A retrosynthetic biology approach to metabolic pathway design for therapeutic production

Probabilistic pathway construction

(2011) Mona Yousofshahi et al.   METABOLIC ENGINEERING

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Finding metabolic pathways using atom tracking

(2010) Allison P. Heath et al.   BIOINFORMATICS

Molecular signatures-based prediction of enzyme promiscuity

(2010) Pablo Carbonell et al.   BIOINFORMATICS

Prediction of novel synthetic pathways for the production of desired chemicals

(2010) Ayoun Cho et al.   BMC Systems Biology

Build life to understand it

(2010) Michael Elowitz et al.   NATURE

Artificial gene amplification reveals an abundance of promiscuous resistance determinants in Escherichia coli

(2010) V. W. C. Soo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterologous production of ribostamycin derivatives in engineered Escherichia coli

(2010) Nagendra Prasad Kurumbang et al.   RESEARCH IN MICROBIOLOGY

Manufacturing Molecules Through Metabolic Engineering

(2010) J. D. Keasling   SCIENCE

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Structural synthetic biotechnology: from molecular structure to predictable design for industrial strain development

(2010) Zhen Chen et al.   TRENDS IN BIOTECHNOLOGY

Increased Malonyl Coenzyme A Biosynthesis by Tuning the Escherichia coli Metabolic Network and Its Application to Flavanone Production

(2009) Z. L. Fowler et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Rahnuma: hypergraph-based tool for metabolic pathway prediction and network comparison

(2009) Aziz Mithani et al.   BIOINFORMATICS

Automatic assignment of reaction operators to enzymatic reactions

(2009) M. Leber et al.   BIOINFORMATICS

Quantitative assignment of reaction directionality in constraint-based models of metabolism: Application to Escherichia coli

(2009) R.M.T. Fleming et al.   BIOPHYSICAL CHEMISTRY

Diversification of echinomycin molecular structure by way of chemoenzymatic synthesis and heterologous expression of the engineered echinomycin biosynthetic pathway

(2009) Kenji Watanabe et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Route Designer: A Retrosynthetic Analysis Tool Utilizing Automated Retrosynthetic Rule Generation

(2009) James Law et al.   Journal of Chemical Information and Modeling

DESHARKY: automatic design of metabolic pathways for optimal cell growth

(2008) Guillermo Rodrigo et al.   BIOINFORMATICS

MetaRoute: fast search for relevant metabolic routes for interactive network navigation and visualization

(2008) Torsten Blum et al.   BIOINFORMATICS

Group Contribution Method for Thermodynamic Analysis of Complex Metabolic Networks

(2008) Matthew D. Jankowski et al.   BIOPHYSICAL JOURNAL

Current status, strategies, and potential for the metabolic engineering of heterologous polyketides in Escherichia coli

(2008) Brett A. Boghigian et al.   BIOTECHNOLOGY LETTERS

Metabolic engineering for plant natural product biosynthesis in microbes

(2008) Joseph A Chemler et al.   CURRENT OPINION IN BIOTECHNOLOGY

Microbial production of plant benzylisoquinoline alkaloids

(2008) H. Minami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic flux analysis and metabolic engineering of microorganisms

(2007) Hyun Uk Kim et al.   Molecular BioSystems