Bedside to bench in juvenile myelomonocytic leukemia: insights into leukemogenesis from a rare pediatric leukemia

Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm

(2014) Guangyao Kong et al.   JOURNAL OF CLINICAL INVESTIGATION

The RASopathies

(2013) Katherine A. Rauen   Annual Review of Genomics and Human Genetics

Fludarabine and Exposure-Targeted Busulfan Compares Favorably with Busulfan/Cyclophosphamide-Based Regimens in Pediatric Hematopoietic Cell Transplantation: Maintaining Efficacy with Less Toxicity

(2013) I.H. Bartelink et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Analysis of risk factors influencing outcomes after cord blood transplantation in children with juvenile myelomonocytic leukemia: a EUROCORD, EBMT, EWOG-MDS, CIBMTR study

(2013) F. Locatelli et al.   BLOOD

Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia

(2013) S. Gandre-Babbe et al.   BLOOD

Inhibition of SRC Corrects GM-CSF Hypersensitivity That Underlies Juvenile Myelomonocytic Leukemia

(2013) S. Bunda et al.   CANCER RESEARCH

CBL Linker Region and RING Finger Mutations Lead to Enhanced Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) Signaling via Elevated Levels of JAK2 and LYN

(2013) Mojib Javadi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In hematopoietic cells with a germline mutation of CBL, loss of heterozygosity is not a signature of juvenile myelo-monocytic leukemia

(2013) M Strullu et al.   LEUKEMIA

Deficiency of CREB and over expression of miR-183 in juvenile myelomonocytic leukemia

(2013) Y L Liu et al.   LEUKEMIA

Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness

(2013) Qing Li et al.   NATURE

Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia

(2013) Hirotoshi Sakaguchi et al.   NATURE GENETICS

Increased risk of gastrointestinal acute GVHD following the addition of melphalan to busulfan/cyclophosphamide conditioning

(2013) T. Mårtensson et al.   PEDIATRIC TRANSPLANTATION

Validation of flow cytometric phospho-STAT5 as a diagnostic tool for juvenile myelomonocytic leukemia

(2013) D Hasegawa et al.   Blood Cancer Journal

Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras-Driven Hematopoietic Transformation

(2013) J. Xu et al.   Cancer Discovery

Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia

(2012) S. Doisaki et al.   BLOOD

Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10

(2012) K. Oakley et al.   BLOOD

Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples

(2012) K. Kumano et al.   BLOOD

Spliceosomal gene aberrations are rare, coexist with oncogenic mutations, and are unlikely to exert a driver effect in childhood MDS and JMML

(2012) S. Hirabayashi et al.   BLOOD

A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation

(2012) H. Huang et al.   GENES & DEVELOPMENT

Genetic disruption of the PI3K regulatory subunits, p85 , p55 , and p50 , normalizes mutant PTPN11-induced hypersensitivity to GM-CSF

(2012) C. B. Goodwin et al.   HAEMATOLOGICA

Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice

(2012) Tiffany Chang et al.   JOURNAL OF CLINICAL INVESTIGATION

Neoplasms Associated with Germline and Somatic NF1 Gene Mutations

(2012) S. Patil et al.   ONCOLOGIST

Outcomes of immunological interventions for mixed chimerism following allogeneic stem cell transplantation in children with juvenile myelomonocytic leukemia

(2012) Jiro Inagaki et al.   PEDIATRIC BLOOD & CANCER

Gene mutations in the Ras pathway and the prognostic implication in Korean patients with juvenile myelomonocytic leukemia

(2011) Hyung-Doo Park et al.   ANNALS OF HEMATOLOGY

Aberrant DNA methylation characterizes juvenile myelomonocytic leukemia with poor outcome

(2011) C. Olk-Batz et al.   BLOOD

Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemia

(2011) Mignon L. Loh   BRITISH JOURNAL OF HAEMATOLOGY

Hurdles Toward a Cure for CML: The CML Stem Cell

(2011) Paolo Gallipoli et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

A MEK Inhibitor Abrogates Myeloproliferative Disease in Kras Mutant Mice

(2011) N. Lyubynska et al.   Science Translational Medicine

Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus

(2010) Q. Li et al.   BLOOD

Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation

(2010) M. Takagi et al.   BLOOD

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common  -subunit

(2010) M. Perugini et al.   BLOOD

Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis

(2010) J. E. Niemela et al.   BLOOD

Genetic typing of CBL, ASXL1, RUNX1, TET2 and JAK2 in juvenile myelomonocytic leukaemia reveals a genetic profile distinct from chronic myelomonocytic leukaemia

(2010) Benoîte Pérez et al.   BRITISH JOURNAL OF HAEMATOLOGY

MicroRNA miR-183 Functions as an Oncogene by Targeting the Transcription Factor EGR1 and Promoting Tumor Cell Migration

(2010) A. L. Sarver et al.   CANCER RESEARCH

Mutations in the let-7 binding site - a mechanism of RAS activation in juvenile myelomonocytic leukemia?

