Cohesin gene mutations in tumorigenesis: from discovery to clinical significance

Mutant Cohesin in Premature Ovarian Failure

(2014) Sandrine Caburet et al.   NEW ENGLAND JOURNAL OF MEDICINE

STAG2 is a clinically relevant tumor suppressor in pancreatic ductal adenocarcinoma

(2014) Lisa Evers et al.   Genome Medicine

Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications

(2013) F. Thol et al.   BLOOD

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Cohesin in development and disease

(2013) S. Remeseiro et al.   DEVELOPMENT

Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres

(2013) María Carretero et al.   EMBO JOURNAL

Cohesin: Functions beyond sister chromatid cohesion

(2013) Gunjan D. Mehta et al.   FEBS LETTERS

Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin

(2013) M. Hahn et al.   GENES & DEVELOPMENT

Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes

(2013) Claire F. Taylor et al.   HUMAN MOLECULAR GENETICS

Frameshift mutations of chromosome cohesion–related genes SGOL1 and PDS5B in gastric and colorectal cancers with high microsatellite instability

(2013) Min Sung Kim et al.   HUMAN PATHOLOGY

Glioblastoma Cells Containing Mutations in the Cohesin Component STAG2 Are Sensitive to PARP Inhibition

(2013) M. L. Bailey et al.   MOLECULAR CANCER THERAPEUTICS

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

Wapl is an essential regulator of chromatin structure and chromosome segregation

(2013) Antonio Tedeschi et al.   NATURE

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms

(2013) Ayana Kon et al.   NATURE GENETICS

Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation

(2013) Guangwu Guo et al.   NATURE GENETICS

The landscape of somatic mutations in Down syndrome–related myeloid disorders

(2013) Kenichi Yoshida et al.   NATURE GENETICS

Frequent truncating mutations of STAG2 in bladder cancer

(2013) David A Solomon et al.   NATURE GENETICS

Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy

(2013) Cristina Balbás-Martínez et al.   NATURE GENETICS

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

(2013) M. L. Hoang et al.   Science Translational Medicine

RAD21 Mutations Cause a Human Cohesinopathy

(2012) Matthew A. Deardorff et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

A unique role of cohesin-SA1 in gene regulation and development

(2012) Silvia Remeseiro et al.   EMBO JOURNAL

Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres

(2012) Silvia Remeseiro et al.   EMBO JOURNAL

Cohesin Association to Replication Sites Depends on Rad50 and Promotes Fork Restart

(2012) Mireille Tittel-Elmer et al.   MOLECULAR CELL

Dissecting the genomic complexity underlying medulloblastoma

(2012) David T. W. Jones et al.   NATURE

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

(2012) Li Ding et al.   NATURE

Clonal Architecture of Secondary Acute Myeloid Leukemia

(2012) Matthew J. Walter et al.   NEW ENGLAND JOURNAL OF MEDICINE

SMC1A codon 496 mutations affect the cellular response to genotoxic treatments

(2011) Linda Mannini et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Specific Sites in the C Terminus of CTCF Interact with the SA2 Subunit of the Cohesin Complex and Are Required for Cohesin-Dependent Insulation Activity

(2011) T. Xiao et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer

(2011) D. A. Solomon et al.   SCIENCE

Alteration of cohesin genes in myeloid diseases

(2010) Julien Rocquain et al.   AMERICAN JOURNAL OF HEMATOLOGY

Mediator and cohesin connect gene expression and chromatin architecture

(2010) Michael H. Kagey et al.   NATURE

Premature chromatid separation is not a useful diagnostic marker for Cornelia de Lange syndrome

(2009) Paola Castronovo et al.   CHROMOSOME RESEARCH

Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells

(2009) Silvia Canudas et al.   JOURNAL OF CELL BIOLOGY

Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin

(2009) C. Bauerschmidt et al.   NUCLEIC ACIDS RESEARCH

Transcriptional Dysregulation in NIPBL and Cohesin Mutant Human Cells

(2009) Jinglan Liu et al.   PLOS BIOLOGY

Multiple Organ System Defects and Transcriptional Dysregulation in the Nipbl+/− Mouse, a Model of Cornelia de Lange Syndrome

(2009) Shimako Kawauchi et al.   PLoS Genetics

Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms

(2008) Vania Parelho et al.   CELL

Acetylation of Smc3 by Eco1 Is Required for S Phase Sister Chromatid Cohesion in Both Human and Yeast

(2008) Jinglan Zhang et al.   MOLECULAR CELL

The cohesin ring concatenates sister DNA molecules

(2008) Christian H. Haering et al.   NATURE

Cohesin mediates transcriptional insulation by CCCTC-binding factor

(2008) Kerstin S. Wendt et al.   NATURE

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers

(2008) T. D. Barber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Molecular Determinant for the Establishment of Sister Chromatid Cohesion

(2008) E. U nal et al.   SCIENCE