Article
Entomology
Maristella Mastore, Sara Caramella, Silvia Quadroni, Maurizio Francesco Brivio
Summary: In recent years, climate change and international fruit trade have facilitated the introduction of harmful insects to new areas leading to increased use of chemical insecticides. This study focuses on improving biological control methods for managing Spotted Wing Drosophila, with promising results showing enhanced efficacy through the combined use of entomopathogenic bacteria. Further research and field testing of these bioinsecticides are recommended for future application.
Article
Pharmacology & Pharmacy
Alice Brookes, Liuhang Ji, Tracey D. Bradshaw, Michael Stocks, David Gray, James Butler, Pavel Gershkovich
Summary: This review explores the feasibility of oral lipid-based drug delivery to the brain and discusses various lipids that can potentially be delivered orally. Current data suggests that oral administration can increase the permeability of the blood-brain barrier (BBB), and further research is needed to investigate the use of lipid-based drug delivery for brain targeting.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Ozbej Zupanc, Varun Kushwah, Amrit Paudel
Summary: This review highlights the importance of controlling the digestion process of orally administered lipid-based delivery systems (LBDS) to maintain their structural integrity and drug stability. Proper formulation selection, in vitro digestion models, and digestion inhibition methods can effectively control the digestion rate of LBDS.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Yao Qian, Xiangyu Guo, Yunfang Wang, Zheng Ouyang, Xiaoxiao Ma
Summary: A mobility-modulated sequential dissociation (MMSD) strategy was developed for mass spectrometry imaging, enabling spatial lipidomics capable of multiplexed MS/MS imaging of 24 structurally distinct lipids. The method revealed a potential biomarker in a human hepatocellular carcinoma tissue.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Sandra M. Camunas-Alberca, Maria Moran-Garrido, Jorge Saiz, Alberto Gil-de-la-Fuente, Coral Barbas, Ana Gradillas
Summary: It is important to conduct a detailed molecular structure analysis of isomeric lipids to understand their biological roles better. Conventional tandem mass spectrometry (MS/MS) is complicated by isomeric interference, necessitating the development of specialized methodologies to separate lipid isomers. This review discusses recent lipidomic studies using ion mobility spectrometry combined with mass spectrometry (IMS-MS) and describes examples of separating and elucidating the structural and stereoisomers of lipids based on their ion mobility behavior.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Chemistry, Multidisciplinary
David S. Roberts, Morgan Mann, Jake A. Melby, Eli J. Larson, Yanlong Zhu, Allan R. Brasier, Song Jin, Ying Ge
Summary: Researchers have successfully elucidated the complete structure of newly discovered O-glycans on the S protein regional-binding domain (SR-BD) of the SARS-CoV-2 virus through a hybrid mass spectrometry approach. This method can provide insights into the interactions between the virus and host cells, laying a foundation for understanding the functional roles of O-glycans in SARS-CoV-2 and other glycoproteins.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Virology
Yvonne Linscheid, Tobias Kessel, Andreas Vilcinskas, Kwang-Zin Lee
Summary: Drosophila suzukii (Ds) is an invasive pest insect that causes severe damage to soft fruit crops. Oral infection of Ds adults with La Jolla virus (LJV) reduces survival, while oral infection of Ds larvae causes developmental arrest during pupation. LJV remains stable and infectious under different pH and temperature conditions.
Article
Chemistry, Multidisciplinary
Louis J. Sparvero, Hua Tian, Andrew A. Amoscato, Wan-Yang Sun, Tamil S. Anthonymuthu, Yulia Y. Tyurina, Oleksandr Kapralov, Sabzali Javadov, Rong-Rong He, Simon C. Watkins, Nicholas Winograd, Valerian E. Kagan, Hulya Bayir
Summary: Using gas cluster ion beam secondary ion mass spectrometry (GCIB-SIMS) imaging, peroxidized phosphatidylethanolamine (PEox) could be mapped with high spatial resolution in ferroptotic cardiomyocytes and neurons after traumatic brain injury, revealing their accumulation at very low physiological levels in subcellular compartments.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Marcos Bouza, Yafeng Li, Aurelia C. Wang, Zhong Lin Wang, Facundo M. Fernandez
Summary: This study demonstrated the successful structural characterization and annotation of lipids using large-area triboelectric nanogenerators combined with time-aligned parallel fragmentation mass spectrometry analysis, providing detailed information on double bonds, sn-chain positions, and C=C isomerism. This methodology offers a new avenue for lipid analysis in biological samples.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Saleh M. Khalil, Richard R. Sprenger, Martin Hermansson, Christer S. Ejsing
Summary: Matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) is a useful technique for visualizing the spatial distribution of lipid molecules in tissues. The limitation of confident lipid identification in MSI has been overcome by the development of DDA-imaging technology. This study demonstrates the successful transfer of DDA-imaging technology onto another mass spectrometer and shows its reliability in lipid identification.
JOURNAL OF MASS SPECTROMETRY
(2022)
Review
Biochemistry & Molecular Biology
Dylan H. Ross, Jian Guo, Aivett Bilbao, Tao Huan, Richard D. Smith, Xueyun Zheng
Summary: The identification of lipids is crucial in lipidomics studies, impacting the interpretation of analyses and biological understandings. Mass spectrometry coupled with liquid chromatography is commonly used for lipidomics studies, providing detailed lipid identifications. Ion mobility spectrometry has also gained adoption, offering additional separation dimension and supporting lipid identification. However, the availability of software tools for IMS-MS lipidomics data analysis is still limited, especially for isomer identifications and integration with MS-based imaging. This review evaluates existing software tools and lipid identifications in IMS-MS lipidomics data using open-access data from peer-reviewed literature.
