Analytical
Jake A. Carter, John T. Sloop, Tina Harville, Bradley T. Jones, George L. Donati
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2020)