Article
Immunology
Petra Mooij, Daniella Mortier, Aafke Aartse, Alexandre B. Murad, Ricardo Correia, Antonio Roldao, Paula M. Alves, Zahra Fagrouch, Dirk Eggink, Norbert Stockhofe, Othmar G. Engelhardt, Ernst J. Verschoor, Marit J. van Gils, Willy M. Bogers, Manuel J. T. Carrondo, Edmond J. Remarque, Gerrit Koopman
Summary: Influenza-naive cynomolgus macaques were immunized with virus-like particles (VLPs) displaying different hemagglutinin (HA) antigens from seasonal H1N1 strains. Subsequent infection with pandemic H1N1 (H1N1pdm09) resulted in increased immune response against intermediate antigenic variants but not against all H1N1 vaccine strains.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Behavioral Sciences
Daiva Radzisauskiene, Monika Vitkauskaite, Karolina Zvinyte, Ruta Mameniskiene
Summary: The study described a case series of influenza A-associated neurological complications, with a low incidence rate of influenza-associated neurological complications in hospitalized patients in 2019 at 1.9%. The findings suggest that during influenza epidemics, patients with unexplained neurological symptoms resembling aseptic and septic meningitis/encephalitis should be tested for influenza virus.
BRAIN AND BEHAVIOR
(2021)
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Immunology
Min Gu, Kaibiao Chen, Zhichuang Ge, Jun Jiao, Tianyu Cai, Suhan Liu, Xiaoquan Wang, Xinan Jiao, Daxin Peng, Xiufan Liu
Summary: This study investigated the genetic and biologic characteristics of two Eurasian avian-like H1N1 swine influenza viruses from pigs in China. One swine isolate showed high similarity to contemporary human Eurasian avian-like H1N1 isolates, had a preference for binding to human-type receptors, and demonstrated vigorous replication in mice without the need for adaptation.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Emergency Medicine
B. S. Katherine Burton, Jonathan Mondragon, Clifford Buckley, Nicolas Ong
Summary: This case highlights the challenges of diagnosing thyroid storm in the emergency department and emphasizes the importance of considering it in treatment when more common diagnoses fail to respond. Diagnosis of thyroid storm relies on clinical suspicion, laboratory findings, and response to therapy.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Immunology
Moe Okuda, Yuko Sakai-Tagawa, Michiko Koga, Tomohiko Koibuchi, Tadashi Kikuchi, Eisuke Adachi, Lay Ahyoung Lim, Shinya Yamamoto, Hiroshi Yotsuyanagi, Kyota Negishi, Daisuke Jubishi, Seiya Yamayoshi, Yoshihiro Kawaoka
Summary: This study compared the antibody titers of various functions between subclinically infected individuals and patients infected with H3N2 virus, and identified the antibody functions that play a central role in preventing the onset of seasonal influenza.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Hyesun Jang, Ted M. Ross
Summary: The study found that the humoral response to trivalent seasonal influenza virus vaccines was influenced by rapid antigenic switching of H1 HA. While successful induction of antibodies against H1N1 and H3N2 vaccine components was observed, a strong immune response against CA/09 H1N1 influenza virus negatively influenced the induction of novel humoral responses to other vaccine strains.
Article
Mechanics
Leslie K. K. Norvihoho, Hang Li, Zhi-Fu Zhou, Jing Yin, Shu-Yan Chen, Dong-Qing Zhu, Bin Chen
Summary: This research investigates the effectiveness of protected occupied zone ventilation (POV) in a simplified office setting using computational fluid dynamics models. The findings suggest that different exhaust layouts and ventilation rates of POV can influence the spread of cough droplets in the office. Moreover, the placement of the exhaust outlet significantly affects indoor aerosol dispersion, with large particles unable to travel long distances and viral particles predominantly depositing on solid surfaces in various work areas.
Article
Chemistry, Multidisciplinary
Xia Liu, Danyang Chen, Jingyao Su, Ruilin Zheng, Zhihui Ning, Mingqi Zhao, Bing Zhu, Yinghua Li
Summary: Influenza A (H1N1) viruses pose a threat to public health worldwide. While vaccination is the main preventive strategy, antiviral drugs play an important role in controlling influenza. Selenium nanoparticles (SeNPs), which have antiviral effects, have gained attention in biomedical interventions. SeNPs have potential therapeutic efficacy in diseases mediated by oxidative stress and inflammation, and can inhibit H1N1 infection and improve apoptosis in cells.
Article
Biotechnology & Applied Microbiology
Vaclav Brazda, Otilia Porubiakova, Alessio Cantara, Natalia Bohalova, Jan Coufal, Martin Bartas, Miroslav Fojta, Jean-Louis Mergny
Summary: The study identified multiple potential G-quadruplex forming sequences in the G4-EA-H1N1 genomes, which could serve as potential therapeutic targets.
