Journal
ANALYTICAL CHEMISTRY
Volume 87, Issue 3, Pages 1462-1465Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac503543z
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Funding
- National Key Scientific Instrument Development Program of China [2011YQ030139]
- National Nature Science Foundation of China [31300657, 21472142]
- Natural Science Foundation of Zhejiang Province [LY13C050002]
- Qanjiang talents Program [QJD1202019, 2013R10020]
- Public Projects of Zhejiang Province [2013C37050]
- Science and Technology Program of Ningbo [2013C50040]
- Natural Science Foundation of Ningbo [2013A6110165]
- Science and Technology Program of Longwan [2013YS01]
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A new hydrazide derivative was synthesized and used for the first time as a specific, brief, and economical probe to selectively visualize glycoproteins in 1-D and 2-D sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) with high sensitivity. The detection limit of the newly developed staining method is 2- and 4-fold higher than that of the widely used Pro-Q Emerald 300 and 488 stains, respectively.
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