Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition

The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers

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Mining TCGA Data Using Boolean Implications

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A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells

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Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia

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The Origin and Evolution of Mutations in Acute Myeloid Leukemia

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Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation

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Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

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Polycomb repressive complex 2 is required for MLL-AF9 leukemia

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Base-Pair Resolution DNA Methylation Sequencing Reveals Profoundly Divergent Epigenetic Landscapes in Acute Myeloid Leukemia

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Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

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Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

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Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

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Mutations of the Wilms tumor 1 gene (WT1) in older patients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

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Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

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DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

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Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes

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Mutation of the Wilms’ Tumor 1 Gene Is a Poor Prognostic Factor Associated With Chemotherapy Resistance in Normal Karyotype Acute Myeloid Leukemia: The United Kingdom Medical Research Council Adult Leukaemia Working Party

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An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

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Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line

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Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

(2008) Manching Ku et al.   PLoS Genetics

Boolean implication networks derived from large scale, whole genome microarray datasets

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Cancer Epigenetics: Modifications, Screening, and Therapy

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