Review
Endocrinology & Metabolism
Xue-Ling Xu, Zheng-Yuan Huang, Kun Yu, Jun Li, Xiang-Wei Fu, Shou-Long Deng
Summary: This review focuses on the role of ER alpha and ER beta in polycystic ovary syndrome (PCOS), ovarian cancer, and premature ovarian failure (POF), as well as the major challenges of existing therapies. It provides a reference for the treatment of estrogen target tissue ovarian diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Layla Damen, Melitza S. M. Elizabeth, Stephany H. Donze, Sjoerd A. A. van den Berg, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega
Summary: In children with Prader-Willi syndrome receiving GH treatment, high immunoreactive IGF-I levels are often observed, while free IGF-I levels are low, indicating a significant discrepancy between the two.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Shui Lian Chou, Samiraj Ramesh, Chia-Hua Kuo, Ayaz Ali, Tsung-Jung Ho, Ko Peng Chang, Dennis Jine-Yuan Hsieh, V. Bharath Kumar, Yueh-Shan Weng, Wei-Wen Kuo, Chih-Yang Huang
Summary: TSN IIA exerts cardioprotective effects by activating ER and inhibiting the PI3K-Akt pathway to suppress Leu27IGF-II-induced IGF-IIR mediated cardiac apoptosis.
ENVIRONMENTAL TOXICOLOGY
(2022)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Eirini-Maria Giatagana, Aikaterini Berdiaki, Margrethe Gaardlos, Sergey A. Samsonov, George N. Tzanakakis, Dragana Nikitovic
Summary: Osteosarcoma is an aggressive bone cancer, and biglycan plays a role in promoting its growth and resistance to chemotherapy by activating the IGF-IR signaling pathway. This mechanism varies in different levels of differentiation in osteosarcoma cells.
Article
Endocrinology & Metabolism
Xihong Zhang, Sidhant Varma, Douglas Yee
Summary: Inhibition of IRS-1 protein can suppress both IGFR-IR and IR, leading to inhibition of growth and regulation in hormone-dependent breast cancer cells. This study reveals the crucial role of IRS-1 in endocrine responsive breast cancer.
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Article
Biology
Jie Li, Jiayi Wu, Catherine Hall, Xiao-chen Bai, Eunhee Choi, Emily J. Gallagher
Summary: The insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) play crucial roles in metabolic homeostasis and cell growth. This study reveals that the structural rigidity of the disulfide-linked alpha CTs is critical for optimal IR and IGF1R signaling activation.
Review
Biochemistry & Molecular Biology
Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljada
Summary: This comprehensive review thoroughly explores the intricate involvement of insulin receptor isoforms and insulin-like growth factor receptors in the insulin and insulin-like growth factor signaling pathway, emphasizing their crucial roles in cancer development and resistance to anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Laris Achlaug, Lina Somri-Gannam, Shilhav Meisel-Sharon, Rive Sarfstein, Manisha Dixit, Shoshana Yakar, Mordechai Hallak, Zvi Laron, Haim Werner, Ilan Bruchim
Summary: This study evaluated the expression of ZYG11A in EOC patients and found reduced ZYG11A expression in high grade tumors, suggesting a potential tumor suppressor role. The study also identified an inverse correlation between ZYG11A and p53 levels in individual tumors. Further exploration of ZYG11A as a novel biomarker in EOC is warranted based on these findings.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
H. Mirzaei-Alamouti, R. Hadionnejad, A. Abdollahi, A. Bahari, F. Fatahnia, R. Masoumi, M. P. Green, M. Vazirigohar, M. Mansouryar
Summary: This study investigated the effects of varying the plane of nutrition on gene expression related to mammary gland development in a seasonal sheep breed. The findings showed a positive impact of high-nutrient diet on mammary gland development, and revealed a complex relationship between the expression of genes critical for mammary gland function and development. These findings provide valuable insights for future nutritional strategies to optimize animal liveweight gain and mammary gland development.
ANIMAL BIOTECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Haim Werner, Zvi Laron
Summary: The GH-IGF1 signaling pathway plays a key role in aging and longevity. Patients with LS, a congenital IGF1 deficiency, seem to be protected from cancer. Aging and cancer may be different manifestations of the same underlying processes. Genome-wide screenings have identified genes associated with aging and longevity in LS patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiahong Tan, Chunyan Song, Daoqi Wang, Yigang Hu, Dan Liu, Ding Ma, Qinglei Gao
Summary: High-grade serous ovarian cancer (HGSOC) with high expression of hormone receptors, including androgen receptor (AR), estrogen receptor alpha (ER), and progesterone receptor (PR), is associated with longer progression-free survival (PFS), overall survival (OS), and platinum-free interval (PFI). Correlation analysis shows significant positive correlations between hormone receptor expression and survival, indicating that AR, ER, and PR could serve as feasible prognostic biomarkers for HGSOC through immunohistochemical analysis. Co-expression of AR, ER, and PR has an improved predictive performance with an area under the curve (AUC) value of 0.945.
BIOSCIENCE REPORTS
(2021)
Article
Veterinary Sciences
Elshymaa A. Abdelnaby, Noha A. E. Yasin, Yara S. Abouelela, Eman Rashad, Samer M. Daghash, Hossam R. El-Sherbiny
Summary: Understanding the changes in reproductive hemodynamics during the estrous cycle is crucial for improving reproductive competence and fertility potential. This study investigated the hemodynamic variations in ovarian and uterine arteries, as well as the histological and morphometric changes in ovarian and uterine tissues in rabbits. Immunohistochemistry was used to determine the distribution of ER, PR, and VEGF-A. The results provide insights into the regulation of uterine functions that play a role in reproduction.
BMC VETERINARY RESEARCH
(2022)
Article
Oncology
Zhenhua Li, Yaqiang Pan, Qinghua Liu, Jian Wang, Chang Liu, Laihao Qu, Dingbiao Li
Summary: The expression of GPER1 is associated with ER and EGFR mutations in lung adenocarcinoma. GPER1 regulates ER expression and MAPK signaling, and co-inhibition of GPER1 and ER can decrease phosphorylation of ERK1/2 and Akt in cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Victoria V. Snegovskikh, Vineet Bhandari, Jo Rae Wright, Serkalem Tadesse, Thomas Morgan, Colin MacNeill, Nastaran Foyouzi, Joong Shin Park, Yuguang Wang, Errol R. Norwitz
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2011)
Article
Biochemistry & Molecular Biology
Yuguang Wang, Daling Zhu, Yuan An, Jingxia Sun, Liying Cai, Jianhua Zheng
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2012)