Journal
ANALYTICAL CHEMISTRY
Volume 87, Issue 2, Pages 907-913Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac5028758
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Funding
- National Natural Science Foundation of China [21327807, 21421004]
- National Science Fund for Distinguished Young Scholars of China [21125522]
- Shanghai Science and Technology Committee [12JC1403500]
- Shanghai Institutions of Higher Learning
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Data analysis for nanopore experiments remains a fundamental and technological challenge because of the large data volume, the presence of unavoidable noise, and the filtering effect. Here, we present an accurate and robust data process that recognizes the current blockades and enables evaluation of the dwell time and current amplitude through a novel second-order-differential-based calibration method and an integration method, respectively. We applied the developed data process to analyze both generated blockages and experimental data. Compared to the results obtained using the conventional method, those obtained using the new method provided a significant increase in the accuracy of nanopore measurements.
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