Article
Biochemistry & Molecular Biology
Tom C. Karagiannis, Meaghan Wall, Katherine Ververis, Eleni Pitsillou, Stephanie M. Tortorella, Peter A. Wood, Haloom Rafehi, Ishant Khurana, Scott S. Maxwell, Andrew Hung, Jitraporn Vongsvivut, Assam El-Osta
Summary: Human erythroleukemic K562 cells are a widely used cell culture model for studying chronic myeloid leukemia (CML). They have been used to investigate the BCR/ABL1 oncogene, drug resistance, and targeted therapies. This study provides a comprehensive characterization of K562 cells, including their karyotype, TfR expression, and response to HDAC inhibition. The findings highlight the importance of K562 cells in the development of novel therapeutics for CML.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Oncology
Yan-Hong Liu, Man Zhu, Pan-Pan Lei, Xiao-Yan Pan, Wei-Na Ma
Summary: The study revealed that the novel compound ND-09 inhibited CML cell growth by targeting BCR-ABL and altering its kinase activity, ultimately leading to growth arrest in CML cells.
Article
Plant Sciences
Xiaoying Lan, Min Hu, Liling Jiang, Jiamin Wang, Yi Meng, Xinmei Chen, Aochu Liu, Wa Ding, Haichuan Zhang, Huan Zhou, Bingyuan Liu, Guanjie Peng, Siyan Liao, Xin Chen, Jinbao Liu, Xianping Shi
Summary: The natural substance piperlongumine from the herbal medicine Piper longum L. has been found to overcome imatinib resistance in chronic myelogenous leukemia (CML), providing a new therapeutic strategy.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Oncology
Yun Xu, Ziting Wang, Lei Zhang, Congying Gao, Fahui Li, Xueming Li, Yu Ke, Hong-Min Liu, Zhenbo Hu, Liuya Wei, Zhe-Sheng Chen
Summary: The compound JOA can inhibit the proliferation of chronic myeloid leukemia cells, including those with the BCR-ABL-T315I mutation, and induce cell differentiation. This effect may be mediated by the inhibition of the BCR-ABL/c-MYC signaling pathway. JOA shows potential as a lead compound for overcoming imatinib resistance in CML therapy.
Article
Biochemistry & Molecular Biology
Kazuya Sumi, Kenji Tago, Yosuke Nakazawa, Kyoko Takahashi, Tomoyuki Ohe, Tadahiko Mashino, Megumi Funakoshi-Tago
Summary: In this study, it was discovered that BPF induces apoptosis in CML cells through the generation of ROS and the activation of the MEK-ERK pathway. BPF also effectively induces cell death in cells expressing the BCR-ABL and T315I mutations, indicating its ability to overcome resistance to BCR-ABL inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jin-Man Zhang, Cui-Fang Wang, Mei-Yan Wei, Hui Dong, Yu-Cheng Gu, Xiao-Mei Mo, Chang-Lun Shao, Ming Liu
Summary: In this study, we found that Brefeldin A (BFA) is a cytotoxic compound that inhibits the activation of BCR-ABL and degrades the BCR-ABL protein in K562 cells, thereby suppressing the development of CML.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Tingting Lu, Jiangyan Cao, Fengming Zou, Xixiang Li, Aoli Wang, Wenliang Wang, Huamin Liang, Qingwang Liu, Chen Hu, Cheng Chen, Zhenquan Hu, Wenchao Wang, Lili Li, Jian Ge, Yang Shen, Tao Ren, Jing Liu, Ruixiang Xia, Qingsong Liu
Summary: CHMFL-48 is a novel type II kinase inhibitor that potently inhibits the wild-type BCR-ABL kinase and a panel of imatinib-resistant mutants. This drug shows strong inhibitory activity in a cellular context, blocking autophosphorylation of BCR-ABL kinase, affecting downstream signaling mediators, and inducing cell cycle progression blockade and apoptosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Yosuke Tanaka, Reina Takeda, Tsuyoshi Fukushima, Keiko Mikami, Shun Tsuchiya, Moe Tamura, Keito Adachi, Terumasa Umemoto, Shuhei Asada, Naoki Watanabe, Soji Morishita, Misa Imai, Masayoshi Nagata, Marito Araki, Hitoshi Takizawa, Tomofusa Fukuyama, Chrystelle Lamagna, Esteban S. Masuda, Ryoji Ito, Susumu Goyama, Norio Komatsu, Tomoiku Takaku, Toshio Kitamura
