Article
Integrative & Complementary Medicine
Ming-Liang Zhang, Xu Zhao, Wei-Xia Li, Xiao-Yan Wang, Ming Niu, Hui Zhang, Yu-Long Chen, De-Xin Kong, Yuan Gao, Yu-Ming Guo, Zhao-Fang Bai, Yan-Ling Zhao, Jin-Fa Tang, Xiao-He Xiao
Summary: Psoralea corylifolia Linn. (BGZ) has different effects on liver protection and damage in rats with kidney-yang deficiency syndrome and kidney-yin deficiency syndrome. The transcriptomics and metabonomics analysis revealed that BGZ affects different metabolic pathways in these two syndrome models. It is important to consider the predisposed populations when using drugs related to energy metabolism.
Article
Multidisciplinary Sciences
Elisa B. Randi, Karim Zuhra, Laszlo Pecze, Theodora Panagaki, Csaba Szabo
Summary: In mammalian cells, cyanide exhibits a biphasic effect on mitochondrial Complex IV activity, stimulating it at low concentrations and inhibiting it at higher concentrations. Low levels of cyanide lead to increased cell proliferation and ATP production, while higher levels result in inhibition of cellular bioenergetics. The presence of cyanide-producing enzymes in mammalian cells suggests a regulatory role for endogenous cyanide.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Plant Sciences
Eunhui Seo, Cao-Sang Truong, Hee-Sook Jun
Summary: This study validated the beneficial effects of Psoralea corylifolia (PCS) extract on dexamethasone-induced muscle atrophy in mice. PCS extract inhibited muscle degradation factors and increased muscle regeneration and synthesis factors. This effect was likely mediated by suppressing oxidative stress and inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Oncology
Bhawna Chopra, Ashwani Kumar Dhingra, Ajmer Singh Grewal, Akash Jain, Jasmine Chaudhary, Parul Grover
Summary: The present study aims to explore the anticancer potential of bakuchiol and provide insights for the design and development of novel molecular entities for various disorders. Relevant literature and patents emphasizing the anticancer potential of bakuchiol were identified and reviewed. The findings suggest that bakuchiol has promising anticancer potential against various types of cancer, and it also shows synergistic or potentiating effects when used in combination with other anticancer drugs or natural compounds. Therefore, bakuchiol holds great potential as a therapeutic option for tumors.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Nancy Tripathi, Nivedita Bhardwaj, Sanjay Kumar, Shreyans K. Jain
Summary: Medicinal plants have long been important in drug discovery, and the natural products derived from these plants have attractive characteristics for drug development. Psoralen, a compound found in the plant Psoralea corylifolia, has potential biological functions and shows promise in various areas such as anti-cancer, anti-inflammatory, and anti-osteoporotic activities.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Liqiong Sun, Zhijuan Tang, Minxin Wang, Jun Shi, Yajuan Lin, Tiefeng Sun, Zhilu Zou, Zebin Weng
Summary: This study developed a fast and reliable method to screen antimicrobial compounds targeting MRSA membrane from Psoralea corylifolia Linn. seed. The research identified prenylated flavonoids in Psoralea corylifolia Linn. seed and showed that these compounds have a unique destructive effect on MRSA cell membranes without leading to drug resistance.
Review
Biochemistry & Molecular Biology
Bindu D. Paul, Solomon H. Snyder, Khosrow Kashfi
Summary: Hydrogen sulfide (H2S) was once thought to be only toxic, but is now known to also act as an endogenous signaling molecule. The effects of H2S on cellular physiology are dose-dependent, with lower concentrations being beneficial and higher concentrations being cytotoxic. In particular, H2S has contrasting effects on mitochondrial function, inhibiting the electron transport chain at higher concentrations and stimulating bioenergetics at lower concentrations.
Article
Biochemistry & Molecular Biology
Ana P. Marques, Rosa Resende, Diana F. Silva, Mariana Batista, Daniela Pereira, Brigite Wildenberg, Sofia Morais, Antonio Macedo, Claudia Pais, Joana B. Melo, Nuno Madeira, Claudia F. Pereira
Summary: The study aims to evaluate mitochondrial changes in early stages of bipolar disorder (BD). Fibroblasts derived from BD patients show fragmented mitochondria, altered dynamics, decreased MMP, and increased mitophagy compared to controls. These results suggest that mitochondrial disturbance is an early event in BD pathophysiology that may trigger neuronal changes and brain circuitry modifications.
