Article
Biochemistry & Molecular Biology
Gloria Bertoli, Antonella Panio, Claudia Cava, Francesca Gallivanone, Martina Alini, Giulia Strano, Federico Molfino, Loredana Brioschi, Paola Viani, Danilo Porro
Summary: Prostate cancer is a common male neoplasm and is the second leading cause of cancer death in American men. Traditional diagnosis of prostate cancer relies on prostate secreted antigen (PSA) evaluation, but false positives are common, making additional tests necessary. This study explores the role of miR-153 in controlling cell growth and invasion in high Gleason Score prostate cancer, and suggests that miR-153 could serve as a circulating biomarker for diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Gabriel A. Bonaterra, Alexander Schleper, Maximilian Skowronek, Lucia S. Kilian, Theresa Rink, Hans Schwarzbach, Hendrik Heers, Joerg Haenze, Peter Rexin, Annette Ramaswamy, Carsten Denkert, Beate Wilhelm, Axel Hegele, Rainer Hofmann, Eberhard Weihe, Ralf Kinscherf
Summary: Prostate cancer (PCa) is the second most diagnosed cancer and cause of death in men worldwide. Recent evidence has shown that growth differentiation factor-15 (GDF-15) is elevated in cancer patients, providing new possibilities for diagnosis and treatment. This study found that the density of GDF-15+ cells was higher in PCa patients compared to benign prostate hyperplasia (BPH). Some GDF-15+ cells were found to migrate into the glandular lumen, suggesting their potential as non-invasive biomarkers. GDF-15 is proposed as a novel tool for diagnosing PCa and assessing malignancy, as well as a potential target for anti-tumor therapy.
Article
Medicine, General & Internal
Stefan Zoltan Lutz, Joerg Hennenlotter, Andras Franko, Corinna Dannecker, Louise Fritsche, Konstantinos Kantartzis, Robert Wagner, Andreas Peter, Norbert Stefan, Andreas Fritsche, Tilman Todenhoefer, Arnulf Stenzl, Hans-Ulrich Haering, Martin Heni
Summary: The study found that patients with prostate cancer have higher fasting blood glucose levels and insulin resistance, with no significant changes in insulin secretion. Meanwhile, the serum triglyceride levels of cancer patients are lower, but there is an increase in adrenal steroid biosynthesis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marcus R. Makowski, Keno K. Bressem, Luise Franz, Avan Kader, Stefan M. Niehues, Sarah Keller, Daniel Rueckert, Lisa C. Adams
Summary: This study aimed to differentiate prostate cancers with different Gleason scores on biparametric magnetic resonance imaging using radiomics, with the support vector machine showing the highest accuracy. Image augmentation improved accuracy, while removing T1 mapping features decreased the accuracy of some machine learning algorithms and led to higher generalization error.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Fida Asali, Ismaiel Abu Mahfouz, Lujain Al-Marabhah, Shirin Alatoom, Lana Al Takriti, Zeina Abu Eisheh, Oqba Al Kuran, Hatim Jaber
Summary: This study aims to measure anxiety scores associated with elective caesarean section (CS) and identify women's characteristics and obstetric variables that are associated with higher anxiety scores. The results showed that risk factors for higher anxiety scores include age 25-34, CS for foetal indications, general anaesthesia choice, and layperson as a source of information for anaesthesia choice.
Article
Endocrinology & Metabolism
Katharina Wissmiller, Sara Bilekova, Andras Franko, Stefan Z. Lutz, Miriam Katsburg, Sebastian Gulde, Natalia S. Pellegata, Arnulf Stenzl, Martin Heni, Lucia Berti, Hans-Ulrich Haering, Heiko Lickert
Summary: The novel insulin/IGF1 signaling modulator inceptor has been found to play a crucial role in prostate cancer progression, with its expression positively correlated with certain genes involved in androgen signaling. In vitro experiments showed that inceptor expression was associated with androgen status, increased cell migration, and IGF1R signaling. These findings provide a basis for further investigation of inceptor in the context of prostate cancer.
