Article
Endocrinology & Metabolism
Rafiatu Azumah, Katja Hummitzsch, Richard A. Anderson, Raymond J. Rodgers
Summary: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder that affects around 10% of women of reproductive age. It has various risk factors such as infertility, depression or anxiety, obesity, insulin resistance, and type 2 diabetes. PCOS has a genetic predisposition, and several genetic loci associated with PCOS have been identified. These loci contain candidate genes that are currently being studied to define the syndrome. PCOS is not limited to the ovaries and has been associated with other organ systems in the body.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Roberta Lattanzi, Rossella Miele
Summary: The prokineticin family is a group of secreted peptides classified as chemokines based on their structure and functions. Prokineticins bind with high affinity to two G protein-coupled receptors and play important roles in various physiological functions. Dysregulation of the system leads to inflammatory processes associated with many pathological conditions. The use of PKR antagonists can reduce the upregulation of PK2/PKRs triggered by inflammatory processes, suggesting a potential strategy for treating inflammatory/neuroinflammatory diseases.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Ben Davidson, Olesya Solheim
Summary: The objective of this study was to analyze the expression and clinical role of cancer stem cell markers in malignant ovarian germ cell tumors. The study found differential expression of CD34, CD44, and SOX2 in different tumor types, but no significant association with other clinical parameters.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Danesh H. Sopariwala, Andrea S. Rios, Guangsheng Pei, Anirban Roy, Meiricris Tomaz da Silva, Hao Thi Thu Nguyen, Addison Saley, Rachel Van Drunen, Anastasia Kralli, Kristin Mahan, Zhongming Zhao, Ashok Kumar, Vihang A. Narkar
Summary: In this study, the role of nuclear receptor ERR alpha/gamma in regulating skeletal muscle composition, contractility, and exercise capacity was elucidated. The deletion of ERR alpha/gamma led to decreased expression of genes associated with mitochondrial and oxidative metabolism, resulting in impaired mitochondrial function, angiogenesis, and exercise capacity.
Article
Oncology
Massimiliano Dall'Ora, Giulia Rovesti, Luca Reggiani Bonetti, Giulia Casari, Federico Banchelli, Luca Fabbiani, Elena Veronesi, Tiziana Petrachi, Paolo Magistri, Fabrizio Di Benedetto, Andrea Spallanzani, Chiara Chiavelli, Maria Carlotta Spano, Antonino Maiorana, Massimo Dominici, Giulia Grisendi
Summary: This study assessed the expression of TRAIL receptors in PDAC tumor tissue and stromal cells, finding that functional receptors were widely expressed and represented a promising treatment target. Low expression of decoy receptors in primary PDAC tumor cells was associated with a poor prognosis. A cellular-dense tumor stroma in PDAC was linked to reduced relapse-free survival.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Endocrinology & Metabolism
Genevieve Jolivet, Nathalie Daniel-Carlier, Erwana Harscoet, Eloise Airaud, Aurelie Dewaele, Cloe Pierson, Frank Giton, Laurent Boulanger, Nathalie Daniel, Beatrice Mandon-Pepin, Maelle Pannetier, Eric Pailhoux
Summary: This study demonstrates the essential role of estradiol in the formation of the ovarian reserve and the proliferation and differentiation of somatic and germ cells during female rabbit embryonic gonad development.
Article
Biology
Colin M. Cleary, Brenda M. Milla, Fu-Shan Kuo, Shaun James, William F. Flynn, Paul Robson, Daniel K. Mulkey
Summary: The study reveals a limited diversity of inhibitory neurons in the parafacial region around RTN, with Sst+ neurons seemingly uniquely inhibited by CO2/H+. These neurons play an important role in the respiratory activity of RTN.