Summary: Leukemia stem cells in chronic myeloid leukemia are resistant to imatinib, but can be eliminated by combining imatinib with IRAK1/4 inhibitors that inhibit the IRAK1/4-NF-kappa B-PD-L1 signaling pathway.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Anila Vadakumchery, Hemin Faraidun, Omar El Ayoubi, Issame Outaleb, Vera Schmid, Hend Abdelrasoul, Timm Amendt, Ahmad Khadour, Corinna Setz, Katharina Goehring, Karoline Lodd, Christoffer Hitzing, Alabbas Alkhatib, Mayas Bilal, Julian Benckendorff, Abdul Kader Al Shugri, Cord Herbert Brakebusch, Niklas Engels, Moumita Datta, Elias Hobeika, Ameera Alsadeq, Hassan Jumaa
Summary: The adaptor protein SLP65 controls the down-regulation of PI3K signaling in B cells by inducing the activity of small GTPase RHOA, which activates the negative regulator PTEN. RHOA plays a unique role in B cell generation and selection, and blocking its function offers potential for treating B cell malignancies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Sophie Bartsch, Kimia Mirzakhani, Laura Neubert, Alexander Stenzel, Marzieh Ehsani, Mohsen Esmaeili, Thanakorn Pungsrinont, Merve Kacal, Seyed Mohammad Mahdi Rasa, Julia Kallenbach, Divya Damodaran, Federico Ribaudo, Marc-Oliver Grimm, Francesco Neri, Aria Baniahmad
Summary: The expression of human telomerase reverse transcriptase subunit (hTERT) is hormonally controlled, with androgen treatment suppressing hTERT expression in prostate cancer cells. This inhibition and activation of hTERT by androgens is mediated by androgen receptor (AR) co-repressors ING1 and ING2. This reveals a dual role of AR in controlling hTERT expression during prostate cancer tumorigenesis.
Article
Biochemistry & Molecular Biology
Yonglan Liu, Mingzhen Zhang, Chung-Jung Tsai, Hyunbum Jang, Ruth Nussinov
Summary: Researchers have used extensive molecular dynamics simulations to decipher the activation and autoinhibition mechanism of c-Abl. The myristoyl group serves as a switch for c-Abl inhibition/activation, and precise SH2/N-lobe interaction is required for full activation. Bcr-Abl allosteric drugs mimic the endogenous myristoyl-mediated autoinhibition state and alter the active-site conformation, affecting the action of ATP-competitive drugs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Oncology
Angela McLigeyo, Jamilla Rajab, Peter Oyiro, Mohammed Ezzi, Yatich Bett, Matilda Ong'ondi, Andrew Odhiambo, Sitna Mwanzi, Nicholas Othieno-Abinya
Summary: This study analyzed the baseline characteristics and factors associated with cytopenia in Chronic Myeloid Leukemia patients treated with imatinib. The results showed no significant differences in gender, age, marital status, occupation, and education level between patients with and without cytopenia. Multivariable analysis revealed that baseline anemia, neutropenia, thrombocytopenia, and thrombocytosis increased the odds of developing cytopenia.
Article
Cell Biology
Zhan Gao, Zhicai Li, Xiaowei Li, Jun Xiao, Cuiying Li
Summary: Under low oxygen concentration (<5%), erythroid differentiation is accelerated and the EPAS1-IRS2 axis may play a crucial role in regulating this process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Plant Sciences
Hoang Thanh Chi, Nguyen Thi Lien Thuong, Bui Thi Kim Ly
Summary: The study found that the methanol extract of Sphagneticola trilobata (L.) Pruski (MeST) has an inhibitory effect on the growth of leukemia cells, especially those harboring imatinib-resistant BCR/ABL. The cell death induced by MeST is through apoptosis and it can also suppress the expression of the BCR/ABL protein.