MOLECULAR METABOLISM
(2023)
Article
Cell Biology
Tatjana Vlajnic, Patrik Brunner, Serenella Eppenberger-Castori, Cyrill A. Rentsch, Tobias Zellweger, Lukas Bubendorf
Summary: The study found significant inter- and intratumoral variability of Ki67 LI in high-grade PC, with a subset of cases having surprisingly low Ki67 LI. There was no association observed between Ki67 LI and the status of ERG, PTEN, or Bcl-2. Further research is needed to explore the molecular basis and potential clinical implications of the paradoxically low proliferation rate in high-grade PC.
Article
Urology & Nephrology
Rebecka Arnsrud Godtman, Karin Stinesen Kollberg, Carl-Gustaf Pihl, Marianne Mansson, Jonas Hugosson
Summary: This study found associations between age, increased risk of prostate cancer, and higher Gleason score. The risk of clinically significant prostate cancer increased with age, indicating the importance of considering age in counseling men about early diagnosis and treatment for prostate cancer.
Review
Andrology
Rodolfo Montironi, Liang Cheng, Alessia Cimadamore, Roberta Mazzucchelli, Marina Scarpelli, Matteo Santoni, Francesco Massari, Antonio Lopez-Beltran
Summary: The Gleason grading system is crucial for prostate cancer prognostic factors, with a new Grade Group system introduced in 2014 to address previous deficiencies.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Oncology
Marian Cruz-Burgos, Sergio A. Cortes-Ramirez, Alberto Losada-Garcia, Miguel Morales-Pacheco, Eduardo Martinez-Martinez, Jorge Gustavo Morales-Montor, Alejandro Servin-Haddad, J. Samuel Izquierdo-Luna, Griselda Rodriguez-Martinez, Maria del Pilar Ramos-Godinez, Vanessa Gonzalez-Covarrubias, Abraham Canavera-Constantino, Imelda Gonzalez-Ramirez, Boyang Su, Hon S. Leong, Mauricio Rodriguez-Dorantes
Summary: Metastasis is the main cause of death in prostate cancer patients. This study investigates the potential diagnostic value of extracellular vesicle-derived microRNAs in liquid biopsies for prostate cancer. Through microarray analysis, differential expression of microRNAs was observed in metastatic lymph nodes compared to prostate tumors and non-metastatic lymph node tissues. Specifically, miR-150-5p shows promise as a diagnostic marker for high-grade Gleason scores and early detection of metastasis.
Review
Oncology
Xiaochuan Wang, Yu Zhang, Zhengguo Ji, Peiqian Yang, Ye Tian
Summary: The study evaluated the predictive performance of age for the risk of Gleason score change and pathologic upstaging, finding that older age was significantly associated with increased risk of upgrading. Furthermore, older men had a significantly higher risk of pathologic upstaging compared to younger men.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Pathology
Motoko Sasaki, Yasunori Sato
Summary: The study examined 51 bile duct biopsy samples and found that IMP3, EZH2, and p53 have high sensitivity and accuracy in diagnosing malignancy. The conclusion is that the immunohistochemical markers of these three can increase the diagnostic sensitivity and accuracy of bile duct biopsy for the diagnosis of cholangiocarcinoma.
Article
Medical Laboratory Technology
Karla Paola Gutierrez Castro, Alma Patricia Gonzalez, Russell Caccavello, Ma Eugenia Garay-Sevilla, Alejandro Gugliucci
Summary: Euglycemic lean adolescents with insulin resistance display dyslipoproteinemia involving TRL and LPL dysfunction.
CLINICA CHIMICA ACTA
(2022)
Article
Oncology
Anqi Wang, Mariana Lazo, Jiayun Lu, David J. Couper, Anna E. Prizment, Mara Z. Vitolins, Samuel R. Denmeade, Corinne E. Joshu, Elizabeth A. Platz
Summary: This study reveals that subclinical liver impairment due to fibrosis may affect the development and detectability of prostate cancer. It found that black men with higher levels of liver fibrosis had a lower risk of prostate cancer, while there was no such association in white men.
