Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling

The Akt signaling pathway

(2012) SubbaRao V. Madhunapantula et al.   CANCER BIOLOGY & THERAPY

The Role of the PI3K-AKT Pathway in Melanoma

(2012) Michael A. Davies   CANCER JOURNAL

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

(2011) Radhamani Kannaiyan et al.   APOPTOSIS

Celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells

(2011) Won Yong Seo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells

(2011) Guozhu Chen et al.   BMC CANCER

Celastrol-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-κB activity

(2011) Lin-Li Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Superoxide Flashes

(2011) Qi Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways

(2011) Haibo Mou et al.   TOXICOLOGY IN VITRO

SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii

(2010) Young Bae Ryu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway

(2010) X. Pang et al.   CANCER RESEARCH

Celastrol isolated from Tripterygium regelii induces apoptosis through both caspase-dependent and -independent pathways in human breast cancer cells

(2010) Hee-Sun Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

Celastrol, a Triterpene, Enhances TRAIL-induced Apoptosis through the Down-regulation of Cell Survival Proteins and Up-regulation of Death Receptors

(2010) Bokyung Sung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vitamin A Enhances Antitumor Effect of a Green Tea Polyphenol on Melanoma by Upregulating the Polyphenol Sensing Molecule 67-kDa Laminin Receptor

(2010) Ju Hye Lee et al.   PLoS One

Arachidonic acid-induced apoptosis of human neuroblastoma SK-N-SH cells is mediated through mitochondrial alteration elicited by ROS and Ca2+-evoked activation of p38α MAPK and JNK1

(2009) Ku-Chung Chen et al.   TOXICOLOGY

Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells

(2008) Woo Young Choi et al.   BIOMEDICINE & PHARMACOTHERAPY

Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule

(2008) Amy Trott et al.   MOLECULAR BIOLOGY OF THE CELL

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

(2008) T. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Caspase-independent cell death: leaving the set without the final cut

(2008) S W G Tait et al.   ONCOGENE