Article
Biochemistry & Molecular Biology
Henry M. Sanders, Blagojce Jovcevski, Michael T. Marty, Tara L. Pukala
Summary: The study demonstrates that lipid membrane composition influences the aggregation of misfolding proteins and the efficacy of amyloid inhibitors. Different mechanisms were observed for two well-known polyphenol inhibitors in the presence of lipid membranes, highlighting the importance of considering lipid environments in amyloid inhibitor design.
Article
Chemistry, Multidisciplinary
Mai H. Philipsen, Elias Ranjbari, Chaoyi Gu, Andrew G. Ewing
Summary: The changes in brain lipids induced by Modafinil treatment in Drosophila melanogaster show a decrease in phosphatidylcholine and sphingomyelin species, while an increase in phosphatidylethanolamine and phosphatidylinositol levels, which is consistent with previous studies on cognition-related drugs. These alterations offer insight into the potential mechanism of action of Modafinil in the brain and provide a potential target for the treatment of certain disorders.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemical Research Methods
Michael Witting, Ulrike Schmidt, Hans-Joachim Knoelker
Summary: The study utilized chromatographic and ion mobility separation combined with DIA for lipid analysis in the biomedical model organism Caenorhabditis elegans, showing that this method is effective for initial lipid identification, successfully identifying 45 marado- and lysomaradolipids.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Florent Penen, Rene Raave, Annemarie Kip, Sandra Heskamp, Per Malmberg
Summary: ToF-SIMS imaging is a quick and sensitive technique that can visualize HER2 specific radiotracers in ovarian and breast cancer xenograft tumor sections to reflect the heterogeneous distribution of trastuzumab.
MICROCHEMICAL JOURNAL
(2022)
Article
Physics, Atomic, Molecular & Chemical
Sanna Samfors, Marcus Stahlman, Martina Klevstig, Jan Boren, John S. Fletcher
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
(2019)
Article
Biochemistry & Molecular Biology
Mai H. Philipsen, Nhu T. N. Phan, John S. Fletcher, Per Malmberg, Andrew G. Ewing
ACS CHEMICAL NEUROSCIENCE
(2018)
Article
Biophysics
Marwa Munem, Oscar Zaar, Kelly Dimovska Nilsson, Noora Neittaanmaki, John Paoli, John S. Fletcher
Article
Biochemical Research Methods
Sanna Samfors, Andrew G. Ewing, John S. Fletcher
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2018)
Article
Biophysics
Marwa Munem, Oscar Zaar, Kelly Dimovska Nilsson, Noora Neittaanmaki, John Paoli, John S. Fletcher
Review
Radiology, Nuclear Medicine & Medical Imaging
Tiffany Porta Siegel, Gregory Hamm, Josephine Bunch, Jo Cappell, John S. Fletcher, Kristina Schwamborn
MOLECULAR IMAGING AND BIOLOGY
(2018)
Article
Chemistry, Analytical
Kelly Dimovska Nilsson, Martin Palm, James Hood, Jake Sheriff, Anne Farewell, John S. Fletcher
ANALYTICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Ibrahim Kaya, Eva Jennische, Johan Dunevall, Stefan Lange, Andrew G. Ewing, Per Malmberg, Ahmet Tarik Baykal, John S. Fletcher
ACS CHEMICAL NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Mai Hoang Philipsen, Nhu T. N. Phan, John Stephen Fletcher, Andrew G. Ewing
ACS CHEMICAL NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Ibrahim Kaya, Eva Jennische, Stefan Lange, Ahmet Tarik Baykal, Per Malmberg, John S. Fletcher
JOURNAL OF NEUROCHEMISTRY
(2020)
Article
Chemistry, Analytical
Sanna Samfors, John S. Fletcher
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 13
(2020)
Article
Biophysics
Kelly Dimovska Nilsson, Noora Neittaanmaki, Oscar Zaar, Tina B. Angerer, John Paoli, John S. Fletcher
Article
Biochemical Research Methods
Ibrahim Kaya, Sanna Samfors, Malin Levin, Jan Boren, John S. Fletcher
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2020)
Article
Chemistry, Physical
Kelly Dimovska Nilsson, Johan Granden, Anne Farewell, John S. Fletcher
Summary: ToF-SIMS was used to analyze the chemical changes in the bacterial envelope of a fabF knock-out Escherichia coli strain. The results showed a substantial depletion of FA(18:1) in the fabF mutant during logarithmic growth, as well as a reduction in FA(cp19:0) during stationary phase. Additionally, the wild type strain exhibited a reduction in cyclopropanation at lower culture temperatures and a 'thickening' of the lipid A layer on the surface of the bacteria during stationary phase.
SURFACE AND INTERFACE ANALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Inci Barut, Xiulan He, Erol Sener, Sanna Samfors, Andrew G. Ewing, John S. Fletcher
Summary: The abnormal functioning of proteasome is associated with crucial pathological conditions, such as neurodegeneration. However, the complex underlying causes at the cellular level are still unclear, and there are conflicting reports on the neuroprotective and neurodegenerative effects of proteasomal inhibitors like lactacystin, which are used as models for neurodegenerative diseases. The conflicting results may be due to different doses of lactacystin. Hence, a dose-dependent study was conducted to investigate the effects of lactacystin on cell membrane lipid profile and exocytosis dynamics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)