CANCER PREVENTION RESEARCH
(2023)
Article
Oncology
Sheng-Jia Shi, Dong-Hui Han, Jing-Liang Zhang, Yu Li, An-Gang Yang, Rui Zhang
Summary: VIM-AS1 is a cancer-specific long non-coding RNA that plays a pivotal role in cancer. This study investigated the effects of VIM-AS1 on prostate cancer cell proliferation and resistance to anti-androgen therapy. The study identified the VIM-AS1/IGF2BP2/HMGCS1 axis as a potential therapeutic target for castration-resistant prostate cancer.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Pathology
Mauro Vasella, Ulrich Wagner, Christine Fritz, Kati Seidl, Luca Giudici, Gerhard Ulrich Exner, Holger Moch, Peter Johannes Wild, Beata Bode-Lesniewska
Summary: This case report presents a rare BCOR-rearranged sarcoma initially misdiagnosed as an unusual EMC, successfully treated with complete resection and adjuvant radiotherapy, with no recurrence at 7-year follow-up. Retrospective identification of RGAG1-BCOR gene fusion through NGS expands the spectrum of partner genes in BCOR-rearranged sarcomas.
Article
Oncology
Nadine Flinner, Steffen Gretser, Alexander Quaas, Katrin Bankov, Alexander Stoll, Lara E. Heckmann, Robin S. Mayer, Claudia Doering, Melanie C. Demes, Reinhard Buettner, Josef Rueschoff, Peter J. Wild
Summary: In this study, an ensemble convolutional neural network was trained to predict the molecular subtypes of gastric cancer directly from hematoxylin-eosin histology. Traditional staining methods were unable to accurately discriminate all subtypes. The study also identified patients with predicted intra-tumoral heterogeneity or features from multiple subtypes, challenging the current TCGA-based decision tree for gastric cancer subtyping. Deep learning in the future may enable targeted testing and therapy for molecular subtypes in a broader group of gastric cancer patients.
JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Emmanouil Fokas, Anke Schlenska-Lange, Buelent Polat, Gunther Klautke, Gerhard G. Grabenbauer, Rainer Fietkau, Thomas Kuhnt, Ludger Staib, Thomas Brunner, Anca-Ligia Grosu, Simon Kirste, Lutz Jacobasch, Michael Allgaeuer, Michael Flentje, Christoph-Thomas Germer, Robert Gruetzmann, Guido Hildebrandt, Matthias Schwarzbach, Wolf O. Bechstein, Heiko Suelberg, Tim Friede, Jochen Gaedcke, Michael Ghadimi, Ralf-Dieter Hofheinz, Claus Roedel
Summary: This study reported the long-term results of total neoadjuvant therapy in locally advanced rectal cancer, showing that chemoradiotherapy followed by chemotherapy resulted in higher pathological complete response without compromising disease-free survival, toxicity, quality of life, or stool incontinence, and is proposed as the preferred sequence for total neoadjuvant therapy if organ preservation is a priority.
Article
Oncology
M. Janning, J. Sueptitz, C. Albers-Leischner, P. Delpy, A. Tufman, J-L Velthaus-Rusik, M. Reck, A. Jung, D. Kauffmann-Guerrero, I Bonzheim, S. Braendlein, H-D Hummel, M. Wiesweg, H-U Schildhaus, J. A. Stratmann, M. Sebastian, J. Alt, J. Buth, I Esposito, J. Berger, L. Toegel, F. C. Saalfeld, M. Wermke, S. Merkelbach-Bruse, A. M. Hillmer, F. Klauschen, C. Bokemeyer, R. Buettner, J. Wolf, S. Loges
Summary: This retrospective multicenter study investigated the response of atypical EGFR mutations in different systemic treatments. The study found that uncommon mutations responded well to EGFR-TKI, while exon 20 insertions were insensitive to EGFR-TKI. Very rare point and compound mutations also showed sensitivity to TKI, but treatment responses varied greatly. Co-occurring TP53 mutations may have a detrimental effect on treatment outcome in certain cases.
ANNALS OF ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Vanessa Kuhl, Wyatt Clegg, Stephanie Meek, Lauren Lenz, Darl D. Flake, Tracy Ronan, Max Kornilov, Deborah Horsch, Marsel Scheer, Daniel Farber, Hillary Zalaznick, Olivier Cussenot, Eva Comperat, Geraldine Cancel-Tassin, Peter J. Wild, Felix K. H. Chun, Philipp Mandel, Farid Moinfar, Todd Cohen, Sylvette Delee, Ralf Kronenwett, Jennifer Doedt
Summary: A 16-gene kit-based version of the Prolaris(R) cell cycle progression test has been developed and validated, showing high correlation with the 46-gene test. The results demonstrate consistent and reliable performance of the 16-gene test.
