Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways

Somatic Mutations of PPP2R1A in Ovarian and Uterine Carcinomas

(2011) Ie-Ming Shih et al.   AMERICAN JOURNAL OF PATHOLOGY

Cancer statistics, 2011

(2011) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas

(2011) Melissa K McConechy et al.   JOURNAL OF PATHOLOGY

Human Cancer-Associated Mutations in the A  Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A  Knock-In and Knockout Mice

(2011) R. Ruediger et al.   MOLECULAR AND CELLULAR BIOLOGY

Essential Requirement for PP2A Inhibition by the Oncogenic Receptor c-KIT Suggests PP2A Reactivation as a Strategy to Treat c-KIT+ Cancers

(2010) K. G. Roberts et al.   CANCER RESEARCH

The ARF tumor suppressor: Structure, functions and status in cancer

(2010) Peggy Ozenne et al.   INTERNATIONAL JOURNAL OF CANCER

Selective activation of p53-mediated tumour suppression in high-grade tumours

(2010) Melissa R. Junttila et al.   NATURE

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

(2010) Delin Chen et al.   NATURE

Stage-specific sensitivity to p53 restoration during lung cancer progression

(2010) David M. Feldser et al.   NATURE

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma

(2010) Siân Jones et al.   SCIENCE

MYC-Dependent Regulation and Prognostic Role of CIP2A in Gastric Cancer

(2009) Anchit Khanna et al.   JNCI-Journal of the National Cancer Institute

Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias

(2008) Danilo Perrotti et al.   CANCER AND METASTASIS REVIEWS

A tumor suppressor role for PP2A-B56α through negative regulation of c-Myc and other key oncoproteins

(2008) Hugh K. Arnold et al.   CANCER AND METASTASIS REVIEWS

Distinct Thresholds Govern Myc's Biological Output In Vivo

(2008) Daniel J. Murphy et al.   CANCER CELL

Conditional Loss of Uterine Pten Unfailingly and Rapidly Induces Endometrial Cancer in Mice

(2008) T. Daikoku et al.   CANCER RESEARCH

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

(2008) Jeffrey A Engelman et al.   NATURE MEDICINE

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail)

(2008) Veerle Janssens et al.   TRENDS IN BIOCHEMICAL SCIENCES

Multiple pathways regulated by the tumor suppressor PP2A in transformation

(2008) Jukka Westermarck et al.   TRENDS IN MOLECULAR MEDICINE