Article
Infectious Diseases
Boyu Liu, Xiaolei Chen, Lei Zhou, Junyi Li, Dan Wang, Wentao Yang, Hui Wu, Jiyuan Yao, Guilian Yang, Chunfeng Wang, Jiang Feng, Tinglei Jiang
Summary: This study transplanted the gut microbiota of wild bats into mice and found that the bat gut microbiota could regulate the immune system and protect mice from viral infection.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Microbiology
Jien-Wei Liu, Yee-Huang Ku, Chien-Ming Chao, Hsuan-Fu Ou, Chung-Han Ho, Khee-Siang Chan, Wen-Liang Yu
Summary: The study conducted retrospective and prospective analysis on the correlation between pulmonary aspergillosis and PM-associated bioaerosols (PM2.5 and PM10) in Tainan, Taiwan from 2015 to 2019. Results showed a significant increase in the incidence of aspergillosis, with PM-related bioaerosols and influenza A (H1N1) playing a role in contributing to the occurrence of the disease.
Article
Virology
Denisa Bojkova, Marco Bechtel, Tamara Rothenburger, Joshua D. D. Kandler, Lauren Hayes, Ruth Olmer, Ulrich Martin, Danny Jonigk, Sandra Ciesek, Mark N. N. Wass, Martin Michaelis, Jindrich Cinatl Jr
Summary: Recent findings show that SARS-CoV-2 Omicron BA.1 induces a stronger interferon response compared to Delta. In this study, it was demonstrated that BA.1 and BA.5, but not Delta, induce an antiviral state in air-liquid interface cultures of primary human bronchial epithelial cells and primary human monocytes. Both Omicron subvariants trigger the production of biologically active interferons and protect cells from super-infection with influenza A viruses. These findings highlight the significance of Omicron in the immune response against viral infections.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Mathematics, Applied
Asad Ali, Sami Ullah Khan, Ishtiaq Ali, Farman Ullah Khan
Summary: In this study, a robust and efficient numerical scheme based on Legendre spectral collocation method (LSCM) is introduced to explore the asymptomatic behavior of stochastic influenza avian model. The effect of transitions caused by internal and external environmental noise is considered. The simulations results suggest that the pace of complete predominance of influenza will be high if all the individuals show symptoms upon infection and experience a deficient treatment. On the other hand, the prevalence rate of influenza is low if all the individuals first move to symptomatic class and then treated effectively. The overall prevalence rate reaches an average level when more individuals upon disease move towards asymptomatic class.
MATHEMATICAL METHODS IN THE APPLIED SCIENCES
(2022)
Article
Immunology
Dorota S. Temple, Meghan Hegarty-Craver, Robert D. Furberg, Edward A. Preble, Emma Bergstrom, Zoe Gardener, Pete Dayananda, Lydia Taylor, Nana Marie Lemm, Loukas Papargyris, Micah T. McClain, Bradly P. Nicholson, Aleah Bowie, Maria Miggs, Elizabeth Petzold, Christopher W. Woods, Christopher Chiu, Kristin H. Gilchrist
Summary: In this study, wearable electrocardiogram sensors integrated with accelerometers were used to monitor participants, and a semisupervised machine learning algorithm successfully detected infections in both symptomatic and asymptomatic individuals, on average 23 hours before symptom onset. This research shows promise for early detection of respiratory illnesses, but further validation is needed in larger and more diverse cohorts.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Geriatrics & Gerontology
Pi-Shan Hsu, Ie-Bin Lian, Day-Yu Chao
CLINICAL INTERVENTIONS IN AGING
(2020)
Article
Virology
Jedhan U. Galula, Chung-Yu Yang, Brent S. Davis, Gwong-Jen J. Chang, Day-Yu Chao
Article
Multidisciplinary Sciences
Wei-Shan Liang, Yu-Chen He, Hong-Dar Wu, Yao-Tsun Li, Tai-Hwa Shih, Gour-Shenq Kao, Horng-Yuh Guo, Day-Yu Chao
Review
Microbiology
Hui-Ying Ko, Gielenny M. Salem, Gwong-Jen J. Chang, Day-Yu Chao
FRONTIERS IN MICROBIOLOGY
(2020)
Meeting Abstract
Infectious Diseases
Y. -H. Pan, Y. -W. Chien, T. -S. Ho, H. -Y. Ko, S. -F. Chang, C. -Y. Yu, P. -Y. Shu, D. -Y. Chao, C. -C. Ku, C. -C. King
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Infectious Diseases
Pin-Wei Shih, Ta-Chien Chan, Chwan-Chuen King
Summary: The study found that the spatial distribution of poultry-raising locations in Taiwan is associated with the occurrence of HPAI H5 outbreaks, and that an increase in the number of poultry-raising locations is correlated with higher risks of outbreaks. It is recommended to extend the post-outbreak containment policy radius to 7 km to effectively control the further spread of HPAI H5 among neighboring farms.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Infectious Diseases
Yi-Hua Pan, Mei-Ying Liao, Yu-Wen Chien, Tzong-Shiann Ho, Hui-Ying Ko, Chin-Rur Yang, Shu-Fen Chang, Chia-Yi Yu, Shu-Yu Lin, Pin-Wei Shih, Pei-Yun Shu, Day-Yu Chao, Chao-Ying Pan, Hong-Ming Chen, Guey-Chuen Perng, Chia-Chi Ku, Chwan-Chuen King
Summary: This study conducted a post-outbreak serosurvey in 2016 among older and elderly adults in Kaohsiung and Tainan cities in southern Taiwan to measure past DENV infections. The results showed higher overall seroprevalence with age, district- and city-level differences in anti-DENV IgG antibody prevalence, and similar percentages of secondary DENV infection in both cities. The study highlights the importance of monitoring antibody status and investigating dengue vaccination safety and efficacy in older populations.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Medicine, General & Internal
Jedhan Ucat Galula, Gielenny M. Salem, Raul V. Destura, Roland Remenyi, Day-Yu Chao
Summary: The study compared the diagnostic performances of two NS1-based ELISA methods with an E-based VLP ELISA in determining dengue serostatus, finding that NS1-based methods have comparable accuracies and could effectively assist clinicians in assessing vaccine eligibility.
Article
Multidisciplinary Sciences
Hong-Dar Isaac Wu, Day-Yu Chao
Summary: The study utilized Knox test, scan statistics, and visual tools to investigate the dynamic changes of avian influenza outbreak farms, finding that Knox-based and AGC mapping were more sensitive for small-scale spatio-temporal clustering.
SCIENTIFIC REPORTS
(2021)
Review
Infectious Diseases
Fatima Ericka S. Vista, Ourlad Alzeus G. Tantengco, Micah D. Dispo, Danna Mae S. Opiso, Christian Luke D. C. Badua, John Patrick Z. Gerardo, Juan Raphael M. Perez, Karol Ann T. Baldo, Day-Yu Chao, Leslie Michelle M. Dalmacio
Summary: This review analyzes the trends in seroprevalence studies of flaviviruses using IgG ELISA. The results show that dengue virus is the most studied, while Japanese Encephalitis Virus is the least studied. Geographically, serosurveys align with known disease prevalence. Temporally, the number of serosurveys increases after outbreaks and epidemics, except for JEV which is studied to demonstrate vaccination effectiveness. Commercial kits are commonly used for DENV, WNV, and ZIKV. Overall, most studies use an indirect ELISA format and the choice of antigens varies per virus. Endemicity, cross-reactivities, and kit availabilities affect assay choice in serosurveys.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Virology
Ching-Hung Lin, BoJia Chen, Day-Yu Chao, Feng-Cheng Hsieh, Chun-Chun Yang, Hsuan-Wei Hsu, Hon-Man-Herman Tam, Hung-Yi Wu
Summary: This study investigates the characteristics of defective viral genomes (DVGs) in coronavirus, including their structures, reproducibility, origins, and adaptability to different infection environments. The findings contribute to the understanding of gene expression mechanisms and pathogenesis in coronavirus, and could potentially aid in the development of antiviral strategies.
Meeting Abstract
Biophysics
Jan K. Marzinek, Venkata Raghuvamsi Palur, Gielenny Salem, Fan-Chi Chen, Shang-Rung Wu, Peter J. Bond, Day-Yu Chao
BIOPHYSICAL JOURNAL
(2023)
Meeting Abstract
Biophysics
Venkata Raghuvamsi Palur, Gielenny Salem, Fan-Chi Chen, Shang-Rung Wu, Peter J. Bond, Day-Yu Chao, Jan K. Marzinek
BIOPHYSICAL JOURNAL
(2023)
Article
Immunology
Hong -Dar Isaac Wu, Ruey-Shing Lin, Wen -Han Hwang, Mei-Liang Huang, Bo-Jia Chen, Tseng-Chang Yen, Day -Yu Chao
Summary: The ongoing circulation and reassortment of low-pathogenic avian influenza viruses have caused economic losses and public health concerns. Virologic surveillance of wild birds is recommended as part of a global monitoring system. However, underreporting and biased sampling have hindered understanding of highly pathogenic avian influenza transmission. In this study, we used the eBird database to examine the distribution of wild birds in Taiwan and their potential for virus exchange with domestic poultry. Our findings provide a methodological blueprint for incorporating this into the global surveillance system.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Virology
Yao-Tsun Li, Chen-Chih Chen, Ai-Mei Chang, Day-Yu Chao, Gavin J. D. Smith