Downregulation of RUNX1/CBF  by MLL fusion proteins enhances hematopoietic stem cell self-renewal

MLL fusion protein-driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction

(2013) A. G. Muntean et al.   BLOOD

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

(2013) Susumu Goyama et al.   JOURNAL OF CLINICAL INVESTIGATION

The MLL recombinome of acute leukemias in 2013

(2013) C Meyer et al.   LEUKEMIA

RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction

(2013) Adam C. Wilkinson et al.   Cell Reports

Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells

(2012) Y. Zhang et al.   BLOOD

Disordered epigenetic regulation in MLL-related leukemia

(2012) Yue Zhang et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

(2011) G. Huang et al.   BLOOD

Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through down-regulation of p19ARF

(2011) N. Nishimoto et al.   BLOOD

Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin

(2011) N. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of leukemogenesis by MLL fusion proteins

(2010) Rolf Marschalek   BRITISH JOURNAL OF HAEMATOLOGY

MLL fusions: Pathways to leukemia

(2010) Han Liu et al.   CANCER BIOLOGY & THERAPY

The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis

(2010) Andrew G. Muntean et al.   CANCER CELL

Mixed lineage leukemia: a structure-function perspective of the MLL1 protein

(2010) Michael S. Cosgrove et al.   FEBS Journal

Mixed lineage leukemia: roles in human malignancies and potential therapy

(2010) Rolf Marschalek   FEBS Journal

The leukemogenic AF4–MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures

(2010) A Benedikt et al.   LEUKEMIA

Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi

(2010) Johannes Zuber et al.   NATURE BIOTECHNOLOGY

CHIP functions an E3 ubiquitin ligase of Runx1

(2009) Yu Shang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure of the MLL CXXC domain–DNA complex and its functional role in MLL-AF9 leukemia

(2009) Tomasz Cierpicki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-κB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes

(2009) I Robert et al.   ONCOGENE

The PHD fingers of MLL block MLL fusion protein-mediated transformation

(2008) A. G. Muntean et al.   BLOOD

Loss of MLL PHD Finger 3 Is Necessary for MLL-ENL-Induced Hematopoietic Stem Cell Immortalization

(2008) J. Chen et al.   CANCER RESEARCH

Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2

(2008) C Bach et al.   ONCOGENE