Article
Biochemistry & Molecular Biology
HaiXu Song, Jiayin Li, Chengfei Peng, Dan Liu, Zhu Mei, Zheming Yang, Xiaoxiang Tian, Xiaolin Zhang, Quanmin Jing, Chenghui Yan, Yaling Han
Summary: CREG1 protein is expressed in platelets and megakaryocytes, and its decreased expression is associated with thrombocytopenia. The study found that CREG1 plays an important role in megakaryocyte maturation and platelet production.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cell & Tissue Engineering
Sudjit Luanpitpong, Jirarat Poohadsuan, Phatchanat Klaihmon, Xing Kang, Kantpitchar Tangkiettrakul, Surapol Issaragrisil
Summary: This study reveals a novel regulatory role of O-GlcNAcylation in megakaryopoiesis and thrombopoiesis, showing that inhibition of O-GlcNAc transferase can promote platelet formation by interfering with c-Myc stability. The findings suggest a potential pathway for clinical applications towards ex vivo platelet production for transfusion in hematologic disorders.
Article
Toxicology
Xiaoting Jin, Hongyan Yu, Baoqiang Wang, Zhendong Sun, Ze Zhang, Qian S. Liu, Yuxin Zheng, Qunfang Zhou, Guibin Jiang
Summary: The study found that exposure to PM promotes thrombopoiesis in a concentration-dependent manner, inducing maturation and development of megakaryocytes by causing morphological changes, DNA ploidy occurrence, and alterations in biomarkers for platelet formation. The proteomics assay revealed that the main metabolic pathway regulating these changes was mitochondrial oxidative phosphorylation (OXPHOS). The findings suggest a potential perturbation of haze exposure in thrombopoiesis from megakaryocytes, providing new insights for assessing health risks from PM pollution.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
HaiXu Song, Jiahao Liu, Xiaoxiang Tian, Dan Liu, Jiayin Li, Xiaojie Zhao, Zhu Mei, Chenghui Yan, Yaling Han
Summary: The transcription factor CCAAT/enhancer-binding protein ? (C/EBP?) plays a crucial role in the differentiation and cell cycle control of megakaryocytes (MKs), potentially aiding in the treatment of thrombocytopenia and other platelet-related disorders.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Hematology
Andrew P. Stone, Thais F. Nascimento, Maria N. Barrachina
Summary: Megakaryocytes (MKs), the largest hematopoietic cells, can be generated from multiple pathways. Recent studies have shown that changes in the bone marrow microenvironment can affect MK development. MKs can also actively shape the bone marrow niche.
Article
Cell Biology
Huan Liu, Hellen Ishikawa-Ankerhold, Julia Winterhalter, Michael Lorenz, Mykhailo Vladymyrov, Steffen Massberg, Christian Schulz, Mathias Orban
Summary: The thrombopoietic activity of fetal liver megakaryocytes was found to be higher than that of yolk sac megakaryocytes. Fetal platelets are released mainly through membrane budding. This study also demonstrated the independence of embryonic thrombopoiesis from definitive hematopoiesis during early development.
Article
Medicine, Research & Experimental
Jia Lai, Yueyue Li, Mei Ran, Qianqian Huang, Feihong Huang, Linjie Zhu, Yuesong Wu, Wenjun Zou, Xiang Xie, Yong Tang, Fei Yang, Anguo Wu, Guangbo Ge, Jianming Wu
Summary: The active monomer xanthotoxin (XAT) was found to promote the differentiation and maturation of megakaryocytes and stimulate platelet formation. It activates the IL-1R1 target and MEK/ERK signaling pathway to accelerate the differentiation and maturation of megakaryocytes, providing a new pharmacotherapy strategy for thrombocytopenia.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Medicinal
Xijun Wu, Xinmei Yang, Krishnapriya M. Varier, Qing Rao, Jingrui Song, Lei Huang, Yubing Huang, Babu Gajendran, Zhixu He, Chunmao Yuan, Yanmei Li
Summary: Chronic myeloid leukemia is a significant disease causing human deaths worldwide, and the treatment plan is extremely important. Flavaglines are a natural class of compounds that exhibit various bioactivities, including anticancer effects. This study discovered that a newly synthesized flavagline derivative, A2074, can inhibit the proliferation of erythroleukemia cells, promote apoptosis, and enhance megakaryocyte differentiation. It also revealed the critical role of the c-MYC-miR-17-92-BIM axis in the growth and survival of chronic myeloid leukemia cells.
