Article
Orthopedics
Tessa De Vrieze, Nick Gebruers, Ines Nevelsteen, Steffen Fieuws, Sarah Thomis, An De Groef, Wiebren A. A. Tjalma, Jean-Paul Belgrado, Liesbeth Vandermeeren, Chris Monten, Marianne Hanssens, Nele Devoogdt
Summary: In patients with chronic BCRL, adding manual lymphatic drainage (MLD) to decongestive lymphatic therapy (DLT) did not provide clinically important additional benefit.
JOURNAL OF PHYSIOTHERAPY
(2022)
Article
Dermatology
Jingyi Liu, Di Chen, Xiaoting Yin
Summary: The aim of this study was to explore the application value of manual lymphatic drainage combined with vacuum sealing drainage in axillary web syndrome (AWS) after breast cancer surgery. The results showed that compared with the control group, the study group had significant improvements in the duration time to the disappearance of clinical symptoms, degree of pain, upper limb disability function, and quality of life.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Oncology
Jia Qiao, Li-ning Yang, Yu-han Kong, Xin Huang, Yi Li, Ding-qun Bai
Summary: The efficacy of manual lymphatic drainage (MLD) for breast cancer-related postmastectomy lymphedema (BCRL) was analyzed in this study. The results showed that there was no significant difference in upper extremity edema between the MLD treatment and control groups. However, significant reductions in upper extremity volume were observed when the treatment course was >= 20 sessions or the duration of treatment was >2 weeks.
Review
Oncology
Belinda Thompson, Katrina Gaitatzis, Xanne Janse de Jonge, Robbie Blackwell, Louise A. Koelmeyer
Summary: Recent research on manual lymphatic drainage (MLD) massage for lymphedema has shown conflicting results, with some studies reporting positive effects on symptoms and quality of life, while others finding no additional benefit. Additionally, studies have shown that MLD may reduce the incidence of lymphedema in at-risk patients, but there are also studies showing no such benefits. Further experimental studies are needed to determine the effectiveness of MLD in lymphedema treatment.
JOURNAL OF CANCER SURVIVORSHIP
(2021)
Article
Oncology
Nele Devoogdt, Sarah Thomis, An De Groef, An-Kathleen Heroes, Ines Nevelsteen, Nick Gebruers, Wiebren A. A. Tjalma, Jean-Paul Belgrado, Chris Monten, Marianne Hanssens, Tessa De Vrieze
Summary: This multicentre randomised controlled trial aimed to investigate the added value of fluoroscopy-guided manual lymph drainage (MLD) in decongestive lymphatic therapy (DLT) for superficial lymphatic architecture in patients with chronic mild to moderate breast cancer-related lymphoedema (BCRL). The trial found no significant differences between the groups in terms of changes in superficial lymphatic vessels, dermal backflow score, and superficial lymph nodes, indicating that MLD did not provide additional benefits to the other components of DLT for patients with BCRL.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ingi Min, Sung Joon Lim, Gi Jeong Cheon, Minseok Suh, Kwan Sik Seo
Summary: The study aims to compare the effectiveness of conventional stress lymphoscintigraphy (CSL) and pneumatic compression-assisted lymphoscintigraphy (PCAL). Among participants with relatively preserved lymphatic flow extent, the PCAL group showed better percentage reduction of volume compared to the CSL group. The use of IPC devices in lymphoscintigraphy can help in quantitatively describing lymphedema status and selecting appropriate treatment methods.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Medicine, General & Internal
Maria Nieves Munoz-Alcaraz, Antonio Jose Jimenez-Vilchez, Mirian Santamaria-Pelaez, Luis A. Perula-de Torres, Maria Victoria Olmo-Carmona, Maria Teresa Munoz-Garcia, Presentacion Jorge-Gutierrez, Jesus Serrano-Merino, Esperanza Romero-Rodriguez, Lorena Rodriguez-Elena, Raquel Refusta-Ainaga, Maria Pilar Lahoz-Sanchez, Belen Miro-Palacios, Mayra Medrano-Cid, Rosa Magallon-Botaya, Luis A. Minguez-Minguez, Josefa Gonzalez-Santos, Jeronimo J. Gonzalez-Bernal
Summary: This study aims to compare the efficacy and efficiency of TAPA, an occupational therapy-based approach, with the standard conservative treatment CDT for the rehabilitation of BCRL. The results suggest that TAPA may be an alternative to conservative treatment for women with BCRL.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Yan Lin, Yan Yang, Xiaoyu Zhang, Wandi Li, Haoran Li, Dali Mu
Summary: This systematic review and meta-analysis evaluated the effectiveness of manual lymphatic drainage (MLD) on breast cancer-related lymphedema (BCRL) patients. The findings demonstrate that MLD significantly improves pain in BCRL patients, but does not have significant effects on volumetric changes of lymphedema and quality of life. The potential preventive effect of MLD on BCRL requires further discussion.
