Review
Endocrinology & Metabolism
Yue Zhuo, Meng Li, Qiyao Jiang, Hanzhong Ke, Qingchun Liang, Ling-Feng Zeng, Jiansong Fang
Summary: This article summarizes the known TCM-derived terpenoids for the treatment of osteoporosis, discusses their mechanisms of action, and evaluates their therapeutic potential for osteoporosis treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jiaying Li, Hong Cao, Xuchang Zhou, Jianmin Guo, Chengqiang Zheng
Summary: Bone metabolic homeostasis relies on the balance between bone formation and bone resorption, which can be affected by oxidative stress. Traditional Chinese medicine has been shown to alleviate oxidative stress-mediated bone metabolic disorders by modulating multiple signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Junjie Lu, Desheng Hu, Chen Ma, Bo Shuai
Summary: Osteoporosis is a silent disease with no obvious symptoms, leading to insufficient treatment and preventive measures. The high disability and mortality rates of OP-related fractures impose a heavy burden on individuals and society. Early intervention and treatment are necessary to reduce fracture risk. This review summarizes the research progress of common anti-OP drugs and targeted therapies to promote pharmacological research and novel drug development.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Dongyang Qian, Hui Zhou, Pan Fan, Tao Yu, Anish Patel, Morgan O'Brien, Zhe Wang, Shiguang Lu, Guoqiang Tong, Yimin Shan, Lei Wang, Yuan Gao, Yuan Xiong, Lily Zhang, Xin Wang, Yuancai Liu, Shuanhu Zhou
Summary: The study found that traditional Chinese medicine herbal extracts can prevent alcohol-induced osteopenia in male mice, effectively regulate abnormal bone metabolism, improve bone density, and have the potential therapeutic effect.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Zhihai Cao, Yuan Xue, Jiaqian Wang
Summary: Osteoporosis is caused by decreased bone formation and increased bone absorption, with ferroptosis playing a key role. Ferroptosis may inhibit bone formation and promote bone absorption through oxidative stress, leading to osteoporosis.
Review
Pharmacology & Pharmacy
Shenglei Yang, Yuying Sun, Leonid Kapilevich, Xin'an Zhang, Yue Huang
Summary: Osteoporosis is a common skeletal disorder that primarily affects the elderly and postmenopausal women. Drug therapy is currently used as the main treatment, but long-term use can lead to drug resistance and side effects. Therefore, researchers are exploring natural plant compounds as an alternative. Curcumin, a natural phenolic compound, has shown potential as a candidate for treating osteoporosis due to its various pharmacological and biological activities. This review summarizes the mechanisms and therapeutic applications of curcumin in preventing and mitigating osteoporosis, providing valuable references for further research and development of curcumin.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kangtao Jin, Lin Zheng, Lin Ye, Ziang Xie, Jiawei Gao, Chao Lou, Wenzheng Pan, Bin Pan, Shijie Liu, Zhenzhong Chen, Dengwei He
Summary: The study demonstrates that CSB6B suppresses osteoclast differentiation and bone resorption while enhancing osteoblast mineralization by inhibiting the NF-KB pathway and promoting Runx expression. In murine models, CSB6B has shown protective effects against pathological bone destruction and bone loss induced by estrogen deficiency. MIF inhibition by CSB6B could be a potential therapeutic approach for osteolytic bone disorders and osteoporosis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Integrative & Complementary Medicine
Chenyang Ai, Yi Zou, Hao Liu, Zheqiong Yang, Jinlei Xi
Summary: The prevalence of allergic disorders has increased, leading to a lower quality of life for patients and a higher demand for drugs to treat these diseases. Traditional Chinese medicine offers distinct benefits in treating allergic illnesses, such as long-term treatment maintenance, prevention of disease recurrence, and fewer adverse reactions. Recent developments in Chinese herbal formula, Chinese patent medicine, and active ingredients of traditional Chinese medicine have been analyzed, discussing their components, efficacy, and mechanisms of action. The importance of improving traditional Chinese herbal formulas and developing safe and effective Chinese patent medicines is emphasized in the field of traditional Chinese medicine research.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Chao Liu, Yining Li, Ren Sheng, Xiaowan Han, Li Bao, Chenyin Wang, Weizhi Wang, Xinhai Jiang, Jiangxue Han, Lijuan Lei, Ni Li, Jing Zhang, Minghua Chen, Yan Li, Yexiang Wu, Shunwang Li, Yu Ren, Yanni Xu, Shuyi Si
Summary: The study demonstrated that the N-methylpyridine-chlorofuranformamide analog 3i1 shows promise in upregulating OPG activity, inhibiting RANKL-induced osteoclastogenesis, and promoting osteoblast differentiation, potentially serving as a new therapeutic agent for osteoporosis.
