Article
Radiology, Nuclear Medicine & Medical Imaging
Rajiv G. Menon, Anmol Monga, Richard Kijowski, Ravinder R. Regatte
Summary: Multiparameter MR fingerprinting (MRF) can quantify multiple relaxation parameters of intervertebral disc (IVD) simultaneously, which may vary by age and sex. This study investigated age- and sex-related differences in the relaxation parameters of the lumbar spine's IVD using a multiparameter MRF technique. The results showed that the 3D-MRF technique has potential to characterize age-related differences in T-1, T-2, or T-1 rho of IVD in healthy subjects.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Endocrinology & Metabolism
Giovanni Tossetta, Sonia Fantone, Caterina Licini, Daniela Marzioni, Monica Mattioli-Belmonte
Summary: HtrA1 is an important protease involved in various biological functions and plays a key role in many human diseases. Studies have shown that HtrA1's role in degrading articular cartilage and regulating cell signaling pathways has sparked great interest in its involvement in skeletal diseases. By studying the role of HtrA1 in conditions such as osteoporosis, rheumatoid arthritis, osteoarthritis, and intervertebral disc degeneration, new approaches for prevention and treatment of these diseases can be discovered.
Review
Biochemistry & Molecular Biology
Zhipeng Zeng, Xuchang Zhou, Yan Wang, Hong Cao, Jianmin Guo, Ping Wang, Yajing Yang
Summary: Bone diseases are often caused by abnormal metabolism and death of bone cells, with mitochondrial dysfunction being an important factor. Recent studies suggest that mitophagy plays a crucial regulatory role in bone diseases, indicating that regulating mitophagy levels may be a new strategy for treating bone-related diseases.
Letter
Multidisciplinary Sciences
Eduardo F. Motti
Summary: This is a letter to the editor.
Review
Biochemistry & Molecular Biology
Site Feng, Jiahao Li, Jingjing Tian, Sheng Lu, Yu Zhao
Summary: This review summarizes the application of single-cell techniques in the study of musculoskeletal disorders. It provides a review of cell isolation, experimental methods, and feasible experimental designs for single-cell studies in musculoskeletal system diseases based on tissue characteristics. Furthermore, it highlights the latest findings of single-cell studies in musculoskeletal disorders and discusses the potential application and future development directions of single-cell and spatial omics in research on musculoskeletal diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Zhenyu Wu, Luying Liu
Summary: Genistein, a natural isoflavone, exhibits various biological effects and has been investigated for its potential therapeutic benefits in bone and cartilage diseases. It shows estrogen-like activity in protecting against osteoporosis and osteoarthritis, and also acts as an inhibitor of tyrosine kinase involved in pathological development of these diseases. Multiple signaling pathways are involved in its regulatory activity, but the molecular mechanisms are not fully understood yet.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Gaoming Liu, Jun Wei, Wenfeng Xiao, Wenqing Xie, Qin Ru, Lin Chen, Yuxiang Wu, Ali Mobasheri, Yusheng Li
Summary: Degenerative musculoskeletal disorders are age-related diseases that severely affect patients' ability to work and can have serious consequences. Notch signaling pathway plays a crucial role in these disorders, retarding the progress of degeneration and having important functions in stem/progenitor cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Clinical Neurology
Murray Echt, Ryan Holland, Wenzhu Mowrey, Phillip Cezayirli, Rafael De la Garza Ramos, Mousa Hamad, Yaroslav Gelfand, Michael Longo, Merritt D. Kinon, Vijay Yanamadala, Saad Chaudhary, Samuel K. Cho, Reza Yassari
Summary: The study shows that discectomy for upper lumbar disc herniations has an overall success rate of approximately 80% and has not improved with minimally invasive surgical techniques. Discectomy for herniations at L3-4 trends toward better outcomes compared with L1-2 and L2-3, but was not significant.
