Peptide deformylase inhibitor actinonin reduces celastrol’s HSP70 induction while synergizing proliferation inhibition in tumor cells

Role of the eIF4E binding protein 4E-BP1 in regulation of the sensitivity of human pancreatic cancer cells to TRAIL and celastrol-induced apoptosis

(2013) Reka Chakravarthy et al.   BIOLOGY OF THE CELL

Overexpression of peptide deformylase in breast, colon, and lung cancers

(2013) Harsharan Randhawa et al.   BMC CANCER

miR-224 is Critical for Celastrol-Induced Inhibition of Migration and Invasion of Hepatocellular Carcinoma Cells

(2013) Hangyu Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90

(2013) Mirela Matokanovic et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network

(2013) Sujuan Chen et al.   JOURNAL OF NEUROCHEMISTRY

Celastrol exerts synergistic effects with PHA-665752 and inhibits tumor growth of c-Met-deficient hepatocellular carcinoma in vivo

(2013) Hong-Lei Jiang et al.   MOLECULAR BIOLOGY REPORTS

The Extent of Neurodegeneration and Neuroprotection in Two Chemical In Vitro Models Related to Parkinson’s Disease is Critically Dependent on Cell Culture Conditions

(2013) D. Jantas et al.   NEUROTOXICITY RESEARCH

Celastrol Analogues as Inducers of the Heat Shock Response. Design and Synthesis of Affinity Probes for the Identification of Protein Targets

(2012) Lada Klaić et al.   ACS Chemical Biology

Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling

(2012) Ju-Hye Lee et al.   APOPTOSIS

Protective effect of celastrol in rat cerebral ischemia model: Down-regulating p-JNK, p-c-Jun and NF-κB

(2012) Yanhua Li et al.   BRAIN RESEARCH

Celastrol Suppresses Growth and Induces Apoptosis of Human Hepatocellular Carcinoma through the Modulation of STAT3/JAK2 Signaling Cascade In Vitro and In Vivo

(2012) P. Rajendran et al.   Cancer Prevention Research

Induction of heat shock proteins in cerebral cortical cultures by celastrol

(2012) Ari M. Chow et al.   CELL STRESS & CHAPERONES

A systematic protocol for the characterization of Hsp90 modulators

(2010) Robert L. Matts et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway

(2010) X. Pang et al.   CANCER RESEARCH

Celastrol can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells

(2010) Shantel E. Walcott et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Celastrol Acts as a Potent Antimetastatic Agent Targeting  1 Integrin and Inhibiting Cell-Extracellular Matrix Adhesion, in Part via the p38 Mitogen-Activated Protein Kinase Pathway

(2010) H. Zhu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way

(2010) Bin Peng et al.   Molecular Cancer

Actinonin, a Meprin a Inhibitor, Protects the Renal Microcirculation During Sepsis

(2010) Zhen Wang et al.   SHOCK

Modulation of Hsf1 activity by novobiocin and geldanamycin

(2009) Renaud Conde et al.   Biochemistry and Cell Biology

Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease

(2009) Katharina Faust et al.   BMC NEUROSCIENCE

Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation

(2009) Asmaa Sina et al.   CANCER LETTERS

A routinely applicable way for using FCM in cell enumeration with CFSE-labeled CellBeads as internal standard

(2009) Fan-Fan Cao et al.   CYTOMETRY PART A

Celastrol causes apoptosis and cell cycle arrest in rat glioma cells

(2009) Pengfei Ge et al.   NEUROLOGICAL RESEARCH