Article
Biochemistry & Molecular Biology
Angelica I. Borja-Magno, Janette Furuzawa-Carballeda, Martha Guevara-Cruz, Clorinda Arias, Julio Granados, Hector Bourges, Armando R. Tovar, Barry Sears, Lilia G. Noriega, Francisco Enrique Gomez
Summary: This study aimed to investigate the mitochondrial bioenergetics status and cell subset composition of PBMCs in individuals with obesity, and to determine the effect of w-3 FA supplementation. The results showed that PBMCs from the obese group exhibited higher mitochondrial bioenergetic markers and lower BHI. After 1 month of w-3 FA intervention, mitochondrial function improved, along with a reduction in pro-inflammatory and anti-inflammatory immune cell subsets.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Clinical Neurology
Theophania Ashleigh, Russell H. Swerdlow, M. Flint Beal
Summary: Mitochondrial dysfunction plays a central role in the pathogenesis of Alzheimer's disease, challenging the conventional thinking of amyloid beta pathology. A unified model that accurately identifies the underlying mechanism of AD is crucial for the development of effective therapies.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Neeru A. Vallabh, Jane Armstrong, Gabriela Czanner, Brian McDonagh, Anshoo Choudhary, David N. Criddle, Colin E. Willoughby
Summary: Glaucoma is a progressive optic neuropathy that leads to irreversible visual impairment and eventual blindness. The mitochondrial function of ocular fibroblasts in glaucoma patients is compromised, with elevated oxidative stress levels. Therapeutic interventions targeting oxidative stress or providing mitochondrial energetic support are important in managing glaucoma.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Ming-Liang Zhang, Wei-Xia Li, Xiao-Yan Wang, Hui Zhang, Ya-Li Wu, Liu-Qing Yang, Xiao-Fei Chen, Shu-Qi Zhang, Yu-Long Chen, Ke-Ran Feng, Jin-Fa Tang
Summary: Drug-induced liver injury (DILI) is a common cause of drug withdrawal, and immune status plays a significant role in its development. This study constructed a highly accurate DILI predictive gene set (DILI_PGS) using gene expression data and bioinformatics methods, and verified its predictability. Additionally, the study identified the characteristics of host factors involved in DILI.
FRONTIERS IN CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Pauline Andrieux, Christophe Chevillard, Edecio Cunha-Neto, Joao Paulo Silva Nunes
Summary: Mitochondria are the energy powerhouse of the cell, playing essential roles in inflammation, pathogen response, and oxidative stress. Pathogens can exploit mitochondria to disrupt cellular functions by affecting oxidative phosphorylation mechanisms. Targeting mitochondria could be a promising therapeutic strategy for infectious and inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Olga O. Gonchar, Andriy V. Maznychenko, Olena M. Klyuchko, Iryna M. Mankovska, Kamila Butowska, Agnieszka Borowik, Jacek Piosik, Inna Sokolowska
Summary: C-60 fullerene can prevent 3-NPA-induced mitochondrial dysfunction through various mechanisms, including restoring enzyme activity, scavenging ROS, modulating redox balance, and inhibiting apoptosis. Additionally, C-60 improves mitochondrial protection by strengthening the endogenous glutathione system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Inigo San-Millan
Summary: The role of mitochondrial function in health and disease has gained increasing recognition in recent years. Mitochondrial dysfunction and disruptions of cellular bioenergetics have been found to be present in various prevalent diseases, such as type 2 diabetes, cardiovascular disease, metabolic syndrome, cancer, and Alzheimer's disease. However, the causes and mechanisms of mitochondrial dysfunction in these diseases are still not fully understood, making it a significant medical challenge. Advances in our understanding of cellular metabolism and genetics offer promise in unraveling the mysteries of mitochondria and developing therapeutic treatments.