GLOBAL SPINE JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Rizwan Arshad, Hendrik Schmidt, Marwan El-Rich, Kodjo Moglo
Summary: Musculoskeletal disorders of the cervical spine have increased in recent years. This study aimed to develop a dynamic model of the cervical spine and estimate the differences in disc loads, translations, intradiscal pressure, and muscle force/activity in a neutral posture. The results could help distinguish between normal and pathological cervical spine conditions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell Biology
Min Xiang, Ling Liu, Tingrui Wu, Bo Wei, Huan Liu
Summary: RNA-binding proteins (RBPs), which consist of multiple intermediate sequences, play important roles in various biological functions by interacting with proteins, mRNA, and non-coding RNAs. This article focuses on the functions of RBPs in degenerative joint diseases (IVDD and OA) and reviews the latest advancements in understanding the regulatory mechanisms of RBPs. It provides a novel perspective on the pathophysiology, early diagnosis, and treatment of OA and IVDD.
AGEING RESEARCH REVIEWS
(2023)
Article
Orthopedics
Sachin Gupta, Rui Xiao, Matthew Fainor, Robert L. Mauck, Harvey E. Smith, Sarah E. Gullbrand
Summary: This study characterizes alterations to human facet cartilage and subchondral bone across a spectrum of degeneration and investigates correlations between disc and facet degeneration. The findings suggest that the mechanical properties of facet cartilage and the structural properties of facet subchondral bone change with increasing degenerative grade and are correlated with aspects of disc degeneration.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Xiao-Chuan Li, Shao-Jian Luo, Fan Wu, Qing-Chun Mu, Jun-Hui Yang, Cheng Jiang, Wei Wang, Tian-Li Zhou, Tan-Dan Qin, Rong-Xiong Tan, Chun-Ming Huang, Mao-Sheng Wang, Xiao-Chun Bai, Jian-Li
Summary: Macrophage infiltration and polarization play a crucial role in lumbar intervertebral disc herniation (LDH). This study examined the association between macrophage polarization in herniated nucleus pulposus (NP) tissue of LDH patients and different clinical characteristics or symptoms. The findings suggest that macrophage polarization or macrophage-like cells contribute to the pathological features of LDH and that certain macrophage populations are associated with pain intensity during LDH. These results can potentially lead to personalized pharmacological interventions for LDH patients considering pain heterogeneity.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Medicine, General & Internal
Yunxiang Hu, Yufei Wang, Sanmao Liu, Hong Wang
Summary: Ferroptosis, a form of cell death involving iron metabolism and lipid peroxidation, differs from other forms such as apoptosis, autophagy, pyroptosis, and cuproptosis. It plays a crucial role in various diseases including malignant tumors, neurodegenerative diseases, and cardiovascular diseases. Both iron overload and lipid peroxide accumulation contribute to musculoskeletal diseases, providing new opportunities for clinical diagnosis and treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Jianfeng Sun, Yibo Tan, Jingyue Su, Herasimenka Mikhail, Volotovski Pavel, Zhenhan Deng, Yusheng Li
Summary: Ghrelin is a brain-gut peptide that can promote the release of growth hormone, potentially playing a role in bone growth and development. Recent studies have reported a correlation between ghrelin and degenerative diseases of the musculoskeletal system, suggesting that ghrelin may be a factor influencing degenerative pathologies. With the aging population, the risk of health problems caused by degenerative diseases of the musculoskeletal system increases. This article summarizes the roles of ghrelin in musculoskeletal disorders, highlighting the potential effects of ghrelin as a key target in the treatment of related bone and muscle diseases and the need for further research.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Martin Prymek, Robert Vyskocil, Jan Sklensky, Jan Kocanda, Andrea Sprlakova-Pukova, Milan Filipovic, Martin Repko
Summary: This study aims to evaluate the feasibility of using bending films to determine the lowest instrumented vertebra (LIV), and provide real-world data on outcomes. The results show that adjusting the position of the fusion vertebra based on bending films can effectively reduce the risk of postoperative spinal decompensation.