CLINICAL BREAST CANCER
(2022)
Article
Orthopedics
Tessa De Vrieze, Nick Gebruers, Ines Nevelsteen, Sarah Thomis, An De Groef, Wiebren A. A. Tjalma, Jean-Paul Belgrado, Liesbeth Vandermeeren, Chris Monten, Marianne Hanssens, Anne Asnong, Lore Dams, Elien Van der Gucht, An-Kathleen Heroes, Nele Devoogdt
Summary: The study found that fluoroscopy-guided MLD, traditional MLD, and placebo MLD had similar effectiveness when added to DLT for treating chronic BCRL. The improvement in reducing local tissue water, extracellular fluid, skin thickness, and improving skin elasticity and fibrosis was limited.
Article
Oncology
Burcu Duyur Cakit, F. Figen Ayhan, Sefa Gumruk Aslan, Hakan Genc
Summary: The study suggests that ultrasonography is a reliable method for measuring soft tissue thickness and treatment efficacy after Complex Decongestive Therapy (CDT) in non-obese and stage 2 patients with Breast Cancer-Related Lymphoedema (BCRL).
EUROPEAN JOURNAL OF CANCER CARE
(2021)
Article
Multidisciplinary Sciences
Yuiko Suzuki, Yukari Nakajima, Toshio Nakatani, Mayumi Okuwa, Junko Sugama
Summary: This study aimed to identify the normal hindlimb lymphatic systems in rats and compare them with detours after lymphatic flow blockage. The results revealed three types of detours located in the fatty layer above the panniculus carnosus muscle, characterized by wide lumina, which were suggested to be pre-collecting lymphatic vessels. The detours observed after lymphatic blockage were different from the normal rat lymphatic system, suggesting a potential new method for simple lymphatic drainage.
Article
Health Care Sciences & Services
Wilmer Danilo Esparza, Arian Ramon Aladro-Gonzalvo, Antonio Ruiz-Hontangas, Daniela Celi, Maria Belen Aguirre
Summary: This study aimed to explore the effect of craniofacial MLD in combination with pharmacological treatment for improving cranial pain intensity, vital signs, and cerebral edema in moderate traumatic brain injury (mTBI) patients. The results showed that patients who received both pharmacological and MLD treatment experienced decreased cranial pain intensity, reduced systolic blood pressure, and decreased cerebral edema.
Article
Medicine, General & Internal
Jose Maria Pereira de Godoy, Livia Maria Pereira de Godoy, Henrique Jose Pereira de Godoy, Maria de Fatima Guerreiro Godoy
Summary: Manual lymphatic therapy (MLT) (Godoy method) is effective in reducing the development of lymphedema after breast cancer treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Oncology
Pinar Borman, Aysegul Yaman, Sina Yasrebi, Adeviye Pinar Inanli, Ayse Arikan Donmez
Summary: This study aimed to evaluate the effects of complex decongestive therapy (CDT) on patients with breast cancer-related lymphedema (BCRL), and found that a 3-week daily combined CDT treatment significantly reduced volume, improved disability, and enhanced quality of life (QoL), especially when performed earlier.
CLINICAL BREAST CANCER
(2022)
Article
Oncology
Karin Ekstrom, Rossella Crescitelli, Hafsteinn Ingi Petursson, Junko Johansson, Cecilia Lasser, Roger Olofsson Bagge
Summary: Lymphatic drainage exudate retrieved from breast cancer patients after surgery contains EVs that can be isolated using SEC isolation. The EVs have several cancer-related markers including CD24, CD29, CD44 and CD146, proteins of potential interest as biomarkers as well as to increase the understanding of the mechanisms of cancer biology.
Letter
Rheumatology
Maja Skov Kragsnaes, Jens Kjeldsen, Hans Christian Horn, Heidi Lausten Munk, Jens Kristian Pedersen, Soren Andreas Just, Palle Ahlquist, Jesper Romhild Davidsen, Anna Christine Nilsson, Richard Rottger, Mogens Kruhoffer, Julian R. Marchesi, Karsten Kristiansen, Robin Christensen, Torkell Ellingsen
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Morten B. Pedersen, Peter Thinggaard, Rinie Geenen, Marianne U. Rasmussen, Maarten De Wit, Lyn March, Philip Mease, Ernest Choy, Philip G. Conaghan, Lee Simon, Anne Faber Hansen, Simon Tarp, Berit Schiottz-Christensen, Carsten B. Juhl, Sabrina M. Nielsen, Kirstine Amris, Robin Christensen
Summary: Biopsychosocial rehabilitation has a significant but clinically small beneficial effect on pain relief among patients with inflammatory arthritis and osteoarthritis (OA), with no difference in harm.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Rheumatology
Maarten H. P. Butink, Casper Webers, Suzanne M. M. Verstappen, Louise Falzon, Neil Betteridge, Dieter Wiek, Anthony D. Woolf, Tanja A. Stamm, Gerd R. Burmester, Johannes W. J. Bijlsma, Robin Christensen, Annelies Boonen
Summary: A systematic review found that non-pharmacological interventions have small effects on work participation in people with rheumatic and musculoskeletal diseases. The effectiveness of these interventions depends on contextual factors such as disease, population risk status, intervention characteristics, and outcome of interest.