BIOMARKERS IN MEDICINE
(2022)
Article
Oncology
Ashok Kumar Jayavelu, Sebastian Wolf, Florian Buettner, Gabriela Alexe, Bjoern Haeupl, Federico Comoglio, Constanze Schneider, Carmen Doebele, Dominik C. Fuhrmann, Sebastian Wagner, Elisa Donato, Carolin Andresen, Anne C. Wilke, Alena Zindel, Dominique Jahn, Bianca Splettstoesser, Uwe Plessmann, Silvia Muench, Khali Abou-El-Ardat, Philipp Makowka, Fabian Acker, Julius C. Enssle, Anjali Cremer, Frank Schnutgen, Nina Kurrle, Bjoern Chapuy, Jens Loeber, Sylvia Hartmann, Peter J. Wild, Ilka Wittig, Daniel Huebschmann, Lars Kaderali, Juergen Cox, Bernhard Bruene, Christoph Roellig, Christian Thiede, Bjoern Steffen, Martin Bornhaeuser, Andreas Trumpp, Henning Urlaub, Kimberly Stegmaier, Hubert Serve, Matthias Mann, Thomas Oellerich
Summary: This study conducted a comprehensive proteogenomic analysis of bone marrow biopsies from 252 uniformly treated AML patients to uncover the molecular pathophysiology of AML and provide insights for future diagnosis and treatment. The analysis identified five proteomic AML subtypes, with one subtype (Mito-AML) associated with poor prognosis and heightened response to the BCL2 inhibitor venetoclax.
Review
Pathology
Danny Jonigk, Christopher Werlein, Till Acker, Martin Aepfelbacher, Kerstin U. Amann, Gustavo Baretton, Peter Barth, Rainer M. Bohle, Andreas Buettner, Reinhard Buettner, Reinhard Dettmeyer, Philip Eichhorn, Sefer Elezkurtaj, Irene Esposito, Katja Evert, Matthias Evert, Falko Fend, Nikolaus Gassler, Stefan Gattenloehner, Markus Glatzel, Heike Goebel, Elise Gradhand, Torsten Hansen, Arndt Hartmann, Axel Heinemann, Frank L. Heppner, Julia Hilsenbeck, David Horst, Jan C. Kamp, Gita Mall, Bruno Maerkl, Benjamin Ondruschka, Jessica Pablik, Susanne Pfefferle, Alexander Quaas, Helena Radbruch, Christoph Roecken, Andreas Rosenwald, Wilfried Roth, Martina Rudelius, Peter Schirmacher, Julia Slotta-Huspenina, Kevin Smith, Linna Sommer, Konrad Stock, Philipp Stroebel, Stephanie Strobl, Ulf Titze, Gregor Weirich, Joachim Weis, Martin Werner, Claudia Wickenhauser, Thorsten Wiech, Peter Wild, Tobias Welte, Saskia von Stillfried, Peter Boor
Summary: This article discusses the importance of autopsies in the context of the COVID-19 pandemic and presents findings from autopsies conducted in German autopsy centers. The study reveals the distribution of SARS-CoV-2 in various organs and tissues, and provides insights into the pathological features and mechanisms of COVID-19. However, the pathological changes in non-respiratory organs remain unclear.
Article
Biochemical Research Methods
Sandra Goetze, Peter Schueffler, Alcibiade Athanasiou, Anika Koetemann, Cedric Poyet, Christian Daniel Fankhauser, Peter J. Wild, Ralph Schiess, Bernd Wollscheid
Summary: Using Mass Spectrometry-GUidED Immunoassay DEvelopment (MS-GUIDE), we screened 48 literature-derived biomarker candidates to evaluate their potential utility in risk stratification scoring of prostate cancer patients. Machine learning analysis prequalified fibronectin and vitronectin as candidate biomarkers. Clinical-grade ELISAs were developed for these candidates and tested in a larger patient cohort.
