Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer

Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial

(2021) Thierry Conroy et al.   LANCET ONCOLOGY

Use of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer

(2021) Osama E. Rahma et al.   JAMA Oncology

Preliminary results of the organ preservation of rectal adenocarcinoma (OPRA) trial.

(2020) Julio Garcia-Aguilar et al.   JOURNAL OF CLINICAL ONCOLOGY

Outcome measures in multimodal rectal cancer trials

(2020) Emmanouil Fokas et al.   LANCET ONCOLOGY

Compliance and tolerability of short-course radiotherapy followed by preoperative chemotherapy and surgery for high-risk rectal cancer – Results of the international randomized RAPIDO-trial

(2020) Maxime J.M. van der Valk et al.   RADIOTHERAPY AND ONCOLOGY

Long-term bowel dysfunction following low anterior resection

(2020) Audrius Dulskas et al.   Scientific Reports

Playing With Dynamite? A Cautious Assessment of TNT

(2020) Diana D. Shi et al.   JOURNAL OF CLINICAL ONCOLOGY

Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial

(2020) Renu R Bahadoer et al.   LANCET ONCOLOGY

Total Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer

(2020) Anup Kasi et al.   JAMA Network Open

Challenges and solutions in the design and execution of the PROSPECT Phase II/III neoadjuvant rectal cancer trial (NCCTG N1048/Alliance)

(2019) Deborah Schrag et al.   Clinical Trials

NRG-GI002: A phase II clinical trial platform using total neoadjuvant therapy (TNT) in locally advanced rectal cancer (LARC)—First experimental arm (EA) initial results.

(2019) Thomas J. George et al.   JOURNAL OF CLINICAL ONCOLOGY

Long-course preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study

(2019) B Ciseł et al.   ANNALS OF ONCOLOGY

Total Neoadjuvant Therapy in Rectal Cancer

(2019) Fausto Petrelli et al.   ANNALS OF SURGERY

Randomized Phase II Trial of Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: CAO/ARO/AIO-12

(2019) Emmanouil Fokas et al.   JOURNAL OF CLINICAL ONCOLOGY

Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer

(2018) Andrea Cercek et al.   JAMA Oncology

Long-course oxaliplatin-based preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for cT4 or fixed cT3 rectal cancer: results of a randomized phase III study

(2016) K. Bujko et al.   ANNALS OF ONCOLOGY

Chemoradiation, surgery and adjuvant chemotherapy versus induction chemotherapy followed by chemoradiation and surgery: long-term results of the Spanish GCR-3 phase II randomized trial

(2015) C. Fernandez-Martos et al.   ANNALS OF ONCOLOGY

Organ Preservation in Rectal Adenocarcinoma: a phase II randomized controlled trial evaluating 3-year disease-free survival in patients with locally advanced rectal cancer treated with chemoradiation plus induction or consolidation chemotherapy, and total mesorectal excision or nonoperative management

(2015) J. Joshua Smith et al.   BMC CANCER

Oxaliplatin added to fluorouracil-based preoperative chemoradiotherapy and postoperative chemotherapy of locally advanced rectal cancer (the German CAO/ARO/AIO-04 study): final results of the multicentre, open-label, randomised, phase 3 trial

(2015) Claus Rödel et al.   LANCET ONCOLOGY

Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial

(2012) Claus Rödel et al.   LANCET ONCOLOGY

Phase II, Randomized Study of Concomitant Chemoradiotherapy Followed by Surgery and Adjuvant Capecitabine Plus Oxaliplatin (CAPOX) Compared With Induction CAPOX Followed by Concomitant Chemoradiotherapy and Surgery in Magnetic Resonance Imaging–Defined, Locally Advanced Rectal Cancer: Grupo Cáncer de Recto 3 Study

(2010) Carlos Fernández-Martos et al.   JOURNAL OF CLINICAL ONCOLOGY