Article
Engineering, Biomedical
Maurits G. L. Olthof, Diederik H. R. Kempen, James L. Herrick, Michael J. Yaszemski, Wouter J. A. Dhert, Lichun Lu
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2018)
Article
Engineering, Biomedical
Anita Krouwels, Ferry P. W. Melchels, Mattie H. P. van Rijen, Corlinda B. M. Ten Brink, Wouter J. A. Dhert, F. Cumhur Oner, Marianna A. Tryfonidou, Laura B. Creemers
ACTA BIOMATERIALIA
(2018)
Article
Cell & Tissue Engineering
Maurits G. L. Olthof, Diederik H. R. Kempen, Xifeng Liu, Mahrokh Dadsetan, Marianna A. Tryfonidou, Michael J. Yaszemski, Wouter J. A. Dhert, Lichun Lu
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Clinical Neurology
Anita Krouwels, Jelena Popov-Celeketic, Saskia G. M. Plomp, Wouter J. A. Dhert, F. Cumhur Oner, Ruud A. Bank, Laura B. Creemers
Article
Cell & Tissue Engineering
Maurits G. L. Olthof, Marianna A. Tryfonidou, Xifeng Liu, Behdad Pouran, Bjorn P. Meij, Wouter J. A. Dhert, Michael J. Yaszemski, Lichun Lu, Jacqueline Alblas, Diederik H. R. Kempen
TISSUE ENGINEERING PART A
(2018)
Article
Cell & Tissue Engineering
Maaike V. J. Braham, Tilman Ahlfeld, A. Rahul Akkineni, Monique C. Minnema, Wouter J. A. Dhert, F. Cumhur Oner, Catherine Robin, Anja Lode, Michael Gelinsky, Jacqueline Alblas
TISSUE ENGINEERING PART C-METHODS
(2018)
Article
Cell & Tissue Engineering
Anita Krouwels, Ferry P. W. Melchels, Mattie H. P. van Rijen, F. Cumhur Oner, Wouter J. A. Dhert, Marianna A. Tryfonidou, Laura B. Creemers
TISSUE ENGINEERING PART C-METHODS
(2018)
Article
Cell & Tissue Engineering
Maurits G. L. Olthof, Marianna A. Tryfonidou, Mahrokh Dadsetan, Wouter J. A. Dhert, Michael J. Yaszemski, Diederik H. R. Kempen, Lichun Lu
TISSUE ENGINEERING PART C-METHODS
(2018)
Article
Medicine, Research & Experimental
Vivian H. M. Mouser, Noel M. M. Dautzenberg, Riccardo Levato, Mattie H. P. van Rijen, Wouter J. A. Dhert, Jos Malda, Debby Gawlitta
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2018)
Article
Multidisciplinary Sciences
M. Croes, M. C. Kruyt, W. M. Groen, K. M. A. van Dorenmalen, W. J. A. Dhert, F. C. Oner, J. Alblas
SCIENTIFIC REPORTS
(2018)
Review
Orthopedics
T. S. de Windt, S. L. Niemansburg, L. A. Vonk, J. M. van Delden, K. C. B. Roes, W. J. A. Dhert, D. B. F. Saris, A. L. Bredenoord
OSTEOARTHRITIS AND CARTILAGE
(2019)
Article
Cell & Tissue Engineering
Maurits G. L. Olthof, Lichun Lu, Marianna A. Tryfonidou, Loek D. Loozen, Behdad Pouran, Michael J. Yaszemski, Bjorn P. Meij, Wouter J. A. Dhert, Jacqueline Alblas, Diederik H. R. Kempen
TISSUE ENGINEERING PART A
(2019)
Article
Engineering, Biomedical
Maaike V. J. Braham, Amelie S. P. Li Yim, Jara Garcia Mateos, Monique C. Minnema, Wouter J. A. Dhert, F. Cumhur Oner, Catherine Robin, Jacqueline Alblas
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Multidisciplinary Sciences
Marijn Rutgers, Frances Bach, Lucienne Vonk, Mattie van Rijen, Vanessa Akrum, Antonette van Boxtel, Wouter Dhert, Laura Creemers
Article
Cell & Tissue Engineering
L. D. Loozen, A. Vandersteen, A. H. M. Kragten, F. C. Oner, W. J. A. Dhert, M. C. Kruyt, J. Alblas
EUROPEAN CELLS & MATERIALS
(2018)