Article
Immunology
Kensuke Suzuki, Masaki Tajima, Yosuke Tokumaru, Yuya Oshiro, Satoshi Negate, Haruhiko Kameda, Miho Kihara, Kohei Nakano, Tasuku Honjo, Akio Ohta
Summary: The PD-1 receptor plays a crucial role in suppressing immune responses and preventing inflammatory diseases. The use of anti-PD-1 antibodies as cancer treatment has become widespread, but understanding of the characteristics required for these antibodies to stimulate immunosuppressive activity is limited. A study showed that PD-1 agonist antibodies, which recognize the membrane-proximal extracellular region, can effectively suppress immune responses and have potential for treating inflammatory disorders.
SCIENCE IMMUNOLOGY
(2023)
Article
Developmental Biology
Jesus Lopez, Gabe Hohensee, Jing Liang, Meirav Sela, Joshua Johnson, Amanda N. Kallen
Summary: Ovarian aging is a complex process influenced by age, genetics, environment, and other factors that contribute to the depletion of the follicle pool. Molecular processes regulating the timing of ovarian aging have been identified, which are critical for maintaining follicular health. Further research is needed to determine the extent to which these potential regulators control follicle and oocyte behavior, as well as how these signals are integrated to control overall ovarian aging.
SEXUAL DEVELOPMENT
(2023)
Article
Obstetrics & Gynecology
Malene Lundgaard Riis, John E. Nielsen, Casper P. Hagen, Ewa Rajpert-De Meyts, Niels Graem, Anne Jorgensen, Anders Juul
Summary: Germ cell development in fetal Turner syndrome (TS) ovaries is severely affected in early second trimester pregnancies, with accelerated oogonia loss and impaired initiation of primordial follicle formation; the phenotype in TS mosaic ovaries is less severe.
HUMAN REPRODUCTION
(2021)
Article
Microbiology
Itai Doron, Marissa Mesko, Xin Li, Takato Kusakabe, Irina Leonardi, Dustin G. Shaw, William D. Fiers, Woan-Yu Lin, Meghan Bialt-DeCelie, Elvira Roman, Randy S. Longman, Jesus Pla, Patrick C. Wilson, Iliyan D. Iliev
Summary: sIgA in gut barrier protection plays a crucial role, with a portion induced and directed by intestinal fungi. sIgA can influence fungal morphotypes, regulating fungal commensalism, which might be dysregulated in patients with Crohn's disease.
NATURE MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Denyse Cavalcante Lago, Martin Hasselmann, Klaus Hartfelder
Summary: In this study, a comparative RNA-seq analysis was conducted on the larval gonads of honey bees at a critical stage of development. Differential gene expression was identified among the three sex and caste phenotypes, with enrichment in metabolism, protein or ion binding, and oxidoreductase activity. The analysis also revealed metabolic pathways as enriched. Despite programmed cell death in worker ovaries, the transcriptomes of queen and worker ovaries showed higher similarity compared to drone testis. RT-qPCR analysis identified DMRT A2 and Hsp83 as potential molecular markers for sex- and caste-specific gonad development in honey bees due to their upregulation in response to juvenile hormone.
INSECT MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Briana Hempel, Madeline Crissman, Sruti Pari, Benjamin Klein, Guo-Hua Bi, Hannah Alton, Zheng-Xiong Xi
Summary: This study found that approximately 70% of midbrain dopamine neurons express PPARα and PPARγ; in the amygdala, approximately 60% of glutamatergic neurons express PPARα, while approximately 60% of GABA neurons express PPARγ; no PPARα/γ signal was detected in GABA neurons in the nucleus accumbens. Furthermore, PPARα/γ play functional roles in the central nervous system effects of Delta(9)-THC, regulating the rewarding effects, anxiety, and locomotor activity induced by Delta(9)-THC.