Article
Pharmacology & Pharmacy
Hong Zhang, Ting Song, Ziqian Wang, Yafei Guo, Hang Wang, Qishuang Gao, Zhichao Zhang, Uwituze Laura Bonneete
Summary: By using a specific inhibitor of Hsp70/Bim complex and knocking down Bcr-Abl, researchers have found that Bcr-Abl can prevent cell apoptosis by driving the formation of Hsp70/Bim complex. Additionally, Bcr-Abl can stabilize oncogenic clients by driving the formation of Hsp70/Bim complex.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Ting Sheng, Miao Xu, Qin Li, Yihan Wu, Jing Zhang, Jinliang Liu, Xiaohui Zhu, Yong Zhang
Summary: Upconversion nanoparticles (UCNPs) are a class of optical nanomaterials that can convert low-energy excitation photons to high-energy fluorescence emissions. In recent years, significant achievements have been made in engineering the spectral properties of UCNPs through various energy management approaches. This review summarizes different energy management strategies, focusing on clarifying the underlying mechanisms of spectral tuning.
MATERIALS TODAY PHYSICS
(2021)
Article
Chemistry, Analytical
Danny Jian Hang Tng, Bryan Chu Yang Yin, Jing Cao, Kwan Ki Karrie Ko, Kenneth Choon Meng Goh, Delia Xue Wen Chua, Yong Zhang, Melvin Lee Kiang Chua, Jenny Guek Hong Low, Eng Eong Ooi, Khee Chee Soo
Summary: This study reports an Amplified Parallel ART (AP-ART) that can quickly detect the COVID-19 virus with high sensitivity, even when using non-fasted saliva samples. Compared to existing techniques, AP-ART achieved a lower limit of detection. This new method has the potential to be used for rapid testing in resource-limited settings and play a crucial role in early diagnosis.
Review
Chemistry, Multidisciplinary
Zhen Zhang, Yongming Chen, Yong Zhang
Summary: Significant progress has been made in the development of multifunctional upconversion nanoparticles (UCNPs) based nanoplatforms for specific multimodal or multiplexed applications. The review highlights the optimization of synthesis methods for UCNPs assemblies and their various applications, including dual-modality cell imaging, molecular delivery, detection, and therapy. Challenges and potential solutions for UCNPs assembly in this field are also discussed.
Article
Chemistry, Multidisciplinary
Jing Zhan, Zhendong Lei, Yong Zhang
Summary: This study shows that the surface interaction of graphene oxide (GO) affects the reaction process by changing the microenvironment. The presence of GO not only changes the morphology, structure, and even chemical composition of the synthesized crystals, but also allows the formation of a new bismuth-containing crystal under specific conditions.
ADVANCED MATERIALS INTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Jing Zhan, Zhendong Lei, Yong Zhang
Summary: In this review, the interactions between graphene and different objects are systematically examined, revealing their significant effects on the performance of graphene materials. The findings help to design and develop graphene-based materials with improved functionality.
Review
Engineering, Biomedical
Akshaya Bansal, Swati Shikha, Yong Zhang
Summary: Optogenetics is a valuable tool for studying neural circuits and therapeutic applications. Future advancements should focus on improving gene delivery vectors, developing red-shifted photoresponsive proteins, enhancing transduction of near-infrared light, and creating wireless implantable light-delivery devices.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Changsong Wu, Meihui Cui, Li Cai, Chen Chen, Xiaohui Zhu, Yihan Wu, Jinliang Liu, Hanjie Wang, Yong Zhang
Summary: This study constructs a two-step synergistic therapy platform for tumor treatment using upconversion nanoparticles and engineered bacteria. The first step involves the activation of a photosensitizer to treat primary tumors, while the second step activates engineered bacteria to produce interferon and regulate immune pathways for joint immunotherapy to inhibit the growth of distant tumors.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Jing Zhan, Zhendong Lei, Xing Liu, Mengjia Yang, Minyue Li, Haiping Fang, Yong Zhang, Yong Wang, Guosheng Shi
Summary: This study focused on the development of high-performance potassium-ion batteries using graphene paper as the research material. By fabricating a KxCl-rGO electrode, the researchers achieved a high reversible capacity, improved cycling stability, and enhanced potassium-ion diffusion. The results showed promising potential for the application of KxCl-rGO in potassium-ion batteries.
