Article
Clinical Neurology
Edith H. Svensson, Martin Soderholm
Summary: Higher baseline FGF23 levels were significantly associated with incident intracerebral hemorrhage (ICH), particularly in lobar and non-lobar ICH. FGF23 was also significantly associated with fatal ICH, ICH with large volume, and ICH with poor functional outcome. Further studies are needed to determine if this association is causal.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Trine Apostolaki-Hansson, Teresa Ullberg, Mats Pihlsgard, Bo Norrving, Jesper Petersson
Summary: This study found that both OAC-related ICH and antiplatelet-related ICH had worse 90-day mortality outcomes compared to nonantithrombotic ICH. Antiplatelet-related ICH is common and associated with poor clinical outcomes, warranting further research to determine appropriate clinical management.
Article
Cardiac & Cardiovascular Systems
Bin Wang, Xueke Bai, Yang Yang, Jianlan Cui, Lijuan Song, Jiamin Liu, Jiapeng Lu, Jun Cai
Summary: Elevated blood pressure is highly prevalent among stroke survivors in China, regardless of age, sex, and region. It contributes significantly to cardiovascular mortality in stroke survivors, particularly in young and middle-aged patients. National strategies are needed to address the burden of stroke related to elevated blood pressure in China.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
Abdulaziz T. Bako, Alan Pan, Thomas Potter, Jonika Tannous, Carnayla Johnson, Eman Baig, Jennifer Meeks, Daniel Woo, Farhaan S. Vahidy
Summary: This study reports contemporary trends in nationwide incidence of intracerebral hemorrhage (ICH), finding an increase in ICH incidence among young and middle-aged Americans, highlighting the need for prevention strategies.
Article
Clinical Neurology
William E. Spears, David M. Greer, Thanh N. Nguyen
Summary: This article describes the updated guidelines for aneurysmal subarachnoid hemorrhage, including preventive care, treatment modalities, complications, diagnosis and treatment of cerebral ischemia, and recovery.
Article
Clinical Neurology
Jacqueline H. Geer, Guido J. Falcone, Kevin N. Vanent, Audrey C. Leasure, Daniel Woo, Jennifer R. Molano, Lauren H. Sansing, Carl D. Langefeld, Margaret A. Pisani, Henry K. Yaggi, Kevin N. Sheth
Summary: The study found that obstructive sleep apnea (OSA) is associated with the risk of intracerebral hemorrhage (ICH). Cases with OSA were more likely to be male and have hypertension, heart disease, hyperlipidemia, and higher body mass index compared to those without OSA. Logistic regression analysis showed that OSA is a risk factor for ICH.
Article
Health Care Sciences & Services
Hyun-Young Choi, Yongil Cho, Wonhee Kim, Yang-Ki Minn, Gu-Hyun Kang, Yong-Soo Jang, Yoonje Lee, Jae-Guk Kim, Jihoon Kim, Youngsuk Cho, Hyungoo Shin, Shinje Moon, Chiwon Ahn, Juncheol Lee, Dong-Geum Shin, Jae-Keun Park
Summary: This study investigated the impact of intracerebral hemorrhage (ICH) on the cumulative mortality of patients with hyperacute ischemic stroke. The results showed that the mortality rate was significantly higher in patients with ICH compared to those without ICH among patients who received intravenous thrombolysis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Leanna Laor, Prithvi Sendi, Paul Martinez, Balagangadhar R. Totapally
Summary: This study aimed to describe the prevalence, underlying causes, and outcomes of cerebral edema in hospitalized children. The results showed that cerebral edema is uncommon but has a high mortality rate in hospitalized children in the United States. Stroke and anoxic brain injury are the two most common causes of cerebral edema in these children. Anoxic brain injury has the highest mortality, while cerebral edema associated with central nervous system malignancy or diabetic ketoacidosis has a lower mortality rate.
PEDIATRIC NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jawed Nawabi, Frieder Schlunk, Andrea Dell Orco, Sarah Elsayed, Federico Mazzacane, Dmitriy Desser, Ly Vu, Estelle Vogt, Haoyin Cao, Maik F. H. Boehmer, Burak Han Akkurt, Peter B. Sporns, Marco Pasi, Ulf Jensen-Kondering, Gabriel Broocks, Tobias Penzkofer, Jens Fiehler, Alessandro Padovani, Uta Hanning, Andrea Morotti
Summary: Non-contrast computed tomography (NCCT) markers are reliable predictors for predicting parenchymal hematoma expansion in intracerebral hemorrhage (ICH). This study investigates whether NCCT features can also identify patients at risk of intraventricular hemorrhage (IVH) growth.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Morotti, Giorgio Busto, Gregoire Boulouis, Elisa Scola, Alessandro Padovani, Ilaria Casetta, Enrico Fainardi
Summary: The combined analysis of non-contrast CT and CT perfusion markers improves the prediction of hematoma expansion and outcome in intracerebral hemorrhage.