MOLECULAR PSYCHIATRY
(2023)
Article
Cell Biology
Gufeng Liu, Quan Sun, Xiaoyi Wu, Ying Liu, Yang Chen, Zhengguo Cao, Yanhe Hu, Haibin Xia
Summary: This study confirmed the presence of clock genes in the cementum and described the potential regulatory effects of REV-ERB alpha. Immunohistochemistry analysis revealed clock protein expression in murine tooth-periodontal ligament-alveolar bone complexes. Experimental results showed that SR8278 inhibited the proliferation but promoted mineralization of cementoblast cells.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2023)
Article
Biochemistry & Molecular Biology
Shanu George, John Bear, Michael J. Taylor, Karthik Kanamalla, Christopher D. Fekete, Tzu-Ting Chiou, Celia P. Miralles, Theofilos Papadopoulos, Angel L. De Blas
Summary: Collybistin (CB) is a guanine nucleotide exchange factor selectively localized at GABAergic and glycinergic postsynapses. Different isoforms of collybistin are expressed in the brain, with CBSH3- protein playing a significant role in the regulation of the size of GABAergic postsynapse clusters, particularly in parvalbumin positive interneurons. The lack of CBSH3- expression is an important issue because it has a strong effect in promoting the postsynaptic clustering of gephyrin and GABA-A receptors.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Oncology
Sharon L. Eddie, Suzanne M. Quartuccio, Jie Zhu, Jessica A. Shepherd, Rajul Kothari, J. Julie Kim, Teresa K. Woodruff, Joanna E. Burdette
GYNECOLOGIC ONCOLOGY
(2015)
Article
Oncology
Suzanne M. Quartuccio, Subbulakshmi Karthikeyan, Sharon L. Eddie, Daniel D. Lantvit, Eoghainin O. HAinmhire, Dimple A. Modi, Jian-Jun Wei, Joanna E. Burdette
INTERNATIONAL JOURNAL OF CANCER
(2015)
Article
Oncology
Sharon L. Eddie, Suzanne M. Quartuccio, Eoghainin O. HAinmhire, Georgette Moyle-Heyrman, Dan D. Lantvit, Jian-Jun Wei, Barbara C. Vanderhyden, Joanna E. Burdette
Article
Chemistry, Medicinal
Kerry Anne Ness, Sharon L. Eddie, Stephanie Burton, Timothy Harrison, Paul Mullan, Rich Williams
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2016)
Review
Medicine, Research & Experimental
Sharon L. Eddie, J. Julie Kim, Teresa K. Woodruff, Joanna E. Burdette
EXPERIMENTAL BIOLOGY AND MEDICINE
(2014)
Article
Endocrinology & Metabolism
Rosemary A. L. Bayne, Sharon L. Eddie, Craig S. Collins, Andrew J. Childs, Henry N. Jabbour, Richard A. Anderson
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2009)
Article
Developmental Biology
Sharon L. Eddie, Andrew J. Childs, Henry N. Jabbour, Richard A. Anderson
MOLECULAR HUMAN REPRODUCTION
(2012)
Article
Multidisciplinary Sciences
Sander van den Driesche, Marion Walker, Chris McKinnell, Hayley M. Scott, Sharon L. Eddie, Rod T. Mitchell, Jonathan R. Seckl, Amanda J. Drake, Lee B. Smith, Richard A. Anderson, Richard M. Sharpe
Article
Reproductive Biology
Shelby M. King, Dimple A. Modi, Sharon L. Eddie, Joanna E. Burdette
JOURNAL OF OVARIAN RESEARCH
(2013)
Article
Genetics & Heredity
Lee B. Smith, Laura Milne, Nancy Nelson, Sharon Eddie, Pamela Brown, Nina Atanassova, Moira K. O'Bryan, Liza O'Donnell, Danielle Rhodes, Sara Wells, Diane Napper, Patrick Nolan, Zuzanna Lalanne, Michael Cheeseman, Josephine Peters
Article
Oncology
Charles M. Haughey, Debayan Mukherjee, Rebecca E. Steele, Amy Popple, Lara Dura-Perez, Adam Pickard, Mehjabin Patel, Suneil Jain, Paul B. Mullan, Rich Williams, Pedro Oliveira, Niamh E. Buckley, Jamie Honeychurch, Simon S. McDade, Timothy Illidge, Ian G. Mills, Sharon L. Eddie