Article
Dermatology
Elisabeth H. Taudorf, Mattias Henning, Jonas Olsen, Linnea Thorlacius, Robin Christensen, Gregor Jemec
Summary: This study aimed to compare the efficacy of Nd:YAG laser and IPL in treating PAH. The results showed no significant difference in sweat secretion between the treated group and the control group, and both treatments were well tolerated with minimal side effects.
LASERS IN SURGERY AND MEDICINE
(2023)
Review
Rheumatology
Andriko Palmowski, Sabrina M. Nielsen, Zhivana Boyadzhieva, Abelina Schneider, Anne Pankow, Linda Hartman, Jose A. P. Da Silva, John Kirwan, Siegfried Wassenberg, Christian Dejaco, Robin Christensen, Maarten Boers, Frank Buttgereit
Summary: The study aimed to assess the safety and efficacy of long-term low-dose glucocorticoids in Rheumatoid Arthritis (RA). The analysis found that low-dose glucocorticoids did not increase the risk of adverse events, except for a higher risk of infections. It also showed moderate to high evidence of improvement in disease activity and function in RA.
Article
Rheumatology
Z. R. Stisen, S. M. Nielsen, S. B. Ditlev, M. Skougaard, A. Egeberg, M. Mogensen, T. S. Jorgensen, L. Dreyer, R. Christensen, L. E. Kristensen
Summary: The study aimed to assess the changes and trajectories in serum NGAL during 12 months of anti-inflammatory treatment in PsA patients. The results showed that serum NGAL did not show significant changes or correlations with PsA outcomes, indicating that it is not a suitable biomarker for disease activity and monitoring.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Review
Rheumatology
P. H. Duhn, E. E. Waehrens, M. B. Pedersen, S. M. Nielsen, H. Locht, H. Bliddal, R. Christensen, K. Amris
Summary: This systematic review evaluates the benefits and potential harms of patient education as a stand-alone intervention for individuals with chronic widespread pain and fibromyalgia. The results show that patient education as a stand-alone intervention can improve patients' global assessment. However, no significant differences were found in terms of functioning, pain level, emotional distress, and pain cognition when comparing patient education with usual care, no intervention, or waiting list.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Melanie B. Morillon, Alexander Norup, Jasvinder A. Singh, Nicola Dalbeth, William J. Taylor, Martin A. Kennedy, Birthe Mette Pedersen, Rebecca Grainger, Peter Tugwell, Fernando Perez-Ruiz, Cesar Diaz-Torne, N. Lawrence Edwards, Beverley Shea, Torkell J. Ellingsen, Robin Christensen, Lisa K. Stamp
Summary: This study aimed to assess the adherence of gout clinical trials to the core outcome domains endorsed by OMERACT in 2009 and evaluate the reporting before and after the endorsement. The results showed that only a small percentage of acute trials (8%) and no chronic trials reported all the core domains. Therefore, there is a need for continuous encouragement and further guidance on outcome measurement reporting among gout researchers.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Review
Medicine, General & Internal
Mina Nicole Handel, Isabel Cardoso, Cecilie von Bulow, Jeanett Friis Rohde, Anja Ussing, Sabrina Mai Nielsen, Robin Christensen, Jean-Jacques Body, Maria Luisa Brandi, Adolfo Diez-Perez, Peyman Hadji, Muhammad Kassim Javaid, Willem Frederik Lems, Xavier Nogues, Christian Roux, Salvatore Minisola, Andreas Kurth, Thierry Thomas, Daniel Prieto-Alhambra, Serge Livio Ferrari, Bente Langdahl, Bo Abrahamsen
Summary: This study aimed to review the comparative effectiveness of osteoporosis treatments, including the bone anabolic agents, abaloparatide and romosozumab, on reducing the risk of fractures in postmenopausal women, and to characterize the effect of antiosteoporosis drug treatments on the risk of fractures according to baseline risk factors. The results showed that osteoporosis treatments had a protective effect on reducing fracture risk, and bone anabolic agents were more effective than bisphosphonates.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Armita Armina Abedi, Claus Varnum, Alma Becic Pedersen, Kirill Gromov, Jesper Hallas, Pernille Iversen, Thomas Jakobsen, Espen Jimenez-Solem, Kristian Kidholm, Anne Kjerulf, Jeppe Lange, Anders Odgaard, Flemming S. Rosenvinge, Soren Solgaard, Kim Sperling, Marc Stegger, Robin Christensen, Soren Overgaard
Summary: Prosthetic joint infection (PJI) is a feared complication after total hip arthroplasty (THA) and is associated with high morbidity and mortality. Prophylactic antibiotics can reduce the risk of PJI, but there is no consensus on the dosages. This study aims to compare the effect of a single versus multiple doses of prophylactic antibiotics on PJI.
