Article
Biochemistry & Molecular Biology
Megumi Miyabe, Nobuhisa Nakamura, Tomokazu Saiki, Satoru Miyabe, Mizuho Ito, Sachiko Sasajima, Tomomi Minato, Tatsuaki Matsubara, Keiko Naruse
Summary: Atherosclerosis is a leading cause of death globally, and there is a correlation between periodontal disease and atherosclerosis. This study used Porphyromonas gingivalis-derived LPS (Pg-LPS) to investigate the proliferation and migration of human aortic smooth muscle cells (HASMCs). The results suggest that Pg-LPS promotes atherosclerosis through the activation of the TLR4-MAPK signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Mengdie Yin, Chao Li, Jiali Jiang, Jingqing Le, Bangyue Luo, Fang Yang, Yifan Fang, Mingyue Yang, Zhenhua Deng, Wenxin Ni, Jingwei Shao
Summary: Atherosclerosis is a leading cause of human morbidity and mortality worldwide, characterized by pathological constriction of blood vessels due to chronic low-grade inflammation and lipid deposition. Cell adhesion molecules play a key role in regulating the inflammatory response and endothelial function, with potential therapeutic strategies based on CAM inhibitors showing promising results in combating atherosclerotic progression.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Zichao Luo, Erlinda The, Peijian Zhang, Yufeng Zhai, Qingzhou Yao, Lihua Ao, Qingchun Zeng, David A. Fullerton, Xianzhong Meng
Summary: This study found that monocytes enhance inflammatory responses in aortic valve interstitial cells (AVICs) to soluble extracellular matrix (ECM) protein. Monocyte beta(2)-integrin interacts with AVIC ICAM-1 to augment AVIC inflammatory responses by enhancing the activation of YAP and NF-kappa B signaling pathways.
INFLAMMATION RESEARCH
(2022)
Article
Hematology
Katherine M. Owsiany, Rebecca A. Deaton, Karen G. Soohoo, Anh Tram Nguyen, Gary K. Owens
Summary: This study investigates the contribution of MCP1 produced by classical smooth muscle cells (SMCs) and Lgals3-transitioned SMCs in atherosclerosis. The results show that MCP1 produced by classical SMCs has an atheroprotective effect, while MCP1 produced by Lgals3-transitioned SMCs exacerbates plaque pathogenesis. These findings highlight the need for caution when considering therapeutic interventions involving MCP1.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Junli Zhuang, Hua Zhu, Ziqi Cheng, Xinyao Hu, Xiaohui Yu, Jie Li, Huagang Liu, Peng Tang, Ying Zhang, Xiaoxing Xiong, Hongping Deng
Summary: The study aimed to investigate the potential role of PCSK9 in the neck of AAA. Through bioinformatics methods, it was found that PCSK9 was highly expressed in the proximal neck of human AAA and may exert its role through interacting with immune check-points and ferroptosis-related genes.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Floriana Maria Farina, Simone Serio, Ignacio Fernando Hall, Stefania Zani, Giada Andrea Cassanmagnago, Montserrat Climent, Efrem Civilini, Gianluigi Condorelli, Manuela Quintavalle, Leonardo Elia
Summary: DOT1L inhibition in VSMCs significantly reduces atherosclerosis progression by directly modulating Nf-kappa B1 and Nf-kappa B2 transcription, which are master regulators of inflammation inducing expression of CCL5 and CXCL10 cytokines, key in atherosclerosis development. DOT1L could be a promising therapeutic target for vascular diseases as its inhibition reduces plaque progression.
EUROPEAN HEART JOURNAL
(2022)
Article
Cell Biology
Yiting Jia, Lu Zhang, Ziyi Liu, Chenfeng Mao, Zihan Ma, Wenqiang Li, Fang Yu, Yingbao Wang, Yaqian Huang, Weizhen Zhang, Jingang Zheng, Xian Wang, Qingbo Xu, Jian Zhang, Wei Feng, Caihong Yun, Chuanju Liu, Jinpeng Sun, Yi Fu, Qinghua Cui, Wei Kong
Summary: The study finds that naringenin, a naturally occurring citrus flavonoid, can effectively inhibit the formation and progression of abdominal aortic aneurysm (AAA). This is achieved by activating TFEB, which promotes lysosome-dependent inflammation inhibition and reparative macrophage polarization. Overall, naringenin or TFEB activation shows promising efficacy for AAA treatment.