BIOORGANIC CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Sophia Ogechi Ekeuku, Kok-Lun Pang, Kok-Yong Chih
Summary: Caffeic acid, a metabolite of hydroxycinnamate and phenylpropanoid, acts as an antioxidant to reduce osteoclastogenesis and bone resorption. However, in some cases, it may have no effect on bone resorption or even impair bone mechanical properties in normal rats.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Engineering, Biomedical
Wei Zhang, Xingzhi Zhou, Weiduo Hou, Erman Chen, Chenyi Ye, Mo Chen, Qian Lu, Xiaohua Yu, Weixu Li
Summary: In this study, a molecular therapeutic strategy mediated by a SIRT-1 agonist was reported to reverse the imbalance in bone homeostasis by regulating osteogenesis and osteoclastogenesis simultaneously. The sustained release of SRT2104 from mineral coated acellular matrix microparticles effectively enhanced osteogenic differentiation and mineralization, while attenuating the formation and function of excessive osteoclasts by integrating multiple vital upstream signals. Animal models also demonstrated the accelerated healing and improved osseointegration of osteoporotic bone defects.
BIOACTIVE MATERIALS
(2023)
Article
Integrative & Complementary Medicine
Jillian L. Capodice, Barbara M. Chubak
Summary: Traditional Chinese Medicine (TCM) is a comprehensive medical system that has been developed over thousands of years and is utilized in the treatment of COVID-19. This paper highlights the use of TCM in treating COVID-19, discussing concepts and challenges of integrating TCM into medical settings.
Review
Pharmacology & Pharmacy
Yan Li, Lingyu Li, Xiaoyun Li, Bingjie Luo, Qianyun Ye, Haoyu Wang, Li Yang, Xiaofeng Zhu, Li Han, Ronghua Zhang, Huaqin Tian, Panpan Wang
Summary: Bone reconstruction relies on the balance between bone formation and bone absorption. Polyphenols found in Chinese herbal medicines can affect this balance and have potential therapeutic effects on bone metabolic diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Environmental
Yonggang Ma, Di Ran, Ying Cao, Hongyan Zhao, Ruilong Song, Hui Zou, Jianhong Gu, Yan Yuan, Jianchun Bian, Jiaqiao Zhu, Zongping Liu
Summary: Long-term exposure to cadmium inhibits osteogenesis of bone marrow stem cells and differentiation of bone marrow macrophages, leading to osteoporosis. P2X7 plays a crucial role in this process, with its deletion or overexpression affecting bone cell differentiation. Short-term exposure to cadmium inhibits bone formation, increases osteoclast numbers, but does not result in osteoporosis.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Endocrinology & Metabolism
Chenyu Zhu, Shiwei Shen, Shihua Zhang, Mei Huang, Lan Zhang, Xi Chen
Summary: Bone homeostasis is regulated by autophagy, which plays a critical role in the differentiation, apoptosis, and survival of bone cells. Oxidative stress induces autophagy as a protective response against cell damage. Understanding how autophagy regulates bone formation and bone resorption provides insights for potential therapeutic targets in osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Y. Enomoto, H. Nakatani, S. Kondo, T. Kasai, Y. Tsuchiya
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2019)
Article
Oncology
Junichiro Chikuda, Kurataka Otsuka, Iwao Shimomura, Kagenori Ito, Hiroaki Miyazaki, Ryou-u Takahashi, Masahiro Nagasaki, Yoshiki Mukudai, Takahiro Ochiya, Toshikazu Shimane, Tatsuo Shirota, Yusuke Yamamoto
Review
Biochemistry & Molecular Biology
Akiko Kogure, Yusuke Yoshioka, Takahiro Ochiya
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Akiko Kogure, Yutaka Naito, Yusuke Yamamoto, Masakazu Yashiro, Tohru Kiyono, Kazuyoshi Yanagihara, Kosei Hirakawa, Takahiro Ochiya
Article
Medicine, General & Internal
Aya Yoshino, Shintaro Ishida, Shinsuke Nakamura, Ryosuke Kita, Mika Seto, Shinji Matsumoto, Morishige Takeshita, Seiji Kondo
Article
Multidisciplinary Sciences
Shintaro Ishida, Seiji Kondo, Shunsuke Funakoshi, Atsushi Satoh, Toshiki Maeda, Miki Kawazoe, Chikara Yoshimura, Kazuhiro Tada, Koji Takahashi, Kenji Ito, Tetsuhiko Yasuno, Kosuke Masutani, Hitoshi Nakashima, Hisatomi Arima
Summary: The study found an association between white blood cell count and future development of hypertension in the general Japanese population, with an increase in white blood cell count associated with a higher incidence of hypertension. This association remained significant even after adjusting for other risk factors.
