Review
Oncology
Anneloes van Duijn, Sjoerd H. Van der Burg, Ferenc A. Scheeren
Summary: This article focuses on the interactions between myeloid immune cells and anti-tumor immune responses in the tumor microenvironment. Blocking the CD47/SIRP alpha axis can enhance adaptive immune response. The potential therapeutic role of CD47/SIRP alpha axis is discussed in tumors with acquired resistance to classic immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Zachary Tsai, Kyle A. Carver, Henry H. Gong, Kosuke Kosai, Jane C. Deng, Matthew J. Worley
Summary: Neutrophils eliminate Streptococcus pneumoniae through extracellular killing at lower bacterial concentrations, while both extracellular and intracellular elimination methods are used under higher bacterial burdens with TLR2 activation.
Article
Clinical Neurology
Che-Feng Chang, Brittany A. Goods, Michael H. Askenase, Hannah E. Beatty, Artem Osherov, Jonathan H. DeLong, Matthew D. Hammond, Jordan Massey, Margaret Landreneau, J. Christopher Love, Lauren H. Sansing
Summary: Our study shows that microglia and MDMs have distinct functional properties in the brain after ICH, with MDMs exhibiting higher phagocytic activity, erythrophagocytosis, and antigen-presenting capabilities compared to microglia. This suggests that the different origins of microglia and MDMs lead to divergent responses and functions in the inflamed brain following ICH.
Article
Immunology
Jomkuan Theprungsirikul, Sladjana Skopelja-Gardner, Ashley S. Burns, Rachel M. Wierzbicki, William F. C. Rigby
Summary: Chronic Pseudomonas aeruginosa infection is often associated with CF, BE, and COPD patients, and is linked to abnormalities in BPI immune function. Experimental findings show that BPI plays a crucial role in the in vivo immune response against P. aeruginosa.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yan Wang, Haiqing Ni, Shuaixiang Zhou, Kaijie He, Yarong Gao, Weiwei Wu, Min Wu, Zhihai Wu, Xuan Qiu, Ying Zhou, Bingliang Chen, Donghui Pan, Chenrong Huang, Mingzhu Li, Yicong Bian, Min Yang, Liyan Miao, Junjian Liu
Summary: The newly designed CD47/PD-L1 bispecific antibody, IBI322, effectively inhibits CD47-SIRP alpha signal, promotes tumor cell phagocytosis, accumulates in PD-L1-positive tumors, shows synergistic therapeutic effects, and has minimal impact on red blood cells, making it a promising option for cancer treatment.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Marc Pfefferle, Irina L. Dubach, Raphael M. Buzzi, Elena Duerst, Nadja Schulthess-Lutz, Livio Baselgia, Kerstin Hansen, Larissa Imhof, Sandra Koernig, Didier Le Roy, Thierry Roger, Rok Humar, Dominik J. Schaer, Florence Vallelian
Summary: The study revealed that CD40 signaling in Clec4f(+) Kupffer cells triggers anti-CD40 antibody-induced liver toxicity. However, controlled erythrophagocytosis and the linked anti-inflammatory signaling by the endogenous metabolite heme can be exploited to reprogram liver macrophages and prevent necroinflammatory liver disease caused by high-dose administration of anti-CD40 antibodies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Dai-xiao Yang, Hao Yang, Yun-chao Cao, Ming Jiang, Jun Zheng, Bo Peng
Summary: The study found that succinate is a crucial biomarker for phagocytosis in monocytes/macrophages, and exogenous succinate can enhance phagocytic rate, a process that is related to the TCA cycle. Furthermore, succinate also regulates gene expression associated with immune response and phagocytosis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Matthew R. Woeste, Rejeena Shrestha, Anne E. Geller, Shu Li, Diego Montoya-Durango, Chuanlin Ding, Xiaoling Hu, Hong Li, Aaron Puckett, Robert A. Mitchell, Traci Hayat, Min Tan, Yan Li, Kelly M. McMasters, Robert C. G. Martin, Jun Yan
Summary: This study investigates the combination therapy of IRE and beta-glucan in the treatment of pancreatic cancer, and finds that this combination can enhance immune response, reduce tumor burden, and prolong survival in patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Han-Ying Cheng, Chia-Hsin Hsieh, Po-Han Lin, Yu-Tung Chen, Dennis Shin-Shian Hsu, Shyh-Kuan Tai, Pen-Yuan Chu, Muh-Hwa Yang
Summary: This study found that cancer cells undergoing Snail-induced EMT suppress NLRP3 inflammasome activities of TAMs through the delivery of exosomal miR-21 in response to chemotherapy. The Snail-miR-21 axis shapes the post-chemotherapy TME by repopulating TAMs and activating CD8(+) T cells. In head and neck cancer patients, high Snail expression cases lacked post-chemotherapy IL-1 beta surge and correlated with a worse response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Aotian Ouyang, Mengwei Zhang, Gailing Yuan, Xiaoling Liu, Jianguo Su
Summary: This study reveals that chitooligosaccharide (COS) has the ability to reverse cortisol-induced immunosuppression in fish and enhance the immune activity of macrophages. Oral administration of COS directly absorbed through the intestine significantly improves the innate immunity of blunt snout bream, leading to increased survival and reduced tissue damage. Thus, COS offers potential strategies for immunosuppression prevention and control in fish.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Microbiology
Elisabet Bjanes, Victor Nizet
Summary: The complement system is a crucial defense mechanism in immune responses against various pathogens, playing multiple roles beyond direct membrane lysis. While Gram-positive bacteria possess inherent resistance to complement-mediated killing, complement can still flag and destroy these bacteria through alternative mechanisms, demonstrating its versatility in the immune defense.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2021)
Review
Immunology
Min-Sub Lee, Steven J. Bensinger
Summary: Cholesterol plays a critical role in maintaining the integrity, fluidity, and biochemical function of mammalian cells. Macrophages can rapidly reprogram their cholesterol metabolism in response to immune activation signals. This review discusses current knowledge of cellular cholesterol homeostasis and highlights the reprogramming of cholesterol metabolism in macrophages during immune responses. It also explores the effects of these changes on sensitivity to microbial toxins and the potential therapeutic applications in diseases associated with tissue damage caused by cholesterol-dependent toxins.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Cell Biology
Xuehua Xu, Miao Pan, Tian Jin
Summary: The discovery of how phagocytes effectively find and kill pathogens through chemotaxis and phagocytosis sheds light on the evolutionarily conserved mechanisms underlying these processes in mammals.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Edna Ayerim Mandujano-Tinoco, Eliya Sultan, Aner Ottolenghi, Orly Gershoni-Yahalom, Benyamin Rosental
Summary: The evolution of the immune system is aimed at protecting organisms from infections and providing regenerative capacities and tissue maintenance. Despite the diverse range of effector cells, common features and interesting convergent mechanisms can be observed across different animals. The review explores the evolution of phagocytic and cytotoxic immune lineages, highlighting the diverse function plasticity within evolved immune effector cells.
Review
Hematology
Helin Tercan, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Siroon Bekkering
Summary: Trained immunity is a persistent hyperresponsive phenotype developed by innate immune cells after stimulation, causing cells to remember pathogens and endogenous molecules. While providing cross-protection in infectious diseases, trained immunity may lead to excessive immune responses in diseases driven by chronic systemic inflammation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)