ARCHIV DER PHARMAZIE
(2022)
Article
Pharmacology & Pharmacy
Ting Zhang, Qi Mo, Nan Jiang, Yuesong Wu, Xin Yang, Wang Chen, Qinyao Li, Shuo Yang, Jing Yang, Jing Zeng, Feihong Huang, Qianqian Huang, Jiesi Luo, Jianming Wu, Long Wang
Summary: Radiation-induced thrombocytopenia (RIT), a common condition in cancer patients undergoing radiotherapy, lacks effective drugs for treatment. In this study, a drug screening model using naive Bayes was developed to identify compounds promoting platelet production. Methylophiopogonanone A (MO-A) was identified as the most active compound and shown to induce megakaryocyte differentiation in vitro. Moreover, MO-A significantly improved platelet recovery and megakaryocyte differentiation in RIT mice. Mechanistic analysis revealed that MO-A activates the FGF1/FGFR1/PI3K/Akt/NF-kappa B signaling pathway. This study provides a promising drug discovery strategy and identifies MO-A as a potential treatment for RIT.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Fei-Er Feng, Gao-Chao Zhang, Feng-Qi Liu, Yun He, Xiao-Lu Zhu, Xiao Liu, Yu Wang, Jing-Zhi Wang, Hai-Xia Fu, Yu-Hong Chen, Wei Han, Ying-Jun Chang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang, Xiao-Hui Zhang
Summary: Thrombocytopenia caused by HCMV infection may be influenced by the virus through specific pathways during megakaryocyte maturation, apoptosis, and platelet generation; Inhibitors targeting PDGFRα and αvβ3 significantly reduce HCMV infection in megakaryocytes, suggesting potential therapeutic alternatives for viral infections.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Hong Li, Xueqin Jiang, Xin Shen, Yueshan Sun, Nan Jiang, Jing Zeng, Jing Lin, Liang Yue, Jia Lai, Yan Li, Anguo Wu, Long Wang, Dalian Qin, Feihong Huang, Qibing Mei, Jing Yang, Jianming Wu
Summary: The study demonstrates that 3,3',4'-trimethylellagic acid can promote platelet formation and regulate megakaryocyte differentiation through the PI3K/Akt/mTOR signaling pathway, providing a potential therapeutic strategy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yu-Chuen Huang, Chun-Ping Huang, Chin-Ping Lin, Kai-Chien Yang, Yu-Jie Lei, Hao-Pei Wang, Yueh-Hsiung Kuo, Yu-Jen Chen
Summary: Daphnoretin extracted from the stem and roots of Wikstroemia indica has been found to inhibit cell growth and induce megakaryocytic differentiation in chronic myeloid leukemia cells. It shows potential as a differentiation therapy agent for CML, but further investigations are needed to validate its efficacy in vivo and in patients.
Article
Cell Biology
Mukul Mishra, Anil Kumar Singh, Gatha Thacker, Vishal Upadhyay, Sabyasachi Sanyal, Arun Kumar Trivedi
Summary: ORM can induce megakaryocytic and myeloid differentiation in the K562 cell line. This induction is mediated by activation of ERK and induction of autophagy. Additionally, inhibition of caspases can mitigate megakaryocytic differentiation. These findings suggest that ORM has potential as an inducer of megakaryocytic differentiation.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Wang Chen, Linjie Zhu, Long Wang, Jing Zeng, Min Wen, Xiyan Xu, LiLe Zou, Feihong Huang, Qianqian Huang, Dalian Qin, Qibing Mei, Jing Yang, Qiaozhi Wang, Jianming Wu
Summary: This study found that the aqueous extracts of Cibotii rhizoma (AECRs) can promote megakaryopoiesis and thrombopoiesis through activating the PI3K/AKT, MEK/ERK, and JAK2/STAT3 signaling pathways, which has the potential to treat radiation-induced thrombocytopenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yangge Du, Min Zhang, Xuejiao Liu, Zheng Li, Menglong Hu, Yueming Tian, Longwei Lv, Xiao Zhang, Yunsong Liu, Ping Zhang, Yongsheng Zhou
Summary: CDC20, in addition to its well-known role in cell cycle regulation, plays a crucial role in osteogenic commitment of BMSCs. It governs bone formation through regulating ubiquitination and degradation of p65, and knockdown of p65 rescues bone loss in Cdc20 conditional knockout mice.
