Article
Cardiac & Cardiovascular Systems
Fatih Kahraman, Ahmet Seyda Yilmaz, Ibrahim Ersoy, Mevlut Demir, Hikmet Orhan
Summary: Investigating the predictive values of expanded SAPS II and APACHE II scores in CCU patients, it was found that both scores have good ability to predict in-hospital mortality. Therefore, they can be used as tools to predict short-term mortality in cardiovascular emergencies.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Clinical Neurology
William E. Spears, David M. Greer, Thanh N. Nguyen
Summary: This article describes the updated guidelines for aneurysmal subarachnoid hemorrhage, including preventive care, treatment modalities, complications, diagnosis and treatment of cerebral ischemia, and recovery.
Article
Medicine, General & Internal
Feng Wei, Yan Cui, Xiuhua Guo, Guoping Dong, Xiulong LI
Summary: This study explored the correlations between inflammatory factors, CCCK-18, MMP-9, DD and the APACHE II Score and prognosis of patients with ACH. The results showed that the APACHE II Score was positively associated with the levels of inflammatory factors, CCCK-18, MMP-9, and DD. Increased levels of hs-CRP, CCCK-18, MMP-9, and DD were identified as independent risk factors for poor neurologic outcomes in ACH patients.
Article
Virology
Arik Bernard Schulze, Michael Mohr, Jan Sackarnd, Lars Henning Schmidt, Phil-Robin Tepasse, Felix Rosenow, Georg Evers
Summary: This study examined the treatment and survival predictors for HIV-positive patients with AIDS in ICU. The researchers collected data from a low-incidence region in Germany and compared it with data from high-incidence regions. They found that ventilatory parameters, pH level, and platelet count were significant predictors of 30-day and 60-day survival. Different ICU scoring systems also predicted overall survival. In multivariable Cox regression, platelet count and pH level remained independently associated with survival.
Article
Biology
Wei Hu, Tingting Jin, Ziqi Pan, Huimin Xu, Lingyan Yu, Tingting Chen, Wei Zhang, Huifang Jiang, Wenjun Yang, Junjun Xu, Feng Zhu, Haibin Dai
Summary: In this study, a novel ensemble learning model was developed and validated to predict in-hospital mortality from ischemic stroke (IS) in the intensive care unit (ICU). The model achieved high predictive performance and identified key predictors of mortality. It also provided a risk stratification system for IS patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Cell Biology
Yunfei Xu, Kexin Li, Yao Zhao, Lin Zhou, Ying Liu, Jie Zhao
Summary: This article discusses the pathogenesis of stroke and highlights the important role of ferroptosis. It is found that regulating ferroptosis can successfully intervene in the process of stroke, indicating that ferroptosis may be a new potential target for the treatment of stroke.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Min Hyuk Choi, Dokyun Kim, Eui Jun Choi, Yeo Jin Jung, Yong Jun Choi, Jae Hwa Cho, Seok Hoon Jeong
Summary: Improving predictive models for ICU inpatients requires a new strategy that periodically includes the latest clinical data and can be updated to reflect local characteristics. Machine learning algorithms outperformed conventional scoring models in predicting in-hospital mortality. Combining machine learning models with conventional scoring systems can provide more useful information for predicting the prognosis of critically ill patients. Training the predictive model with individual data from each hospital can enhance its robustness.
SCIENTIFIC REPORTS
(2022)
Review
Nutrition & Dietetics
Edoardo Parrella, Cristina Gussago, Vanessa Porrini, Marina Benarese, Marina Pizzi
Summary: Polyphenols are a crucial family of molecules found in plants that have beneficial effects on health, potentially protecting against cancer, cardiovascular diseases, and stroke. Research indicates that polyphenols impact the cardio- and cerebrovascular systems and may also have neuroprotective effects in preclinical stroke models. Studies suggest that polyphenolic compounds could be used to aid in the recovery of stroke patients.
Review
Medicine, General & Internal
Luis F. Rendon, Stephanie Malta, Jacob Leung, Rafael Badenes, Ala Nozari, Federico Bilotta
Summary: Cocaine consumption has increased, and it can lead to serious neurovascular complications. This systematic review and meta-analysis aimed to describe the clinical features and outcomes of strokes associated with cocaine use. The findings show that cocaine use increases the risk of strokes and leads to worse outcomes such as mortality, vasospasm, and seizures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Emily P. Zeitler, Stephen Kearing, Megan Coylewright, Devi Nair, Jonathan C. Hsu, Douglas Darden, A. James O'Malley, Andrea M. Russo, Sana M. Al-Khatib
Summary: In a real-world population of older Medicare beneficiaries with atrial fibrillation, left atrial appendage occlusion (LAAO) was associated with a significant reduction in the risk of death and stroke among both women and men, compared with anticoagulation. The bleeding risk was higher in LAAO recipients shortly after the procedure but decreased after the 6-week periprocedural period. These findings should be taken into account in shared decision-making with patients considering strategies for reducing AF-related stroke.
Article
Medicine, Research & Experimental
Matthew J. Marget, Raven Dunn, Christie L. Morgan
Summary: The objective of this study was to assess the reliability of the Acute Physiology, Age, Chronic Health Evaluation II (APACHE-II) score in predicting 30-day mortality in adult patients with ventilator-dependent respiratory failure (VDRF) who undergo tracheostomy. A retrospective study was conducted with 238 VDRF patients who underwent tracheostomy. It was found that patients with an APACHE-II score ≥ 30 had a higher risk of mortality within 30 days of tracheostomy.