(2010) D. Steinemann et al.   HAEMATOLOGICA

Gene Expression–Based Classification As an Independent Predictor of Clinical Outcome in Juvenile Myelomonocytic Leukemia

(2010) Silvia Bresolin et al.   JOURNAL OF CLINICAL ONCOLOGY

Germline mutations of the CBL gene define a new genetic syndrome with predisposition to juvenile myelomonocytic leukaemia

(2010) B. Perez et al.   JOURNAL OF MEDICAL GENETICS

Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia

(2010) Charlotte M Niemeyer et al.   NATURE GENETICS

De novo mutations of SETBP1 cause Schinzel-Giedion syndrome

(2010) Alexander Hoischen et al.   NATURE GENETICS

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis

(2009) G. Chan et al.   BLOOD

Intriguing response to azacitidine in a patient with juvenile myelomonocytic leukemia and monosomy 7

(2009) I. Furlan et al.   BLOOD

Mutations in CBL occur frequently in juvenile myelomonocytic leukemia

(2009) M. L. Loh et al.   BLOOD

Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia

(2009) H. Muramatsu et al.   BLOOD

Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms

(2009) F. H. Grand et al.   BLOOD

Germ-line mutation of theNRASgene may be responsible for the development of juvenile myelomonocytic leukaemia

(2009) Paola De Filippi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Mutations of E3 Ubiquitin Ligase Cbl Family Members Constitute a Novel Common Pathogenic Lesion in Myeloid Malignancies

(2009) Hideki Makishima et al.   JOURNAL OF CLINICAL ONCOLOGY

Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms

(2009) Masashi Sanada et al.   NATURE

Correlation of Clinical Features With the Mutational Status of GM-CSF Signaling Pathway-Related Genes in Juvenile Myelomonocytic Leukemia

(2009) Nao Yoshida et al.   PEDIATRIC RESEARCH

Oncogenic Kras Initiates Leukemia in Hematopoietic Stem Cells

(2009) Amit J Sabnis et al.   PLOS BIOLOGY

Genotype-phenotype correlation in cases of juvenile myelomonocytic leukemia with clonal RAS mutations

(2008) C. Flotho et al.   BLOOD

Feasibility study of preemptive withdrawal of immunosuppression based on chimerism testing in children undergoing myeloablative allogeneic transplantation for hematologic malignancies

(2008) B Horn et al.   BONE MARROW TRANSPLANTATION

Paediatric myelodysplastic syndromes and juvenile myelomonocytic leukaemia: molecular classification and treatment options

(2008) Charlotte Marie Niemeyer et al.   BRITISH JOURNAL OF HAEMATOLOGY

Single-Cell Profiling Identifies Aberrant STAT5 Activation in Myeloid Malignancies with Specific Clinical and Biologic Correlates

(2008) Nikesh Kotecha et al.   CANCER CELL

A SNP in a let-7 microRNA Complementary Site in the KRAS 3' Untranslated Region Increases Non-Small Cell Lung Cancer Risk

(2008) L. J. Chin et al.   CANCER RESEARCH

250K Single Nucleotide Polymorphism Array Karyotyping Identifies Acquired Uniparental Disomy and Homozygous Mutations, Including Novel Missense Substitutions of c-Cbl, in Myeloid Malignancies

(2008) A. J. Dunbar et al.   CANCER RESEARCH

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Aberrant GM-CSF signal transduction pathway in juvenile myelomonocytic leukemia assayed by flow cytometric intracellular STAT5 phosphorylation measurement

(2008) G Gaipa et al.   LEUKEMIA

Juvenile myelomonocytic leukemia: A report from the 2nd International JMML Symposium

(2008) Rebecca J. Chan et al.   LEUKEMIA RESEARCH