Microglia sense and suppress epileptic neuronal hyperexcitability

Chloride ion dysregulation in epileptogenic neuronal networks

(2023) Shennan Aibel Weiss   NEUROBIOLOGY OF DISEASE

Seizure-induced strengthening of a recurrent excitatory circuit in the dentate gyrus is proconvulsant

(2022) Kaoutsar Nasrallah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy

(2022) Lukas Henning et al.   GLIA

Differential regulation of the BDNF gene in cortical and hippocampal neurons

(2022) Eli-Eelika Esvald et al.   JOURNAL OF NEUROSCIENCE

Inhibition of connexin hemichannels alleviates neuroinflammation and hyperexcitability in temporal lobe epilepsy

(2022) Anni Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy

(2022) Balagopal Pai et al.   Acta Neuropathologica Communications

ADAM10 suppresses demyelination and reduces seizure susceptibility in cuprizone-induced demyelination model

(2021) Xinjian Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

PER2 mediates CREB-dependent light induction of the clock gene Per1

(2021) Andrea Brenna et al.   Scientific Reports

Astrocytes modulate sensory-evoked neuronal network activity

(2020) Justin Lines et al.   Nature Communications

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

How microglia sense and regulate neuronal activity

(2020) Anthony D. Umpierre et al.   GLIA

Neuronal firing and waveform alterations through ictal recruitment in humans

(2020) Edward M. Merricks et al.   JOURNAL OF NEUROSCIENCE

Microglia elimination increases neural circuit connectivity and activity in adult mouse cortex

(2020) Yong-Jun Liu et al.   JOURNAL OF NEUROSCIENCE

Microglial Gi-dependent dynamics regulate brain network hyperexcitability

(2020) Mario Merlini et al.   NATURE NEUROSCIENCE

Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions

(2020) Csaba Cserép et al.   NEURON

Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy

(2020) F. T. Sparks et al.   Nature Communications

Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin

(2019) Sean J. Miller et al.   NATURE NEUROSCIENCE

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

(2019) Csaba Cserép et al.   SCIENCE

The identity and function of microglia in neurodegeneration

(2018) Wilbur M. Song et al.   NATURE IMMUNOLOGY

Microglia and early brain development: An intimate journey

(2018) Morgane S. Thion et al.   SCIENCE

Disruption of the ATP/adenosine balance in CD39−/− mice is associated with handling-induced seizures

(2017) Amanda J. Lanser et al.   IMMUNOLOGY

Microglia in steady state

(2017) Katrin Kierdorf et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

CRTC1 mediates preferential transcription at neuronal activity-regulated CRE/TATA promoters

(2017) Arnaldo Parra-Damas et al.   Scientific Reports

Microglia-Neuron Communication in Epilepsy

(2016) Ukpong B. Eyo et al.   GLIA

CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy

(2016) D. Dubey et al.   NEUROSCIENCE

Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal

(2015) Kristopher Burkewitz et al.   CELL

CREB phosphorylation at Ser133regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling

(2014) Shaista Naqvi et al.   BIOCHEMICAL JOURNAL

Region-Specific Activation of CRTC1-CREB Signaling Mediates Long-Term Fear Memory

(2014) Mio Nonaka et al.   NEURON

Mapping and kinetics of microglia/neuron cell-to-cell contacts in the 6-OHDA murine model of Parkinson's disease

(2013) Angélique Virgone-Carlotta et al.   GLIA

 -Amyloid Disrupts Activity-Dependent Gene Transcription Required for Memory through the CREB Coactivator CRTC1

(2013) J. Espana et al.   JOURNAL OF NEUROSCIENCE

Glia and epilepsy: excitability and inflammation

(2013) Orrin Devinsky et al.   TRENDS IN NEUROSCIENCES

Activity-Dependent Transport of the Transcriptional Coactivator CRTC1 from Synapse to Nucleus

(2012) Toh Hean Ch'ng et al.   CELL

SIK2 Is a Key Regulator for Neuronal Survival after Ischemia via TORC1-CREB

(2011) Tsutomu Sasaki et al.   NEURON

cAMP/CREB-mediated Transcriptional Regulation of Ectonucleoside Triphosphate Diphosphohydrolase 1 (CD39) Expression

(2010) Hui Liao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY