Article
Infectious Diseases
Natalia Gonzalez, Said Abdellati, Irith De Baetselier, Jolein Gyonne Elise Laumen, Christophe Van Dijck, Tessa de Block, Chris Kenyon, Sheeba Santhini Manoharan-Basil
Summary: Emerging resistance to ceftriaxone and azithromycin has led to increased interest in ciprofloxacin for treating Neisseria gonorrhoeae. This study evaluated the molecular pathways leading to ciprofloxacin resistance in two reference strains of N. gonorrhoeae, WHO-F and WHO-P, and found strain-specific differences in the emergence of ciprofloxacin resistance.
Article
Biology
Eme Ekeng, Serges Tchatchouang, Blaise Akenji, Bassira Boubacar Issaka, Ifeoluwa Akintayo, Christopher Chukwu, Ibrahim Dan Dano, Sylvie Melingui, Sani Ousmane, Michael Oladotun Popoola, Ariane Nzouankeu, Yap Boum, Francisco Luquero, Anthony Ahumibe, Dhamari Naidoo, Andrew Azman, Justin Lessler, Shirlee Wohl
Summary: Researchers conducted a regional sequencing study in Nigeria on 46 recent V. cholerae isolates from Cameroon, Niger, and Nigeria, revealing that all isolates belonged to the T12 V. cholerae seventh pandemic lineage. This indicated continuous transmission of the T12 lineage within West Africa since 2009, providing a reference model for future surveillance efforts.
Article
Ophthalmology
Samrat Chatterjee, Deepshikha Agrawal, Sharad N. Gomase, Swapnil M. Parchand, Anil B. Gangwe, Mihir Mishra
Summary: Fluoroquinolone resistance was high among bacteria from ocular infections in central India, but there has been a recent decline in resistance. Cefuroxime and colistin emerged as alternatives in fluoroquinolone-resistant Gram-positive and Gram-negative bacterial infections, respectively.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Alexandre Balaphas, Kyriaki Gkoufa, Nicola Colucci, Konstantinos-Cedric Perdikis, Christophe Gaudet-Blavignac, Zoltan Pataky, Sebastian Carballo, Frederic Ris, Jerome Stirnemann, Christian Lovis, Nicolas Goossens, Christian Toso
Summary: This study aimed to investigate the characteristics of abdominal pain in COVID-19 patients and its association with disease severity and liver injury. The study found that more than one fifth of COVID-19 patients experienced abdominal pain, and those with pain in the upper abdomen were more likely to experience dyspnea, have altered transaminases, and have a higher risk of adverse outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Nour Shbaklo, Silvia Corcione, Costanza Vicentini, Susanna Giordano, Denise Fiorentino, Gabriele Bianco, Francesco Cattel, Rossana Cavallo, Carla Maria Zotti, Francesco Giuseppe De Rosa
Summary: The COVID-19 pandemic has led to major adjustments in healthcare systems and has caused an increase in multidrug-resistant (MDR) hospital-acquired infections (HAIs) at Molinette Hospital. The study also found changes in antibiotic consumption, with a reduction in fluoroquinolone use and an increase in the use of fourth- and fifth-generation cephalosporins and piperacillin-tazobactam during the COVID-19 period. The findings highlight the need for improved infection control practices and microbiological diagnosis during pandemics.
Article
Public, Environmental & Occupational Health
Jose A. Rodrigues, Wonhee Cha, Rebekah E. Mosci, Sanjana Mukherjee, Duane W. Newton, Paul Lephart, Hossein Salimnia, Walid Khalife, James T. Rudrik, Shannon D. Manning
Summary: In a four-year active surveillance study at four metropolitan hospitals in Michigan, an increasing trend in Campylobacter jejuni infections was observed. Analysis of 214 C. jejuni isolates revealed widespread antibiotic resistance, with differences in infection rates by hospital type and patient characteristics associated with disease severity.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Public, Environmental & Occupational Health
Anu Kantele, Tinja Laaveri
Summary: Antibiotic treatment for diarrhoeagenic Escherichia coli (DEC) in travellers' diarrhoea is becoming less effective, with increasing proportions of ESBL-producing DEC and resistance to various antibiotics.
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Chemistry, Medicinal
Yanshu Jia, Liyan Zhao
Summary: Bacterial infection is a common disease and fluoroquinolones are widely used antibacterial agents. However, the emergence of drug resistance and more virulent pathogens highlights the need for developing new drugs. Research aims to summarize recent advances in fluoroquinolone derivatives and structure-activity relationships.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Zolzaya Byambajav, Erdenebat Bulgan, Yuji Hirai, Momoko Nakayama, Misaki Tanaka, Yurika Nitta, Akio Suzuki, Takashi Umemura, Bold Altankhuu, Alimaa Tsagaan, Batbaatar Vanaabaatar, Erdenebaatar Janchivdorj, Nyam-Osor Purevdorj, Narantuya Ayushjav, Takeshi Yamasaki, Motohiro Horiuchi
Summary: This study isolated and characterized Campylobacter spp. from chickens in Mongolia, finding resistance to multiple antibiotics. Some C. jejuni/C. coli isolates were resistant to nalidixic acid and fluoroquinolones, with specific genetic mechanisms for resistance identified. Multilocus sequence typing and phylogenetic analyses revealed genetic variation and potential links to other countries. This study represents the first report on antimicrobial resistance of Campylobacter spp. in farm animals in Mongolia, providing valuable insights for antibiotic use in this region.
Article
Chemistry, Physical
Amr Selim Abu Lila, Bader Huwaimel, Ahmed Alobaida, Talib Hussain, Zeeshan Rafi, Khalid Mehmood, Marwa H. Abdallah, Turki Al Hagbani, Syed Mohd Danish Rizvi, Afrasim Moin, Abobakr F. Ahmed
Summary: DFX-AuNPs have been successfully synthesized and demonstrated higher antibacterial activity in an acidic environment, showing potential therapeutic effects against drug-resistant strains.
Article
Microbiology
Paolo Cattaneo, Caleb Mike Mulongo, Gianfranco Morino, Maria Vittoria De Vita, Gabriele Paone, Simone Scarlata, Salome Kinyita, Hillary Odhiambo, Cristina Mazzi, Federico Gobbi, Dora Buonfrate
Summary: This study aimed to estimate the prevalence of rifampicin-resistant tuberculosis (RR-TB) in Kajiado County, Kenya. The study found that the prevalence of RR-TB was four times higher than what could be inferred from official notifications, and higher than the overall prevalence in Kenya. Moreover, the incidence of pulmonary TB among adults in Kajiado significantly differed from cases notified in the same area, while the rate of HIV coinfection was in line with national and regional data.
Article
Medicine, General & Internal
Mina Al Fartousi, Kaylen Guda, Tjerk H. Geersing, Peter H. J. van der Voort, Eric J. F. Franssen
Summary: The aim of this study was to investigate the relationship between ganciclovir exposure with therapeutic drug monitoring (TDM) and the development of acute kidney injury (AKI) in ICU patients. The study included adult ICU patients treated with ganciclovir and used nonparametric statistical tests to assess the incidence of AKI. The results showed that ICU patients using ganciclovir with TDM-guided dosing did not develop AKI as measured by serum creatinine, RIFLE score, and renal SOFA score.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Tina Bech Olesen, Henry Jensen, Henrik Moller, Jens Winther Jensen, Berit Andersen, Ilse Vejborg, Sisse H. Njor
Summary: This study examined the participation in mammography screening during the COVID-19 pandemic in Denmark. It was found that there was a reduction in short-term participation at the start of the pandemic, but only a minor overall reduction with longer follow-up time. However, certain groups of women had lower participation, suggesting that social inequity in screening participation was exacerbated during the pandemic.
Article
Public, Environmental & Occupational Health
Rebbecca Lilley, Gabrielle Davie, Simon Horsburgh, Bronwen McNoe, Tim Driscoll
Summary: This study estimates the societal burden of work-related fatal injuries, including bystanders and commuters, using population data from New Zealand. The findings show that work-related fatal injuries contribute to a quarter of all injury deaths, with nearly half of these deaths occurring among non-working bystanders and commuters. The burden of work-related fatal injuries is widespread across different demographics. These findings are relevant to other OECD nations and can guide efforts to reduce such injuries.
SSM-POPULATION HEALTH
(2023)
Article
Clinical Neurology
Christian Uhl, Doerthe Huscher, Jenny Sommerfeld, Benn Schoenberg, Peter Vajkoczy, Nora F. Dengler
Summary: In Germany, the incidence of aSAH decreased between 2005 and 2018, especially in younger age groups. This may reflect effects of lifestyle adjustments most pronounced in younger age groups.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Immunology
Mark W. Tenforde, Wesley H. Self, Yuwei Zhu, Eric A. Naioti, Manjusha Gaglani, Adit A. Ginde, Kelly Jensen, H. Keipp Talbot, Jonathan D. Casey, Nicholas M. Mohr, Anne Zepeski, Tresa McNeal, Shekhar Ghamande, Kevin W. Gibbs, D. Clark Files, David N. Hager, Arber Shehu, Matthew E. Prekker, Heidi L. Erickson, Michelle N. Gong, Amira Mohamed, Nicholas J. Johnson, Vasisht Srinivasan, Jay S. Steingrub, Ithan D. Peltan, Samuel M. Brown, Emily T. Martin, Arnold S. Monto, Akram Khan, Catherine L. Hough, Laurence W. Busse, Caitlin ten Lohuis, Abhijit Duggal, Jennifer G. Wilson, Nida Qadir, Steven Y. Chang, Christopher Mallow, Carolina Rivas, Hilary M. Babcock, Jennie H. Kwon, Matthew C. Exline, Mena M. Botros, Adam S. Lauring, Nathan Shapiro, Natasha Halasa, James D. Chappell, Carlos G. Grijalva, Todd W. Rice, Ian D. Jones, William B. Stubblefield, Adrienne Baughman, Kelsey N. Womack, Jillian P. Rhoads, Christopher J. Lindsell, Kimberly W. Hart, Caitlin Turbyfill, Samantha Olson, Nancy Murray, Katherine Adams, Manish M. Patel
Summary: Among hospitalized adults, the effectiveness of the two-dose mRNA vaccine against COVID-19-associated hospitalization decreased from 90% to 82% after 6 months post-vaccination. This study highlights the limited long-term durability of protection provided by the COVID-19 mRNA vaccines against hospitalization.
CLINICAL INFECTIOUS DISEASES
(2023)
Letter
Critical Care Medicine
Yike Li, Kelsey E. Richard, Alan R. Schwartz, David Zealear, Christopher J. Lindsell, Holly A. Budnick, David T. Kent
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Immunology
Mark W. Tenforde, Manish M. Patel, Nathaniel M. Lewis, Katherine Adams, Manjusha Gaglani, Jay S. Steingrub, Nathan Shapiro, Abhijit Duggal, Matthew E. Prekker, Ithan D. Peltan, David N. Hager, Michelle N. Gong, Matthew C. Exline, Adit A. Ginde, Nicholas M. Mohr, Christopher Mallow, Emily T. Martin, H. Keipp Talbot, Kevin W. Gibbs, Jennie H. Kwon, James D. Chappell, Natasha Halasa, Adam S. Lauring, Christopher J. Lindsell, Sydney A. Swan, Kimberly W. Hart, Kelsey N. Womack, Adrienne Baughman, Carlos G. Grijalva, Wesley H. Self
Summary: During the 2021-2022 US influenza season, circulating A(H3N2) viruses were antigenically different from the vaccine. The vaccine effectiveness against hospitalized illness was 26% (95% CI: -14-52%) for adults 18-64 years old and -3% (95% CI: -54-31%) for adults ≥ 65 years old. Our study showed that the influenza vaccine had some effectiveness in preventing hospitalization among immunocompetent adults aged 18-64, but provided no significant protection for adults ≥ 65.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Matthew W. McCarthy, Susanna Naggie, David R. Boulware, Christopher J. Lindsell, Thomas G. Stewart, G. Michael Felker, Dushyantha Jayaweera, Mark Sulkowski, Nina Gentile, Carolyn Bramante, Upinder Singh, Rowena J. Dolor, Juan Ruiz-Unger, Sybil Wilson, Allison DeLong, April Remaly, Rhonda Wilder, Sean Collins, Sarah E. Dunsmore, Stacey J. Adam, Florence Thicklin, George Hanna, Adit A. Ginde, Mario Castro, Kathleen McTigue, Elizabeth Shenkman, Adrian F. Hernandez
Summary: This study aimed to evaluate the efficacy of low-dose fluvoxamine (50 mg twice daily for 10 days) compared with placebo for the treatment of mild to moderate COVID-19. The results showed that treatment with fluvoxamine did not improve the time to sustained recovery compared with placebo. These findings do not support the use of fluvoxamine at this dose and duration in patients with mild to moderate COVID-19.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Melissa A. Rolfes, H. Keipp Talbot, Huong Q. McLean, Melissa S. Stockwell, Katherine D. Ellingson, Karen Lutrick, Natalie M. Bowman, Emily E. Bendall, Ayla Bullock, James D. Chappell, Jessica E. Deyoe, Julie Gilbert, Natasha B. Halasa, Kimberly E. Hart, Sheroi Johnson, Ahra Kim, Adam S. Lauring, Jessica T. Lin, Christopher J. Lindsell, Son H. McLaren, Jennifer K. Meece, Alexandra M. Mellis, Miriana Moreno Zivanovich, Constance E. Ogokeh, Michelle Rodriguez, Ellen Sano, Raul A. Silverio A. Francisco, Jonathan E. Schmitz, Celibell Y. Vargas, Amy Yang, Yuwei Zhu, Edward A. Belongia, Carrie Reed, Carlos G. Grijalva
Summary: The COVID-19 pandemic resulted in a decrease in global influenza virus infections. However, there was an increased risk of influenza virus infection during the 2021-2022 influenza season due to loss of natural immunity and antigenic changes in circulating viruses.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Public, Environmental & Occupational Health
Jennifer A. Lewis, Lauren R. Samuels, Jacy Weems, Daniel Park, Robert Winter, Christopher J. Lindsell, Carol Callaway-Lane, Carolyn Audet, Christopher G. Slatore, Renda Soylemez Wiener, Robert S. Dittus, Sunil Kripalani, David F. Yankelevitz, Claudia I. Henschke, Drew Moghanaki, Michael E. Matheny, Timothy J. Vogus, Christianne L. Roumie, Lucy B. Spalluto
Summary: This study evaluated the association between healthcare organizations' preparedness and change valence with lung cancer screening utilization. The results showed that higher readiness and change valence were associated with increased utilization of lung cancer screening.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Microbiology
Robert R. Lavieri, Erik R. Dubberke, Sarah K. McGill, Luther Bartelt, Stephanie A. Smith, Balint K. Pandur, Sharon E. Phillips, Krista Vermillion, Jana Shirey-Rice, Jill Pulley, Yaomin Xu, Christopher J. Lindsell, Nicole Zaleski, Rebecca Jerome, Ryan S. Doster, David M. Aronoff
Summary: We conducted a randomized controlled trial on the use of misoprostol for preventing recurrent C. difficile and analyzed our challenging experience. Despite careful screening and protocol modifications, the study was closed prematurely with only 7 participants enrolled over 3 years. We emphasize the importance of feasibility studies, inclusion of biomarker outcomes, and dissemination of findings for informing future research design and implementation successes.
Article
Infectious Diseases
Alexander M. Kaizer, Nathan I. Shapiro, Jessica Wild, Samuel M. Brown, B. Jessica Cwik, Kimberly W. Hart, Alan E. Jones, Michael S. Pulia, Wesley H. Self, Clay Smith, Stephanie A. Smith, Patrick C. Ng, B. Taylor Thompson, Todd W. Rice, Christopher J. Lindsell, Adit A. Ginde
Summary: This study aimed to evaluate the efficacy and safety of lopinavir/ritonavir (LPV/r) for early treatment of non-hospitalized individuals with COVID-19. The results showed that LPV/r did not significantly improve symptom resolution or reduce hospitalization in non-hospitalized participants.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Susanna Naggie, David R. Boulware, Christopher J. Lindsell, Thomas G. Stewart, Alex J. Slandzicki, Stephen C. Lim, Jonathan Cohen, David Kavtaradze, Arch P. Amon, Ahab Gabriel, Nina Gentile, G. Michael Felker, Dushyantha Jayaweera, Matthew W. McCarthy, Mark Sulkowski, Russell L. Rothman, Sybil Wilson, Allison DeLong, April Remaly, Rhonda Wilder, Sean Collins, Sarah E. Dunsmore, Stacey J. Adam, Florence Thicklin, George J. Hanna, Adit A. Ginde, Mario Castro, Kathleen McTigue, Elizabeth Shenkman, Adrian F. Hernandez
Summary: The study evaluated the effectiveness of ivermectin at a maximum targeted dose of 600 μg/kg daily for 6 days in the treatment of early mild to moderate COVID-19. The results showed that compared to placebo, ivermectin treatment did not improve the time to sustained recovery, suggesting no benefits of ivermectin for patients with mild to moderate COVID-19.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Shawniqua Williams Roberson, Samuel Nwosu, Erin M. Collar, Amy L. Kiehl, Fiona E. Harrison, Julie Bastarache, Jo Ellen Wilson, Matthew F. Mart, Jonathan E. Sevransky, E. Wesley Ely, Christopher J. Lindsell, James C. Jackson
Summary: This study aimed to investigate the effects of early antioxidant and anti-inflammatory therapy on cognitive, psychological, and functional outcomes in sepsis survivors. The results showed that treatment with vitamin C, thiamine, and hydrocortisone did not improve or worsen cognitive, psychological, and functional outcomes at 6 months compared to placebo.
