Spectrum and Management of Complement Immunodeficiencies (Excluding Hereditary Angioedema) Across Europe

New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3

(2014) Elizabeth Rodriguez et al.   BIOSCIENCE REPORTS

Invasive Pneumococcal Disease in Children Can Reveal a Primary Immunodeficiency

(2014) Jean Gaschignard et al.   CLINICAL INFECTIOUS DISEASES

Primary Immunodeficiency Disorders in Iran: Update and New Insights from the Third Report of the National Registry

(2014) Asghar Aghamohammadi et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Preventing secondary cases of invasive meningococcal capsular group B (MenB) disease using a recently-licensed, multi-component, protein-based vaccine (Bexsero®)

(2014) Shamez N. Ladhani et al.   JOURNAL OF INFECTION

Are complement deficiencies really rare? Overview on prevalence, clinical importance and modern diagnostic approach

(2014) Anete Sevciovic Grumach et al.   MOLECULAR IMMUNOLOGY

Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria

(2013) Peter Hillmen et al.   BRITISH JOURNAL OF HAEMATOLOGY

Successful cure of C1q deficiency in human subjects treated with hematopoietic stem cell transplantation

(2013) Peter D. Arkwright et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Complement therapy in atypical haemolytic uraemic syndrome (aHUS)

(2013) Edwin K.S. Wong et al.   MOLECULAR IMMUNOLOGY

Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome

(2013) C.M. Legendre et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atypical Hemolytic Uremic Syndrome

(2013) David Kavanagh et al.   SEMINARS IN NEPHROLOGY

Meningococcal disease and the complement system

(2013) Lisa A Lewis et al.   Virulence

Antibiotic Prophylaxis in Primary Immune Deficiency Disorders

(2013) Merin Kuruvilla et al.   Journal of Allergy and Clinical Immunology-In Practice

Genetically Determined Partial Complement C4 Deficiency States Are Not Independent Risk Factors for SLE in UK and Spanish Populations

(2012) Lora Boteva et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function

(2012) L. T. Roumenina et al.   BLOOD

Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies

(2012) Aude Servais et al.   KIDNEY INTERNATIONAL

Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies

(2012) Julien Zuber et al.   Nature Reviews Nephrology

Membranoproliferative Glomerulonephritis — A New Look at an Old Entity

(2012) Sanjeev Sethi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Eculizumab and Refractory Membranoproliferative Glomerulonephritis

(2012) Seetha Radhakrishnan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Complement factor I deficiency: a not so rare immune defect. Characterization of new mutations and the first large gene deletion

(2012) María Alba-Domínguez et al.   Orphanet Journal of Rare Diseases

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Autoimmunity and recurrent infections in partial complement C3 immunodeficiency

(2010) A. Rodriguez-Marco et al.   RHEUMATOLOGY

Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome

(2009) Frank Bienaime et al.   KIDNEY INTERNATIONAL

Impaired Opsonization with C3b and Phagocytosis of Streptococcus pneumoniae in Sera from Subjects with Defects in the Classical Complement Pathway

(2008) J. Yuste et al.   INFECTION AND IMMUNITY