CLINICAL PROTEOMICS
(2022)
Article
Medicine, General & Internal
Maximilian N. Kinzler, Christina Klasen, Falko Schulze, Eva Herrmann, Andreas A. Schnitzbauer, Joerg Trojan, Stefan Zeuzem, Peter J. Wild, Dirk Walter
Summary: Intrahepatic cholangiocarcinoma (iCCA), the most frequent subtype of cholangiocarcinoma (CCA), has seen an increased incidence globally. This study aimed to assess the impact of fibrosis on survival in iCCA patients undergoing palliative chemotherapy. The results showed that fibrosis did not significantly affect overall survival (OS) or progression-free survival (PFS) in iCCA patients. However, patients with cirrhosis and iCCA receiving palliative chemotherapy had lower OS rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Jens von der Gruen, Ria Winkelmann, Iris Burck, Daniel Martin, Franz Roedel, Peter Johannes Wild, Katrin Bankov, Andreas Weigert, Ivan-Maximiliano Kur, Christian Brandts, Natalie Filmann, Christian Issing, Philipp Thoenissen, Anna Maria Tanneberger, Claus Roedel, Shahram Ghanaati, Panagiotis Balermpas
Summary: This study investigated the efficacy of neoadjuvant chemoradiotherapy (nCRT) in locally advanced oral cavity cancer (LA-OCC) patients. The results showed that nCRT followed by radical surgery is feasible and has high response rates. Additionally, changes in diffusion-weighted magnetic resonance imaging (DW-MRI) signal intensities and immunohistochemistry can serve as predictive biomarkers for treatment response and prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Maximilian N. Kinzler, Falko Schulze, Steffen Gretser, Nada Abedin, Joerg Trojan, Stefan Zeuzem, Andreas A. Schnitzbauer, Dirk Walter, Peter J. Wild, Katrin Bankov
Summary: MUC16/CA125, a commonly used blood biomarker for ovarian cancer, is associated with cancer proliferation in various tumor types. However, limited data is available on its expression in cholangiocarcinoma (CCA) tissue. This study found that 34% of surgically resected CCA patients had evidence of MUC16 expression, and MUC16(+) patients had significantly poorer overall survival compared to MUC16(-) patients. The findings suggest that MUC16 could serve as an independent risk factor for poor prognosis in CCA patients.
Article
Oncology
Jan Jeroch, Tobias Riedlinger, Christina Schmitt, Silvana Ebner, Ria Winkelmann, Peter J. Wild, Melanie Demes
Summary: Automated systems are increasingly used in laboratory workflows to save time and personnel capacities and minimize loss of patient material. This study evaluates the advantages of the AVENIO Millisect system over manual dissection for extracting DNA from tissue samples. The results show that manual dissection yields higher DNA concentrations and is faster and cheaper than automated dissection. However, the DNA quality achieved with both methods is comparable, making automated dissection a useful tool for precise tumor enrichment.
Article
Oncology
Katrin Bankov, Falko Schulze, Steffen Gretser, Henning Reis, Nada Abedin, Fabian Finkelmeier, Jorg Trojan, Stefan Zeuzem, Andreas A. Schnitzbauer, Dirk Walter, Peter J. Wild, Maximilian N. Kinzler
Summary: Limited data on the prevalence and impact of autophagy in primary cholangiocarcinoma (CCA) tissue have been reported. This study found that active autophagy was present in a minority of CCA patients and its absence was associated with impaired overall survival. Furthermore, patients with active autophagy exhibited higher levels of pan-acetylation. These findings highlight the importance of active autophagy as a prognostic marker and potential therapeutic target in CCA patients.
Article
Health Care Sciences & Services
Saskia von Stillfried, Roman David Buelow, Rainer Roehrig, Peter Boor
Summary: The German COVID-19 Autopsy Registry (DeRegCOVID) serves as a central hub for multicenter autopsy-based studies and provides support for researchers and data analysis. The registry shows that COVID-19 is the underlying cause of death in most autopsy cases, with diffuse alveolar damage and multi-organ failure being the most common immediate causes of death. The registry is of great importance for medical research, policy-making, and public discussion.
LANCET REGIONAL HEALTH-EUROPE
(2022)
Article
Critical Care Medicine
Saskia von Stillfried, Roman David Buelow, Rainer Roehrig, Patrick Meybohm, Peter Boor
Summary: This study analyzed data from the German COVID-19 autopsy registry and found that bleeding events were more frequent in ECMO cases, with a higher proportion of intracranial bleeding. The study suggests the potential value of autopsies and a joint interdisciplinary multicenter approach in addressing fatal complications in COVID-19.
