Article
Biochemistry & Molecular Biology
Wedad S. Sarawi, Ahlam M. Alhusaini, Hanan K. Alghibiwi, Juman S. Alsaab, Iman H. Hasan
Summary: This study investigates the effects of curcumin and nano-curcumin on copper-induced lung injury and finds that they can alleviate lung damage by suppressing oxidative damage and inflammation, activating Nrf2/HO-1 signaling, and preventing apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ting Zhou, Shihan Zhang, Yingli Zhou, Simin Lai, Yanjiong Chen, Yan Geng, Jing Wang
Summary: Recent studies have shown that PGRN deficiency exacerbates psoriatic skin lesions, while treatment with curcumin can alleviate the deterioration caused by PGRN deficiency in psoriatic skin lesions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Max L. B. Gronloh, Janine J. G. Arts, Sebastian Palacios Martinez, Amerens A. van Der Veen, Lanette Kempers, Abraham C. van Steen, Joris J. T. H. Roelofs, Martijn A. Nolte, Joachim Goedhart, Jaap D. van Buul
Summary: Using a photoconvertible probe, researchers traced and identified the original endothelial transmigration hotspots, and found that these hotspots function to limit vascular leakage during transmigration events. The distribution of ICAM-1 determines the location of the transmigration hotspot.
Article
Pharmacology & Pharmacy
Zhihui Liu, Bendong Shi, Yu Wang, Qingyang Xu, Hongxin Gao, Jun Ma, Xiaowen Jiang, Wenhui Yu
Summary: Curcumin has been shown to alleviate aristolochic acid I-induced renal injury in rats by activating the SIRT1/Nrf2/HO-1 signaling pathway.
Article
Immunology
Mona Singh, Mony Thakur, Manish Mishra, Manisha Yadav, Rajkamal Vibhuti, Athira M. Menon, Girima Nagda, Ved Prakash Dwivedi, Tikam Chand Dakal, Vinod Yadav
Summary: ICAM-1 is a key inducible cell adhesion molecule involved in immune functions, with its expression regulated by various inflammatory mediators such as transcription factors and signaling pathways. Transcriptional regulation and epigenetic modifications play important roles in controlling ICAM-1 expression.
IMMUNOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Ling-Ya Chiu, Nan-Lin Wu, Chi-Feng Hung, Peter Bai, Yang-Shia Dai, Wan-Wan Lin
Summary: UV irradiation can damage the epidermis, leading to inflammation and tissue disorders. PARP-1 and EGFR play crucial roles in mediating the response to UVB-induced skin injury, with interactions affecting inflammatory gene expression. Inhibition of PARP-1 or EGFR can mitigate UVB-induced inflammation, suggesting regulatory loops among these factors in response to UVB stress.
Article
Medical Laboratory Technology
Varinder Singh, Rupinder Kaur, Pratima Kumari, Chirag Pasricha, Ravinder Singh
Summary: Leukocyte migration is vital for lymphocyte recirculation and immune response. ICAM-1 and VCAM-1 play a crucial role in leukocyte adherence to endothelial cells in various diseases. They contribute to inflammation, leukocyte migration, and have implications in multiple pathological states. Understanding their immunoregulatory role and pathophysiological effects helps in disease management.
CLINICA CHIMICA ACTA
(2023)
Article
Immunology
Xiaoxue Bai, Yingjie Zhu, Jing Jie, Dan Li, Lei Song, Jingjing Luo
Summary: This study found that Maackiain, a natural compound from Sophora flavescens, protects against sepsis by reducing organ injury, inflammation, and oxidative stress. Maackiain activates the AMPK/Nrf2/HO-1 pathway, leading to its anti-inflammatory and antioxidant effects. Inhibition of this pathway abolishes the protective effects of Maackiain.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chenyang Duan, Hanbin Wang, Dian Jiao, Yanqin Geng, Qiaoli Wu, Hua Yan, Chunhui Li
Summary: Curcumin can inhibit oxidative stress and promote neurological recovery after ICH by activating the Nrf2/HO-1 pathway, providing a potential therapeutic target for clinical treatment of ICH.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Deborah L. W. Chong, Carine Rebeyrol, Ricardo J. Jose, Andrew E. Williams, Jeremy S. Brown, Chris J. Scotton, Joanna C. Porter
Summary: Neutrophil migration into the lung is mediated by cell adhesion molecules such as ICAM-1 and ICAM-2, which are upregulated during inflammatory stimulation. While beta(2) integrins interacting with ICAMs may regulate neutrophil traffic in healthy lung, these interactions may become redundant later in inflammation when epithelial junctions are disrupted.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Agnieszka Irena Mazur-Bialy, Ewa Pochec
Summary: This study found that irisin effectively reduced free radical production by macrophages and altered the kinetics of key factors in the Nrf2/HO-1/HMGB1 pathway, leading to increased production of Nrf2 and HO-1 while significantly reducing HMGB1 release.
Article
Immunology
Thomas M. Martin, Susan J. Burke, Clive H. Wasserfall, J. Jason Collier
Summary: ICAM-1 plays a crucial role in the development of type 1 diabetes by participating in immune responses and cell adhesion and activation. Understanding the mechanisms of ICAM-1 is essential for controlling glucose homeostasis.
AUTOIMMUNITY REVIEWS
(2023)
Article
Environmental Sciences
Jitendra Kumar, Rakesh Verma, Chandana Haldar
Summary: The study found that BPS has detrimental effects on the testes of male golden hamsters, while melatonin can alleviate these damages.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Siwen Li, Xiali Wang, Yewei Xiao, Yanling Wang, Ying Wan, Xinlian Li, Qiuyue Li, Xiaoqing Tang, Daihong Cai, Bing Ran, Chunling Wu
Summary: The study demonstrates that curcumin can protect the liver from mercuric chloride-induced damage through various mechanisms, including reducing levels of liver enzymes, suppressing inflammatory damage and oxidative burst, promoting antioxidant pathway activity, and modulating CYP450 signaling. Additionally, curcumin enhances Nrf2-mediated HO-1 expression in liver cells, providing protection against cell death induced by HgCl2.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Immunology
Shuhui Dai, Jialiang Wei, Hongchen Zhang, Peng Luo, Yuefan Yang, Xiaofan Jiang, Zhou Fei, Wenbin Liang, Jianli Jiang, Xia Li
Summary: Intermittent fasting (IF) protects against intracerebral hemorrhage (ICH) by suppressing inflammatory responses and cellular injuries through the Sirt3/Nrf2/HO-1 pathway.
JOURNAL OF NEUROINFLAMMATION
(2022)