Review
Clinical Neurology
Mojtaba Dayyani, Behnam Sadeghirad, James C. Grotta, Samira Zabihyan, Saba Ahmadvand, Yuting Wang, Gordon H. Guyatt, Sepideh Amin-Hanjani
Summary: Network meta-analysis showed that nimodipine and cilostazol were likely the most effective treatments in preventing morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage. Clazosentan, nicardipine, fasudil, and magnesium showed beneficial effects on delayed cerebral ischemia and vasospasm but they were not found to reduce mortality or disability.
Article
Cardiac & Cardiovascular Systems
Jessica Magid-Bernstein, Romuald Girard, Sean Polster, Abhinav Srinath, Sharbel Romanos, Issam A. Awad, Lauren H. Sansing
Summary: This review article provides an overview of the epidemiology, cause, mechanisms of injury, current treatment strategies, and future research directions of intracerebral hemorrhage (ICH). The incidence of hemorrhagic stroke has increased globally in the past 40 years, with changes in the cause over time due to improved hypertension management and increased use of anticoagulants. Preclinical and clinical trials have shed light on the underlying cause and mechanisms of injury from ICH, including the complex interaction between edema, inflammation, iron-induced injury, and oxidative stress. Although several trials have investigated the optimal medical and surgical management of ICH, there has been no clear improvement in survival and functional outcomes. Ongoing research into novel approaches for ICH management offers hope for reducing the devastating impact of this disease in the future.
CIRCULATION RESEARCH
(2022)
Article
Health Care Sciences & Services
Katarzyna Smilowska, Marek Smilowski, Robert Partyka, Danuta Kokocinska, Przemyslaw Jalowiecki
Summary: The study found that serum suPAR levels in ischemic stroke patients increased over time, with higher suPAR and CRP concentrations in patients with hypertension, ischemic heart disease, and type 2 diabetes. A suPAR-3 concentration above 10.5ng/mL, NIHSS-1 score above 12 points, and CRP-3 concentration above 15.6mg/L significantly increased mortality risk in patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Trine Apostolaki-Hansson, Teresa Ullberg, Mats Pihlsgard, Bo Norrving, Jesper Petersson
Summary: This study found that both OAC-related ICH and antiplatelet-related ICH had worse 90-day mortality outcomes compared to nonantithrombotic ICH. Antiplatelet-related ICH is common and associated with poor clinical outcomes, warranting further research to determine appropriate clinical management.
Article
Radiology, Nuclear Medicine & Medical Imaging
H. J. Lee, J. T. Kim, M. H. Shin, D. Y. Choi, Y. S. Park, J. T. Hong
CLINICAL RADIOLOGY
(2015)
Article
Clinical Neurology
Moon Seok Kim, Jun Young Kim, Il Sup Kim, Kyoung Seok Cho, Sang Don Kim, Ho Jin Lee, Jong Tae Kim, Jae Taek Hong
EUROPEAN SPINE JOURNAL
(2016)
Article
Clinical Neurology
Jong-Tae Kim, Myung-Hoon Shin, Ho-Jin Lee, Du-Yong Choi
EUROPEAN SPINE JOURNAL
(2015)
Article
Dermatology
Kyung Mm Kim, Hei Sung Kim, Jeesuk Yu, Jong Tae Kim, Sang Hyun Cho
ANNALS OF DERMATOLOGY
(2016)
Article
Clinical Neurology
Jong Tae Kim, Ho Jin Lee, Jung Hee Kim, Jae Taek Hong
EUROPEAN SPINE JOURNAL
(2016)
Article
Clinical Neurology
Jong Tae Kim, Ho Jin Lee, Doo Yong Choi, Myoung Hoon Shin, Jae Taek Hong
EUROPEAN SPINE JOURNAL
(2016)
Article
Clinical Neurology
Ho Jin Lee, Doo Yong Choi, Myoung Hoon Shin, Jong Tae Kim, Il Sup Kim, Jae Taek Hong
EUROPEAN SPINE JOURNAL
(2016)
Article
Clinical Neurology
Jin Eun, Joon Huh, Seo-Yeon Yang, Han-Yong Huh, Jae-Kun Ahn, Kwang-Wook Cho, Young-Woo Kim, Sung-Lim Kim, Jong-Tae Kim, Do-Sung Yoo, Hae-Kwan Park, Cheol Ji
WORLD NEUROSURGERY
(2018)
Article
Clinical Neurology
Dong-Bin Kim, Myung-Hoon Shin, Jong-Tae Kim
WORLD NEUROSURGERY
(2019)
Article
Clinical Neurology
Se-Jin Song, Myung-Hoon Shin, Jong-Tae Kim
WORLD NEUROSURGERY
(2019)
Article
Biochemistry & Molecular Biology
Jong Tae Kim, Yonggoo Kim, Ji Yeon Kim, Seungok Lee, Myungshin Kim, Dong Wook Jekarl
Summary: This study investigates the pathogenesis of ossification of the posterior longitudinal ligament (OPLL) by analyzing primary spinal ligament-derived cells (SLDCs) from cervical herniated nucleus pulposus tissue. The results suggest that decreased ferritin levels and increased alkaline phosphatase levels can promote osteogenesis in SLDCs in OPLL. It is proposed that enhancing ferritin levels might alleviate osteogenesis in OPLL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Myung Soo Song, Ho Jin Lee, Jong Tae Kim, Jung Hee Kim, Jae Taek Hong
CLINICAL NEUROLOGY AND NEUROSURGERY
(2017)
Article
Clinical Neurology
Doo Yong Choi, Jong Tae Kim, Jiyoung Kim, Ho Jin Lee
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2015)
Article
Clinical Neurology
Joon Huh, Seo-Yeon Yang, Han-Yong Huh, Jae-Kun Ahn, Kwang-Wook Cho, Young-Woo Kim, Sung-Lim Kim, Jong-Tae Kim, Do-Sung Yoo, Hae-Kwan Park, Cheol Ji
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2018)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)