Review
Chemistry, Inorganic & Nuclear
Chen Chen, Changsong Wu, Jiming Yu, Xiaohui Zhu, Yihan Wu, Jinliang Liu, Yong Zhang
Summary: Photodynamic therapy (PDT) has proved its significance in cancer treatment, but its therapeutic effect is limited by the low penetration of light source, tumor microenvironment (TME) hypoxia, and tumor cell metastasis and recurrence. This review presents the design of PDT platforms and discusses the latest studies on combinatorial cancer therapy strategies using PDT, aiming to evaluate its potential in future clinical cancer treatments. The latest progress mainly focuses on three aspects: combining with drugs or gases to overcome TME hypoxia, employing advanced light sources to increase penetration depth, and combining with immunotherapy to inhibit tumor metastasis. The integration of diagnosis and treatment using an imaging-guided therapeutic nanoplatform has brought more optimized treatment effects to PDT.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Shanshan Yuan, Jing Wang, Yi Xiang, Shanshan Zheng, Yihan Wu, Jinliang Liu, Xiaohui Zhu, Yong Zhang
Summary: This article reviews the design, preparation, optical properties, and applications of luminescent Janus nanoparticles. The introduction of luminescence has expanded the functionalities and applications of Janus nanoparticles. The opportunities and challenges in developing next-generation luminescent Janus nanoparticles are also discussed.
Review
Materials Science, Multidisciplinary
Xiang Zheng, Ranjith Kumar Kankala, Chen-Guang Liu, Yuan Wen, Shi-Bin Wang, Ai-Zheng Chen, Yong Zhang
Summary: This review discusses the recent advances in tailoring upconversion luminescence (UCL) through internal material designs and external regulation strategies. The intricate material design of upconversion nanoparticles (UCNPs), including orthogonal designs, hybrid upconversion systems, and highly doped designs, is thoroughly discussed. The review also covers remote regulation strategies for tailoring UCL, such as manipulation with a microcavity, near-field effect, excitation power density, heat, and polarization angle. These innovations have significantly contributed to the field and have the potential to inspire new experimental designs in other areas, promoting the future practical application of UCNPs.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Bowen Sun, Juwita Norasmara Bte Rahmat, Han Joon Kim, Ratha Mahendran, Kesavan Esuvaranathan, Edmund Chiong, John S. Ho, Koon Gee Neoh, Yong Zhang
Summary: A novel approach combining photodynamic therapy and chemotherapy is proposed in this study, which utilizes nanocarriers and an LED light source to deliver drugs precisely to tumor sites, significantly improving therapeutic outcomes.
Article
Chemistry, Physical
Pon Janani Sugumaran, Jing Zhang, Yong Zhang
Summary: In this study, OHP-UCNP heterostructured nanocrystals were successfully synthesized by growing cubic phase NaGdF4 UCNP over cubic phase CsPbBr3 OHP in a seed-mediated process with a small lattice mismatch and converting cubic phase UCNP to hexagonal phase through heating. The resulting nanocrystals showed efficient energy transfer and improved stability, making them promising for optoelectronic and biological applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Engineering, Biomedical
Bowen Sun, Jiayi Liu, Han Joon Kim, Juwita Norasmara Bte Rahmat, Koon Gee Neoh, Yong Zhang
Summary: In this study, a smart nanocarrier was designed to overcome the light penetration limitations in photodynamic therapy (PDT) and enhance the treatment efficacy against tumor cells. A wirelessly activated light-emitting diode (LED) implant allows remote and programmable control of photosensitizer release and treatment process.
ACTA BIOMATERIALIA
(2023)
Article
Automation & Control Systems
Jing Cao, Yuning Wang, Yong Zhang, Kun Qian
Summary: Recent developments in mass spectrometry-based metabolic fingerprinting analysis have facilitated its practical clinical applications by addressing challenges such as rapid signal readout, high throughput, direct MS analysis, and intelligent data mining of complex biological samples.
ADVANCED INTELLIGENT SYSTEMS
(2022)