Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS

Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells

(2013) Yannick D. Benoit et al.   EXPERIMENTAL CELL RESEARCH

EZH2 Promotes Malignant Behaviors via Cell Cycle Dysregulation and Its mRNA Level Associates with Prognosis of Patient with Non-Small Cell Lung Cancer

(2013) Wei Cao et al.   PLoS One

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

(2013) S. K. Knutson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells

(2012) Sergio Valente et al.   BIOCHIMIE

The ablation of EZH2 uncovers its crucial role in rhabdomyosarcoma formation

(2012) Irene Marchesi et al.   CELL CYCLE

Dysregulation of the Repressive H3K27 Trimethylation Mark in Head and Neck Squamous Cell Carcinoma Contributes to Dysregulated Squamous Differentiation

(2012) O. M. Gannon et al.   CLINICAL CANCER RESEARCH

Epigenetic Changes in Pediatric Solid Tumors: Promising New Targets

(2012) E. R. Lawlor et al.   CLINICAL CANCER RESEARCH

A transcriptional repressor co-regulatory network governing androgen response in prostate cancers

(2012) Kern Rei Chng et al.   EMBO JOURNAL

Comparison of Genome-Wide Binding of MyoD in Normal Human Myogenic Cells and Rhabdomyosarcomas Identifies Regional and Local Suppression of Promyogenic Transcription Factors

(2012) K. L. MacQuarrie et al.   MOLECULAR AND CELLULAR BIOLOGY

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells

(2012) Irina Alimova et al.   NEURO-ONCOLOGY

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

(2012) W. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes CASZ1, CLU, RUNX3, and NGFR

(2011) C. Wang et al.   CANCER RESEARCH

Deregulated expression of miR-26a and Ezh2 in Rhabdomyosarcoma

(2011) Roberta Ciarapica et al.   CELL CYCLE

Polycomb protein EZH2 regulates cancer cell fate decision in response to DNA damage

(2011) Z Wu et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21Cip1 expression and hampers tumour cell growth in vitro and in vivo

(2011) L Raimondi et al.   CELL DEATH AND DIFFERENTIATION

EZH2-Dependent Suppression of a Cellular Senescence Phenotype in Melanoma Cells by Inhibition of p21/CDKN1A Expression

(2011) T. Fan et al.   MOLECULAR CANCER RESEARCH

The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer

(2010) Liudmila L. Kodach et al.   CARCINOGENESIS

TNF/p38α/Polycomb Signaling to Pax7 Locus in Satellite Cells Links Inflammation to the Epigenetic Control of Muscle Regeneration

(2010) Daniela Palacios et al.   Cell Stem Cell

Selecting multimodal therapy for rhabdomyosarcoma

(2010) Iyad Sultan et al.   Expert Review of Anticancer Therapy

Outcomes for Children and Adolescents With Cancer: Challenges for the Twenty-First Century

(2010) Malcolm A. Smith et al.   JOURNAL OF CLINICAL ONCOLOGY

Search for New Particles in Two-Jet Final States in 7 TeV Proton-Proton Collisions with the ATLAS Detector at the LHC

(2010) G. Aad et al.   PHYSICAL REVIEW LETTERS

Polycomb Target Genes Are Silenced in Multiple Myeloma

(2010) Antonia Kalushkova et al.   PLoS One

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells

(2009) W. Fiskus et al.   BLOOD

EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance

(2009) M.-L. Suva et al.   CANCER RESEARCH

Mir-214-Dependent Regulation of the Polycomb Protein Ezh2 in Skeletal Muscle and Embryonic Stem Cells

(2009) Aster H. Juan et al.   MOLECULAR CELL

Targeting Id protein interactions by an engineered HLH domain induces human neuroblastoma cell differentiation

(2009) R Ciarapica et al.   ONCOGENE

NF-κB–YY1–miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma

(2008) Huating Wang et al.   CANCER CELL

MicroRNA-26a Targets the Histone MethyltransferaseEnhancer of Zeste homolog 2during Myogenesis

(2008) Chung Fai Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic Factors in Metastatic Rhabdomyosarcomas: Results of a Pooled Analysis From United States and European Cooperative Groups

(2008) Odile Oberlin et al.   JOURNAL OF CLINICAL ONCOLOGY

Roles of the EZH2 histone methyltransferase in cancer epigenetics

(2008) Jeffrey A. Simon et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Pediatric Soft Tissue Sarcomas

(2008) David M. Loeb et al.   SURGICAL CLINICS OF NORTH AMERICA