Review
Rheumatology
Josefine B. H. Adelhelm, Robin Christensen, Gustavo G. M. Balbi, Anne Voss
Summary: This study aims to evaluate the effectiveness of DOACs compared with VKAs in the secondary prevention of thromboembolic events in patients with APS. According to the results, DOACs are associated with a significant increase in the risk of new thrombotic events, especially arterial thrombosis.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Medicine, General & Internal
Oriana Ciani, Anthony M. Manyara, Philippa Davies, Derek Stewart, Christopher J. Weir, Amber E. Young, Jane Blazeby, Nancy J. Butcher, Sylwia Bujkiewicz, An-Wen Chan, Dalia Dawoud, Martin Offringa, Mario Ouwens, Asbjorn Hrobjartssson, Alain Amstutz, Luca Bertolaccini, Vito Domenico Bruno, Declan Devane, Christina D. C. M. Faria, Peter B. Gilbert, Ray Harris, Marissa Lassere, Lucio Marinelli, Sarah Markham, John H. Powers, Yousef Rezaei, Laura Richert, Falk Schwendicke, Larisa G. Tereshchenko, Achilles Thoma, Alparslan Turan, Andrew Worrall, Robin Christensen, Gary S. Collins, Joseph S. Ross, Rod S. Taylor
Summary: Interventional trials that use surrogate endpoints to evaluate treatment effects are increasingly common. However, there is currently inconsistency and lack of clarity in the definition and interpretation of surrogate endpoints. Surrogate endpoints are used as substitutes for the treatment effects on ultimate outcomes of interest. While traditionally biomarkers have been the focus of surrogate endpoint consideration, intermediate outcomes that include measures of function or symptoms can also act as surrogate endpoints. However, there is a lack of consensus among stakeholders on accepting and interpreting intermediate outcomes as surrogate endpoints. Better understanding and reporting on the use of surrogate endpoints in interventional trials is urgently needed.
Article
Rheumatology
Andriko Palmowski, Zhivana Boyadzhieva, Sabrina M. Nielsen, Burkhard Muche, Sandra Hermann, Maarten Boers, Henning Bliddal, Robin Christensen, Edgar Wiebe, Frank Buttgereit
Summary: This study investigated whether the association between glucocorticoid (GC) use and reduced bone mineral density (BMD) in rheumatoid arthritis (RA) patients is modified by sex or age. The results showed no significant differences in the association between GC use and BMD reduction, regardless of sex or age.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Rheumatology
Dorthe B. Berthelsen, Lee S. Simon, John P. A. Ioannidis, Marieke Voshaar, Pam Richards, Niti Goel, Vibeke Strand, Sabrina M. Nielsen, Beverly J. Shea, Peter Tugwell, Susan J. Bartlett, Glen S. Hazlewood, Lyn March, Jasvinder A. Singh, Maria E. Suarez-Almazor, Maarten Boers, Randall M. Stevens, Daniel E. Furst, Thasia Woodworth, Amye Leong, Peter M. Brooks, Caroline Flurey, Robin Christensen
Summary: This study aims to develop an understanding of the safety/harm concept in clinical trials for patients with rheumatic and musculoskeletal diseases (RMDs). The study presents a detailed definition of safety/harms and concludes that enough qualitative data are available to begin a Delphi survey.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Review
Multidisciplinary Sciences
Anne Sofie Aggestrup, Frederik Martiny, Maria Faurholt-Jepsen, Morten Hvenegaard, Robin Christensen, Annette Sofie Davidsen, Klaus Martiny
Summary: This article explores the recurrent nature of Major Depressive Disorder (MDD) and the residual symptoms of depression that may contribute to a high risk of relapse for patients transitioning from outpatient mental health services to primary care. The proposed scoping review aims to identify interventions that promote recovery from MDD and fill the knowledge gaps in this area.