Article
Biochemistry & Molecular Biology
Eu Jeong Ku, Bo-Rahm Kim, Jee-In Lee, Yun Kyung Lee, Tae Jung Oh, Hak C. Jang, Sung Hee Choi
Summary: Anakinra, a recombinant human IL-1 receptor antagonist, has been found to have inhibitory effects on the progression of atherosclerosis. It reduces plaque size and serum triglyceride levels, and suppresses inflammatory gene expressions and cell migration. In animal experiments, it also decreases macrophage infiltration and monocyte chemoattractant protein-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Frank M. Davis, Lam C. Tsoi, Feiyang Ma, Rachael Wasikowski, Bethany B. Moore, Steven L. Kunkel, Johann E. Gudjonsson, Katherine A. Gallagher
Summary: This study provides the first comprehensive evaluation of the single-cell composition of abdominal aortic aneurysm (AAA) tissues and reveals how the gene expression landscape is altered in human AAAs. The study identified distinct transcriptional profiles of immune cells in AAAs compared to controls, as well as multiple pathways expressed only in AAA tissues. Additionally, it determined that the expression of SORT1 in vascular smooth muscle cells is critical for maintaining normal aortic wall function.
Article
Biochemistry & Molecular Biology
Hsin-Ying Lu, Hung-Lung Hsu, Chih-Han Li, Shao-Jung Li, Shing-Jong Lin, Chun-Ming Shih, Chun-Che Shih
Summary: Research suggests that H2S may inhibit the formation of AD by reducing inflammatory response, oxidative stress, and positively participating in vascular remodeling. These findings provide evidence for H2S as a novel and promising therapeutic strategy to prevent the development of AD.
Review
Cardiac & Cardiovascular Systems
Junqi Wang, Xiaoping Chen
Summary: This review summarizes the roles of JAMs in the development of atherosclerosis and predicts future research directions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Maria Francesca Greco, Alessandra Stefania Rizzuto, Marta Zara, Marco Cafora, Chiara Favero, Giulia Solazzo, Ilaria Giusti, Maria Pia Adorni, Francesca Zimetti, Vincenza Dolo, Cristina Banfi, Nicola Ferri, Cesare R. Sirtori, Alberto Corsini, Silvia Stella Barbieri, Anna Pistocchi, Valentina Bollati, Chiara Macchi, Massimiliano Ruscica
Summary: This study reveals that PCSK9 plays an inflammatory role through EVs released by vascular smooth muscle cells, affecting the function and content of neighboring cells, and may have a significant role in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Mandy O. J. Grootaert, Martin R. Bennett
Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Taiki Tojo, Minako Yamaoka-Tojo
Summary: This study investigated the molecular and cellular mechanisms underlying stenotic calcification of the aortic valve. Gene expression analysis of human aortic stenosis and normal aortic valve tissue identified differentially expressed genes (DEGs) associated with valve calcification and disease progression. Protein-protein interaction analysis revealed hub genes that could serve as potential biomarkers and therapeutic targets for aortic stenosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Yang Li, Shijuan Gao, Yingchun Han, Li Song, Yu Kong, Yao Jiao, Shan Huang, Jie Du, Yulin Li
Summary: This study investigated the genetic characteristics of sporadic isolated thoracic aortic aneurysm (iTAA) and revealed the potential role of focal adhesion scaffold genes in the pathogenesis of iTAA. Pathogenic mutations and suspected functional variants were found to be significantly enriched in iTAA patients, with Testin (TES) identified as a potential causal gene. The study also showed that knockdown of focal adhesion scaffold genes like TLN1 and ZYX resulted in decreased contractility of vascular smooth muscle cells in iTAA patients.
CIRCULATION RESEARCH
(2021)
