Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn’s disease

Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies

(2021) Itai Doron et al.   CELL

Debaryomyces is enriched in Crohn’s disease intestinal tissue and impairs healing in mice

(2021) Umang Jain et al.   SCIENCE

Adaptive immunity induces mutualism between commensal eukaryotes

(2021) Kyla S. Ost et al.   NATURE

High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis

(2020) Bing Zhai et al.   NATURE MEDICINE

Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis

(2020) Irina Leonardi et al.   Cell Host & Microbe

BCR selection and affinity maturation in Peyer’s patch germinal centres

(2020) Huan Chen et al.   NATURE

Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ

(2020) Balázs Koscsó et al.   Science Immunology

High microbiota reactivity of adult human intestinal IgA requires somatic mutations

(2020) Johanna Kabbert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption

(2020) Aleksandra S. Chikina et al.   CELL

Mucosal IgA Prevents Commensal Candida albicans Dysbiosis in the Oral Cavity

(2020) Nicolas Millet et al.   Frontiers in Immunology

Implementation of a CRISPR-Based System for Gene Regulation in Candida albicans

(2019) Elvira Román et al.   mSphere

Malassezia Is Associated with Crohn’s Disease and Exacerbates Colitis in Mouse Models

(2019) Jose J. Limon et al.   Cell Host & Microbe

Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection

(2019) Jessica N. Witchley et al.   Cell Host & Microbe

Hemizygosity Enables a Mutational Transition Governing Fungal Virulence and Commensalism

(2019) Shen-Huan Liang et al.   Cell Host & Microbe

Profound mycobiome differences between segregated mouse colonies do not influence Th17 responses to a newly introduced gut fungal commensal

(2019) Itai Doron et al.   FUNGAL GENETICS AND BIOLOGY

Gut Mycobiota in Immunity and Inflammatory Disease

(2019) Xin V. Li et al.   IMMUNITY

Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants

(2019) Kathyayini P. Gopalakrishna et al.   NATURE MEDICINE

IgA and the intestinal microbiota: the importance of being specific

(2019) Oliver Pabst et al.   Mucosal Immunology

CX3CR1+mononuclear phagocytes control immunity to intestinal fungi

(2018) Irina Leonardi et al.   SCIENCE

Candida albicans -Induced Epithelial Damage Mediates Translocation through Intestinal Barriers

(2018) Stefanie Allert et al.   mBio

IgA Responses to Microbiota

(2018) Jeffrey J. Bunker et al.   IMMUNITY

Antibodies Set Boundaries Limiting Microbial Metabolite Penetration and the Resultant Mammalian Host Response

(2018) Yasuhiro Uchimura et al.   IMMUNITY

Response to Fungal Dysbiosis by Gut-Resident CX3CR1+ Mononuclear Phagocytes Aggravates Allergic Airway Disease

(2018) Xin Li et al.   Cell Host & Microbe

Experimental evolution of a fungal pathogen into a gut symbiont

(2018) Gloria Hoi Wan Tso et al.   SCIENCE

Intestinal fungi contribute to development of alcoholic liver disease

(2017) An-Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Diversity and functions of intestinal mononuclear phagocytes

(2017) T Joeris et al.   Mucosal Immunology

Natural polyreactive IgA antibodies coat the intestinal microbiota

(2017) Jeffrey J. Bunker et al.   SCIENCE

IgA-coatedE. colienriched in Crohn’s disease spondyloarthritis promote TH17-dependent inflammation