EUROPEAN RADIOLOGY
(2023)
Review
Clinical Neurology
Sarah N. N. Ohashi, Jonathan H. H. DeLong, Mariel G. G. Kozberg, David J. J. Mazur-Hart, Susanne J. J. van Veluw, Nabil J. J. Alkayed, Lauren H. H. Sansing
Summary: Hemorrhagic stroke is the deadliest form of stroke and includes the subtypes of intracerebral hemorrhage and subarachnoid hemorrhage. Inflammatory immune responses play a crucial role in the pathophysiology of these types of stroke, both affecting tissue recovery and injury. Understanding these processes can lead to the development of effective therapeutic strategies.
Article
Neurosciences
Guangshuo Li, Shang Wang, Yunyun Xiong, Hongqiu Gu, Yingyu Jiang, Xin Yang, Chunjuan Wang, Chuanying Wang, Zixiao Li, Xingquan Zhao
Summary: This study found that higher levels of blood glucose were associated with higher mortality and proportion of evacuation of intracranial hematoma in patients with intracerebral hemorrhage.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Julianne Kleitsch, Dominic A. Nistal, Natalia Romano Spica, Miryam Alkayyali, Rui Song, Deeksha Chada, Kaitlin Reilly, Cappi Lay, Alexandra S. Reynolds, Johanna T. Fifi, Joshua B. Bederson, J. Mocco, John W. Liang, Christopher P. Kellner, Neha S. Dangayach
Summary: This study found that a centralized approach to ICH management and the establishment of a dedicated ICH center in a New York City hospital system increased access to specialist services, including MIS. Most patients undergoing MIS were transferred from outside hospitals, highlighting the need for additional studies and descriptions of experiences to further elucidate the impact of and best protocols for the IHT of ICH patients.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Emanuele Rezoagli, Aldo Bonaventura, Jonathan M. Coutinho, Alessandra Vecchie, Vera Gessi, Roberta Re, Alessandro Squizzato, Fulvio Pomero, Matteo Bonzini, Walter Ageno, Francesco Dentali
Summary: In this large epidemiological study, the incidence of CVT was found to be comparable to population-based studies after 2000. The incidence of CVT increased among women over time. In-hospital CFR was low but higher in patients with concomitant ICH, with age, ICH, and a high number of comorbidities being independent predictors of in-hospital mortality.
Article
Clinical Neurology
Jatinder S. Minhas, Tom J. Moullaali, Gabriel J. E. Rinkel, Craig S. Anderson
Summary: Blood pressure is an important factor in managing intracerebral hemorrhage and aneurysmal subarachnoid hemorrhage. However, there are controversies surrounding the management of blood pressure for these conditions. Current research involves analyzing patient data to determine the strength and direction of blood pressure changes and provide recommendations for clinical practice and future research.
Article
Clinical Neurology
Romuald Girard, Yan Li, Agnieszka Stadnik, Robert Shenkar, Nicholas Hobson, Sharbel Romanos, Abhinav Srinath, Thomas Moore, Rhonda Lightle, Abdallah Shkoukani, Amy Akers, Timothy Carroll, Gregory A. Christoforidis, James Koenig, Cornelia Lee, Kristina Piedad, Steven M. Greenberg, Helen Kim, Kelly D. Flemming, Yuan Ji, Issam A. Awad
Summary: The study aims to optimize biomarkers for accurate diagnosis of cerebral cavernous angioma with symptomatic hemorrhage (CASH), predict the risk of future hemorrhage, and monitor cases after bleeding and in response to therapy.
Article
Hematology
Jessica Magid-Bernstein, Charles B. Beaman, Fernanda Carvalho-Poyraz, Amelia Boehme, Eldad A. Hod, Richard O. Francis, Mitchell S. Elkind, Sachin Agarwal, Soojin Park, Jan Claassen, E. Sander Connolly, David Roh
Summary: Acute platelet transfusion after intracerebral hemorrhage that is ABO-incompatible may lead to poorer platelet recovery and neurological outcomes compared to ABO-compatible transfusions. Further research into the underlying mechanisms is needed to better understand these observations.
Article
Multidisciplinary Sciences
Aileen A. Ren, Daniel A. Snellings, Yourong S. Su, Courtney C. Hong, Marco Castro, Alan T. Tang, Matthew R. Detter, Nicholas Hobson, Romuald Girard, Sharbel Romanos, Rhonda Lightle, Thomas Moore, Robert Shenkar, Christian Benavides, M. Makenzie Beaman, Helge Mueller-Fielitz, Mei Chen, Patricia Mericko, Jisheng Yang, Derek C. Sung, Michael T. Lawton, J. Michael Ruppert, Markus Schwaninger, Jakob Koerbelin, Michael Potente, Issam A. Awad, Douglas A. Marchuk, Mark L. Kahn
Summary: Vascular malformations are caused by increased signaling through the PI3K-mTOR pathway and loss of function of the CCM complex, which are found in the majority of human CCMs. Using mouse models, researchers discovered that the formation of CCMs can be effectively blocked by the mTORC1 inhibitor rapamycin.
