Mixed lineage leukemia: roles in human malignancies and potential therapy

Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients

(2009) Luca Trentin et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

New insights to the MLL recombinome of acute leukemias

(2009) C Meyer et al.   LEUKEMIA

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

(2009) Andrea Viale et al.   NATURE

KLF4 and PBX1 Directly RegulateNANOGExpression in Human Embryonic Stem Cells

(2009) Ken Kwok-Keung Chan et al.   STEM CELLS

Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia

(2009) Dorothee Mueller et al.   PLOS BIOLOGY

HOXA9 is required for survival in human MLL-rearranged acute leukemias

(2008) J. Faber et al.   BLOOD

In Childhood Acute Lymphoblastic Leukemia, Blasts at Different Stages of Immunophenotypic Maturation Have Stem Cell Properties

(2008) Christoph le Viseur et al.   CANCER CELL

Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes

(2008) Akihiko Yokoyama et al.   CANCER CELL

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

(2008) Andrei V. Krivtsov et al.   CANCER CELL

Glycogen Synthase Kinase-3 Inhibition Induces Glioma Cell Death through c-MYC, Nuclear Factor- B, and Glucose Regulation

(2008) S. Kotliarova et al.   CANCER RESEARCH

Identification of an antiapoptotic protein complex at death receptors

(2008) M Sun et al.   CELL DEATH AND DIFFERENTIATION

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

(2008) X. Guo et al.   GENES & DEVELOPMENT

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

(2008) Zhong Wang et al.   NATURE