Article
Anesthesiology
Britany L. Raymond, Brian F. S. Allen, Robert E. Freundlich, Crystal G. Parrish, Jennifer E. Jayaram, Jonathan P. Wanderer, Todd W. Rice, Christopher J. Lindsell, Kevin H. Scharfman, Mary L. Dear, Yue Gao, William D. Hiser, Matthew D. McEvoy
Summary: This study aims to investigate the impact of perioperative ketamine infusion on mature ERAS pathways. 1544 patients undergoing major abdominal surgery will be randomly allocated to receive either ketamine or placebo infusion. The primary outcome is length of stay, and secondary outcomes include various clinical endpoints.
BMC ANESTHESIOLOGY
(2023)
Correction
Medicine, General & Internal
S. Naggie, D. R. Boulware, C. J. Lindsell
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Pharmacology & Pharmacy
Tate D. Parrott, Matthew D. Wallace, Kristina M. Niehoff, Sarah H. Eble, Lauren Blumenfeld, Carla M. Sevin, Neesha N. Choma, Yue Gao, Leena Choi, Christopher J. Lindsell, Autumn D. Zuckerman
Summary: Patients with asthma and COPD often rely on inhaler therapy. This study assessed the appropriateness of long-acting inhaler regimens for hospitalized patients based on guidelines and insurance coverage. A pharmacist-led review found that 42% of inhalers were inappropriate, necessitating changes in therapy for over half of the patients. Interventions are needed to improve the appropriateness of prescribed inhalers and reduce disease progression and exacerbation risk.
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
(2023)
Article
Medicine, Research & Experimental
Kristian Thorlund, Davey Smith, Christopher Linsell, Nicholas White, Christopher Butler, David Boulware, Judith Currier, Ofir Harari, Edouard Lhomme, Nathalie Strub-Wourgaft, Stacey Adam, Edward Mills
Summary: Clinical trial endpoints should be carefully selected to inform policy- and decision-making, considering the preferences of different stakeholders. The selection of endpoints for COVID-19 clinical trials has been problematic, as they did not always match the usual efficacy endpoints required by guideline panels. This has made it difficult to compare and evaluate interventions timely. Selecting appropriate endpoints is crucial for researchers to provide reliable, valid, and interpretable results.
COMMUNICATIONS MEDICINE
(2023)
Article
Infectious Diseases
Jin H. Han, James C. Jackson, Onur M. Orun, Samuel M. Brown, Jonathan D. Casey, Lindsay Clark, Sean P. Collins, Kemberlyne Cordero, Adit A. Ginde, Michelle N. Gong, Catherine L. Hough, Theodore J. Iwashyna, Amy L. Kiehl, Alana Lauck, Lindsay M. Leither, Christopher J. Lindsell, Mayur B. Patel, Rameela Raman, Todd W. Rice, Nancy J. Ringwood, Karen L. Sheppard, Matthew W. Semler, B. Taylor Thompson, E. Wesley Ely, Wesley H. Self
Summary: This study aimed to identify potentially modifiable in-hospital factors associated with global cognition, post-traumatic stress disorder (PTSD) symptoms, and depression symptoms in patients hospitalized with acute COVID-19. The study found that the use of remdesivir was associated with significantly better cognitive function at 12 months. Delirium was associated with worsening PTSD and depression symptoms at 12 months. Multiple virtual visits per day during hospitalization were associated with fewer depression symptoms at 12 months.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)