Article
Medicine, General & Internal
Hideyuki Fujii, Shunsuke Funakoshi, Toshiki Maeda, Atsushi Satoh, Miki Kawazoe, Shintaro Ishida, Chikara Yoshimura, Soichiro Yokota, Kazuhiro Tada, Koji Takahashi, Kenji Ito, Tetsuhiko Yasuno, Shota Okutsu, Shigeaki Mukoubara, Hitoshi Nakashima, Shigeki Nabeshima, Seiji Kondo, Masaki Fujita, Kosuke Masutani, Hisatomi Arima, Daiji Kawanami
Summary: The study revealed that faster eating speed was associated with an increased risk for the incidence of diabetes in a general Japanese population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anatomy & Morphology
Mai Kurihara, Yoshiki Mukudai, Hitoshi Watanabe, Mariko Asakura, Yuzo Abe, Asami Houri, Junichiro Chikuda, Toshikazu Shimane, Tatsuo Shirota
Summary: The study uncovered the role of Vitamin D in suppressing osteocyte cell death and inducing autophagy under hypoxic conditions, primarily through the Akt and mTOR pathways. This suggests the potential of Vitamin D as a therapeutic intervention for diseases where osteocyte cell death mainly occurs via hypoxia.
CELLS TISSUES ORGANS
(2021)
Article
Biochemistry & Molecular Biology
Yuzo Abe, Yoshiki Mukudai, Mai Kurihara, Asami Houri, Junichiro Chikuda, Atsutoshi Yaso, Kosuke Kato, Toshikazu Shimane, Tatsuo Shirota
Summary: The expression of TPD52 increases in OSCC cells under hypoxia in a HIF-independent manner and plays an important role in the proliferation and survival of the cells in concordance with HIF. TPD52 enhances mRNA stability in OSCC cells, leading to increased expression levels. Simultaneous knockdown of TPD52 and inhibition of HIF significantly reduce cell viability.
CELL AND BIOSCIENCE
(2021)
Article
Medicine, General & Internal
Aya Yoshino, Yoshihiko Nakamura, Yuhei Irie, Taisuke Kitamura, Tohru Takata, Hiroyasu Ishikura, Seiji Kondo
Summary: This study investigated the association between oral health and survival rate in critically ill COVID-19 patients in the ICU, and found that poor oral health was associated with a higher mortality rate during ECMO treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Aya Yoshino, Yoshihiko Nakamura, Shiho Hashiguchi, Shintaro Ishida, Ryosuke Mano, Shinsuke Nakamura, Ryosuke Kita, Mika Seto, Tohru Takata, Hiroyasu Ishikura, Seiji Kondo
Summary: The interplay between oral deterioration, gut dysbiosis, and impaired immunity is specifically associated with mortality in COVID-19 patients receiving ECMO in the ICU. The oral-gut axis may play a crucial role in systemic health issues during COVID-19 infections.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Aya Yoshino, Shiho Hashiguchi, Ryosuke Mano, Seiji Kondo, Satoshi Kubota, Masaharu Takigawa
Summary: This study demonstrates that the increase in CCN2 mRNA expression under hypoxia may be regulated through the activation of p38 MAPK to modulate its stability.
ORAL SCIENCE INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mika Seto, Ryosuke Kita, Shintaro Ishida, Seiji Kondo
ORAL SCIENCE INTERNATIONAL
(2020)
Article
Dentistry, Oral Surgery & Medicine
Mika Seto, Ryosuke Kita, Seiji Kondo
JOURNAL OF THE KOREAN ASSOCIATION OF ORAL AND MAXILLOFACIAL SURGEONS
(2019)
Article
Dentistry, Oral Surgery & Medicine
Aya Yoshino, Mika Seto, Ryosuke Mano, Ryosuke Kita, Shintaro Ishida, Naoko Aoyagi, Tomoki Shimamura, Seiji Kondo
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2019)