Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome

Regulation of NF-κB by ubiquitination and degradation of the IκBs

(2012) Naama Kanarek et al.   IMMUNOLOGICAL REVIEWS

BDNF and DYRK1A Are Variable and Inversely Correlated in Lymphoblastoid Cell Lines from Down Syndrome Patients

(2012) Asma Tlili et al.   MOLECULAR NEUROBIOLOGY

Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway

(2011) Daniela Valenti et al.   BIOCHEMICAL JOURNAL

Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes

(2011) Mireia Vilardell et al.   BMC GENOMICS

The E3 ubiquitin ligase MIB1 negatively regulates basal IκBα level and modulates NF-κB activation

(2011) Li-Juan Liu et al.   CELL RESEARCH

Dysfunction of the ubiquitin–proteasome system in the cerebellum of aging Ts65Dn mice

(2011) Daniela Necchi et al.   EXPERIMENTAL NEUROLOGY

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

Massive-Scale RNA-Seq Analysis of Non Ribosomal Transcriptome in Human Trisomy 21

(2011) Valerio Costa et al.   PLoS One

Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications

(2010) Qian Huang et al.   APOPTOSIS

Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy

(2010) Daniela Valenti et al.   BIOCHEMICAL JOURNAL

Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome

(2010) Federico V. Pallardó et al.   BIOGERONTOLOGY

Impairment of circulating endothelial progenitors in Down syndrome

(2010) Valerio Costa et al.   BMC Medical Genomics

Multi-Targeted Natural Products Evaluation Based on Biological Activity Prediction with PASS

(2010) Alexey Lagunin et al.   CURRENT PHARMACEUTICAL DESIGN

Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in Down's syndrome

(2010) Vittoria Infantino et al.   MOLECULAR GENETICS AND METABOLISM

Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration

(2010) N. Rogers et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes

(2010) Rossella De Cegli et al.   GENOME BIOLOGY

The ubiquitin proteasome system in neuropathology

(2009) Norman L. Lehman   ACTA NEUROPATHOLOGICA

Apoptosis by dietary agents for prevention and treatment of prostate cancer

(2009) Naghma Khan et al.   ENDOCRINE-RELATED CANCER

Clinical development of novel proteasome inhibitors for cancer treatment

(2009) Huanjie Yang et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways

(2009) Heng Liu et al.   FASEB JOURNAL

Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model

(2009) Jennifer H. K. Choi et al.   JOURNAL OF NEUROCHEMISTRY

Utility of lymphoblastoid cell lines

(2009) L. Sie et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

(2009) Fayçal Guedj et al.   PLoS One

Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses

(2009) D. K. Slonim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DYRK1A-Dosage Imbalance Perturbs NRSF/REST Levels, Deregulating Pluripotency and Embryonic Stem Cell Fate in Down Syndrome

(2008) Claudia Canzonetta et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Green Tea Epigallocatechin 3-Gallate Accumulates in Mitochondria and Displays a Selective Antiapoptotic Effect Against Inducers of Mitochondrial Oxidative Stress in Neurons

(2008) Emily K. Schroeder et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of dysregulated genes in lymphocytes from children with Down syndrome

(2008) Cesar A. Sommer et al.   GENOME

LRRK2 mutation in familial Parkinson’s disease in a Taiwanese population: clinical, PET, and functional studies

(2008) Chin-Hsien Lin et al.   JOURNAL OF BIOMEDICAL SCIENCE

Growth rate of patient-derived lymphoblastoid cells with LRRK2 mutations

(2008) Eng-King Tan et al.   MOLECULAR GENETICS AND METABOLISM

The neuronal ubiquitin-proteasome system: Murine models and their neurological phenotype

(2008) Paula van Tijn et al.   PROGRESS IN NEUROBIOLOGY

Mitochondrial dysfunction in mouse trisomy 16 brain

(2007) L.L. Bambrick et al.   BRAIN RESEARCH

Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer’s disease

(2007) Soo-Ryoon Ryoo et al.   JOURNAL OF NEUROCHEMISTRY