Article
Cell Biology
Shilei Chen, Mengjia Hu, Mingqiang Shen, Yang Xu, Cheng Wang, Xinmiao Wang, Fengju Li, Dongfeng Zeng, Fang Chen, Gaomei Zhao, Mo Chen, Fengchao Wang, Tianmin Cheng, Yongping Su, Jinghong Zhao, Song Wang, Junping Wang
Article
Hematology
Mengjia Hu, Hao Zeng, Shilei Chen, Yang Xu, Song Wang, Yong Tang, Xinmiao Wang, Changhong Du, Mingqiang Shen, Fang Chen, Mo Chen, Cheng Wang, Jining Gao, Fengchao Wang, Yongping Su, Junping Wang
Article
Hematology
Shilei Chen, Mengjia Hu, Mingqiang Shen, Song Wang, Cheng Wang, Fang Chen, Yong Tang, Xinmiao Wang, Hao Zeng, Mo Chen, Jining Gao, Fengchao Wang, Yongping Su, Yang Xu, Junping Wang
Article
Biochemistry & Molecular Biology
Hao Zeng, Mengjia Hu, Yukai Lu, Zihao Zhang, Yang Xu, Song Wang, Mo Chen, Mingqiang Shen, Cheng Wang, Fang Chen, Changhong Du, Yong Tang, Yongping Su, Shilei Chen, Junping Wang
Article
Biology
Shuang Long, Guojian Wang, Mingqiang Shen, Na Zhao, Huimin Wan, Yang Xu, Song Wang, Cheng Wang, Jining Gao, Yuhui Hao, Aiping Wang, Rong Li, Xinze Ran, Yongping Su, Junping Wang, Tao Wang
RADIATION RESEARCH
(2019)
Article
Chemistry, Medicinal
Fang Chen, Yong Tang, Hong Zheng, Yang Xu, Junping Wang, Cheng Wang
Article
Oncology
Shuguang Pan, Ying Hu, Mengjia Hu, Yang Xu, Mo Chen, Changhong Du, Jinchi Cui, Ping Zheng, Jiejuan Lai, Yujun Zhang, Jie Bai, Peng Jiang, Jin Zhu, Yu He, Junping Wang
INTERNATIONAL JOURNAL OF ONCOLOGY
(2020)
Article
Hematology
Mengjia Hu, Yukai Lu, Hao Zeng, Zihao Zhang, Shilei Chen, Yan Qi, Yang Xu, Fang Chen, Yong Tang, Mo Chen, Changhong Du, Mingqiang Shen, Fengchao Wang, Yongping Su, Song Wang, Junping Wang
Summary: miR-21 plays a crucial role in maintaining HSC homeostasis and function, in part by regulating the PDCD4-mediated NF-kappa B pathway.
Correction
Oncology
Shuguang Pan, Ying Hu, Mengjia Hu, Yang Xu, Mo Chen, Chwanghong Du, Jinchi Cui, Ping Zheng, Jiejuan Lai, Yujun Zhang, Jie Bai, Peng Jiang, Jin Zhu, Yu He, Junping Wang
INTERNATIONAL JOURNAL OF ONCOLOGY
(2020)
Article
Endocrinology & Metabolism
Shilei Chen, Yan Qi, Song Wang, Yang Xu, Mingqiang Shen, Mengjia Hu, Changhong Du, Fang Chen, Mo Chen, Yukai Lu, Zihao Zhang, Yong Quan, Cheng Wang, Fengchao Wang, Junping Wang
JOURNAL OF PINEAL RESEARCH
(2020)
Article
Oncology
Mengjia Hu, Yukai Lu, Yan Qi, Zihao Zhang, Song Wang, Yang Xu, Fang Chen, Yong Tang, Shilei Chen, Mo Chen, Changhong Du, Mingqiang Shen, Fengchao Wang, Yongping Su, Youcai Deng, Junping Wang
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Na Zhao, Guojian Wang, Shuang Long, Dengqun Liu, Jining Gao, Yang Xu, Cheng Wang, Aiping Wang, Fengchao Wang, Yuhui Hao, Xinze Ran, Junping Wang, Yongping Su, Tao Wang
Summary: The study identifies an endogenous pattern involving Spink7 in the immune compartment as a key player in controlling chemokines/cytokines production, contributing to the resolution of inflammation in colitis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Cheng Wang, Shaobo Wang, Yin Chen, Jianqi Zhao, Songling Han, Gaomei Zhao, Jing Kang, Yong Liu, Liting Wang, Xiaoyang Wang, Yang Xu, Song Wang, Yi Huang, Junping Wang, Jinghong Zhao
Summary: Membrane nanoparticles derived from ACE2-rich cells were found to effectively block SARS-CoV-2 infection by trapping viral ligands and reducing viral recruitment to host cells. These ACE2-NPs also inhibited viral entry into cells and blocked infection, providing a promising avenue for COVID-19 treatment.
Article
Medicine, Research & Experimental
Yong Tang, Mengjia Hu, Yang Xu, Fang Chen, Shilei Chen, Mo Chen, Yan Qi, Mingqiang Shen, Cheng Wang, Yukai Lu, Zihao Zhang, Hao Zeng, Yong Quan, Fengchao Wang, Yongping Su, Dongfeng Zeng, Song Wang, Junping Wang
Article
Materials Science, Biomaterials
Gaomei Zhao, Yin Chen, Yongwu He, Fang Chen, Yali Gong, Shilei Chen, Yang Xu, Yongping Su, Cheng Wang, Junping Wang
BIOMATERIALS SCIENCE
(2019)