Hypoxia increases membrane metallo-endopeptidase expression in a novel lung cancer ex vivo model – role of tumor stroma cells

Podoplanin-Positive Cancer-Associated Fibroblasts Could Have Prognostic Value Independent of Cancer Cell Phenotype in Stage I Lung Squamous Cell Carcinoma

(2013) Shotaro Ono et al.   CHEST

Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes

(2013) Dmitriy Mazurov et al.   FEBS Journal

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

(2013) Takeshi Katsuda et al.   Scientific Reports

Cancer Cells Cue the p53 Response of Cancer-Associated Fibroblasts to Cisplatin

(2012) J. O. Schmid et al.   CANCER RESEARCH

Negative regulation of NEP expression by hypoxia

(2012) Ranjana Mitra et al.   PROSTATE

HIF-1 versus HIF-2 — Is one more important than the other?

(2012) Agnieszka Loboda et al.   VASCULAR PHARMACOLOGY

HIF and the Lung

(2011) Larissa A. Shimoda et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neurotrophic Tyrosine Kinase Receptor B/Neurotrophin 4 Signaling Axis Is Perturbed in Clinical and Experimental Pulmonary Fibrosis

(2011) Sibel Avcuoglu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hypoxia-induced cisplatin resistance is reversible and growth rate independent in lung cancer cells

(2011) Christoph Wohlkoenig et al.   CANCER LETTERS

Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling

(2011) Kristin Wollenick et al.   NUCLEIC ACIDS RESEARCH

CD10 Expression in Epithelial and Stromal Cells of Non-small Cell Lung Carcinoma (NSCLC): A Clinic and Pathologic Correlation

(2011) Duygu Gürel et al.   PATHOLOGY & ONCOLOGY RESEARCH

Hypoxia-Induced Down-Regulation of Neprilysin by Histone Modification in Mouse Primary Cortical and Hippocampal Neurons

(2011) Zheng Wang et al.   PLoS One

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

(2011) R. Navab et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concise Review: Neutral Endopeptidase (CD10): A Multifaceted Environment Actor in Stem Cells, Physiological Mechanisms, and Cancer

(2011) Veronique Maguer-Satta et al.   STEM CELLS

Decreased Neprilysin and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease

(2010) Marilee J. Wick et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene

(2010) F M Buffa et al.   BRITISH JOURNAL OF CANCER

Understanding the "lethal" drivers of tumor-stroma co-evolution

(2010) Michael P. Lisanti et al.   CANCER BIOLOGY & THERAPY

Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia

(2010) Guo-Min Shen et al.   FEBS LETTERS

Neprilysin Is Identical to Skin Fibroblast Elastase

(2010) Naoko Morisaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic and Predictive Gene Signature for Adjuvant Chemotherapy in Resected Non–Small-Cell Lung Cancer

(2010) Chang-Qi Zhu et al.   JOURNAL OF CLINICAL ONCOLOGY

The Role of Tumor Stroma in Cancer Progression and Prognosis: Emphasis on Carcinoma-Associated Fibroblasts and Non-small Cell Lung Cancer

(2010) Roy M. Bremnes et al.   Journal of Thoracic Oncology

Diverging prognostic impacts of hypoxic markers according to NSCLC histology

(2010) Sigve Andersen et al.   LUNG CANCER

Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction

(2010) Amaya Ortiz-Barahona et al.   NUCLEIC ACIDS RESEARCH

Gene Expression-Based Classification of Non-Small Cell Lung Carcinomas and Survival Prediction

(2010) Jun Hou et al.   PLoS One

Prospectively Isolated Cancer-Associated CD10+ Fibroblasts Have Stronger Interactions with CD133+ Colon Cancer Cells than with CD133− Cancer Cells

(2010) Lin Cui et al.   PLoS One

Neprilysin Null Mice Develop Exaggerated Pulmonary Vascular Remodeling in Response to Chronic Hypoxia

(2009) Edward C. Dempsey et al.   AMERICAN JOURNAL OF PATHOLOGY

Genomic response of hypoxic Müller cells involves the very low density lipoprotein receptor as part of an angiogenic network

(2009) N. Loewen et al.   EXPERIMENTAL EYE RESEARCH

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relapse-Related Molecular Signature in Lung Adenocarcinomas Identifies Patients With Dismal Prognosis

(2009) Shuta Tomida et al.   JOURNAL OF CLINICAL ONCOLOGY

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension

(2008) Christine M. Costello et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Prognostic Significance of Epithelial-Mesenchymal and Mesenchymal-Epithelial Transition Protein Expression in Non-Small Cell Lung Cancer

(2008) A. Soltermann et al.   CLINICAL CANCER RESEARCH

A robustex vivomodel for evaluation of induction of apoptosis by rhTRAIL in combination with proteasome inhibitor MG132 in human premalignant cervical explants

(2008) Brigitte M.T. Hougardy et al.   INTERNATIONAL JOURNAL OF CANCER