Article
Clinical Neurology
Jessica Magid-Bernstein, Setareh S. Omran, Neal S. Parikh, Alexander E. Merkler, Babak Navi, Hooman Kamel
Summary: The study estimated the age- and sex-standardized incidence of hospitalization for reversible cerebral vasoconstriction syndrome (RCVS) in US adults to be approximately 3 cases per million per year. Many patients with RCVS had concomitant neurologic diagnoses, including subarachnoid hemorrhage, ischemic stroke, and intracerebral hemorrhage.
Article
Clinical Neurology
Jessica R. Magid-Bernstein, Yunke Li, Sung-Min Cho, Pirouz J. Piran, David J. Roh, Ajay Gupta, Ashkan Shoamanesh, Alexander Merkler, Cenai Zhang, Radhika Avadhani, Nataly Montano, Constantino Iadecola, Guido J. Falcone, Kevin N. Sheth, Adnan Qureshi, Jonathan Rosand, Joshua Goldstein, Issam Awad, Daniel F. Hanley, Hooman Kamel, Wendy C. Ziai, Santosh B. Murthy
Summary: The study found that the presence of cerebral microbleeds (CMBs) is associated with smaller intracerebral hemorrhage (ICH) volume and lower odds of hematoma expansion among patients with acute hemorrhage. The strength of this association increases with the number of CMBs, indicating potential prognostic significance of underlying cerebral small vessel disease after ICH.
Article
Clinical Neurology
David J. Roh, Ifeyinwa S. Asonye, Fernanda Carvalho Poyraz, Jessica R. Magid-Bernstein, Evan F. Joiner, Radhika Avadhani, Issam Awad, Daniel F. Hanley, Wendy C. Ziai, Santosh B. Murthy
Summary: This study aimed to evaluate factors associated with intraventricular hemorrhage expansion and its impact on long-term outcomes. The authors found that acute hematoma characteristics, such as larger parenchymal volume, hematoma expansion, and thalamic intracerebral hemorrhage location, were associated with intraventricular hemorrhage expansion. Additionally, intraventricular hemorrhage expansion was associated with poor clinical outcomes. This study highlights the importance of optimizing hemostasis and preventing intraventricular hemorrhage expansion.
Article
Clinical Neurology
Abdalla A. Ammar, Aladine A. Elsamadicy, Mahmoud A. Ammar, Benjamin C. Reeves, Andrew B. Koo, Guido J. Falcone, David Y. Hwang, Nils Petersen, Jennifer A. Kim, Rachel Beekman, Morgan Prust, Jessica Magid-Bernstein, Julian N. Acosta, Ryan Herbert, Kevin N. Sheth, Charles C. Matouk, Emily J. Gilmore
Summary: This study compared the safety of immediate EVD placement after the bolus administration of a factor Xa-inhibitor reversal agent versus after the infusion of the agent in patients with intracerebral hemorrhage. The results showed no significant differences in the incidence of hemorrhage, mortality, length of hospital stay, and discharge modified Rankin Score between the two groups. Therefore, it may be considered to perform EVD placement immediately after the infusion of the reversal agent to shorten the treatment time.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Medicine, Research & Experimental
Abhinav Srinath, Bingqing Xie, Ying Li, Je Yeong Sone, Sharbel Romanos, Chang Chen, Anukriti Sharma, Sean Polster, Pieter C. Dorrestein, Kelly C. Weldon, Dorothy DeBiasse, Thomas Moore, Rhonda Lightle, Janne Koskimaki, Dongdong Zhang, Agnieszka Stadnik, Kristina Piedad, Matthew Hagan, Abdallah Shkoukani, Julian Carrion-Penagos, Dehua Bi, Le Shen, Robert Shenkar, Yuan Ji, Ashley Sidebottom, Eric Pamer, Jack A. Gilbert, Mark L. Kahn, Mark D'Souza, Dinanath Sulakhe, Issam A. Awad, Romuald Girard
Summary: Plasma metabolites can reflect the presence of CA and the occurrence of symptomatic hemorrhage, which is significant for the diagnosis and treatment of CA patients.
COMMUNICATIONS MEDICINE
(2023)
Meeting Abstract
Clinical Neurology
Jessica Magid-Bernstein, Alison L. Herman, Conor Johnson, Hannah Beatty, Guido Falcone, Charles Matouk, Kevin Sheth, Lauren Sansing
ANNALS OF NEUROLOGY
(2022)
Meeting Abstract
Clinical Neurology
Jessica Magid-Bernstein, David Roh, Ajay Gupta, Ashkan Shoamanesh, Sung-Min Cho, Alexander Merkler, Radhika Avadhani, Joshua Gruber, Constantino Iadecola, Guido Falcone, Kevin Sheth, Adnan Qureshi, Joshua Goldstein, Jonathan Rosand, Daniel Hanley, Hooman Kamel, Wendy Ziai, Santosh Murthy
Meeting Abstract
Clinical Neurology
Fernanda Carvalho Poyraz, Jessica Magid-Bernstein, Mitchell Elkind, Sachin Agarwal, Soojin Park, Jan Claassen, Eldad Hod, David Roh, E. Sander Connolly