(2017) Monica Viladomiu et al.   Science Translational Medicine

An Update on Candida tropicalis Based on Basic and Clinical Approaches

(2017) Diana L. Zuza-Alves et al.   Frontiers in Microbiology

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life

(2016) Meghan A. Koch et al.   CELL

Fungal microbiota dysbiosis in IBD

(2016) Harry Sokol et al.   GUT

The human intestinal B-cell response

(2016) J Spencer et al.   Mucosal Immunology

Candidalysin is a fungal peptide toxin critical for mucosal infection

(2016) David L. Moyes et al.   NATURE

Bacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn’s Disease

(2016) G. Hoarau et al.   mBio

MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health

(2015) Jason L. Kubinak et al.   Cell Host & Microbe

Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease

(2015) James D. Lewis et al.   Cell Host & Microbe

BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity

(2015) Floris Fransen et al.   IMMUNITY

Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A

(2015) Jeffrey J. Bunker et al.   IMMUNITY

Fungal Dysbiosis in Mucosa-associated Microbiota of Crohn’s Disease Patients

(2015) Giuseppina Liguori et al.   Journal of Crohns & Colitis

Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization

(2015) Di Fan et al.   NATURE MEDICINE

Genus-Wide Comparative Genomics of Malassezia Delineates Its Phylogeny, Physiology, and Niche Adaptation on Human Skin

(2015) Guangxi Wu et al.   PLoS Genetics

Recognition of Aspergillus fumigatus Hyphae by Human Plasmacytoid Dendritic Cells Is Mediated by Dectin-2 and Results in Formation of Extracellular Traps

(2015) Flávio V. Loures et al.   PLoS Pathogens

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Segmented Filamentous Bacterium Uses Secondary and Tertiary Lymphoid Tissues to Induce Gut IgA and Specific T Helper 17 Cell Responses

(2014) Emelyne Lécuyer et al.   IMMUNITY

The HOG Pathway Is Critical for the Colonization of the Mouse Gastrointestinal Tract by Candida albicans

(2014) Daniel Prieto et al.   PLoS One

Fungal Morphogenesis

(2014) X. Lin et al.   Cold Spring Harbor Perspectives in Medicine

Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense

(2013) Julia Farache et al.   IMMUNOLOGY AND CELL BIOLOGY

Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism

(2013) Kalyan Pande et al.   NATURE GENETICS

White-Opaque Switching in Natural MTLa/α Isolates of Candida albicans: Evolutionary Implications for Roles in Host Adaptation, Pathogenesis, and Sex

(2013) Jing Xie et al.   PLOS BIOLOGY

Importance of the Candida albicans cell wall during commensalism and infection

(2012) Neil AR Gow et al.   CURRENT OPINION IN MICROBIOLOGY

Normal Adaptation of Candida albicans to the Murine Gastrointestinal Tract Requires Efg1p-Dependent Regulation of Metabolic and Host Defense Genes

(2012) Jessica V. Pierce et al.   EUKARYOTIC CELL

Mononuclear phagocyte diversity in the intestine

(2012) Milena Bogunovic et al.   IMMUNOLOGIC RESEARCH

A Versatile Overexpression Strategy in the Pathogenic Yeast Candida albicans: Identification of Regulators of Morphogenesis and Fitness

(2012) Murielle Chauvel et al.   PLoS One

Variation in Candida albicans EFG1 Expression Enables Host-Dependent Changes in Colonizing Fungal Populations

(2012) J. V. Pierce et al.   mBio

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

(2011) Markus B. Geuking et al.   IMMUNITY

Candida albicans Yeast and Hyphae are Discriminated by MAPK Signaling in Vaginal Epithelial Cells

(2011) David L. Moyes et al.   PLoS One

Candida albicans Als3, a Multifunctional Adhesin and Invasin

(2010) Yaoping Liu et al.   EUKARYOTIC CELL

Contribution of Candida albicans Cell Wall Components to Recognition by and Escape from Murine Macrophages

(2010) C. G. J. McKenzie et al.   INFECTION AND IMMUNITY

Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

(2010) S. Hapfelmeier et al.   SCIENCE

Candida albicans Colonization and ASCA in Familial Crohn's Disease

(2009) Annie Standaert-Vitse et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions

(2009) Olga Schulz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism

(2009) E. Slack et al.   SCIENCE

The Biology of Intestinal Immunoglobulin A Responses

(2008) Andrea Cerutti et al.   IMMUNITY